Blocking the roads to resistance in breast cancer

Neil Conlon

Breast cancer is the 2nd most common cancer in women

One in ten women diagnosed every year…

Breast cancer is more than one diseaseHER2-positiveHormone receptor

positiveTriple

Negative

HER2-positive(~20%)

AggressivePoorer prognosis

Other breast cancers

400 cases/year

CellHER2

Cell Surface

Cell Growth

HER2

CellDeath

100,000’s have benefited from HER2-targeted drugs

?Drug

Resistance

CellDeath

My Research

Look for druggable weaknesses

Resistance is futile!

Thanks for listening!