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Role of Sensory systems:
audition vision olfaction taste smell
What are our primary senses?
some addtl senses◦ vestibular◦ organ◦ muscular tension
sensory transduction◦ - conversion of physical energy from the
environment into changes in electrical potential
sensory coding-◦ Making sense of that input
definitions
vision - light waves -
taste – chemicals in fluid – hearing – sound waves- touch- pressure, temperature changes,
smell- chemical in air
What is transduced?
vision - rods and cones in retina
taste - - taste buds on tongue hearing - - hair cells in inner ear
(cochlea) touch - specialized receptors
under skin smell - hair cells in olfactory
epithelium
What are the cells responsible for transduction?
Receptors show adaptation◦ most sensitive to changes rather than constant
stimulation
◦ why is this important?
General pathway for most sensory information:
General pathway for most sensory information:
◦ sensory neurons – sensory nerves spinal tracts – thalamus – primary cortex – higher association cortex
Certain sensory neurons have a spontaneous firing rate.
For these cells any change in their firing rate will convey important info (i.e. color vision)
Different rhythms of firing also can convey different information
A general point:
* most highly developed sense in humans
optic nerve for one eye - 1,000,000 axons auditory nerve contains about 30,000
axons
adaptability and plasticity of visual system - make sense out of nonsense
Vision
iris ◦ largely a muscle that expands and contracts pupil
in response to light◦ phenotypically unique – iris scan
sclera◦ tough opaque tissue
pupil◦ often used to determine neurological function
visible parts of the eye
light waves along the visual spectrum
What does the human eye see?
1. inverted image on retina
2. region important for transduction is at very back of the eye
2 interesting points from figure
retina - structure of eye important for transduction
- retina contains neurons, glial cells and two types of photoreceptors
responsible for transduction
numerous differences between rods and cones
rods and cones
rods shaped like a rod insensitive to color work well under low
illumination
some differences cones shaped like a cone sensitive to color work best in bright
light
rods shaped like a rod insensitive to color work well under low
illumination 20,000,000/eye location: found around the
periphery of the retina
some differences cones shaped like a cone sensitive to color work best in bright light 5,000,000/eye location – found
around the fovea of the retina◦responsible for
sharp images and vision
a low ratio of synaptic connections between neurons ensures higher definition and sharpness compared to a higher ratio
sharp, acutevision
less sharp focused visual input
sharp, acutevision
less sharp focused visual input
rods shaped like a rod insensitive to color work well under low
illumination 20,000,000/eye location: found around the
periphery of the retina requires extended time
until optimal function
some differences cones shaped like a cone sensitive to color work best in bright light
5,000,000/eye location – found around
the fovea of the retina responsible for sharp
images and vision works optimally very
quickly
there are at least two levels of communication within the neural cells of the eye◦ rods and cones – bipolar cells – ganglion cells
(axons make up the optic nerve) to CNS
there are at least two levels of communication within the neural cells of the eye◦ rods and cones – bipolar cells – ganglion cells
(axons make up the optic nerve) to CNS◦ across a single layer (rods and cones
communicate with each other; bipolar cells communicate with each other; etc)
optic nerve (ganglion cell axons) – make a blind spot on each eye!
component (trichromatic ) or Young-Helmholz◦ occurs at level of cones
3 different cones more sensitive to different wavelengths (ie colors)
Explanations for color vision
trichromatic or Young-Helmholz◦ occurs at level of cones
explains major type of color blindness◦ deficits in certain types of cones can explain
major type of color blindness
Explanations for color vision
At level of cones- GREAT!
◦ there are different cones that produce greater changes in electrical potentials depending on the color (wave)
◦ abnormalities in cones can explain red/green color blindness
How does this explanation do?
Very rare to see complete color blindness - only usually seen with brain injury
~ 7% of US males (10,000,000) compared to 0.4% women - red/green
X-linked phenomenon
Color blindness
Sex (X) -linked phenomenon
X Y
X XX XY
Xb XXb XbY
40
What happens in hereditary color
deficiency?
· Red or green cone peak sensitivity is shifted.
· Red or green cones absent.
NORMAL CONE SENSITIVITY CURVES(TRICHROMAT)
41
B RG
437 nm 564 nm533 nm
42
B RG
437 nm 564 nm
(green shifted toward red)
5% of Males
43
B R
437 nm 564 nm
(no green cones; only red and blue)
1% of Males (there is no green curve)
44
B G
437 nm533 nm
(no red cones; only green and blue)
1% of Males (there is no red curve)
At level of cones- GREAT!
How does this the trichromatic theory do for explaining color vision?
negative afterimage –◦ phenomenon that occurs as a result of
overactivity or inhibition of neurons (due to color stimulation)
One thing that trichromatic theory cannot explain
opponent process theory◦ occurs at level of bipolar cells and higher black/white, red/green; yellow/blue; one color
excites bipolar cell; other color inhibits it
Explanations for color vision
says nothing about complexity as information reaches occipital lobe –
says nothing about color constancy◦ color constancy and the retinex theory- occurs at
the level of the cortex……
prestriate – primary occipital cortex; multiple layers of higher association cortex
Copyright © 2006 by Allyn and Bacon
Touch (mechanical stimuli) Temperature (thermal stimuli) Pain (nociceptive stimuli) Specialized receptors respond to the various
stimuli
Copyright © 2006 by Allyn and Bacon
Exteroreceptive System- stimuli applied to the skin
Figure 7.15
Copyright © 2006 by Allyn and Bacon
Ruffini ending Merkel’s disks Free nerve endings
Pacinian corpuscles
a necessary sense too little or too much – yikes! No obvious cortical representation (although
there are regions that appear to be involved in the emotional component)
PAIN
Substance P- ◦ Most pain is a result of substances released by
damaged tissues including substance P What else causes substance P release?
Neurotransmitters involved in Pain
Substance P is a large peptide and synthesis can take time SO
Release of large amounts of substance P results in a brief time (when more is being synthesized) that is “pain-free”
Huh?
Substance P
Endogenous opioids◦ endorphins – endogenous morphine-like
substances may explain acupuncture, placebo effects
Neurotransmitters involved in Pain
Descending pain control – pain can be suppressed by cognitive and emotional factors
PAG – periaqueductal gray
Copyright © 2006 by Allyn and Bacon
Descending Pain Control
3 discoveries made this possible
◦ Electrical stimulation of the PAG has analgesic (pain-blocking) effects
◦ PAG and other brain areas have large amounts of opiate receptors
◦ Existence of endogenous opiates (natural analgesics) - endorphins
Copyright © 2006 by Allyn and Bacon
A descending pain control pathway
MIDBRAIN
Congenital insensitivity to pain
Too little or too much pain
Extremely rare – less than 100 cases currently in the U.S.
Inability to thermoregulate (through skin) or feel pain
types: cancers, debilitating arthritis, back pain, undiagnosed, migraine
Approximately 80 million people in the United States suffer
Chronic pain consumes approximately $70 billion per year
Chronic pain
Chronic Pain
Chronic low back pain affects nearly 31 million Americans and represents the most common cause of disability in persons less than 45 years of age
drugs – morphine derivatives◦ oxycontin
ESB periaqueductal gray
Treatments:
drugs – morphine derivatives◦ oxycontin
ESB periaqueductal gray
acupuncture pain management
Treatments:
types: cancers, debilitating arthritis, back pain, undiagnosed
phantom limb
Chronic pain
drugs – antidepressants; antiseizure meds
cutting dorsal roots
anesthetizing stump
Additional Treatments for Phantom Limb: