Tissue Regenration by local

administration of autologeus conditiond

Concentrate of Thrombocytes in Orthopedics and

Sporttraumatology

Thrombocytes concentrates

PRP Platelet-rich Plasma

P-LRP Platelate leucocyt rich plasma

ACP Autologeus Conditiond plasma

Thrombocyte with alpha granules, Lysomoe and Delta granules

(Dense Bodies)

Penetration from Thrombin into Thrombocyte causes releasing of alpha

granules andlysosome to infiltration in wound of

fracture

Growth Factors GF Mechanismus of action

PDGF Platelet devired Growth Factor

TGF – ß Transforming Growth Factor Beta

VFGF Vascular Endothellial Growth Factor

EGF Epidermal Growth Factor

Recurit smoth muscle cell

Remodels extracellular matrix

Affectes Angiogensis and

permealbilty

Promotes angiogensis and epithelial cells

Endothelial cells migrate as reparing cells to traumatized area

Vascular endothelial growth factor (VEGF) stimulates diveloping of new

blood vessels

Platelet drived factor (PDFG-AB) intensifieds mitogenisis and

angiogenesis activates macrophages, stemcells and recriute

smoth muscle and connective tissue celles.

Transforming Growth Factors Beta (TGF) promotes extraecellular matrix and

musculoskletal production

Traumatic rupture of anterior cruciate ligament

Regeneration 3 months after application of ACP

Traumatic rupture of the ligamentum patella

Surgical reconstruction and application of ACP

Rupture of the medial Mensikus

fresh traumatic rupture of the medial meniscus

Traumatic rupture of the medial meniscus surgical suture and aplication of ACP

Achillodynie

MRI of Achillestendon

2 weeks afterwards of ACP application

Technique of autologous conditioned plasma

Thank you so much for your attention

Prof.Dr.med.Y.M-Goudarzi