Theise Upaya 2 2008

transcript

Bushell & Theise

Zen Body, Yogic HealingZen Body, Yogic Healing

William C. Bushell, PhDMIT and Tibet House (Director of East/West Studies)

New York City

Neil Soten Theise, MDDepts. Of Pathology and Medicine

Beth Israel Medical Center – Albert Einstein College of MedicineNew York City

Bushell & Theise

Put group portrait from menla conference HERE

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What kind of models?

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for example,2 models from Ancient Greece:

Is the body made of… indivisible subunitsindivisible subunits or an endlessly divisible fluidan endlessly divisible fluid

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Models of the body are perspective/technique dependent

Look at it this way (cell membranes): the body is made of cells

Look at it that way (organelles): the body is an endlessly divisible fluid

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Models are perspective/technique dependent

Look at it this way (cell membranes): the body is made of cells

Look at it that way (organelles): the body is an endlessly divisible fluid

Yet another way (the genome):… overlapping spatial/temporal fields of molecular

organization

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Put group portrait from menla conference HERE

Bushell & Theise

““There’s no such thing as a central There’s no such thing as a central dogma into which everything will dogma into which everything will fit...any mechanism you can think of, fit...any mechanism you can think of, you will find -- even if it is the most you will find -- even if it is the most bizarre kind of thinking. bizarre kind of thinking.

““Anything... Anything...

““So if the material tells you, ‘It may So if the material tells you, ‘It may be this,’ allow that. Don’t turn it aside be this,’ allow that. Don’t turn it aside and call it an exception, an aberration, and call it an exception, an aberration, a contaminant.a contaminant.

“ “So many good clues have been lost So many good clues have been lost that way.“that way.“

“A Feeling for the Organism”Evelyn Fox Keller, 1983

Nobel-laureate Barbara McClintock:Nobel-laureate Barbara McClintock:

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regeneration

longevity

protection

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regeneration

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regeneration

tissue repair & restitutionfollowing cell loss or injury

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regeneration

longevity

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regeneration

longevity

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regeneration

longevity

protection

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regeneration

longevity

protection

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GLOBAL/SYSTEMIC interventions

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Cognitive

Behavioral

Practices

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Cognitive(mindfulness, visualization, analytical etc.)

Behavioral

Practices

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Cognitive(e.g. mindfulness, contemplative)

Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)

Practices

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Practices

LOCAL effects

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Cognitive (e.g. mindfulness, contemplative)

Behavioral (e.g. prostrations, yoga asanas, pranayama, caloric restriction)

Practices

LOCAL effects

Site Specific, Tissue Regeneration

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Practices

LOCAL effects

e.g.Stabilization of stem cell niche and stem cell integrity

Proliferation and organization of repopulating cellsInhibition of scar formation

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Practices

LOCAL effects

Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking

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Practices

LOCAL effects

Humoral factors

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Practices

LOCAL effects

e.g. Melatonin!!

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Practices

LOCAL effects

e.g. Melatonin!!

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Abbasoglu O et al, 1995. The effect of the pineal gland On liver regeneration in rats, J Hepatology 23: 578-81.

Bellipanni G et al, 2005. Effects of melatonin in perimenopausal and menopausal women: our personal experience, Annals of the NY Academy of Sciences 1057: 393-402Bubenik GA, 2002. Gastrointestinal melatonin: localization, function,

and clinical relevance, Digestive Disease Science 47: 2336-48.

Castagnino HE et al, 2002. Cytoprotection by melatonin and growth hormone in early ratmyocardial infarction as revealed by Feulgen DNA staining, Neurology Endocrinology Letters 23(5-6): 391-5.

Conti et al, 2000. Evidence for melatonin synthesis in mouse and human bone marrow cells.J Pineal Res. 2000 May;28(4):193-202.Csaba G, 1993. Presence in and effects of pineal indoleamines at very low level of phylogeny, Experientia 49: 627-34.

Danilova N et al, 2004. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development, FASEB J 18: 751-3.

Dundar K et al, 2005. Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain, Clinical & Experimental Pharmacology and Physiology 32(11): 926-30. Erkanli K et al, 2005. Melatonin protects against

ischemia/reperfusion injury in skeletal muscle, J Pineal Research 39(3): 238-42.Escames G et al, 2006. Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice, J Pineal Research 40(1): 71-8.

Esrefoglu M et al, 2005. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats, J Pineal Research 39(3): 231-7.

Feng Z et al, 2006. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer’s disease, Free Radicals in Biology & Medicine 40(1): 101-9.

Girotti L et al, 2003. Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure, Endocrine 22(3): 245-8. Karasek M, 2004. Melatonin, human aging, and age-related diseases, Experimental Gerontology 39(11-12): 1723-9.

Kobayashi H, et al, 2005. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors.FASEB J. 2005 Oct;19(12):1710-2.

Lesnikov VA & Pierpaoli W, 1994. Pineal cross-transplantation (old-to-young and young-to-old) as evidence for an endogenous “aging clock” Annals of the NY Academy of Sciences 719: 456-60.

Maestroni GJM et al, 1988. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer, Annals of the NY Academy of Sciences 521: 140-8.

Pierpaoli W, 1998. Neuroimmunomodulation of aging: a program in the pineal gland Annals of the NY Academy of Sciences 840: 491-7. Pierpaoli & Maestroni GJM, 1987. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects, Immunology Letters 16: 355-62.Sainz RM et al, 2003. Melatonin and cell death: differential actions on normal and cancer cells, Cellular & Molecular Life Science 60: 1407-26.

Slominski A, et al, 2005. On the role of melatonin in skin physiology and pathology. Endocrine. 2005 Jul;27(2):137-48.

MELATONINMELATONIN

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Effects of Melatonin

Cytoprotection

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Cytoprotection

Regeneration

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Cytoprotection

Regeneration

Oncostasis

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Cytoprotection

Regeneration

Oncostasis

Longevity…?

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Other MoleculesModulated in Meditation,

Arginine vasopressin

Nitric Oxide

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Practices

LOCAL effects

Humoral factors Cell trafficking

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Practices

LOCAL effects

Humoral factors Cell traffickingNerve signaling

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Neil’s stuff #2

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Practices

LOCAL effects

Humoral factors Cell traffickingNerve signaling

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Bill’s stuff #2

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Bill’s stuff #2NOT ONLY!

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A MIND – BODY CONNECTIONnerves connect to liver stem cells

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Yogic Practicesand the Vagus

Meditation

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Meditation

Mantrayana

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Meditation

Mantrayana

Pranayama

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Meditation

Mantrayana

Pranayama

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Practices

LOCAL effects

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Bioelectromagnetism

Definitions!

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Bioelectromagnetism

NOT necessarily“energy” or “chi” or or or or or…

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Bioelectromagnetism

Electron or ionic flux

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Bioelectromagnetism

Nerveconduction Tissue

Molecularlevel

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Bioelectromagnetism

Nerveconduction Tissue

Molecularlevel

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Practices

LOCAL effects

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Nerves

Cell Trafficking

Humoral factors

Bioelectomagnetic

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Nerves

Cell Trafficking

Humoral factors

Bioelectomagnetic

Yoga Asanas

Chi Kung

Acupuncture

Pranayama

Meditation

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Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

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Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

e.g. physical therapysurgery

e.g. cell therapies

e.g. molecular medicineantibiotics

e.g. electromagnetics

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Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

e.g. yogatai chi

e.g. acupuncture?

e.g. traditional remedies

e.g. energy healing?meditation?

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Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

CoarseBody

EnergyBody

SubtleBody

Indo-Tibetan Medicine/Physiology

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Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

CoarseBody

EnergyBody

SubtleBody

Indo-Tibetan Medicine/Physiology

Bushell & Theise

From the global to the local:Pathways for the transduction of Indo-Sino-Tibetan

cognitive behavioral practices into site specific, tissue regenerative effects.

William C Bushell & Neil D. Theise

Beyond cell doctrine:Complexity thery informs alternate models of the bdy

For cross cultural dialogue

Neil D. Theise

www.neiltheise.com

Bushell & Theise

Theise Upaya 2 2008

Spiritual