8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

1/12

 

Amniotic Membrane Transplantation Using

Fibrin Glue in Pterygium Surgery 

Sirel G. Güngör, MD

Cem ü!ü"er#önme$, MD

 %onca A. A"o&a, MD Baskent University, School of Medicine

Department of Ophthalmology, AnkaraTurkey

The authors acknowledge no financial interest

in the subject matter of this presentation

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

2/12

 

'ntro#uction 

Amniotic membrane transplantation

(AMT) is a t*erapeutic option +or ocular

sur+ace #isor#ers

• Persistent epit*elial #e+ects

• Deep stromal #e+ects

•

Stem cell #eciency• Pterygium

• Symblep*aron

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

3/12

 

Purpose

To e&aluate t*e e++icacy an# sa+ety o+

+ibrin glue +i-ation o+ amniotic

membrane an# to compare t*e

results it* suture +i-ation in surgery

+or primary pterygium

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

4/12

 

Met*o#s

• Prospecti&e,

ran#omi$e# clinical

stu#y o+ /0 eyes (/0

patients) it* primarypterygium #i&i#e# into

1 groups

• Surgical met*o#

2-tensi&e pterygium

remo&al an# AMT

Group 3

• Amniotic membrane

as +i-ate# it* 450

6icryl suturesGroup 1

• Fibrin glue (Tisseel

VH, Baxter AG,

Vienna, Austria) asuse#

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

5/12

 

Met*o#s

• Clinical e-amination an#

#igital p*otograp*ing

as per+orme# at eac*

&isit

• 7peration time,

sub8ecti&e sensation o+

pain, complications an#recurrence rates ere

recor#e#

• Sub8ecti&e pain scale 9

0  none, no pain

1 &ery mil#, presence o+pain but easily tolerate#

2  mil#, pain causingsome #iscom+ort

3 mo#erate, pain t*atpartially inter+eres it*usual acti&ity or sleep

4 se&ere, pain t*atcompletely inter+eresit* usual acti&ity orsleep

9Lim-Bon-Siong et al Am : 7p*t*almol 3;;4< 31=>3?;

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

6/12

 

@esults

  Group 3 Group 1  !

  Mean

operationtime

(minutes) 34. B5 1.1 33.1 B5 ./ pE0.0=

@ecurrence

rate () =.4 =.= p0.0=

Mean +olloup time(mont*s) 3?.4 B5 /.1 3=.; B5 1.= p0.0=

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

7/12 

@esults

'n group 1• Signi+icantly less symptoms at

postoperati&e #ay 3 an# • Postoperati&e signs o+ *yperemia an#

c*emosis ere signi+icantly less obser&e#• 1 eyes #e&elope# gra+t #e*iscence a+ter

surgery, *ic* ere success+ully re+i-ate#it* +ibrin glue

• Ho ot*er complications ere obser&e#

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

8/12 

Clear cornea a+ter e-tensi&e pterygium remo&al an# AMT it* +ibrin glue at 3st

mont*

Preoperati&e primary pterygium 

Clear cornea a+ter e-tensi&e pterygium

remo&al an# AMT it* +ibrin glue at 3st #ay

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

9/12 

Preoperati&e primary pterygium

Clear cornea a+ter e-tensi&e pterygium remo&al

an# AMT it* 450 6icryl sutures at 3st #ay

Clear cornea a+ter e-tensi&e pterygium remo&al an# AMT it* 450 6icryl sutures at

3st mont*

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

10/12 

Discussion

AMT it* sutures• Prolonge# operating time

• Postoperati&e #iscom+ort

• Suturerelate# complications suc* as abscess an#granuloma +ormation

AMT it* +ibrin glue• Completely bio#egra#able

• 2asy to +i-ate t*e amniotic membrane an# s*orter

operation time

• Iess patient #iscom+ort

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

11/12 

Conclusion

Fi-ation o+ amniotic membrane using

+ibrin glue

•

2++ecti&e an# sa+e met*o#• @e#uce# t*e operation time

• 'mpro&e# postoperati&e com+ort

• Ho a##itional e++ect on re#ucingpterygium recurrence

8/18/2019 000135 Amniotic Membrane Transplantation Using Fibrin Glue in Pterygium Surgery

12/12 

HAM2> %onca Ay#Jn A"o&a, M.D.

T'TI2> Pro+essor in 7p*t*almology

DAT2 AHD PIAC2 7F K'@TL> 

7ctober 13, 3;?0, Tur"ey3;4> Doctor o+ Me#icine, 'stanbul

Uni&ersity, Sc*ool o+ Me#icine

3;;0> 'stanbul Uni&ersity, Sc*ool o+Me#icine,Department o+ 7p*t*almology

1000>Pro+essor o+ 7p*t*almology,Kas"ent Uni&ersity, Sc*ool o+Me#icine, Department o+

7p*t*almology, An"ara, Tur"ey1001> C*airperson, Kas"ent

Uni&ersity, Sc*ool o+ Me#icine,Department o+ 7p*t*almology,

An"ara, Tur"ey

HAM2>  Sirel Gür Güngör, M.D.

T'TI2>  @esi#ent in 7p*t*almology

DAT2 AHD PIAC2 7F K'@TL> 

February 3=, 3;;, Tur"ey100>  Doctor o+ Me#icine, An"ara

Uni&ersity, Sc*ool o+Me#icine

1001004 >  @esi#ent, Ka"entUni&ersity, Sc*ool o+Me#icine, Department o+7p*t*almology, An"ara,Tur"ey

HAM2>  Cem ü!ü"er#önme$, M.D.

T'TI2>  Fello in 7p*t*almology

DAT2 AHD PIAC2 7F K'@TL> 

7ctober ;, 3;=, Tur"ey3;;;>  Doctor o+ Me#icine,

Lacettepe Uni&ersity, Sc*oolo+ Me#icine

100 > Ka"ent Uni&ersity, Sc*ool o+Me#icine,Department o+ 7p*t*almology