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Types of shock
•Hypovolemic shock•Cardiogenic shock•Septic shock•Others (Neurogenic shock, Anaphylactic
shock)
Septic shock
( BP )
Systemic VD
Cardiac contractility
Endothelial injury &
activation
Coagulation
system ++
& DICEndotoxin
Pathogenesis (A)
Widespread endothelial
damageRelease of
thrombogenic substance
Obst complic
Neoplasm
Severe burn/ trauma
Infection
Pathogenesis (B)
++coagulation PW
Thrombi in microcirc
Consumption of platelets & coag factors
++fibrinolysis
Effects of DIC
•Widespread fibrin deposition in microcirc.
Ischemia & hemolysis
•Depletion of platelets & coag factorsBleeding diathesis
•Microinfarctions Multiple organ failure