The human genome

Lander et al. 2001Venter et al. 2001Patil et al. 2001

Gabriel et al. 2002Reich et al. 2001Sabeti et al. 2002

Yu et al. 2002

Yu et al. 2002

Repeats

• Genome size:– Yeast: 12 Mbp– Human: 3.000 Mbp– Amoeba: 600.000 Mbp

• Human:– Coding Sequence: < 5%– Repeats: >50 %

The Arabidopsis Genome Initiative (2000)

10% of genome is duplicated100.000 SNPs are derived from paralogous sequences

tRNA anticodonsFrequency of codon in protein sequences Count of tRNA anticodons

The human proteome

• 74 % have homologs from other species in database

• Contains 61 % of Drosophila proteome

• Contains 43 % of C.elegans proteome

• Contains 41 % of S. cerevisae proteome

Human-Mouse

• 1000 7TM receptors – Human: 60% pseudogenes– Mouse: 10% pseudogenes