Post on 22-Jan-2016
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Structural Genomics – an example of transdisciplinary research at Stanford
Goal of structural and functional genomics is to determine and analyze all possible protein structures based on target selection criteria utilizing advanced methodology and technology
Joint Center for Structural Genomics Involves scientists from Stanford, UCSD,
Scripps, Berkeley, and Salk with collaborators from around the world
Is developing advanced methods for automated determination of protein structures using a transdisciplinary approach
Is one of 7 centers in the USAfunded as pilot center by NIH-NIGMS
Is positioned to take on worldwide leadership in structural genomics
Transdisciplinary Approach to Life Sciences Development of crystallographic algorithms to automate structure
determination (Mathematics/Physics/Structural Biology) Utilization of artificial intelligence to develop rule based systems
for optimization of overall process (Computer Sciences) Development of large scale databases for storage of
experimental data and development of data mining for analysis (Information Sciences)
Development of robotics systems for sample handling under cryogenic conditions (mechanical and electrical engineering)
Development of advanced beam line instrumentation for automated data collection (synchrotron research)
Target Selection (genetics and proteomics) Target expression and crystallization (biochemistry and molecular
biology) Structural and functional analysis (proteomics and bioinformatics)
Bio-X Satellite at SSRL –
addressing Stanford’s needs in Structural Molecular Biology and home to Stanford’s structural genomics initiative
Motivation, Perspectives and Goals
Enabling students and postdoctoral fellows to be trained on one of the world’s premier facilities for Structural Molecular Biology in an integrated environment that stimulates and fosters new scientific ideas
Intellectual Strength at Stanford outstanding students and postdoctoral fellows outstanding faculty in strong programs in the life, physical and engineering
sciences with strong interest in and need for knowledge of biomolecular structure
SSRL Advantage in Infrastructure and as a Component of Bio-X SSRL in collaboration with The Scripps Research Institute and UCSD forms the
Joint Center for Structural Genomics funded by the NIH-NIGMS SSRL provides world class capabilities easily accessible to departments on
campus very strong existing SSRL program in structural biology (3 faculty, 9 scientists,
29 support staff) special expertise in large/complex systems, specialized instrumentation and
new methodology Stanford has new beam line (BL11-1) for enabling frontier macromolecular
crystallography research
Possible Integration within the Framework of Bio-X satellite activity on the SLAC campus located adjacent to synchrotron
experimental hall workshop-like atmosphere facilitates interaction among Stanford
students/postdoctorals, scientific staff, and a large and growing international user community
space for on-site “off-line” x-ray equipment for screening and data collection maintained by trained staff and sharing on-site spares for detectors and computers
opportunity for locating and supporting other core activities like parallel compute farms which leverage on expertise at SLAC in managing high performance, high storage capacity systems
Opportunities and Challenges in the Post Genome Sequencing Era