Transforming Drug Development It’s not just for researchers – you can participate!

Health 2.0 New Orleans November 21, 2013 Thomas Krohn, RPh, MBA Eli Lilly and Company

Drug Development - today

Precompetitive Competitive patent

Innovation Process

Business Model Performance

Source: FDA.gov

Productivity Down, Costs Up Future revenues under pressure

Unsustainable Business Model

Moore’s vs. Eroom’s Law

The Far Side by Gary Larson

Incremental Improvement

Disruptive Innovation

to S1'

to S2

S1

Time

Per

form

ance

Disruptive Change

Simpler, Faster, Cheaper?

Disruption in motion

Generation and Access to Data

Patient Digital Monitoring

Patient Communities

Patients as microexperts – not subjects

Patient-Driven Research

The Disruption

Power to the Patient

Clinical Research as part of Healthcare

Public Perception •  94% of people recognize the importance of participating in clinical research

in order to assist in the advancement of medical science. Yet 75% of the general public state they have little to no knowledge about the clinical research enterprise and the participation process. (www.centerwatch.com)

•  Less than five percent of cancer patients participate in clinical trials. If ten percent participated, studies could be completed in one year, instead of the three-five years that studies currently require. (National Cancer Institute)

•  It's not uncommon for your cancer doctor or treatment team to discuss the option of a clinical trial as the best treatment choice for your cancer type. (www.mayoclinic.com)

Standard of Care Clinical Trial Info & Innovation

ClinicalTrials.Gov and Patients

98,000,000 Pageviews/Month1

Sources: 1) clinicaltrials.gov site 2) D. Zarin 2007 Overview

47,000,000 Patient driven pageviews/Month

2

What if….?

1

Patient-Centric Design

Patient Voice

2

Patient-Centric Study Representation & Voice

Study Representation

Informed Consent Document Ct.Gov

Study Design

Open

Platform

Patients

• Clear eligibility • Risk/Benefit • My doctor’s role • Study treatment • Time to results • Logistics

Design Challenge

ctdesign.challengepost.com

November 14

Patient-Centric Information

Open

Platform

Patients

labs.lillycoi.com

Clinical Open Innovation

Open

Platform

Patients

api.lillycoi.com

Daily Updates

Open Web

REST API

Enabling patient matching to studies

Open

Platform

Patients

api.lillycoi.com

Daily Updates

Open Web

REST API

Patient Study “Target Profiles”

Study Sponsors

Patient & Communities

Personal Electronic Medical Records

Match Process

Consent to

Match

Patient Engagement App Challenge

http://patientengagement.challengepost.com

Join the transformation

•  Learn the business model •  Understand patient needs •  Identify options for value creation •  Explore open data and patient engagement •  Participate in challenges

Most people are afraid of making mistakes. Leaders are afraid of missing opportunities.

References

•  Website: www.lillycoi.com •  API: api.lillycoi.com •  App Lab: labs.lillycoi.com •  Whitepaper: link •  Twitter: @Lilly_COI, @takmad

Thanks!