POST- AND PRE-DOCTORAL POSITIONS are offered to carry out a competitive research project in the field of Systems Metabolic

Engineering under Synthetic Biology framework:

System-level bioengineering of functionalized PHA production in Pseudomonas putida

The research project funded under H2020 is aimed to develop highly efficient catalysts for overproduction of functionalized bioplatics using P. putida chassis

Dra. Auxiliadora Prieto (contact person) auxi@cib.csic.eshttp://www.cib.csic.es/en/grupo.php?idgrupo=76Dr. Juan Nogales

Requirements: Postdoc position: PhD in Microbiology. High technical skills in Molecular Biology and Biochemistry. Excellent English (written and spoken) is required

PhD position: Highly motivated student with degree in Biotechnology, Pharmacy,Biochemistry, Biology or similar. Master in Microbiology or similar.

Key words: Systems Biology, Synthetic Biology, Systems Metabolic Engineering, Biomaterials, Bioplastics, Biosustainability

Related publication:Prieto et al., (2014). Environ Microbiol. DOI: 10.1111/1462-2920.12760

Malonyl-CoA

Malonyl-ACP

3-Ketoacyl-ACP Enoyl-ACP

Acyl-ACP

(R)-3-hydroxyacyl-ACP

Acetyl-CoA

Fatty acids

Non-Fatty acid

precursors

(S)-3-hydroxyacyl-CoA

3-Ketoacyl-CoAtrans 2-enoyl-CoA

Acyl-CoA

(R)-3-hydroxyacyl-CoA

PHA

(R)-3-hydroxycarboxylic acid

β-oxidationde novo FA

synthesis

PHA cycle

Acs1

FadD

FadE

FadB FadB

FadA

PhaC1 PhaZ

TCA

Biomass

AccABCDFabD

FabB/F

FabG FabA/Z

PhaJ

FabG

FabB

PhaG(R)-3-hydroxybutyryl-CoA

Acetoacetyl-CoA

PhbA

PhbB

PhbC

PHB

Doctoral thesis will be developed at the Polymer Biotechnology group under the supervision of: