Post on 03-Jun-2015
transcript
Abdominal Aortic Aneurysms
Diagnosis and treatment
AAA defintion
Normal aorta Aorta with an abdominal aneurysm
Varies by age, gender, body surface area
Typically diagnosed if aortic diameter is ≥ 3.0 cm*
*ACC/AHA Guidelines on PAD Circulation 2006;113:e463-465.
Prevalence of AAA
In the US, AAA causes almost 14 000 deaths each year and accounts for 63 000 hospital discharges
Age (years) Men Women
2.9 - 4.9 cm45-54 1.3% 0%
75-84 12.5% 5.2%
ACC/AHA Guidelines on PAD Circulation 2006;113:e463-465.
Risk factors associated with AAA
Older age
Male sex
Family hx
Smoking
Hypertension
Dyslipidemia
Atherosclerotic disease
COPD
ACC/AHA Guidelines on PAD Circulation 2006;113:e463-465.
Types of AAA
Morphological classification
• fusiform aneurysms
• saccular aneurysms
• dissecting aneurysms
• pseudo-aneurysms
Segments involved
• thoracic
• thoraco-abdominal
• abdominal
• main branches of the aorta
• iliac arteries
AAA Sequelae
Natural history• gradual and/or sporadic expansion• accumulation of mural thrombus
Complications• rupture• thromboembolic events• compression of adjacent structures
Progression of a AAA
Pathological changes cause the aorta wall to• become thinner• bulge• tear• rupture
Growth rate of AAA
Initial size (cm)
Mean growth rate (cm/yr) 95% CI
3.0- 3.9 0.39 0.20-0.57
4.0-4.9 0.36 0.21-0.50
5.0-5.9 0.43 0.27-0.60
6.0-6.9 0.64 0.16-1.10
Tan W Abdominal Aortic Aneurysm Rupture www.emedicine.com
Symptoms of AAA rupture
Abdominal/back pain
Pulsatile abdominal mass
Hypotension
Clinical triad occurs in only about one-third of cases.
ACC/AHA Guidelines on PAD Circulation 2006;113:e463-465.
AAA: risk of rupture
Simplifed estimates based on various studies
Tan W Abdominal Aortic Aneurysm Rupture www.emedicine.com
0
Risk of rupture for untreated aneurysm within 5 years (%)
10
7060
4050
3020
80
25%35%
75%
Aneurysm size5-5.9cm 6-6.9cm ≥7cm
Rupture outcomes
Mortality rate can be as high as 80%[1]
More than one third of rupture cases die outside the hospital[2]
Ruptured AAA
1. Adam. J Vasc Surg 1999;30:922-8.
2. Thomas. Br J Surg Aug 1988
Operative mortality
35-70% for ruptured aneurysm
Pae. J Am Surg 2007; Qureshi. Ann Vasc Surg 2007; Greco. J Vasc Surg 2006; Pepplenbosch. J Vasc Surg 2006; Visser. Eur J Vasc Endovasc Surg 2005; Brown. Br J Surg 2002; Heller. J Vasc Surg 2000; Adam. J Vasc Surg 1999; Johansen. J Vasc Surg 1991; Ouriel. J Vasc Surg 1990.
1.0-8.0% for elective AAA casesQureshi. Ann Vasc Surg 2007; Cowan. Ann NY Acad Sci 2006; Heller. J Vasc Surg 2000; Bradbury. Br J Surg 1998; Blankensteijn. Br J Surg 1998.
ACC/AHA screening high-risk
Men ≥ 60 yrs who are siblings or offspring of AAA patients
Men 65-75 yrs who have ever smoked
Physical exam and ultrasound
ACC/AHA Guidelines on PAD Circulation 2006;113:e463-465.
Class IClass IIa
Class IIbClass III
Diagnosis: physical exam
In one study (N=198)• 48% of AAA cases were diagnosed clinically• physical exam missed 38% of cases detected
radiologically
Karkos CD. Eur J Vasc Endovasc Surg 2000;19:299-303.
Sensitivity of physical exam
Lederle. JAMA 1999;281:77-82.
Aneurysm diameter
Sensitivity
3.0-3.9 cm 29%
4.0-4.9 cm 50%
≥ 5.0 cm 76%
Pooled analysis of 15 studies
Sensitivity of ultrasound
Ranges from 82% to 99%
Approx 100% in cases with a pulsatile mass
In a small proportion of patients, visualization of the aorta inadequate due to obesity, bowel gas, or periaortic disease
Quill. Surg Clin North Am 1989;69:713-20.
Ultrasound screening
5
20
8
29
9
27
0
5
10
15
20
25
30
Number
Emergency Ops Rupturedaneurysms
AAA deaths
Screened Control
Lindholdt. BMJ 2005;330:750.
Controlled screening trial of men age 65 to 73 ITT analysis n=6333 screened, n=6306 control
P=0.002P=0.001 P=0.003
ACC/AHA Guidelines AAA repairInfrarenal/juxtarenal AAA ≥5.5 cm should undergo repair; 4.0-5.4 cm, ultrasound/CT scans every 6-12 mo
Repair can be beneficial for infrarenal/juxtarenal AAAs 5.0-6.0
cm
Repair probably indicated for suprarenal/type IV thoracoabdominal AA >5.5-6.0cm
AAA <4.0cm, ultrasound every 2-3 years is reasonable
Intervention not recommended asymptomatic infrarenal/ juxtarenal AAAs <5.0 cm (men) or <4.5 cm (women)
ACC/AHA Guidelines on PAD Circulation 2006;113:e463-465.
Class IClass IIa
Class IIbClass III
Treatment options
Endovascular stent graftingOpen surgery
Open repair: advantages
Established procedure more than 40 years of clinical experience
Excludes aneurysm and prevents sac growth
Proven, long-term results
Open surgical repair (OSR): drawbacks
Significant incision in the abdomen
30–90 minute cross-clamp
Up to 4-hour procedure
1–2 days intensive care7–14 days hospitalization4–6 weeks recovery time
Contraindications to OSR
High anesthesia risk
Severely obese
Significant cardiac co-morbidities
Previous abdominal surgery/hostile abdomen
Difficult recovery for patient:
• risks functional impairment [1]
• risk of erectile dysfunction [2]
1. Williamson. J Vasc Surg 2001;33:913-920.
2. Lee. Ann Vasc Surg 2000;14:13-19.
Early OSR vs watchful waiting
Endpoint Relative risk 95% CI
All cause mortality 1.01 0.77-1.32
Aneurysm-related mortality 0.78 0.56-1.10
Combined ADAM and UKSAT trials of early/immediate OSR vs surveillance/delayed OSR for AAA < 5.5 cm
N = 2226
Lederle. Ann Intern Med 2007;146:735-741.
Endovascular aneurysm repair (EVAR)
Benefits• minimally invasive• reduced risk of
perioperative death• faster recovery
Preoperative angiogram Postoperative angiogram
®
AAA repair with stent graft
EVAR
Drawbacks
Complications and re-interventions• intrasac endoleaks• stent graft migration• modular dislocation
Morphology suitable for endovascular repair
• adequate vascular access
• appropriate aortic neck length and angulation
Endovascular stent grafting
EVAR vs OSR 30-day outcomes
Trial Endpoint EVAR OPEN P
EVAR [1]
N=1082 ≥ 5.5 cm
Mortality 1.7 % 4.7 % 0.009
Secondary interventions
9.8 % 5.8 % 0.02
DREAM [2] N=345
≥ 5.0 cm
Mortality 1.2 % 4.6 % 0.1
Mortality & severe complications
4.7 % 9.8 % 0.1
1. Lancet 2004;364:843-8.
2. N Engl J Med 2004;351:1607-1618.
EVAR vs OSR 2-year outcomesDREAM
Endpoint EVAR OPEN P
Survival 89.7% 89.6% 0.86
Survival free of moderate-severe complications
65.6% 65.9% 0.88
Aneurysm-related death 2.1% 5.7% 0.05
N Engl J Med 2005;352:2398-405.
DREAM: sexual dysfunction*
Both EVAR and open repair have a negative impact on sexual function in the early postoperative period.
After EVAR, recovery to preoperative levels is faster than after open repair.
At 3 months, sexual dysfunction levels are similar in both groups.
*Measured 5 aspects (interest, pleasure, engagement, orgasm, erection)
N=153
Prinssen. J EndovascTher 2004;11:613-620.
Erectile dysfunction
Erectile function worsened after open repair (p=0.002)
Orgasmic function deteriorated after open repair (p=0.001)
Endovascular repair was not accompanied by decreased erectile or orgasmic function (p=0.057 and p=0.068, respectively)
Impairment not associated with age, diabetes, or number of patent hypogastric arteries after repair
Significant association between impaired erectile function and open aneurysm repair (p=0.036)
N=90
Xenos. Ann Vasc Surg 2003;17:530-538.
Agency for Healthcare Research & Quality review of EVAR vs open surgical repair
Lower perioperative morbidity and mortality
Persistent reduction in AAA-defined mortality to 4 years
No improvement in long-term overall survival or health status
For AAA ≥ 5.5 cm
AHRQ Publication No. 06-E017 August 2006
Medicare cohort 4 yr outcomes
Endpoint* EVAR OPEN P
Periop mortality 1.2 % 4.8 % <0.001
AAA rupture 1.8 % 0.5 % <0.001
AAA reintervention 9.0% 1.7% <0.001
Laparotomy-related
Reintervention 4.1% 9.7% <0.001
Hospitalization 8.1% 14.2% <0.001
Schmermerhorn N Engl J Med 2008;358:464-474.
* All 4 yr except perioperative mortality N=22 830 matched patients
Ongoing studies EVAR vs OSR
France• Anévrisme de l’aorte abdominale: chirurgie
versus endoprothèse (ACE)ClinicalTrials.gov identifier: NCT00224718
US• Open versus endovascular repair (OVER) trial
for AAA • ClinicalTrials.gov identifier: NCT00094575