VETERINARSKI GLASNIK ISSN 0350-2457 UDK 619 (05)...aritmije kod pacova* testing of newly synthesized...

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V E T E R I N A R S K I G L A S N I K

nau~ni ~asopisscientific journal

Veterinarski glasnik je ~asopis Fakulteta veterinarske medicine Univerziteta u BeogaduVeterinarski glasnik is published by Faculty of Veterinary Medicine University of Belgrade

VET. GLASNIK Vol. 68 Br. 5-6 Str. 279 -418 Beograd, 2014.

IZDAVA^:FAKULTET VETERINARSKE MEDICINE UNIVERZITETA U BEOGRADUFACULTY OF VETERINARY MEDICINE UNIVERSITY OF BELGRADEFAKULÃTET VETERINARNOY MEDICINÀ UNIVERSITETA V BELGRADE

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GLAVNI I ODGOVORNI UREDNIK – EDITOR IN CHIEF: Vitomir ]upi}

URE\IVA^KI ODBOR – EDITORIAL BOARD: Vojin Iveti}, Milovan Jovi~in,Vera Kati}, Sanja Kova~evi}-Aleksi}, Zoran Kuli{i}, Zoran Ra{i}, Horea[amanc, Vesna Matekalo-Sverak, Dragi{a Trailovi}

ME\UNARODNI URE\IVA^KI ODBOR – INTERNATIONAL EDITORIALBOARD: Arturo Anadon ([panija), Horia Cernescu (Rumunija), Toni Dovenski(Makedonija), Petar D`aja (Hrvatska), Marijan Kosec (Slovenija), Mehmed Mu-minovi} (Bosna i Hercegovina), Dimitrios Raptopoulus (Gr~ka), Peter [otony(Ma|arska), Carlo Valente (Italija)

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Adresa ~asopisa:Veterinarska komora Srbije – Veterinarski glasnik, 11000 Beograd,Bulevar oslobo|enja 18, tel/faks 011/2684-597, 2687-475,e-mail: vetksªeunet.rs; www.vetks.org.rs

ISSN 0350-2457UDK 619 (05)

V E T E R I N A R S K I G L A S N I K

Leishmania infantum

Leishmania infantum301

D. immitis

D. immitis 387

ORIGINALNI RAD / ORIGINAL PAPER

DOI 10.2298/VETGL1406281I UDC 57.085+615.222:616.12+599.1.3./.8.4.

ISPITIVANJE ANTIARITMIJSKE AKTIVNOSTI NOVOSINTETISANIH

ARITMIJE KOD PACOVA* TESTING OF NEWLY SYNTHESIZED PROPAFENONE DERIVATIVES

ANTIARRHYTHMIC ACTIVITY IN ACONITIC MODEL OF

CARDIAC ARRHYTHMIA IN RATS

Primenom akonitinskog testa, u in vivo eksperimentima na pa-covima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal no-

* Rad primljen za štampu 06. 12. 2013. godine

ternational Nonproprietary Name

kalijumskoj struji u srcu i hERG kanalu koji posreduje u njenom prenošenju. Ikr

ppression Trial

Figure 1. A. Phenylpropiophenone structure, B. Propafenone structural formula

u studije razvoja rezistencija na lekove

in silico metoda

sprovedeno je na pacovima soja Wistar

libitum

3 u koncentraciji od

što se

tave aritmiju indukovanu i.v. aplikacijom akonitina primenjen je akonitinski test

kontinuirano se prati promena krvnog pritiska i na svakih 10 minuta registruje na

skog pritiska.

zatim na svaki minut sve do uspostavljanja sinusnog ritma 60 minuta od aplikaci

rigora mortis

Figure 2. ECG of rats (II drain) a) normal sinus rhythm before aconitine application; b) appearance of ventricular extrasystoles induced by i.v. aconitine injection

Table 1. Time and percentage of survival of animals during the investigation on therapeutic role of propafenone, 5OF and 5PF derivatives

4 mg/kg

6 mg/kg

tip 1.5 u srcu opravdana je primena akonitinskog testa u ispitivanju antiaritmijskog

potencijala sintetisanih derivata.

U eksperimentalnim modelima aritmije za hemijsku indukciju aritmije uglav

temperaturom od 37 1 C.

4 mg/kg t.m. nedovoljna da zaustavi aritmiju indukovanu akonitinom ili doza ako

aplikacije ispitivanog jedinjenja i akonitinaFigure 3. a) Changes in heart rate in all the groups in regard to propafenone one, concerning all the three tested

doses (1)-dose 6 mg/kg; (2)-dose 4 mg/kg and (3)-dose 2 mg/kg, b) record of the rats blood pressure, before, during and after application of the tested compound and aconitine

in vitro ispitivanjima antagonizovao

in vivo eksperimentima ispitivan je antiarit

ACKNOWLEDGEMENT:

tokom ove studije. /

Conclusion

TESTING OF NEWLY SYNTHESIZED PROPAFENONE DERIVATIVES ANTIARRHYTHMIC ACTIVITY IN ACONITIC MODEL OF CARDIAC ARRHYTHMIA

IN RATS

ENGLISH

in vivo

Rezultati /

Table 1. Heart rate in trotters (X±1 SD) before and during physical exertion

Inaction (before work)

Walk (5 minutes)

Light trot (1000 m)

Light trot (2000 m)

Light trot (3000 m)

Fast trot (1000 m)

Walk (5 minutes)

Walk (15 minutes)

Inaction (before work) InactionWalk Walk

Light trot (1000 m) Light trot (1000 m)Light trot (2000 m) Light trot (2000 m)Light trot (3000 m) Light trot (3000 m)

Fast trot (1000 m) Fast trot (1000 m)Walk (5 minutes after) Walk (5 minutes after)

Walk (15 minutes after) (15 minutes after)

Heart rate/min

Table 2. Values of basic hematological parameters in trotters (X±1 SD) before and after physical exertion

12 Erythrocytes(x 1012/L)

Haemoglobin (g/L)

Haematocrit (%)

9 Leukocytes (x 109/L)

9 Lymphocytes (x 109/L)

9 Granulocytes(x 109/L)

N/L ratio

9 Thrombocytes (x 109/L)

Conclusion

THE INFLUENCE OF PHYSICAL EXERTION ON BASIC HEMATOLOGICAL PARAMETERS VALUES AND HEART RATE IN TROTTERS

ENGLISH

* Rad primljen za štampu 02. 07. 2013. godine-

SEROPREVALENCIJA PASA NA ANTIGENE LEISHMANIA INFANTUM NA TERITORIJI CRNE GORE*

SEROPREVALENCE OF DOGS TO LEISHMANIA INFANTUM ANTIGENS IN

THE TERITORY OF CRNA GORA

antigene na teritoriji Crne Gore

u regiji Mediterana je

antigene -

protiv antigena -

Figure 1. Direct agglutination test – positive and negative samples

Rezultati /

Figure 2. Direct agglutination test – positive samples

se jasno zelene pro-

nantnom vrstom dodatno opra-

tigene

Diskusija /

SEROPREVALENCE OF DOGS TO LEISHMANIA INFANTUM ANTIGENS IN THE TERITORY OF CRNA GORA

ENGLISH

LEISHMANIA INFANTUM

DOI 10.2298/VETGL1406311P UDC 591.463.1+57.018-022.5: 616.699+599.735.5

nim parametrima kvaliteta semena – volumenom ejakulata, koncen-

Dobijeni rezultati pokazuju da je sa porastom obima testisa ras-

-metri kvaliteta

tkiva u skrotumu mogu ugroziti pravilnu termoregulaciju.

na, testosterona. Testisi su postavljeni izvan tela, u skrotumu. Ovo je od suštinsk-

stepeni u odnosu na normalnu telesnu temperaturu.

za posledicu ima smanjenje kvaliteta ejakulata.

ture testisa.

Table 1. Minimum requirements for testicle size

Starost (meseci) / Obim testisa (cm) /

19 – 21 32

22 – 24 33

Figure 1. Structure of a bull testicle (Cergolj, 2006)Genitals bull MC – musculus cremaster, S – semenovod, TVC – tunica vaginalis communis, TE – telo epididimisa, T – testis, RE – rep epidedimisa)

zinger, 2002) .

lus spermaticus.

Figure 2. Forms of a bull scrotum (Coulter, 1987)

Oni su lako palpirani kroz zid skrotuma i pokretljivi su u skrotumu, glatke i ravne

vanjem ili udaljavanjem od tela.

prouzrokuje zastoj u razvoju testisa kod mla-

Merenje obima testisa bika

Figure 3. Measuring of a bull testicle scope (original photo, I.Prka)

je zavisnost pozitivna i vrlo jaka.

sa oscilacijama.

vodnjom sperme.

Rezultati i diskusija /

/Table 2. Parameters of semen quality in comparison to testicle scope (n=36)

Red. br. /

Grupa bikova prema obimu testisa (cm) /

Broj bikova /

Parametri kvaliteta sperme valjanih ejakulata za 12 meseci

ejakulata /

volumen (ml) / koncentracija (mlrd/ml) /

1. 2 3,7 0,85 78 72

2. 31 2 4,6 1,23 81 39

3. 32 2 5,1 1,28 84 25

4. 33 2 5,3 1,32 86 15

5. 34 5 5,8 1,35 84 13

6. 35 6 6,0 1,45 82 11

7. 36 3 6,5 1,58 86 10

8. 37 2 6,7 1,49 85 7

9. 38 4 6,6 1,38 87 8

10. 39 3 6,8 1,41 86 9

11. 5 6,7 1,46 84 7

x 5,99 1,38 84 15,8

0,82 0,14 2,26 15,5

Graph 1. Bulls testicle scope in regard to ejaculate volume (n=36)* (* – 36 bulls included in research were divided into 11 groups according to obtained testicle scope)

Graph 2. Bulls testicle scope in regard to concentration of sperms (n=36)* (* – 36 bulls included in research were divided into 11 groups according to obtained testicle scope)

jent korelacije 0,95 pokazuje pozitivnu i vrlo jaku zavisnost.

Graph 3. Bulls testicle scope in regard to % of alive and progressively movable spermatozoa (n=36)* (* – 36 bulls included in research were divided into 11 groups according to obtained testicle scope)

Conclusion

27(3-4): 175-80.

11. Van Demark et al

TESTICLE SIZE AS INDICATOR OF FERTILITY IN BULLS

ENGLISH

PLODNOST OVACA PRI INDUKCIJI I SINHRONIZACIJI ESTRUSA U SEZONI ANESTRIJE U ZAVISNOSTI OD TELESNE MASE

TRETIRANIH PLOTKINJA* SHEEP FERTILITY DURING INDUCTION AND ESTRUS SYNCHRONISATION IN

THE ANOESTRUS SEASON DEPENDING OF THE BODY WEIGHT OF TESTED EVES

sinhronizaciji estrusa u sezoni anestrije u zavisnosti od telesne mase tretiranih plotkinja

Cilj našeg rada je da se da doprinos rasvetljavanju pitanja u vezi sa istra-

zaciji estrusa u sezoni anestrije na reproduktivne pokazatelje.

Reproduktivni pokazatelji / -

Table 1. Average values and variability of sheep body weight per treatment, kg

Tretman / Pokazatelji /

S Sd CV%x x

njima.

Table 2. Reproductive indicators of the sheep

Red. br. / Pokazatelji /

Tretmani /

I II IIIUkupno /

% of lambed out of all the treated ones

% of non lambed sheep

Total number of obtained lambs

Sheep fertility

Type of birth

Singles

Triplets -

koncipiranja ne zadovoljava.

Conclusion

menjeni tretman.

10. rd -

SHEEP FERTILITY DURING INDUCTION AND ESTRUS SYNCHRONISATION IN THE ANOESTRUS SEASON DEPENDING OF THE BODY WEIGHT OF TESTED EVES

anoestrus season.

-action to the treatment.

ENGLISH

LEPTOSPIROZA SVINJA NA TERITORIJI BEOGRADA* PIGS LEPTOSPIROSIS AT THE TERITORY OF BELGRADE

Ispitivanje prisustva leptospiroze kod svinja izvedeno je na svi-

dominantan

Uvod /

teti pomona i australis ,

L. serovari-

jetet -

L. . . australis i L. javanika -

pomona

L. pomona -

je antigen L. Leptospira pomona-Pomona

la na leptospire.

pomona

vreme nije ustanovljeno prisustvo serovarijeteta i

Table 1. Number of examined and positive pigs blood sera in period 2000 to 2009.

Godina / Pregledani krvni serumi svinja /

Pregledano / Pozitivno / %

2002 177

2003 3071

2007 17

Dijagram 1.

Diagram 1. Number of positive blood sera of pigs and frequency of certain serovars L. interrogans

pomona i -

zatim slede i

javljala samo

menja i da je prevalencija

na prevalenciju

jer je

2. serovar Pomona

Dijagram 2.

Diagram 2. The height of antibody titers to certain leptospira serovars in pigs in period from 2000 to 2009.

Conclusion

serovar pomona

Leptospira australis

serovar

PIGS LEPTOSPIROSIS AT THE TERITORY OF BELGRADE

L. L. pomona, L. . . . and L. -

investigation.

L. L. pomona, L. . .

L. i L.

ENGLISH

BASIC EXTERIOR CHARACTERISTICS OF BODY AND HEAD IN BULGARIAN SCENT HOUND*

OSNOVNE SPOLJAŠNJE KARAKTERISTIKE TELA I GLAVE

A group of dogs known as hounds is widespread and highly ap-preciated among the hunters on the Balkans. Hounds are referred to as hunting dogs that engage in loud pursuit of game along its trail. These dogs do not need to se the game in order to pursue it and be-gin to bark once they stumble upon game trail.

First serious research along with zootechnical measurement was conducted in 1905, at which occasion three large groups of hounds that inhabit the Balkans were described. This undertaking provided a solid foundation for further research and standardization of certain

were undertaken since then, there are still groups of hounds not en-compassed in previous research work that are well-spread on the

-ety among these non-standardized breeds are Bulgarian scent hound, which differ from described hound breeds by certain exterior charac-teristics.

In this paper, processed and analyzed some of the basic exterior features of body and head of the Bulgarian Scent Hound. Measure-ments were performed in 21 males and 15 females of following pa-rameters, the height at withers, back height, loin height, chest circum-ference, body length, head length, skull length, nozzle length, head

width and nozzle width. The average height of males is 54.60 and fe-male 51.73 cm. Head length of males, on average, was 23.95 cm and females 23, 53 cm.

Key words: hounds, standardization, population, exterior characteristics

Basic body morphology parameters - males (n = 21)

Measures /

Descriptive statistical parameters /

X±SD Sg CV(%) min max

Visina hrbata

Visina le a

Visina slabinskog dela

Obim grudi

Širina glave 9.29

X – srednja vrednost, SD –

Sg – –

Relative measures of males

Measures / Relative measures in % relative to

height at withers /

Visina hrbata 100

Visina ledja

Obim grudi

Širina glave

Basic body morphology parameters - bitches (n = 15)

Measures /

Sg min

Visina hrbata

Visina ledja

Obim grudi

Širina glave

Relative measures of bitches

Measures / Relative measures in % relative

to height at withers /

Visina hrbata

Visina ledja

Obim grudi

Širina glave

Basic body morphology parameters of Bulgarian scent hound (n=36)

Measures /

Sg min

Visina hrbata

Visina ledja

Obim grudi

Širina glave

Relative measures of Bulgarian scent hound

Measures /

Relative measures in % relative to height at withers

Visina hrbata 100

Visina ledja

Obim grudi

Širina glave

ACKNOWLEDGEMENTS / :

OSNOVNE SPOLJAŠNJE KARAKTERISTIKE TELA I GLAVE

SRPSKI

PREGLEDNI RAD / REVIEW PAPER

RENDGENSKOJ SLICI* MANIFESTATIONS OF JOINT DISEASE OF DOMESTIC CARNIVORES IN X-RAY VIEW

Promene kojim se oboljenja zglobova manifestuju u rendgenskoj slici su veoma raznovrsne. Neke od njih postoje kod svih artropatija

p ljenost i intenzitet radioloških promena.

U radu su detaljno analizirane osnovne radiološke manifestacije oboljenja zglobova kao što su: distenzija zglobne kapsule, promena

prisustvo perihondralnih i periartikularnih koštanih proliferacija. Pored

Rendgenski pregled zgloba /

iohexol

Anatomija zgloba u rendgenskoj slici /

Figure 1. X-ray view the articular cavity width in a young animal (a) and in an animal that has ended growth (b)

Manifestacije oboljenja zgloba u rendgenskoj slici /

Kapsularna distenzija /

Intraartikularno nakupljanje gasa /

Figure 2. Graphical display of signs of joint disease in X-ray (A) compared to pathologically unchanged joint (B). -

Rendgenski snimak kolenog zgloba psa u ML projekciji. Na posteriornoj strani zglo-

-ated soft tissue shadow of the distended joint capsule (arrow)

Promena širine zglobnog prostora /

Rendgenski snimak ramenog zgloba psa u ML projekciji. U artikulacionoj šupljini

shadow of gas (arrow)

Promene u strukturi subhondralne kosti /

its instability (arrow)

-struction of subchonral bone in the zone of the lateral femoral epicondyle as a result of osteochondrosis

lateral side of tibia plateau (arrow)

zona u predelu medijalnog ruba medijalnog epikondilusa

edge of medial epicondyle

Periartikularna novostvorena kost /

zone of the joint anterior side (arrow)

-liferates on the medial side of the carpal bone indicates trauma and damage of medial collateral ligament

Remodeliranje kosti /

teonekroze

head of the left femur in the last stages of aseptic osteonecrosis

-traartikularne koštane strukture lokalizovane na anteriornoj i posteriornoj strani zgloba

the anterior and posterior side of the joint

Zastupljenost promena /

tivne prirode.

NAPOMENA / ACKNOWLEDGEMENT:

Conclusion

MANIFESTATIONS OF JOINT DISEASE OF DOMESTIC CARNIVORES IN X-RAY VIEW

ENGLISH

SELECTION CRITERIA IN ORGANIC CATTLE BREEDING

ovaca i koza

Kriterijumi za izbor rasa goveda pogodnih za organsku proizvodnju mleka /

2012).

Kriterijumi za izbor rasa goveda pogodnih za organsku proizvodnju mesa /

regiona.

Kriterijumi za izbor rasa ovaca i koza pogodnih za organski uzgoj /

2006 -

Conclusion

NAPOMENA / ACKNOWLEDGEMENT

The work is funded by Ministry of Science of the Republic of Serbia TP 31085 and HERD Project no.: 09/1548, 332160 UÅ.

21st -

11. 1-160.

SELECTION CRITERIA IN ORGANIC CATTLE BREEDING

ENGLISH

. Rod -

epizootiologiji -

manje prema

dese -

Etiologija /

Map 1. Distibution of Tropilaelaps spp. in Southeast Asia

dese i

Figure 1. Dorsal side of the parasite Figure 2. Ventral side of the parasite

Figure 3. Appearance of mouth apparatus

Figure 4. The parasite on larvas in brood of beesFigure 5. The parasite on doll bees

Terapija /

2. and

Conclusion

11. in

18. and

CASE REPORT

2 sata.

Figure 1. Fluid and electrolyte recoupment, method for obtaining serum from mare blood and intravenous serum administration

Figure 2. Method of ultrasound diagnostics and an ultrasound of carpal joint region

Figure 3. Obtained purulent content after the carpal joint arthrocentesis

artritis

Figure 4. A foal 1.5 months after the treatment

zaštitu.

CASE REPORT - AGALACTIA OF MARE, AGAMMAGLOBULINEMIA AND ARTHRITIS IN FOAL

Conclusion

ENGLISH

* Rad primljen za štampu 16. 07. 2013. god.

CASE REPORT

D. IMMITIS EXAMINATION OF D. IMMITIS PRESENCE IN FOXES IN SERBIA

u populaciji lisica.

Rezultati i diskusija

Figure 1. A fox heart – several specimens of D. immitis in the right ventricle and a. pulmonalis

Tabela 1. The results of fox testing on D. immitis in Suth Banat district

Opština / Municipality

Broj ispitanih lisica / Broj lisica kod kojih je

D. immitis /

Procenat od ukupnog broja ispitanih lisica /

Opovo 1 20

Ukupno / 30 4 13,33

tvo parazita

Table 2. The results of testing foxes on D. immitis in Raška, Rasina, Moravica and Zlatibor district

Okrug / ispitivanjem /

Broj ispitanih lisica po okrugu /

Broj lisica kod

D. immitis /

Raški district

Rasinski district 300

Moravicki district

Zlatiborski district

Ukupno / 25 120 0

Conclusion

319-26.

EXAMINATION OF D. IMMITIS PRESENCE IN FOXES IN SERBIA

ENGLISH

DIPLOMIRANI STUDENTI – DOKTORI VETERINARSKE MEDICINE GRADUATE STUDENTS – DOCTORS OF VETERINARY MEDICINE

FAKULTET VETERINARSKE MEDICINE U BEOGRADU 2013-2014. GODINE

D. immitis387

Leishmania infantum

Staphylococcus aureus

-Porcine circovirus type 2

Clostridium perfringens

LeishmaniaLeporidae, 241

Ornithobacterium rhinotracheale, 197

taphylococcus aureus

Tropilaelaps

UPUTSTVO AUTORIMA ZA PRIPREMANJE RUKOPISA

VETERINARSKI GLASNIK -

OPŠTA UPUTSTVA

NASLOVNA STRANA

Tabele

Sheme -

Uvod, Materijal i metode rada, Rezultati, Diskusija (ili

U uvodu

Materijal i metode rada

Rezultati -

Diskusija -

Literatura -

NAPOMENA

VETERINARSKI GLASNIK ISSN 0350-2457 UDK 619 (05)...aritmije kod pacova* testing of newly synthesized...

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