Post on 05-Jan-2016
description
transcript
Searching theChemical Literature
What types of information are in the literature?
Physical constants Melting point, boiling point, flash point, density, solubility
data, toxicity data, refractive index.
Synthesis pathways
Experimental procedures
Spectroscopy data FTIR, 1H-NMR, 13C-NMR, MS, UV-VIS
Background for research
Where search?
Google?
Reference books
Merck Index
CRC Handbook of Chemistry and Physics
March
The Merck Index
The Merck Index is a one-volume encyclopedia of chemicals, drugs and biologicals that contains more than 10,000 monographs. Each monograph in this authoritative reference source is a concise description of a single substance or a small group of closely related compounds.
Since it was first published in 1889, The Merck Index has become the standard reference for chemists, biochemists, pharmacologists, pharmacists, and related professionals.
The Merck Index Compounds included: human and veterinary drugs biotech drugs and monoclonal antibodies substances used for medical imaging biologicals and natural products plants and herbal medicines nutraceuticals and cosmeceuticals agricultural chemicals industrial chemicals laboratory reagents and catalysts dyes, colors and indicators environmentally significant substances
The Merck Index
Information provided:
chemical, common and generic names trademarks and associated companies CAS Registry Numbers chemical structures molecular formulae, weights and percentage
composition capsule statements identifying compound
classes and scientific significance
The Merck IndexInformation provided continued:
scientific and patent literature references physical and toxicity data therapeutic and commercial uses caution and hazard information In addition, there are Name, Formula, CAS Registry
Number, and Therapeutic Category and Biological Activity indices. The collection of supplementary tables contains physical, chemical and biomedical data and listings of pharmaceutical company names, locations and experimental drug codes. The Organic Name Reactions section contains over 400 reactions featuring descriptions, literature references and graphical depictions.
The Merck Index, 9th ed.
The Merck Index, 9th ed.
The Merck Index, 9th ed.
The Merck Index, 9th ed.
CRC Handbook of Chemistry and Physics
The Table of Physical Constants for Organic Compounds:
Listed in alphabetical order by parent name.
For 2-phenylethanol
Ethanol
-2-phenyl
CRC Handbook of Chemistry and Physics
The Table of Physical Constants for Organic Compounds:
Boiling points:
254760, 12434
CRC CRC Handbook of Handbook of Chemistry Chemistry
and Physics, and Physics, 11stst student student
editionedition
CRC CRC Handbook of Handbook of Chemistry Chemistry
and Physics, and Physics, 1st student 1st student
editionedition
March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure , 6th ed.
MarchMarch, 4, 4thth ed.ed.
March, March, 4th ed.4th ed.
Other sources…. Chemical Abstracts, Beilstein SciFinder Journal articles/Databases
ACS Publications Chemical and Engineering News
GALILEO (Current Contents: JACS, JOC) JStor (Science)
Primary = original Secondary = reviews, accounts
Chemfinder
May need to register yourself (free) to install plug-ins
ChemFinder
search using name, CAS number, molecular formula, MW
ChemACX Net
search using name or CAS number, or Advanced Query for
substructure or exact structure
Organic Synthesis
10 collective volumes, search using substructure, reaction,
keyword, name, CAS number, or volume
Spectroscopy websites
National Institute of Standards and Technology
Chemistry WebBook Mass Spectrometry and Infrared Spectroscopy data,
thermochemical data, and much, much more.
Spectral Data Base System for Organic Compounds
(SDBS) Huge searchable database of spectra, including IR, NMR,
and MS.
Safety Information
Vermont SIRI MSDS Collection Provides access to Material Safety Data Sheets
directly from chemical manufacturers and from an online database. Chemical Toxicity reports can also be found at this site.