of 44
7/29/2019 003 Replicao.pdf
1/44
2. DNA replication
7/29/2019 003 Replicao.pdf
2/44
Dogma central da Biologia Molecular
Francis Crick 1958
(autoreplicao) Transcrio Traduo Protena
DNA
Gentipo Fentipo
(RNA)
7/29/2019 003 Replicao.pdf
3/44
7/29/2019 003 Replicao.pdf
4/44
MeselsonStahl experiment 1958
7/29/2019 003 Replicao.pdf
5/44
MeselsonStahl experiment 1958
7/29/2019 003 Replicao.pdf
6/44
7/29/2019 003 Replicao.pdf
7/44
7/29/2019 003 Replicao.pdf
8/44
Circular Linear
7/29/2019 003 Replicao.pdf
9/44
No replicons tamnaho velocidade
E.Coli 1 4,200 kb 50 kb/min
Drosophila 3,500 40 kb 3,6 kb/minRatinho 25,000 150 kb 2,2 kb min
7/29/2019 003 Replicao.pdf
10/44
Replication Timing: pulse-chase experiments
-Early Single copy-Mid Single copy + moderate repeats-Late Heterochromatin
7/29/2019 003 Replicao.pdf
11/44
ORC Origen recognition complex
7/29/2019 003 Replicao.pdf
12/44
DNA polymerases 53
7/29/2019 003 Replicao.pdf
13/44
7/29/2019 003 Replicao.pdf
14/44
7/29/2019 003 Replicao.pdf
15/44
DNA polimerase 5 -> 3Elongao
7/29/2019 003 Replicao.pdf
16/44
7/29/2019 003 Replicao.pdf
17/44
Primer synthesis
7/29/2019 003 Replicao.pdf
18/44
7/29/2019 003 Replicao.pdf
19/44
Polimerizao
7/29/2019 003 Replicao.pdf
20/44
DNA polymerase
7/29/2019 003 Replicao.pdf
21/44
Okazaki fragmentsRemoval RNA
Extension DNALigation
7/29/2019 003 Replicao.pdf
22/44
7/29/2019 003 Replicao.pdf
23/44
7/29/2019 003 Replicao.pdf
24/44
E.coli
Sliding clamp hypothesis
E.Coli PCNA
7/29/2019 003 Replicao.pdf
25/44
7/29/2019 003 Replicao.pdf
26/44
O replissoma
7/29/2019 003 Replicao.pdf
27/44
Replicao em bactria e mamferos e semelhante
7/29/2019 003 Replicao.pdf
28/44
Replicao em bactria e mamferos e semelhante
Old histones distributed randomlyand new ones added by specific chaperones
7/29/2019 003 Replicao.pdf
29/44
7/29/2019 003 Replicao.pdf
30/44
7/29/2019 003 Replicao.pdf
31/44
A=TG=C
A..C
G..T
7/29/2019 003 Replicao.pdf
32/44
Replication errors 1-5 x 10 -9 / nucleotide
7/29/2019 003 Replicao.pdf
33/44
Supercoiling +
7/29/2019 003 Replicao.pdf
34/44
7/29/2019 003 Replicao.pdf
35/44
Topoisomerase II
7/29/2019 003 Replicao.pdf
36/44
Origens de replicao e metilao
7/29/2019 003 Replicao.pdf
37/44
Replicao do fago lambda
7/29/2019 003 Replicao.pdf
38/44
7/29/2019 003 Replicao.pdf
39/44
7/29/2019 003 Replicao.pdf
40/44
7/29/2019 003 Replicao.pdf
41/44
7/29/2019 003 Replicao.pdf
42/44
7/29/2019 003 Replicao.pdf
43/44
7/29/2019 003 Replicao.pdf
44/44
Telomere length is genetically controlled in yeast