SupportingInformation:

“Directed Formation of Silica by a Non-Polypeptide Block

Copolymer Enzyme Mimic”

ChetanC.Hire,AndrewJ.Oyer,GinaE.Macek,JenniferL.Bento,andDouglasH.

Adamson

PolymercharacterizationincludedbothGPCandNMR.Examplesofeachareincludedbelow.SI1.

ThermalGravimetricAnalysiswasobtainedusingaTAInstruments2950.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

SI2.

SolidstateNMRofsilicaformedbybio‐mimeticblockcopolymer.Thesilicon‐29(29Si)solid‐statemagicanglespinning(MAS)nuclearmagneticresonancespectrawasacquiredusingaBrukerAscend400WBspectrometeroperatingat79.42MHz.A29SiNMRMASspectrumwasobtainedusingasingle45°rfpulse(3.5μs)separatedby120srecycledelays.Thespectralwidthwas30kHz,andatotalof3000scanswereacquired.Thespinningratewas5kHzatroomtemperatureusinga4mmrotor.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

SI3.

TEMimageofsilicaspherefragmentindicatingamorphoussilica.TheimageswereobtainedbyuseofaJEOL2010FasTEM.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

SI4SAXSanalysiswasperformedinthelaboratoryofProf.RickRegisteratPrincetonUniversity.TheinhousesystemconsistsofaPANalyticalPW3830(sealedtube)x‐raygeneratoremployingalongfinefocusCux‐raytube.TothisiscoupledaKratkycameramadebyAnton‐Paar,Graz,Austria.Thecameraisconnectedtoaone‐dimensionalposition‐sensitivedetector(BraunOED‐50M)whichisthenconnectedtoaPCmultichannelanalyzer(TennelecNucleusPCA‐II).Thefiguresbelowaretheresultsofanalysisofsilicaprecipitateshowntobespheresofapproximately100nminsizebyTEM.Duetostrongscattering,itwasnotpossibletoobtaindatabelowaboutq=0.4nm‐1.Noevidenceofinternalmicrostructurewasobserved,althoughthepossibilityexiststhatitismaskedbystrongparticlescattering.

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Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

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Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

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Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

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EDAXoftypicalsilicaprecipitatefrommimicpolymersolution.Topleftissilicon,toprightiscarbonfromthecarbontapeusedtosecurethesamples,andthebottomimageisofoxygen.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013