http://anesthesiology.duke.edu 1 Paschen Receives Major NIH Departmental Research Grant Award Wulf Paschen, PhD, of the Division of Basic Sciences, received a 3-year $1,170,000 NIH Research Grant (R01) from the National Heart, Lung, and Blood Institute (NHLBI) entitled “SUMO Conjugation and Deep Hypothermia-Induced Organ Protection”. Working with Dr. Paschen on the project are co-Investigators Drs. Burkhard Mackensen (front rowleft), Wei Yang (back row-left), and Ma Qing (front row-right). Various pediatric and adult cardiovascular operations involve cardiopulmonary bypass procedures that require a period of circulatory arrest. Major cardiovascular surgery in pediatric and adult patients induces peri-operative organ injury and is therefore associated with significant adverse cerebral, renal and cardiovascular outcomes. To protect organs from ischemic damage, surgery is usually performed during deep hypothermic conditions (deep hypothermic circulatory arrest. Although the protective potential of deep hypothermia is unquestionable, little is known about the mechanisms through which it protects organs or how to maximize its efficacy. We hypothesize that deep hypothermia protects organs from ischemic damage by activating the small ubiquitin-like modifier (SUMO) conjugation pathway. The specific aims of this research project are to examine the relationship between extent and duration of hypothermia and activation of the SUMO conjugation pathway, to identify proteins where SUMO conjugation is activated by deep hypothermia, and to verify whether activation of the SUMO conjugation pathway plays a role in the protective process induced by hypothermia. If our hypothesis proves valid, i.e. deep hypothermia does indeed induce an active process resulting in a rise in levels of SUMO conjugated proteins and activation of the SUMO conjugation pathway does play a key role in that process, it could revolutionize our understanding of the mechanisms underlying the protective effects of hypothermia. News Monday, March 8, 2010 • Volume 12, Issue 10 SUMO conjugation could represent an exciting new target for therapeutic intervention by providing a means of increasing the resistance of organs to a transient interruption of blood supply. Ronald Olson Named Health Care Hero by Triangle Business Journal Triangle Business Journal - by Jeff Drew A group of 10 professionals associated with the Duke University Health System are among the 28 winners of the 2010 Health Care Heroes Awards, Triangle Business Journal announced. The winners – doctors, nurses, volunteers, administrators and others – will be honored at an awards dinner on March 25 at the North Ridge Country Club in Raleigh. Profiles of the winners will be published as part of a special section in the March 26 issue of Triangle Business Journal. “This year’s winners truly exemplify the spirit of the Health Care Heroes Awards,” says Charlene Grunwaldt, publisher of Triangle Business Journal. “By serving the sick, running major health-care operations and building lasting institutions, these winners go above and beyond the call of duty to ensure the Triangle offers cutting-edge services. We thank each of our 28 winners for their years of hard work.” A list of the winners follows: 1. Erin Adcock, Rex Healthcare 2. Cindy Atkins, Duke Cancer Patient Support Program 3. Rosemary Brown, Duke Raleigh Hospital 4. Robin Carver, WakeMed Health & Hospitals 5. Dr. John Chute, Duke University Medical Center 6. Charles Hamner, The Hamner Institutes for Health Sciences 7. G. Mark Holmes, North Carolina Institute of Medicine 8. Dr. Keith Hull, Jr., Raleigh Neurology Associates, PA 9. Dr. William Lagarde, WakeMed Health & Hospitals 10. Andrea Layton, Duke Raleigh Hospital 11. Yvette Meggs, Duke Raleigh Hospital 12. Margie Muir, Durham Regional Hospital 13. Ashley Neville, Durham Regional Hospital 14. Natalie Newell, Rex Healthcare 15. Peg O’Connell, JD, Rex Healthcare 16. Dr. Ron Olson, Duke University 17. Dr. William Pittman, III, WakeMed Health & Hospitals 18. Elaine Rohlik, WakeMed Rehab 19. Donna Bryan Spears, Murdoch Developmental Center 20. Bruce Sullenger, Duke University Medical Center 21. Mary Szymkowski, Animal Hospital of Peak Plaza 22. Jim Taggart, Physicians Pharmacy Alliance 23. Dennis Thiele, Duke University Medical Center 24. Dr. Anthony Viera, UNC Department of Family Medicine 25. Kathy von St. Paul, Rex Healthcare 26. UNC Family Medicine Center; Dr. Sam Weir 27. Joseph Zhou, NC Technical & Community Student Health Plan 28. Otto Zhou, University of North Carolina at Chapel Hill
Transcript
http://anesthesiology.duke.edu 1
Paschen Receives Major NIH Departmental Research Grant AwardWulf Paschen, PhD, of the Division of Basic Sciences, received a 3-year $1,170,000 NIH Research Grant (R01) from the National Heart, Lung, and Blood Institute (NHLBI) entitled “SUMO Conjugation and Deep Hypothermia-Induced Organ Protection”. Working with Dr. Paschen on the project are co-Investigators Drs. Burkhard Mackensen (front rowleft), Wei Yang (back row-left), and Ma Qing (front row-right).
Various pediatric and adult cardiovascular operations involve cardiopulmonary bypass procedures that require a period of circulatory arrest. Major cardiovascular surgery in pediatric and adult patients induces peri-operative organ injury and is therefore associated with significant adverse cerebral, renal and cardiovascular outcomes. To protect organs from ischemic damage, surgery is usually performed during deep hypothermic conditions (deep hypothermic circulatory arrest. Although the protective potential of deep hypothermia is unquestionable, little is known about the mechanisms through which it protects organs or how to maximize its efficacy.
We hypothesize that deep hypothermia protects organs from ischemic damage by activating the small ubiquitin-like modifier (SUMO) conjugation pathway. The specific aims of this research project are to examine the relationship between extent and duration of hypothermia and activation of the SUMO conjugation pathway, to identify proteins where SUMO conjugation is activated by deep hypothermia, and to verify whether activation of the SUMO conjugation pathway plays a role in the protective process induced by hypothermia. If our hypothesis proves valid, i.e. deep hypothermia does indeed induce an active process resulting in a rise in levels of SUMO conjugated proteins and activation of the SUMO conjugation pathway does play a key role in that process, it could revolutionize our understanding of the mechanisms underlying the protective effects of hypothermia.
NewsMonday, March 8, 2010 • Volume 12, Issue 10
SUMO conjugation could represent an exciting new target for therapeutic intervention by providing a means of increasing the resistance of organs to a transient interruption of blood supply.
Ronald Olson Named Health Care Hero by Triangle Business JournalTriangle Business Journal - by Jeff Drew
A group of 10 professionals associated with the Duke University Health System are among the 28 winners of the 2010 Health Care Heroes Awards, Triangle Business Journal announced.
The winners – doctors, nurses, volunteers, administrators and others – will be honored at an awards dinner on March 25 at the North Ridge Country Club in Raleigh. Profiles of the winners will be published as part of a special section in the March 26 issue of Triangle Business Journal.
“This year’s winners truly exemplify the spirit of the Health Care Heroes Awards,” says Charlene Grunwaldt, publisher of Triangle Business Journal. “By serving the sick, running major health-care operations and building lasting institutions, these winners go above and beyond the call of duty to ensure the Triangle offers cutting-edge services. We thank each of our 28 winners for their years of hard work.”
A list of the winners follows:
1. Erin Adcock, Rex Healthcare 2. Cindy Atkins, Duke Cancer Patient Support Program 3. Rosemary Brown, Duke Raleigh Hospital 4. Robin Carver, WakeMed Health & Hospitals 5. Dr. John Chute, Duke University Medical Center 6. Charles Hamner, The Hamner Institutes for Health Sciences 7. G. Mark Holmes, North Carolina Institute of Medicine 8. Dr. Keith Hull, Jr., Raleigh Neurology Associates, PA 9. Dr. William Lagarde, WakeMed Health & Hospitals 10. Andrea Layton, Duke Raleigh Hospital 11. Yvette Meggs, Duke Raleigh Hospital 12. Margie Muir, Durham Regional Hospital 13. Ashley Neville, Durham Regional Hospital 14. Natalie Newell, Rex Healthcare 15. Peg O’Connell, JD, Rex Healthcare
16. Dr. Ron Olson, Duke University 17. Dr. William Pittman, III, WakeMed Health & Hospitals 18. Elaine Rohlik, WakeMed Rehab 19. Donna Bryan Spears, Murdoch Developmental Center 20. Bruce Sullenger, Duke University Medical Center 21. Mary Szymkowski, Animal Hospital of Peak Plaza 22. Jim Taggart, Physicians Pharmacy Alliance 23. Dennis Thiele, Duke University Medical Center 24. Dr. Anthony Viera, UNC Department of Family Medicine 25. Kathy von St. Paul, Rex Healthcare 26. UNC Family Medicine Center; Dr. Sam Weir 27. Joseph Zhou, NC Technical & Community Student Health Plan 28. Otto Zhou, University of North Carolina at Chapel Hill
Residents, Fellows, Medical Students, CRNAs, and Junior Faculty are invited to submit abstracts of work they have
performed for presentation at Academic Evening.
Abstracts may represent original clinical, laboratory scientific or case reports. Submission to other scientific organizations
(e.g. ASA, Gulf Atlantic Residents’ Conference) does not preclude acceptance for Academic Evening. In fact, we
encourage submission of abstract that have been submitted to national meetings such as the ASA.
Abstracts must be no more than one page (8.5” x 11”) including diagrams and tables.
All abstracts submitted will be accepted for presentation. The Abstract Selection Committee will choose a set of abstracts to be judged for prizes. Complete, specific abstract submission
sPeCIAl GVT/CARDIAC CONfeReNCe5-6 p.m. 7683-HAfs“Why The liver?”John Kellum, MDProfessor, Department of Criti-cal Care Medicine, University of Pittsburgh
7:15 a.m., 2001DNGrand Rounds: “Anesthesia & the New Brain” - Thomas Van de Ven, MD
7:15-8:00 a.m., RM203-Pain ClinicMRC Pain Journal Club
12:00-12:45 p.m., 2003DNCritical Care Conference
4-5 p.m., 5680A-HAFSPediatric Conference
further Out:2010 Office Professional Day: April 21, 2010 in conference room 5685-HAFS2010 Academic evening: Tuesday, May 18, 2010. | Millennium Hotel | Durham, NC2010 Resident Graduation Banquet: Saturday, June 12, 2010 | Hope Valley Country Club | Durham, NC2010 AsA Annual Meeting: October 16-20, 2010 | San Diego, CA2010 Annual Alumni Reception: Sunday, October 17, 2010 | San Diego, CA | More information TBA!
http://anesthesiology.duke.edu 3
http://anesthesiology.duke.edu 4
ANesTHesIOlOGY CMe ACTIVITIes
Departmental CMe Activities
Carolina Cadaver CourseMay 22-23, 2010 | The Duke school of Nursing, Durham, NCfor more information, contact Kate shaw: [email protected].
This activity is designed to educate or refresh the knowledge of practicing anesthesiologists, critical care specialists, and certified registered nurse anesthetists (CRNAs) in the anatomical requirements, techniques, and side effects of ultrasound-guided regional anesthesia and peripheral nerve blockade.
3rd Annual emerging Technologies in the ORJune 6-9, 2010 | Disney’s Yacht and Beach Club Resort, lake Buena Vista, flfor more information, contact Katherine siler: [email protected].
13th Annual Duke Cardiothoracic Update and Tee Review CourseAugust 5-8, 2010 | sea Pines Resort, Hilton Head Island, sCfor more information, contact Jaime Cooke: [email protected].
Mark your calendars for another year of cutting-edge research and updated information designed for medical personnel of all skill levels. NEW FOR THIS YEAR! Critical Care Track!
Ultrasound Guided Regional Anesthesia Preceptorship Course2010 Dates Available | Duke University Medical Center, Durham, NCfor more information, contact Katherine siler: [email protected].
Participants in the Duke Preceptorship will spend three days in the regional block area, operating rooms and on the floor with post surgery patients observing ul-trasound guided single shot nerve blocks and catheter techniques in a wide variety of clinical scenarios. They will learn how to set up the block area for maximum efficiency in the OR environment, improve their decision making ability and make choices in the performance of regional anesthesia. A one-on-one discussion with the Duke Faculty member reviewing cases, scanning techniques and the image library as well as covering handout materials will augment the preceptorship experience.
Visiting Preceptorship in Intraoperative Transesophageal echocardiography2010 Dates Available | Duke University Medical Center, Durham, NCfor more information, contact Jaime C. Cooke: [email protected].
Participants in the Duke Intraoperative TEE Preceptorship spend one three-day session in the cardiac operating suites, observing techniques of intraoperative TEE and interpretation of images. Preceptors will participate in active discussions with cardiothoracic anesthesia faculty and fellows, and learn the basic TEE exam. They will also learn how to troubleshoot difficult cases and enhance their decision-making skills in the operating room. Cases will be reviewed with fellows and faculty and images from pathology libraries will be used to augment the preceptorship experience.
http://anesthesiology.duke.edu 5
THe BACK PAGe
ClassifiedsRentals
Department-member owned 3 floor luxury townhouse in Kure Beach NC available for rent. Six bedroom, four bath townhouse with private elevator, granite kitchen, stainless ap-pliances, fully-stocked chef’s kitchen (All-Clad pots and Kitchen Aid appliances). Master has private balcony, King bed, walk-in closet with ocean views, spa -like bathroom with jetted tub, glassed-in shower, other bedrooms have
two twins, one queen, one queen, one queen and two twin sleeper chairs. flat-panel HD TVs and wireless internet. 2 blocks to the Kure beach pier and restau-rants, beach access diagonally across the street. Ocean views from living room and master bedroom. May 1 to October 31 $2300/week November 1 to April 30 $1800/week. Visit http://web.mac.com/bford71/Brad_and_Neil/the_Sandpiper/the_Sandpiper.html for more info.
Department member owned. Private arrangement for $1800.00 per week. 3 BR 2 bath, sleeps 8. On the beach. Snorkel from the front porch or rent a boat to explore the reef or other islands. Located on a small, automobile free, quiet, “don’t need to lock your doors” Bahamian Cay. Groceries, small tourist shops, 2 restaurants, marina. Kids safely roam free. This is the location for the perfect fam-ily vacation. Call for details 919-812-2714.
SAVE THE DATE
2010Office Professional Day
Celebration
Wednesday, April 21, 20105685-HAFS Building
2010 AsA Deadlines
This year the ASA will be held in San Diego, CA from October 16-20, 2010. The deadline for Abstract submissions is April 1, 2010, 11:59 PM, Central standard Time.
Abstract submission site: http://www.call4abstracts.com/asa2010/scientific and educational exhibits submission site: http://www.call4abstracts.com/asa/asa10d2/Medically Challenging Case submissions: http://www.call4abstracts.com/asa/asa10d3
Comings and Goings in the DepartmentPlease welcome Sarah Stogner to the department. Sarah is a new Program Coordinator working in the Business Office. Sarah started on March 3, 2010.
March 8 - 14 Birthday WishesSonya Capps Dr. Christopher MerrittDr. James Caswell Dr. Scott SchulmanDr. Marcia Corvetto Susan TomsoDr. Anne Marie Fras Regina WilliamsDr. Juliann Hobbs Xiong YuanDr. Beilei Lei
Note: If you do not want your name listed here, please send a removal notice to [email protected].
Department of Anesthesiology Research ConferenceMonday, March 29, 20105-6 pm in 5685-HAFS
Speaker: Dan Morris, PhDAssistant ProfessorAnesthesiology-Basic Sciences
Upcoming:Monday, April 12thMonday, June 14th
The singing AnesthesiologistsThe singing Anesthesiologists - This one is funny! listen care-fully to the words!
These singers are all Anesthesiologists in Minnesota and theyCan really sing. They are also funny. Here they sing “Waking up is hard to do” http://www.youtube.com/watch?v=WOrjclJ2Ie0&feature=related
