2017
CHAMPALIMAUD RESEARCH SYMPOSIUM L ISBON, 09-11 OCT. 2017
3
Invited Speakers
CNIOSpain
MariaBlasco
10 TueTalk Session 4
Alber t Eins teinCollege of MedicineUSA
PaulFrenet te
10 TueTalk Session 5
Hokkaido Univ.Japan
YasuyukiFujita
11 Wed Talk Session 7
MPI and UCLGermany, UK
Linda Par tr idge
09 MonTalk Session 3
ChampalimaudPor tugal
EduardoMoreno
10 TueTalk Session 6
iBVFrance
PierreLeopold
09 MonTalk Session 2
09 MonTalk Session 3
Univ. of V irg iniaUSA
JonathanKipnis
11 Wed Talk Session 9
IMBAAustr ia
JosefPenninger
Francis Cr ick Ins t . UK
CaetanoReis e Sousa
10 TueTalk Session 6
ChampalimaudPor tugal
CarlosRibeiro
11 Wed Talk Session 8
09 MonKeynote Speaker
MITUSA
BobHor vitz
Francis Cr ick Ins t . UK
Jean-PaulVincent
11 Wed Talk Session 9
UT SouthwesternUSA
DuojiaPan
09 MonTalk Session 1
ChampalimaudPor tugal
Henrique Veiga-Fernandes
09 MonTalk Session 2
5
CHAMPALIMAUD RESEARCH SYMPOSIUM L ISBON, 09-11 OCT. 2017
Lunch
m o n09
Opening remark s
Duojia Pan
Chris ta Rhiner
Jonathan K ipnis
Pierre Leopold
Raquel Ol iveira
Ri ta Sousa-Nunes
Keynote speakerBob Hor v i t z
L inda Par tr idge
Joana Neves
Ana Carmena
Cof fee Break
Cof fee Break
Poster Session 1Wine & Cheese
Regis trat ionRegis trat ion Regis trat ion
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
08:00-09:00
Programme
Talk Session
111:0
0-13:0
0
Talk Session
915:3
0-17:0
0
Talk Session
214:0
0-15:3
0
Talk Session
79:3
0-10:3
0
Talk Session
811:0
0-12:3
0
Talk Session
316:0
0-17:3
0
t u e w e d10 11
Sunset dr ink s
Banquet & Par t y
Caetano Reis e Sousa Jean-Paul V incent
Maria Blasco Yasuyuk i Fuj i ta
Bruno Costa-Si l va Valent ina Marchesin
Josef Penninger
Valer y Kr izhanovsk y A l isson Gonti jo
Rui Benedito
Cof fee Break Cof fee Break
Lunch Lunch
Closing remark s
Recept ion in amphitheatre
Boat tr ip
Poster Session 2Cof fee & Cookies
Poster Session 3Cof fee & Cookies
Poster in
Stand
s and
Spo
nso
rs Exhib
ition
14:00-15:00
21:00-22:00
11:00-12:00
17:00-18:00
09:00-10:00
08:00-09:00
15:00-16:00
22:00-23:00
12:00-13:00
18:00-19:00
10:00-11:00
16:00-17:00
13:00-14:00
20:00-21:00
19:00-20:00
Eduardo Moreno
Paul Frenet te
Haakan Norel l
Car los Ribeiro
Jorge Beira
Henrique Veiga-Fernandes
Talk Session
49:3
0-10:3
0Talk Sessio
n 5
11:00
-12:30
Talk Session
6 15:3
0-17:0
0
7
09Registration desk opens
Keynote Lecture
m o n
Auditorium hall
Auditorium
08h00 - 09h00
09h00
UT Southwestern, USA
Champalimaud Centre for the
Unknown, Por tugal
MIT, USA
Champalimaud Foundation Board and Chairs of the 2017 Champalimaud Research Symposium
Genetic Control of Programmed Cell Death in Animal Development and Human Disease
Hippo signaling in grow th control and beyond
Activation of quiescent stem cells
Opening remarks
Bob Horvitz
Duojia Pan
Christa Rhiner
Coffee Break
Inst i tuto Gulbenkian de
Ciência, Por tugalDrosophila melanogaster brain is the l imit ing t issue in response to developmental aneuploidy
Raquel Oliveira
k
k
i
i
s
s
s
Coffee Break
Talk Session 2
Lunch Exhibition Hall
Auditorium14h00
Inst i tute of Biolog y Valrose, France
Max Planck Inst i tute for
Biolog y of Ageing , Germany
and UCL , UK
Buck Inst i tute for Research on
Aging , USA
Universit y of V irginia, USA
Inst i tuto de Neurociencias , A l icante , Spain
Immune regulation and the second brain
Coordination of organ grow th in Drosophila
Drugging ageing
MANF as an immune modulator y inter vention to improve regenerative therapies in aging
Immune and lymphatic aspects of neurological disorders
Synergism bet ween canoe and scribble mutations causes tumor- like overgrow th v ia Ras ac tivation in neural stem cells and epithelia
Henrique Veiga-Fernandes
Pierre Leopold
Linda Par tridge
Joana Neves
Jonathan Kipnis
Ana Carmena
13h00 - 14h00
Poster Session 1
Exhibition Hall17h30
Champalimaud Centre for the
Unknown, Por tugal
i
i
s
Talk Session 3
Auditorium16h00
i
s
i
Talk Session 1
Auditorium11h00
King ’s College London, UK
In v ivo expansion of functionally integrated GABAergic interneurons by targeted increase of neural progenitors
Rita Sousa-Nuness
keynote speakerinvi ted speaker
selected speaker
9
10 t u e
Lunch12h30
Talk Session 4
Coffee Break
Auditorium09h30
Alber t Einstein College of
Medicine, USA
Centro Nacional de Invest igaciones Oncológicas , Spain
Weizmann Inst i tute of
Science, Israel
An angio-metabolic switch in prostate cancer
Telomeres as targets for cancer and aging
Accumulation of senescent cells - mechanisms and consequences
Paul Frenet te
Maria Blasco
Valery Krizhanovsky
Champalimaud Centre for the
Unknown, Por tugal
Inst i tuto de Medicina Molecular, Por tugal
Circulating exosomes as a non-invasive source of biomarkers of cancer metastatic progression
Bruno Costa-Silva
Haakan Norell
Exhibition Hall
i
s
s
s
i
Talk Session 6
Poster Session 2
Quiosque do OliveiraPríncipe Real, Lisbon
Auditorium
Exhibition Hall13h30
18h00
Francis Cr ick Inst i tute, UK
Champalimaud Centre for the
Unknown, Por tugal
Centro Nacional de Invest igaciones Cardiovasculares ,
Spain
Sensing infection and t issue damage
Fitness f ingerprints of human cells
Dual i fgMosaic: A new method to study multiple and combinatorial gene function in development and disease
Caetano Reis e Sousa
Eduardo Moreno
Sunset drinks
i
s
i
Rui Benedito
15h30
Registration desk opens
Auditorium hall08h30 - 09h30
Dissecting the dynamics of single-tumor-cell - l ineages that underpin relapse of acute myeloid leukemia
Talk Session 5
Auditorium11h00
i
s
invi ted speaker
selected speaker
1 1
11 w e d
Lunch
Reception in Amphitheatre
Boat trip
Banquet & Party
12h30
17h00
18h30
20h00
Talk Session 4
Coffee Break
Auditorium09h30
Champalimaud Centre for the
Unknown, Por tugal
Hokkaido Universit y, Japan
CEDOC, Chronic Diseases Research
Centre, Por tugal
How animals make nutrient decisions
Cell competit ion bet ween normal and transformed epithelial cells in mammals
Neuroendocrine control of morphogenesis
Carlos Ribeiro
Yasuyuki Fujita
Alisson Gontijo
Imagine Inst i tute, France
ETH Zurich, Switzer land
HNF4 inhibit ion in Drosophila nephrocy tes promotes l ipid droplet accumulation and increased sur vival under star vation.
Valentina Marchesin
Jorge Beira
Exhibition Hall
Amphitheatre
CCU Entrance
Espelho d’Água
i
s
s
s
i
Talk Session 6
Poster Session 2
Auditorium
Auditorium
Exhibition Hall13h30
16h30
Francis Cr ick Inst i tute, UK
Inst i tute of Molecular
Biotechnolog y, Austr ia
Precision Wnt signall ing
From haploid stem cells to swaying sugar trees
Jean-Paul Vincent
Josef Penninger
i
i
15h30
Integrating signall ing inputs with chromatin regulators to direct t issue regeneration or tumorigenesis
Talk Session 5
Auditorium11h00
Chairs of the 2017 Champalimaud Research Symposium
Closing words
i
s
invi ted speaker
selected speaker
CHAMPALIMAUD RESEARCH SYMPOSIUM L ISBON, 09-11 OCT. 2017
1 3
09 m o n
Di ver s i t y in ant igen recogn i t ion by Unconvent iona l T ce l l s
E xosome S igna l l ing : A road map to under s t and met as t as is
Reg ula t ion of t y pe 2 innate l y mphoid ce l l s a t bar r ier s i tes
Sugar appet i te i s cont ro l led by the met abo l i c program of germl ine ce l l s
S i lenc ing the long non - coding RN A ant isense to Zeb2 fac i l i t a tes reprogramming of aged f ibrob las t s and s a feg uards s tem ce l l p lur ipotenc y.
Catarina
Bruno
Sergio
Ana Filipa
Zita
Sofia
Dina
Irina
Euclides
Inês
Patricia
Cristina
André
Yoon-Gu
1
4
7
10
13
16
19
22
25
28
31
34
37
40
Poster number
Almeida
Bernardes de Jesus
Caja Galan
Cardoso
Carvalho -Santos
Cerqueira
Coelho
Dominova
Fernandes Póvoa
Ferreira
Francisco
Godinho-Silva
Macedo
Jang
Erad ic a t ing HI V-1 fo l l i cu lar s anc tuar ies through immunotherapy
Exosomes as intermediar y of Gut-L iver communicat ion in t ype 2 diabetes
Postnatal development of g l ial GL A ST-posi t i ve cel ls
Control of innate lymphoid cel ls and enter ic defence by circadian inputs
Cull ing less f i t neurons protec ts against amyloid-β- induced brain damage and cognit ive and motor decl ine
Commensal bac ter ia and essent ial amino acids control food choice behav ior and reproduc t ion
Unravel ing the regulator y network of a complete C. elegans neural cel l l ineage
VEnCodes al low genet ic access to normal and cancer cel ls in the human body
Spat ial ac t ivat ion of TORC1 is regulated by Hedgehog and E2F1 signal ing in Drosophila eye.
At tenuat ion of synapt ic toxic i t y and MARK4/PAR1-mediated Tau phosphor y lat ion by methy lene blue for A lzheimer ’s disease treatment
Def ining the role of endothel ial notch ac t iv i t y in the biolog y of adult hematopoiet ic s tem and progenitor cel lsBone marrow ce l l s recr u i tment : p layer s a t pre -met as t a t i c n iche and met as t a t i c progres s ion
ROS-expressing neutrophils inhibi t pro-tumor IL-17-producing gamma-delta T cel ls
Cel l c ycle reentr y in the opt ic lobes of the adult Drosophila melanogaster brain
PosterSession I
Understanding the biophysical basis of teratogenesis and i t s cure: a computat ional model of developmental bioelec tr ics for repair of neuroteratorgenesis in v ivoEnaxocin ex tends l i fespan of C. elegans by inhibi t ing MIR-35-5P and mimick ing dietar y res tr ic t ion
Spliceosome subunit Salsa is required for ef f ic ient spl ic ing of gurkentranscr ipt dur ing Drosophila oogensis .
Prolac t in- induced neuroprotec t ion against g lutamate exci totoxic i t y is mediated by the reduc t ion of [Ca2+]i over load and NF-κB ac t ivat ion
Molecular chaperones in synaptogenesis and s tress
Maternal thyroid hormones def ic i t dur ing zebraf ish embr yogenesis hinders development of speci f ic cel l populat ions in the spinal cord
The Molecular and Transgenic Tools plat form at the Champalimaud Foundat ion
Def ibrot ide at tenuates oxidat ive damage of the hear t , l i ver, brain, and k idney t issues in a rat model of chronic obstruc t ive pulmonar y disease
Seongsoo
Carlos
Joana
Sofia
Shyama
Vaibhav
Silas
Om
Nadia
Elena
Nadia
Ana Raquel
Hafize
Lee
Lopez Fernandez de Castillejo
Maia
Mensurado
Nandakumar
Pai
Pinto
Rathore
Rivero
Santana Martín
Silva
Tomás
Uzun
43
46
49
52
55
58
61
64
67
70
73
76
79
CHAMPALIMAUD RESEARCH SYMPOSIUM L ISBON, 09-11 OCT. 2017
1 5
10 t u e PosterSession II
T he S egment at ion C lock in Tempora l Cont ro l o f HoxB Gene E xpres s ion
T he s y s temic RN A i pathway cont ro ls longev i t y, deve lopment and fer t i l i t y in C . e legans
Neurona l reg u la t ion of t y pe 2 innate l y mphoid ce l l s v ia neuromedin U
Gl iob las toma net work dep le te neurona l wg and induces neurodegenerat ion
T he Ro le of E 78 in Met abo l i sm
Raquel
Joanna
Henrique
Vânia
Sergio
Ana Catarina
Adam
Francisco
Mafalda
Fábio
Irene
Ana
Raffaella
Malgorzata
2
5
8
11
14
17
20
23
26
29
32
35
38
41
Andrade
Bou Saab
Camara
Cardoso
Casas Tinto
Certal
Dobson
Esteves
Ferreira
Fiúza Rosa
García-González
Gonçalves
Gozzelino
Lasota
A new, eas y and re l iab le c r yopreser vat ion protoco l for zebra f i sh sperm
Programming ant igen - present ing dendr i t i c ce l l s f rom f ibrob las t s
Neura l c i rcu i t s cont ro l l ing Pro lac t in re lease dur ing sexua l behav ior
Robo/S l i t s igna l ing dur ing normal and hy pop las t i c lung deve lopment in CDH contex t : expres s ion and f unc t iona l s tud ies
Benef ic ia l and de le ter ious long- term programming of age ing and t ranscr ip t ion by ear l y - l i fe in ter vent ions
Stud y ing endothe l ia l deve lopment in zebra f i sh us ing f unc t iona l mos a ic s
Func t iona l charac ter is a t ion of tumour- der i ved exosomes in the zebra f i sh xenogra f t model
In f lammat ion - dr i ven d isr upt ion of i ron homeos t as is in Park inson ’s d isease
Prognos t ic and therapeu t ic s ign i f i c ance of the c- K I T receptor expres s ion and mu t at ion in acu te mye lo id leukemia
Deve lopment of ra t female gen i t a l cor tex and cont ro l o f female puber t y by sexua l touch
S er um of D ie t ar y Res t r i c ted Mice Dow n - Reg ula tes Ucp1 in Mur ine D i f ferent ia ted Brow n Ad ipoc y tes
Ly sosomal c y s t ine e f f lux through C T NS inac t i va tes mTOR upon fas t ing in Drosophi la
Drosophi la melanogas ter bra in i s the l imi t ing t i s sue in response to deve lopment a l aneup lo id y
Intes t ina l organo ids co - cu l tures as a nove l s y s tem to s tud y in tes t ina l l y mphoc y tes
In f lammator y IL-23 s igna ls induce de novo di f ferent ia t ion of per iphera l γδ 17 T ce l l s f rom adul t bone marrow - der i ved precur sor s
A new too l to s tud y macrophage po lar i za t ion and p las t i c i t y w i th in the tumor microenv i ronment
T he ro le of ce l l compet i t ion in Drosophi la ’ s model o f A lzhe imer ’ s D isease
T he r ight cent rosome number : How to e l iminate cent rosomes
Immunomodula tor y ro le of Kerat in 76 in ora l and gas t r i c c ancer
M A NF i s a s y s temic reg u la tor o f met abo l i c and immune homeos t as is dur ing ag ing
Is there a ro le for materna l thy ro id hormones on per ic y te recr u i tment dur ing zebra f i sh b lood -h indbra in bar r ier deve lopment?
T he g us t a tor y bas is o f prote in -spec i f i c appet i te in Drosophi la
Constanze
Raissa
Zvonimir
Mihailo
Joana F
Pedro H
Sofia
Mariana
Patrícia
Ines
Pedro
Marlene
Samuel
Lenschow
Ludwig
Marelja
Mirkovic
Neves
Papotto
Rebelo
Reis
Rodrigues
Sequeira
Sousa-Victor
Trindade
Walker
4 4
47
50
53
56
59
62
65
68
71
74
77
80
Poster number
CHAMPALIMAUD RESEARCH SYMPOSIUM L ISBON, 09-11 OCT. 2017
1 7
11 w e d PosterSession III
A Func t ional Genomics approach to dissec t the pathways involved in the Mesodermal Speci f icat ion of Endothel ial and Blood Progenitor cel ls and i t s L ineage by using CRISPR Cas9
Mutat ions in ATP6AP2 are associated to congenital disorders of g lycosy lat ion with autophagic defec ts
Gamma osci l lat ions organize top-down signal ing to hypothalamus and enable food seek ing
MyT1 counterac ts the neural progenitor program to promote ver tebrate neurogenesis
Disec t ing the Anatomy of the Per iaqueduc tal Gray
Mayank
Baylor
Magda
Marta
Diogo
Andrea
Rita
Marta
Manuela
Irina
Alexandre
Ana
Anna
3
6
9
12
15
18
21
24
27
30
33
36
39
Bansal
Brangers
Cannata Serio
Carus-Cadavieco
Castro
Chai
Domingues
Estrada
Ferreira
Fonseca
Gaspar Maia
Gonçalves
Jagusiak
Spat iotemporal ly reproducible genet ic per turbat ion for ef f ic ient large-scale s tudies of non-autonomous ef fec ts
Consequences of centr iole aberrat ions in cancer
Modell ing tumor-s troma interac t ions to address disease progression and drug response mechanisms
Reveal ing the epithel ial cel ls dynamics associated with the normal and hypoplas t ic fetal lung development
Control of innate lymphoid cel ls and enter ic defence by circadian inputs
Modulat ion of enhancer ac t iv i t y in cancer and cel lular reprogramming by the his tone var iant macroH2A
Control of natural intraepithel ial l ymphoc y tes and ear ly l i fe intes t inal defence by diet-der ived ret inoids
Carbon nanotubes dispersed with supramolecular compounds as a potent ial drug del iver y sys tem - proper t ies of the complex and mechanism of the interac t ion
Understanding the role of competi t i ve interac t ions between cel ls in g l ioblas toma
T iming and reg u la t ion of cent rosome ampl i f i c a t ion in human tumor igenes is
T he ro le of Notch in coronar y ves se l format ion and remodel ing
Unrave l l ing the c i rcu i t s invo l ved in e jacu la t ion in mice
Mechanic a l s t res s - induced ce l l - c yc le modi f i c a t ion in organ propor t ion ing
V EGF R-2 s igna l ing reg u la tes the sens i t i v i t y o f acu te mye lo id leukemia to chemotherapy by reprogramming mi tochondr ia l met abo l i sm
K at 2a reg u la tes A ML se l f - renewal and cont ro ls t ranscr ip t iona l heterogenei t y in mal ignant and deve lopment a l s tem ce l l s y s tems
T he vent romedia l hy potha lamus in female mice sexua l recept i v i t y
Meningea l γδ T ce l l - der i ved IL-17 cont ro ls s y napt ic plas t i c i t y and cogn i t i ve behav iour
Zeb1 potent ia tes genome - w ide gene t ranscr ip t ion in g l iob las toma c ancer s tem ce l l s v ia a nove l Le f1-dependent mechanism
A mye lo id ce l l - cent r i c v iew of c ancer : ant i - tumour macrophages - my th or rea l i t y?
Ident i f i c a t ion of nove l hemang iob las t genes expres sed in the ear l y embr yo
Ef fec t o f er y thropoie t in pret reatment on ox idat i ve s t res s c aused by pent y lenetet razo le -induced se izures in k idney, l i ver and hear t
Katerina
Carla A.M.
Wen
Ana Rita
Kenta
Sandrina
Cristina
Inês
Julie
Pedro
Karine
Ana Teresa
Gülay
Lawlor
Lopes
Luo
Mendes
Morimoto
Nóbrega Pereira
Pina
Preguiça
Ribot
Rosmaninho
Serre
Tavares
Üzüm
42
45
48
51
54
57
60
63
66
69
72
75
78
Poster number
1 9
Symposium Sponsors
Silver Sponsors
Contributors
Institutional Support
LISBON, 09-11 OCT. 2017
Algés
Avenida da ÍndiaAvenida de Brasília
Torrede
Belém
Museu
de ArtePopular
CentroCultural de Belém
PlanetárioCalouste
Gulbenkian
Fortedo BomSucesso
Estádio do Restelo
Padrãodos
Descobrim
entos
Mosteirodos
Jerónimos
Doca Pesca
Algés
Algés - B
elém area
Belém
CH
AM
PALIM
AU
DC
EN
TRE
FOR
THE
UN
KN
OW
N
Largo da Princesa
Eléctrico 15tram
15
pedestrianroute (10 m
in.)
How
to get to the S
ymposium
Site