The History of ISAPThe History of ISAPWilliam A. CraigWilliam A. CraigSymposiumSymposiumMadison, 2008Madison, 2008

Otto CarsOtto CarsUppsala University Uppsala University SwedenSweden

What has Iceland to do with the birth of ISAP ?

What has Guiseppe Verdi to do with the birth of ISAP?

What has this man to do with the birth of ISAP ?

It all began in 1986after a symposium inReykjavik, Iceland

It all began in 1986after a symposium inReykjavik, Iceland

after which we visited

The Icelandic Opera

and saw a performance of …

Verdi…

And after that we went to Hotel Saga to have a few soft drinks and discuss to start an internatonal collaboration on dosing of antibiotics

Through the inspiration of the performance, we decided that the acronym of the group should be that of a Verdi opera

We tried:

FALSTAFF: Federaton for Antibiotics and Like Substances To AchieveFurther Facts

OTELLO: Organization to Terminate Every Little Living Organism

AIDA:Association for Improvement of Dosing of Antibioics

The Association for Improvement of Dosing of Antibiotics

1990 StockholmThe first International Symposium onthe Pharmadodynamics of Antibiotics

AIDA becomes ISAP

Berlin 1991

Madison 1991

Integrated symposia

Satellite symposia

Educational workshops

Conferences

1996

Workshops - History

In 2000, the first ISAP educational workshop was held in 2000 during ECCMID as a separate event. There were entryfees to cover the cost. These were the timesof slides – no ppt. Handouts we provided and prepared : a suitcase was broughtto the conferences.

In the same year the first ISAP educational workshop was held at ICAAC Toronto 2000.A one day workshop with 5 speakers.

Since then (2000), workshops have been held a every ECCMID and ICAAC.It is now integrated in ECCMID. The ICAACworkshop has now two afternoon sessions and includes more than 10 speakers.

Regulation

Standardization

Points to consider on pharmacokinetics andpharmacodynamics inthe development of antibacterial medicinal products (CPMP/EWP/2655/99)

There is a mounting body of evidence to support the use

of PK/PD relationship for individual antibacterial agents

oin identifying those doses and dose intervals that are most

likely to be efficacious and least likely to result in adverse

effects and/or the selection of resistant organisms.

ISAP-EMEA meetingWiks Castes sweden

1265

3

4

7

8

It is time above

MIC………

“It is not difficult to make microbes resistant to penicillin …

…. The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant.”

Alexander Fleming's Nobel Lecture, 1945

Optimal antibiotic dosage

Efficacy Toxicity

Resistance

Take your time!

This ferry is not AUC

driven