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solutions
zulfiayu
S1 Farmasi UNG Mei 2013
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definition
Homogeneous mixture that is prepared by
disolving a solid, liquid or gas in another liquid
and represent a group of the praparation in
substance are dispensed among those of the
solvent
A liquid preparation that contains one or more
soluble chemical substance dissolved in water
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definiton
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True Solution
The dispersed substance (the solute) and
dispersing medium (the solvent, the solution
phase contains the same chemical entity as
,the solvent, the solute is recovered unchange.
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Classification
Depending on the size of the dispersed particle :
a. True solution
b. Colloidal solution
c. Suspension
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Solubility
Kelarutan atau solubilitas adalah kemampuan suatu
zat kimia tertentu, zat terlarut (solute), untuk larut
dalam suatu pelarut (solvent). Kelarutan dinyatakan
dalam jumlah maksimum zat terlarut yang larut
dalam suatu pelarut pada kesetimbangan. Larutan
hasil disebut larutanjenuh. Zat-zat tertentu dapat
larut dengan perbandingan apapun terhadap suatu
pelarut. Contohnya adalah etanol di dalam air. Sifat
ini lebih dalam bahasa Inggris lebih tepatnya disebutmiscible.
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Solubility
Secara kuantitatif,kelarutan suatu zat
dinyatakan sebagai suatu konsentrasi zat
terlarut di dalam larutan jenuhnya pada suhu
.dalam satuan mililiter pelarut yang dapat
melarutkan satu gram zat. Misalnya 1 gr asam
salisilat akan larut dalam 550 ml air. Suatu
kelarutan juga dapat dinyatakan dalam satuanmolalitas, molaritas dan persen
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Solubility
Descritive Term Parts of solvent for 1 partof solute
Very soluble
Less than 1
From 1 to 10
Soluble
Sparingly soluble
Very slightly soluble
Partically insoluble orinsoluble
From 10 to 30
From 30 to 100
From 100 to 1000
From 1000 to 10.000
More than 10.000
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advantages
Patients in occasion ar unable to ingest a solid
dosage form
Therapeutic advantages
O er iversity in t e orm o me ication
Enhance effect of drugs rather in solid dosage
form
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disadvantages
Patient do not acces to accurate measuring
devices and a uniform volume from those o
another
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clasification
solution for internal use
solution for external use
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Internal use
Syrup
elixir
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Elixir
Combines the advantages of sweetness,
pleasant flavor and alcoholic content.
The alcoholic content may vary from as low as
- - .
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syrups
The tof syrups as vehicle has the advantages
of satisfactory masking of unpleasant tastes.
Sirup simplex?
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External use
Collyrium Collutorium
Collunarium
Gargle
Draught
Inhalation/aerosol
Injection
Enema
douche
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definition
Collyrium : solution intended to be used in the
eyes
Collutorium : solution intended to be used as
Collunarium : solution intended to be used in
the nose
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A gargle : solution intended to be used in the mouth
and throat
Spray and drops : solution intended to be
administered by being sprayed or dropped on th
affected area
Draught : intended to be taken as a single dose
Inhalation or aerosol : a solution of volatile
ingredients whose fumes are intended to be inhaled
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Injection : solution intended to be injected
into the body by means of a syringe.
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douches
An aqueous solution, used as an irrigation or
wash, whisch is applied a low pressure o
cleanse, deodorize, soohe, or medicate
, , . May promote healing, or be astringent,
antiseptic, or germicidal.
Used at vaginal tract, surgical prosedure, eye,
ear, nose,throat, bladder, colon, or kidney
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ENEMA
Placed in the rectum or colon to cause
evacuation or to bring a local or systemic
therapeutic ction.
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Terima kasih