New Research Grant Award Terrence Allen, MD, Assistant Professor in the Division of Women’s Anesthesia & Critical Care Medicine was awarded a two-year $45,341 Society for Obstetric Anesthesia and Perinatology 2012 Gertie Marx Education & Research Grant entitled “Mechanisms of Progesterone mediated effect on cytokine induced Metalloproteinase activity in human trophoblast cells”. Preterm delivery (PTD) and preterm premature rupture of membranes (PPROM) are major problems in the United States and internationally. The mechanisms resulting in PPROM are not well understood. Recent evidence from work under Dr. Amy Murtha in the Department of Obstetrics and Gynecology at Duke University has clearly demonstrated that woman with PPROM have global thinning of the chorion layer of the fetal membranes even at sites remote from membrane rupture when compared to term and preterm patient. It is likely that inflammatory cytokines and matrix metalloproteinases (MMPs) are involved in this significant tissue remodelling. Recently the FDA has approved the use of 17 hydroxyprogesterone caproate injections (17- OHP) to reduce the risk of PTD before 37 weeks in women with a previous history of at least one spontaneous PTD. The mechanisms by which 17- OHP and other progestins provides protection remains unclear. Recent work demonstrates that progesterone protects cytotrophoblast cell death induced by oxidative stress and that this effect is likely mediated through PGRMC1. Furthermore, research has also shown that progesterone decrease the MMP9 activity induced by TNF in cultured human fetal membrane. This project will focus on determining the role of PGRMC1 in progesterone’s modulation of MMP 9 activity using a human trophoblastic cell line which produces PGRMC1 and lacks the nuclear progesterone receptor (HTR8/SVneo cells) and cultured human fetal membranes. New Research Publication Chrysostomou C, Sanchez-de-Toledo J, Wearden P, Jooste EH, Lichtenstein SE, Callahan P, Suresh T, O’Malley E, Shiderly D, Haney J, Yoshida M, Orr R, Munoz R, Morell VO. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations. Ann Thorac Surg 2011 Sep; 92:964–72. Zhong L, Bellemer A, Yan H, Honjo K, Robertson J, Hwang RY, Pitt GS, Tracey WD. Thermosensory and nonthermosensory isoforms of drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP channel. Cell Reports 2012;1:1–13. Goldberg JS. Monitoring Maternal Beta Carotene and Retinol Consumption May Decrease the Incidence of Neurodevelopmental Disorders in Offspring. Clinical Medicine Insights: Reproductive Health 2012:6 1-8. http://anesthesiology.duke.edu 1 Department of Anesthesiology Research Conference Monday, January 9, 2012 | 5-6 pm | 5685-HAFS “The Effect of Progestins on Cytokine Induced Metalloproteinase Activity in Human Trophoblast Cells” Terrence K. Allen, MBBS, Assistant Professor SAVE THE DATE: Quarterly Triangle TEE Conference You are cordially invited to the next Quarterly Triangle TEE Conference. The lectures will be given by UNC Anesthesiology Fellows, Dr. Emily Graham and Dr. Harrison Kibe on the topic of “Atrial Myxomas”. The dinner conference will be held from 6:30 – 9:00 pm on Wednesday, January 25, 2012 at Bocci’s Italian Trattoria. Space is limited, so please register at your earliest convenience. The cost of the dinner for faculty is $30/person; fellows are residents may attend free of charge. Contact Jaime Cooke at 681-6532 for more information an to register. Dream Campaign Fiscal Year 2012 Goal The DREAM Innovation Grant (DIG) supports innovative high-risk, and potentially high-re- ward investigations to accelerate anesthesia and pain management research. Our goal is to raise $90,000, which will allow us to fund three $30K DIG recipients in 2013. The win- ners of this grant will be announced in Octo- ber 2012. Total raised to date: $38,280.00. To make a gift, please visit: http://blueprint.duhs.duke.edu/ Comings and Goings Please welcome Hsiang-Hsun Kung, Visiting Research Scholar, to the Department. Dr. Kung started with the Pain Management Division on December 1, 2011. Leaving the department soon? Let’s keep in touch! Please contact Lauren Marcilliat at [email protected]with your new mailing and email address prior to your departure so that we can add you to our database! News Tuesday, January 3, 2012 • Volume 14, Issue 1
Transcript
New Research Grant AwardTerrence Allen, MD, Assistant Professor in the Division of Women’s Anesthesia & Critical Care Medicine was awarded a two-year $45,341 Society for Obstetric Anesthesia and Perinatology 2012 Gertie Marx Education & Research Grant entitled “Mechanisms of Progesterone mediated effect on cytokine induced Metalloproteinase activity in human trophoblast cells”. Preterm delivery (PTD) and preterm premature rupture of membranes (PPROM) are major problems in the United States and internationally. The mechanisms resulting in PPROM are not well understood. Recent evidence from work under Dr. Amy Murtha in the Department of Obstetrics and Gynecology at Duke University has clearly demonstrated that woman with PPROM have global thinning of the chorion layer of the fetal membranes even at sites remote from membrane rupture when compared to term and preterm patient. It is likely that inflammatory cytokines and matrix metalloproteinases (MMPs) are involved in this significant tissue remodelling. Recently the FDA has approved the use of 17 hydroxyprogesterone caproate injections (17-OHP) to reduce the risk of PTD before 37 weeks in women with a previous history of at least one spontaneous PTD. The mechanisms by which 17-OHP and other progestins provides protection remains unclear. Recent work demonstrates that progesterone protects cytotrophoblast cell death induced by oxidative stress and that this effect is likely mediated through PGRMC1. Furthermore, research has also shown that progesterone decrease the MMP9 activity induced by TNF in cultured human fetal membrane. This project will focus on determining the role of PGRMC1 in progesterone’s modulation of MMP 9 activity using a human trophoblastic cell line which produces PGRMC1 and lacks the nuclear progesterone receptor (HTR8/SVneo cells) and cultured human fetal membranes.
New Research PublicationChrysostomou C, Sanchez-de-Toledo J, Wearden P, Jooste EH, Lichtenstein SE, Callahan P, Suresh T, O’Malley E, Shiderly D, Haney J, Yoshida M, Orr R, Munoz R, Morell VO. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations.
Ann Thorac Surg 2011 Sep; 92:964–72.
Zhong L, Bellemer A, Yan H, Honjo K, Robertson J, Hwang RY, Pitt GS, Tracey WD. Thermosensory and nonthermosensory isoforms of drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP channel. Cell Reports 2012;1:1–13.
Goldberg JS. Monitoring Maternal Beta Carotene and Retinol Consumption May Decrease the Incidence of Neurodevelopmental Disorders in Offspring. Clinical Medicine Insights: Reproductive Health 2012:6 1-8.
http://anesthesiology.duke.edu 1
Department of Anesthesiology Research ConferenceMonday, January 9, 2012 | 5-6 pm | 5685-HAFS
“The Effect of Progestins on Cytokine Induced Metalloproteinase Activity in Human Trophoblast Cells”Terrence K. Allen, MBBS, Assistant Professor
SAVE THE DATE: Quarterly Triangle TEE ConferenceYou are cordially invited to the next Quarterly Triangle TEE Conference. The lectures will be given by UNC Anesthesiology Fellows, Dr. Emily Graham and Dr. Harrison Kibe on the topic of “Atrial Myxomas”. The dinner conference will be held from 6:30 – 9:00 pm on Wednesday, January 25, 2012 at Bocci’s Italian Trattoria. Space is limited, so please register at your earliest convenience. The cost of the dinner for faculty is $30/person; fellows are residents may attend free of charge.
Contact Jaime Cooke at 681-6532 for more information an to register.
Dream Campaign Fiscal Year 2012 GoalThe DREAM Innovation Grant (DIG) supports innovative high-risk, and potentially high-re-ward investigations to accelerate anesthesia and pain management research. Our goal is to raise $90,000, which will allow us to fund three $30K DIG recipients in 2013. The win-ners of this grant will be announced in Octo-ber 2012. Total raised to date: $38,280.00.
To make a gift, please visit: http://blueprint.duhs.duke.edu/
Comings and GoingsPlease welcome Hsiang-Hsun Kung, Visiting Research Scholar, to the Department. Dr. Kung started with the Pain Management Division on December 1, 2011.
Leaving the department soon? Let’s keep in touch! Please contact Lauren Marcilliat at [email protected] with your new mailing and email address prior to your departure so that we can add you to our database!
NewsTuesday, January 3, 2012 • Volume 14, Issue 1
THIS MoNTH IN THE DEPARTMENT oF ANESTHESIoloGY
http://anesthesiology.duke.edu 2
January 2012
MoNDAY TUESDAY WEDNESDAY THURSDAY FRIDAY2 3 4 5 6
Medical Center HolidayHappy New Year!
5-6 p.m., 5685-HAFSCT ConferenceCANCELLED
5-6 p.m., 2001DNCA-1 Resident Lectures: “Pharmaco-kinetics: What Every Anesthesiologist Must Know” - Brian Ginsberg, MB
5-6 p.m., 6686-HAFSGVTCCM Conference: “Comparative Effectiveness Research and Non-Inferiority Trials” - Eugene Moretti, MD
IRB Deadline
7:00 a.m., 2001DNGrand Rounds: “DREAM Innova-tion Grant Vignettes” - Drs. Joseph Mathew, Luke James, Wei Yang
4:30 p.m., 5685-HAFSAdvanced Resident Lecture: “What to do with Pacemakers + Defibrillators” - Tim Miller, MD
7:15-8:00 a.m., RM203-PainClinicMRC Pain Journal Club
12-1 p.m., 2003DNCritical Care Grand Rounds: “Percuta-neous Tracheostomy” - Dr. Momen Wahidi
4-5 p.m., 1700B-DNACES Meeting: “TBA” - David Warner, MD
5-6 p.m., 5685-HAFSResearch Conference: “The Effect of Progestins on Cytokine Induced Metalloproteinase Activity in Human Trophoblast Cells” - Terrence Allen, MBBS
5-6 p.m., 2001DNCA-1 Resident Lectures: “Principles of Neuromonitoring” - Luke James, MD
5-6 p.m., 6686-HAFSGVTCCM Conference: TBA - Jeff McKenzie, MD
IRB Deadline
7:00 a.m., 2001DNGrand Rounds
4:30 p.m., 5685-HAFSAdvanced Resident Lecture
7:15-8:00 a.m., RM203-PainClinicMRC Pain Journal Club
12-1 p.m., 2003DNCritical Care Grand Rounds
4-5 p.m., 5680A-HAFSPediatric Conference
Upcoming:2012 Office Professional Day: Wednesday, April 25, 2012 | 11:30am - 1pm | 5685-HAFSDuke Anesthesiology 40th Anniversary Gala: June 1-3, 2012 | Washington Duke Inn, Durham, NC2012 Academic Evening: Friday, June 1, 2012 | Washington Duke Inn, Durham, NC2012 Duke Anesthesiology Alumni Reception: Sunday, October 14, 2012 | Washington, DC2012 ASA: October 13-17, 2012 | Washington, DC
Please join us Saturday January 28, 2012 at 7:00 pm for an evening of
delicious food, specialty drinks and wonderful items for auction (both live and
silent) to benefit Duke CRNAs Global Health Mission.
$40.00 per person
ANESTHESIoloGY NEWS
http://anesthesiology.duke.edu 4
Upcoming CME Activities
6th Annual Winter Anesthesia and Critical Care ReviewMarch 4-9, 2012 | Canyons Resort | Park City, UTFor more information, email Katherine Siler: [email protected].
5th Annual Emerging Technologies in the oR and Great Fluid DebateJune 11-15, 2012 | Disney’s Grand Floridian Resort and Spa lake Buena Vista, FlFor more information, email Katherine Siler: [email protected].
15th Annual Cardiothoracic Update and TEE Board ReviewJuly 5-8, 2012 | The Westin Hilton Head Island Resort and Spa Hilton Head Island, SCFor more information, contact Jaime C. Cooke: [email protected].
Preceptorships
Ultrasound Guided Regional Anesthesia Preceptorship Course2011 Dates Available | Duke University Medical Center, Durham, NCFor more information, email Katherine Siler: [email protected] in the Duke Preceptorship will spend three days in the regional block area, operating rooms and on the floor with post surgery patients observing ultra-sound guided single shot nerve blocks and catheter techniques in a wide variety of clinical scenarios.
Visiting Preceptorship in Intraoperative Transesophageal Echocardiography2011-2012 Dates Available | Duke University Medical Center, Durham, NCFor more information, email Jaime C. Cooke: [email protected] in the Duke Intraoperative TEE Preceptorship spend one three-day session in the cardiac operating suites, observing techniques of intraoperative TEE and interpretation of images.
For more information and to register, visit http://anesthesiology.duke.edu
Anesthesiology on Facebook and TwitterDo you have exciting news or information pertinent to the academic community that you want to share through the department’s social media sites? The department has facebook and twitter accounts for Duke
Anesthesiology, Duke Anesthesiology Alumni, and the DREAM Campaign. Send your announcements to Lauren Marcilliat ([email protected]) to be posed on the department’s social media sites. Remember to keep announcements to 140 characters in length so that they are twitter compatible (about the size of this sentence). Including a link to another online source for more information is highly recommended.
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