Post on 08-Jan-2016
description
transcript
Welcome toMolecular Biology Through Discovery
Thursday, 4 September 2014Protein
I get a 404 error while trying to view the paper chromatography presentation
General Issues
General Issues
I get a 404 error while trying to view the paper chromatography presentation
Fraction of participants handing in questionnaires
Tuesday, Sep 2
47%
Fraction of participants handing in questionnaires
Tuesday, Aug 26
22%
Fraction of participants handing in questionnaires
Thursday, Aug 28
39%
00.10.20.30.40.50.60.70.80.9
1
Response to Questionnaires
Cla
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acti
on r
espo
ndin
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Research Proposal
…I'm debating on whether or not to focus on scar tissue or birth defects.
I am currently searching for a mentor but I will wait until I decide on a topic.
Research Proposal
judges usually give higher scores for the most original projects
http://www.ipl.org/div/projectguide/choosingatopic.html
I could find it but … …did not let me download the pdf.
Are you sure?
What is a Protein?
I would like more information on how how this pertains
to Bioinformatics.
What is a gene?
What is a gene?
Information+
Self-assembly
Structure+
Function
ProteinDNA
CGACCATCGCCTTAGTAC
How do we determine how a linear sequence folds…?
What is a Protein?
Amino acid
What is a Protein?
What is a Protein?
Many?
In a straight line?
What is a Protein?
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?(number of structures) (seconds / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?(number of structures) (10-9 second / structure)
Protein Structure Prediction
360
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
360 . . .
(number of structures) (10-9 second / structure)
Protein Structure Prediction
360
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
360 . . ..(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
360n
(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
360100
=
?
(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
360100
=
?
>>100100
=10200
(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
>>
seconds
Age of the universe: How many seconds?
: 1010 years (x sec/yr)10191
(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
>>
seconds
Age of the universe: How many seconds?
: 1010 years (108 sec/yr)10191
(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
>>
seconds
Age of the universe: How many seconds?
: 1018 secs (1080 computers)10191
(number of structures) (10-9 second / structure)
Protein Structure Prediction
Candidate structures#1: Φ1=0o ; Φ2=0o;…#2: Φ1=1o ; Φ2=0o;…. . .#n: Φ1=47o ; Φ2=29o;…. . .#z: Φ1=359o ; Φ2=359o;…
Candidate ΔG#1: ΔG1
#1: ΔG2
. . .#n: ΔGn
. . .#z: ΔGn
Free energy calculator
How long would it take?
>>
seconds
Age of the universe: How many seconds?
: 1098 secs10191
(number of structures) (10-9 second / structure)
Protein Structure Prediction
What is a Protein?…more specification of
R groups and what makes up the carboxyl groups
How many carboxyl groups are in a protein?
What is a Protein?
Me
Group 1:PedeeJordanRachelSkyler
Group 2:CatherineKamranKiyante
RaeMazin
Group 3:Chris
DarrellFarrahNav
Ramey
Group 4:AkhilGelilaMeganWesal
William
Problem Set 3: Problem 1