Post on 23-Feb-2016
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Tolerance and AutoimmunityAutoimmunity – inappropriate response of the immune system against self component.
Tolerance – mechanisms that exist to protect an individual from potentially self-reactive lymphocytes.
Tolerance and Autoimmunity
Tolerance and Autoimmunity
Establishment and Maintenance of Tolerance
Factors that promote tolerance:
High doses of antigen Persistence of antigen in host Intravenous or oral introduction Absence of adjuvants Low levels of costimulators
Tolerance and Autoimmunity
Establishment and Maintenance of Tolerance
Tolerance and Autoimmunity
Regulatory T cells (Treg cells)
Tolerance and Autoimmunity
Tolerance and Autoimmunity
Tolerance and Autoimmunity
Contributors to autoimmunity:
CD4+ T cell
MHC
TCR
Tolerance and Autoimmunity
Proposed mechanisms for induction of autoimmunity
Tolerance and Autoimmunity
Molecular mimicry
Autoimmunity
Current Treatments:
Immunosuppressive drugs
Thymectomy
Plamapheresis
TNF-a blockers
Autoimmunity