Turning RWD into RWE

transcript

RealWorldDataOpportunityandChallenges

OracleConfidenCal–Internal/Restricted/HighlyRestricted

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OutcomesMaSer

“The biggest influence of health reform is that there is no new money for health care delivery. There is money only for improved outcomes. You can explain it in four words: no outcome, no income. It’s that simple”

- David B Nash, Founding Dean of Thomas Jefferson School of Population Health

The ability to demonstrate the needed outcomes to payers will be the differentiator as our system

continues to evolve and address costs

“The biggest influence of health reform is that there is no new money for health care delivery. There is money only for improved outcomes. You can explain it in four words: no outcome, no income. It’s that simple”

- David B Nash, Founding Dean of Thomas Jefferson School of Population Health

The ability to demonstrate the needed outcomes to payers will be the differentiator as our system

continues to evolve and address costs

PharmaceuCcalsOpportuniCes5Opportuni+estoCreateValuewithData

BusinessDevelopmentR&D

SAFETY MARKETACCESS

FindUnmetMedicalNeed

TargetIdenCficaCon

ManageDiversePartnerData

FindAllRelated

Research

LeverageSignalsinThird-PartySources

RapidlyDiscoverLargerContextof

EnterNewMarkets

DefendPricing

ImproveAdherence

IdenCfyKOLsmoreprecisely

MANUFACTURING

CLINICALTRIALS

AccelerateAdapCveClinical

Trials

RapidlyIdenCfyandValidateTargetCohort

TrackandImprove

Adherence

ReduceBadBatches

BeSerPredictVatfailures

RootCauseacrossALL

SupplyChain

OutcomesMaSer

“Ialsostartedtoshi_ourbusinessawayfromatransacConalmodelthatwasfocusedonphysicallysellingthedrugstodeliveringanoutcome-basedapproachtoaddvaluebeyondjustthepill.Ireallybelievethatinthefuture,companieslikeNovarCsaregoingtobepaidonpa+entoutcomesasopposedtosellingthepill.”

– Joseph Jimenez, CEO, Novartis

“YoucanbuildabeSermousetrapbutcanyouproveit”AnonymousEpidemiologist

EvidenceMaSers

Source:WSJStudiosSurvey2015

DataCapitalChallenge

98%81%

GrowthinSupplyofandDemandforData

ReportIncreaseinDataVolumeInLastYear

PlantoExpandTheirAnaly+csTeams

CiteLosingRevenueDueto

Ineffec+veuseofInforma+on

DataCapitalChallengeinPharma

72%73%

ReportIncreaseinDataVolumeInLastYear

PlantoExpandTheirAnaly+csTeams

CiteLosingRevenueDueto

Ineffec+veuseofInforma+on

DataCapitalChallengeinPharma

MoreData

MoreAnalyCcs

LostRevenue?

What’sGoingOnTheChallengeofDataSupply

OracleConfidenCal–Internal 10

Whatareyoulosingwhileyouwaitfordata?

74%ofresponderssaysittakedaystogetaccesstonewlycaptureddatawhile40%indicateweeks.1

1RexerAnalyCcsSurvey

CommuniCesGeneraCngDataSupplyNotinyourWarehouseoryourapplica+on

Whatareyoulosingwhileyouwait?

60%ofrespondentsindicateittakesbetween3weeksand1yeartodeploynewmodelsintoproducCon.1

1RexerAnalyCcsSurvey.

What’sgoingonTheChallengeofOpera+onalizingAnaly+cs

Thistakestoolong

DataSupply AnalyCcsDemand

HowfastcanyouturnRealWorldDataintoRealWorldEvidence

RealWorldData AnalyCcsEvidence

ResultsfromClientCaseStudy

20%to80%LessAccurateAnaly+cs

Act1:Workaroundtheproblembutcreateanother

DataSupply AnalyCcsDemandWorkWithSample Sizeittoyourlaptop

ResultsfromClientCaseStudy

40%to500%MoreAccurate

Act2:Co-locatealldatawithanalyCcengines

DataSupply AnalyCcsDemand

Step1:ManageandBuyOnce,AnalyzeManyTimesRealWorldDataReservoir

InsuranceClaimsData

ClinicalData

Prescrip+onData

FAERS,MAUDE

Siebel

§ RealWorldEvidence§ Biomarkerdiscovery

§ ProtocolvalidaConandpaCentrecruitment

§ PaCentstraCficaCon§ SafetyandcomparaCveeffecCveness

§ PopulaConhealth§ Precisionmedicine

§ …

ENABLES

Step2:MachineLearningLabBringAnalyCcsTOtheDataReservoir

MachineLearningDirectlyonDataReservoir

CloneDatatoLab

OracleCloudPlaoormCombinesDataManagement,MachineLearningand

ComputeResources

ProtectedProduc+onBIandDataWarehouse

RealWorldData

MachineLearningIncluded

BringYourOwn

Step3:Opera+onalizeBringAnalyCcsTOtheapplicaConsandfrontline

MachineLearningDirectlyonDataReservoir

CloneData

ManageAnyDataAccessViaSQL

ScaleComputeOn-Demand

ProtectedProduc+onApplica+onsandDataWarehouse

MachineLearningIncluded

BringYourOwn

SynctoProd

RealWorldApplicaCons

DataScienceLab

CreateEnvironment

AccelerateData+Analy+csMakeExis+ngTeamProduc+ve

Analy+csSharedService

ProvideAnaly+cSkills

DevelopSkillsPartnerforSkills

Analy+csProductFactory

Analy+cProducts

EmbeddedandSharedAcrosstheEnterprise

CapabilityRoadmap

HybridDeployment

PrescripCons:Tacklingfraudanderrors

•  2million‘ghostpaCents’costNHS£540m

•  8millionprescripConsprocessedperday

•  Opportunityformisuseofdrugs

•  PrescripCons,reimbursementsandbenefitspayments–errorscauseover&underpayments

•  IntegraConofstructured&unstructuredtoenablemorepowerfulinsightsintobehavioranduseofdrugsthroughprescripCons

•  Geomappingtoshowareasofhotspots–highusersanddrugcosts

ReducingfraudanderrorwithintheNHSprescrip+onservice

Business Challenge •  Link database information on genes,

proteins, metabolic pathways,compounds, ligands, etc. to original sources.

•  Increase productivity for accessing, sharing, searching, navigating, cross-linking, analyzing internal /external data

ConsolidatedKnowledgeLayer

Solution •  Semantic integration layer using RDF graph •  Rich domain-specific terminology (biology,

chemistry and medicine) 1.6 M terms •  Terminology Hub: 8 GB of referential data

(ontologies) that cross-reference various data repositories.

EUPublicaConsOfficeLinkedMetadataPlaoormforEuropeanUnion

Objectives §  Commonmetadatamodelsupports:

§  SearchanddiscoveryofEUPublicaCons§  MulCpledomainsandlanguages

Solution §  ValidateandtagEUlaw,tenders,andpublicitytostandardizedvocabularies

§  UnifiedRDFgraphmetadatamodel§  Supportsdiscoveryofcontentthroughuser’sterminologyandlanguage

§  ProvidesvarietyofdisseminaConmodes

§  Evolvingdatamodelthatflexiblysupportsavarietyofbusinessusecases

§  Scalability:§  OverbillionRDFtriplesinOracleGraphDB§  2.5TBofcompresseddatainOracleDB§  Linksto3.9TB(60M)filesofEUpubs

§  Reliabilityandmaintainability§  OracleASM(AutomaCcStorageManagement)§  Twofailoversystems

Benefits

EnablingServiceLayers

UnifiedDataManagementasaService

IntelligenceasaService

MachineLearningasaService

DataIngestandOriginaConasaService

IntelligentApplicaConsandBusinessInsight

Developer

Security

InfrastructureasaService–Compute,Storage,Archive

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OracleCloudPlaoormDataManagement

UnifiedDataManagementasaService

IntelligenceasaService

MachineLearningasaService

DataIngestandOriginaConasaService

IntelligentApplicaCon

OpenAPI’s

DR/BackUp

Dev/Test

DataManagementMaturityModel:CREATEVALUEfromDATAforPharma

QuickWins DataManagementPlaoorm BusinessInsight Business

OpCmizaConBusiness

TransformaCon

DataStagingforanydatafrompartnersandinformaConvendorsSimplifyDataCaptureDeliveryforAnalyCcsScaleSASpredicCveanalyCcs

ImplementaCollaboraCveDataReservoirfordataAs-IsExtendDataWarehousetohandlenewdatatypes

SelfServiceDataIngestandData-DrivenDiscoverySupportanalyCcsonalldatastructuredandunstructured

AccelerateMarketAccesswithRealWorldDataImproveSafetySignalDetecCon

CompleteViewofDiseaseTreatmentfromDiagnosCcstoAdherenceOutcome-BasedPrecisionMedicine

Maturity&Capability

Turning RWD into RWE

Software