The Immune System:Protector of the human body

Parasite: schistosome.Bacteria: streptococci.Virus: herpes virus.

SARS virus Fungus Candida

The immune system functions as the body’s defense against

invadersProtozoa: Plasmodium

Tonsils and adenoids

Lymph nodes

Bone marrow

Appendix

Lymphatic vesselsLymph nodes

Thymus

Peyer’s patches

Spleen

Lymphatic vesselsLymph nodes

Organs of the Immune System

Lymph node Lymphatic vessel

Lymphatic System

Muscle cell

Nervecell

Epithelialcell

Leukocyte

Class I MHC self-marker protein

Self Self vs.vs. Nonself Nonself

Antibody

Epitope Class I MHC protein

EpitopeAntibody

Antigen

AntigenBacteria

Non-self nerve cell

SARS virus

First line of defenceFirst line of defenceThe barricadeThe barricade

skin prevents

entry

tears

antibacterial enzymes

saliva antibacterial

enzymes

stomach acid low pH kills harmful

microbes

mucus linings traps dirt and

microbes

“good” gut bacteria

out compete bad

Human Body

Monocyte:circulate in the blood

Dendritic cell:stationary monitors

Eosinophil

Neutrophil:blood cell

can move into tissues as needed

Basophil

Mast cellnot a blood cell

allergy symptomsMacrophage: secrete signalsimportant in

immune response

Second line of Second line of defencedefence

Non-specific Non-specific patrol patrol

phagocytes

neutrophils

Accumulation of dead

phagocytes, destroyed

bacteria and dead cells

What’s in a What’s in a pimple?pimple?

eeeoooooo!!!!

Second line of defenceSecond line of defence Natural Killer cellsNatural Killer cells

Killer cell

Target-oriented granulesSurface contact

Target cell

The Immune ResponseThe Immune Response Part of the second line of defensePart of the second line of defense

Inflammation

Fever

Third line of defenceThird line of defence “ “Wanted dead or alive”Wanted dead or alive”

Plasma cell

Class II MHC and processed

antigen are displayed

Antigen-presenting bacteria

Antigen

Antigen-specific B cell receptor

AntibodiesB cell

Activated helper T cell

Lymphokines

B lymphocyte

s

Activated killer T cellActivated helper T cell

Resting cytotoxic T cellResting helper T cell

Third line of defenceThird line of defence “ “Wanted dead or alive”Wanted dead or alive”

T lymphocytes

Antibodies & Antibodies & ImmunoglobulinImmunoglobulin “BOOK ‘EM “BOOK ‘EM

DANO!”DANO!”

IgA

IgM

IgG, IgD, IgE, and IgA

The Immune System is The Immune System is key in helping the body key in helping the body maintain Homeostasismaintain Homeostasis

Pediatric office Posters•Create a poster depicting an assigned part of the immune system. •Your poster should educate youngsters about their immune system.•Bonus points available for description of a disease or disorder associated with that part of the immune system

Composition BooksCreate a table that includes the structures and function of the three lines of defense.