http://anesthesiology.duke.edu 1 News Monday, July 26, 2010 • Volume 12, Issue 29 New Departmental Research Publications Wang Z, Yang W, Britz GW, Lombard FW, Warner DS, Sheng H. Development of a simplified spinal cord ischemia model in mice. J Neuroscience Methods 2010, 189:246-251. New Departmental Research Grant Award Dr. Huaxin Sheng of the Division of Basic Sciences and member of the Multidisciplinary Neuroprotection Laboratory received a consortium award ($164,544) from Cognosci, Inc., an established pharmaceutical company with proprietary anti-inflammatory compounds based on apolipoprotein-E. The award is funded through a Small Business Innovation Research Program (SBIR) funded by the National Institute of Neurological Disorders and Stroke (NINDS) entitled “Novel Restorative Therapy for Spinal Cord Injury”. Cognosci have developed COG series of anti-inflammatory/neuroprotective peptides, which is derived from the receptor-binding region of apolipoprotein E (apoE). Our phase I study established proof-of-principle that significantly promoted functional recovery, decreased histopathological lesion in a compressive injury model of human SCI on mice. We EXCEEDED our aims by finding that COG compounds are both neuroprotective and neurorestorative by promoting remyelination and regeneration. Our intensive studies revealed that apoE-based COG peptides exert significant bioactivities relevant to eliminate the secondary damage and foster the recovery of SCI in the following possible pathways: (1) anti-inflammation; (2) anti-excitotoxicity and reducing intracellular Ca2+ overload; (3) reducing the production of free radical species and nitric oxide; (4) promote the myelin reconstruction and protect oligodendrocytes; (5) promote axonal regeneration. This Phase II proposal will capitalize on the success of our previous work to identify the drug lead for acute SCI by comparison of therapeutic efficacy of three more potent and more drug-like COG compounds in two established models of SCI. Furthermore, we will start the preclinical safety and toxicity studies with the identified lead Department of Anesthesiology Research Conference Monday, 5-6 pm in 5685-HAFS September 13, 2010 February 14, 2011 October 11, 2010 March 14, 2011 November 8, 2010 April 25, 2011 December 13, 2010 May 17, 2011 - No Conf. January 10, 2011 June 13, 2011 compound, which is required by the FDA for an IND application before proceeding to the human clinical trials. The completion of this Phase II study will enable us to select one lead candidate for the treatment of acute SCI and to proceed to FDA-required safety/toxicity profiling. 2010 ASA Accommodations The department will not have a hotel room block for this year’s ASA meeting in San Diego, CA. However, you can reserve a hotel at a discounted rate by visiting: https://www.tphousing.com/r/ startres.asp?EICode=1934&AttCode=19 Comings and Goings in the Department Please welcome Alina Nicoara, MD to the department. Dr. Nicoara is a new Assistant Professor working in the Cardiac Division as of July 16, 2010. Please welcome Pablo Heitman to the department. Pablo is a new Non Duke Student/Intern working in the Basic Sciences Division effective July 18, 2010. Christopher Kigongo, Clinical Research Coordinator I, has transferred to another department on July 15, 2010. We wish him all the best. We wish a fond farewell to Barbara Decker, Clinical Trials Assistant II and Marcia Corvetto, Visiting Research Scholar who have left the department. Barbara’s last day was July 23, 2010 and Marcia’s last day was July 16, 2010. July 26-31 Birthday Wishes Dr. Helene Benveniste Dr. Ashraf Habib Jason Caldwell Gloria Howard Cathy Cox Dr. Jessica Meyers Patricia Cruse Note: If you do not want your name listed here, please send a removal notice to [email protected].
Transcript
http://anesthesiology.duke.edu 1
NewsMonday, July 26, 2010 • Volume 12, Issue 29
New Departmental Research PublicationsWang Z, Yang W, Britz GW, Lombard FW, Warner DS, Sheng H. Development of a simplified spinal cord ischemia model in mice. J Neuroscience Methods 2010, 189:246-251.
New Departmental Research Grant AwardDr. Huaxin Sheng of the Division of Basic Sciences and member of the Multidisciplinary Neuroprotection Laboratory received a consortium award ($164,544) from Cognosci, Inc., an established pharmaceutical company with proprietary anti-inflammatory compounds based on apolipoprotein-E. The award is funded through a Small Business Innovation Research Program (SBIR) funded by the National Institute of Neurological Disorders and Stroke (NINDS) entitled “Novel Restorative Therapy for Spinal Cord Injury”. Cognosci have developed COG series of anti-inflammatory/neuroprotective peptides, which is derived from the receptor-binding region of apolipoprotein E (apoE).
Our phase I study established proof-of-principle that significantly promoted functional recovery, decreased histopathological lesion in a compressive injury model of human SCI on mice. We EXCEEDED our aims by finding that COG compounds are both neuroprotective and neurorestorative by promoting remyelination and regeneration. Our intensive studies revealed that apoE-based COG peptides exert significant bioactivities relevant to eliminate the secondary damage and foster the recovery of SCI in the following possible pathways: (1) anti-inflammation; (2) anti-excitotoxicity and reducing intracellular Ca2+ overload; (3) reducing the production of free radical species and nitric oxide; (4) promote the myelin reconstruction and protect oligodendrocytes; (5) promote axonal regeneration.
This Phase II proposal will capitalize on the success of our previous work to identify the drug lead for acute SCI by comparison of therapeutic efficacy of three more potent and more drug-like COG compounds in two established models of SCI. Furthermore, we will start the preclinical safety and toxicity studies with the identified lead
Department of Anesthesiology Research Conference
Monday, 5-6 pm in 5685-HAFS
September 13, 2010 February 14, 2011October 11, 2010 March 14, 2011November 8, 2010 April 25, 2011December 13, 2010 May 17, 2011 - No Conf.January 10, 2011 June 13, 2011
compound, which is required by the FDA for an IND application before proceeding to the human clinical trials. The completion of this Phase II study will enable us to select one lead candidate for the treatment of acute SCI and to proceed to FDA-required safety/toxicity profiling.
2010 ASA AccommodationsThe department will not have a hotel room block for this year’s ASA meeting in San Diego, CA. However, you can reserve
a hotel at a discounted rate by visiting: https://www.tphousing.com/r/startres.asp?EICode=1934&AttCode=19
Comings and Goings in the DepartmentPlease welcome Alina Nicoara, MD to the department. Dr. Nicoara is a new Assistant Professor working in the Cardiac Division as of July 16, 2010.
Please welcome Pablo Heitman to the department. Pablo is a new Non Duke Student/Intern working in the Basic Sciences Division effective July 18, 2010.
Christopher Kigongo, Clinical Research Coordinator I, has transferred to another department on July 15, 2010. We wish him all the best.
We wish a fond farewell to Barbara Decker, Clinical Trials Assistant II and Marcia Corvetto, Visiting Research Scholar who have left the department. Barbara’s last day was July 23, 2010 and Marcia’s last day was July 16, 2010.
July 26-31 Birthday Wishes
Dr. Helene Benveniste Dr. Ashraf HabibJason Caldwell Gloria HowardCathy Cox Dr. Jessica MeyersPatricia Cruse
Note: If you do not want your name listed here, please send a removal notice to [email protected].
THIS MONTH IN THe DePARTMeNT OF ANeSTHeSIOlOGy
July 2010MONDAy TUeSDAy WeDNeSDAy THURSDAy FRIDAy26 27 28 29 30
5-6 p.m., 5685-HAFSCT Conference: “3D-TEE - Compre-hensive Exam & Hands-On Intro-duction to 3D Volumetrics of the Left Ventricle” - G. Burkhard Mackensen & Danny Rivera
5-6 p.m. 6686-HAFSGVTCCM ConferenceSUMMER BREAK
IRB Deadline: Submit 1 originaland 3 copies to Dr. Gan’s office by 5 p.m.
7:15-8:00 a.m., RM203-Pain ClinicMRC Pain Journal Club
12:00-12:45 p.m., 2003DNCritical Care Grand Rounds: “Opioids, The Blessing & the Curse” - Dr. Brian Ginsberg
4-5 p.m., 5680A-HAFSPediatric Conference
Upcoming:ASA Annual Meeting: October 16-20, 2010 | San Diego, CAAnnual Alumni Reception: Sunday, October 17, 2010 | 7:15 to 8:15 p.m. | San Diego Marriott Marina | San Diego, CA Annual Departmental Holiday Party: Saturday, December 11, 2010 | Bay 7, Downtown Durham | 7 p.m. to 11 p.m.Resident Graduation & Awards Banquet and Subspecialty Recognition Ceremony: Saturday, June 11, 2011
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ClassifiedsReal estate and Rentals
Better price than NC coast. Beautiful time of year for boating and diving. Department mem-ber owned. Private arrangement for 1800.00 per week. 3 BR 2 bath, sleeps 8. On the beach. Snor-kel from the front porch or rent a boat to explore the reef or other islands. Located on a small, auto-mobile free, quiet, “don’t need to lock your doors” Bahamian Cay. Groceries, small tourist shops, 2 restaurants, marina. Kids safely roam free. This is
the location for the perfect family vacation. Call for details 919-812-2714.
A lovely home in Hillsborough for sale. 4 Bedroom, 2.5 bath, 2152 sq ft, 0.38 acre, private backyard, 1st floor all hardwood and 2nd floor new carpet. 15 min to Duke and UNC, 3 min to shopping center. Fridge, washer, dryer, custom curtain, and a shed are free and stay with the house. Offered at $229,900. Call 919-633-0632 or visit the following website for more info. http://www.circaproperties.net/Hillsborough/North_Caro-
Department-member owned 3 floor luxury townhouse in Kure Beach NC available for rent. Six bedroom, four bath townhouse with private elevator, granite kitchen, stainless appliances, fully-stocked chef’s kitchen (All-Clad pots and Kitchen Aid appliances). Master has private balcony, King bed, walk-in closet with ocean views, spa -like bathroom with jetted tub, glassed-in shower, other bedrooms have two twins,
one queen, one queen, one queen and two twin sleeper chairs. flat panel HD TVs and wireless internet. 2 blocks to the Kure beach pier and restaurants, beach access diagonally across the street. Ocean views from living room and master bedroom. May 1 to October 31 $2300/week November 1 to April 30 $1800/week. Visit http://web.mac.com/bford71/Brad_and_Neil/the_Sandpiper/the_Sandpiper.html for more info.
Cars and Trucks
2005 Nissan 350Z Enthusiast Coupe: 49,500 miles, V6-3.5 Liter, Automatic Transmission, Power Doors and Windows, CD Player, Remote Entry, Traction Control. This car is great condi-tion, no mechanical or cosmetic flaws. Asking $14,900. E-mail Marc at [email protected] or call 919-667-4414.
Merchandise
New queen size down comforter. Paid $125 asking $85 obo. Email Shelia Johnson at [email protected] or phone 681-3551.
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THe BACK PAGeUpcoming CMe Activities
13th Annual Duke Cardiothoracic Update and Tee Review CourseAugust 5-8, 2010 | Sea Pines Resort, Hilton Head Island, SCFor more information, email: [email protected] your calendars for another year of cutting-edge research and updated information de-signed for medical personnel of all skill levels. NEW FOR THIS YEAR! Critical Care Track!
3rd Annual UNC-Duke Pediatric Anesthesiology Conference“Best Practices in Pediatric Anesthesia Care”September 25, 2010The William & Ida Friday Center for Continuing education | Chapel Hill, UNCInfants and young children constitute a high risk population for undergoing anesthesia and surgery due to unique anatomic, physiologic, and developmental differences compared to adults. A collaborative approach to pediatric anesthesia requires that all team members function with the most up-to-date information on caring for this challenging population. This conference will provide the anesthesia care team with current information on a variety of common pediatric anesthesia problems.
Ultrasound Guided Regional Anesthesia Preceptorship Course2010 Dates Available | Duke University Medical Center, Durham, NCFor more information, email Katherine Siler: [email protected] in the Duke Preceptorship will spend three days in the regional block area, operat-ing rooms and on the floor with post surgery patients observing ultrasound guided single shot nerve blocks and catheter techniques in a wide variety of clinical scenarios. They will learn how to set up the block area for maximum efficiency in the OR environment, improve their decision making ability and make choices in the performance of regional anesthesia. A one-on-one discussion with the Duke Faculty member reviewing cases, scanning techniques and the image library as well as covering handout materials will augment the preceptorship experience.
Visiting Preceptorship in Intraoperative Transesophageal echocardiography2010 Dates Available | Duke University Medical Center, Durham, NCFor more information, email Jaime C. Cooke: [email protected] in the Duke Intraoperative TEE Preceptorship spend one three-day session in the cardiac operating suites, observing techniques of intraoperative TEE and interpretation of im-ages. Preceptors will participate in active discussions with cardiothoracic anesthesia faculty and fellows, and learn the basic TEE exam. They will also learn how to troubleshoot difficult cases and enhance their decision-making skills in the operating room. Cases will be reviewed with fellows and faculty and images from pathology libraries will be used to augment the preceptor-ship experience.
5th Annual Winter Anesthesia and Critical Care ReviewMarch 6-11, 2011 | The Canyons Resort | Park City, UtahFor more information, email Katherine Siler: [email protected] five-day course will focus on reviewing concepts and new advances in pain management, regional anesthesia, critical care, cardiac anesthesia and pediatric anesthesia.
4th Annual emerging Technologies in the ORJune 13-16, 2011 | Disney’s Grand Floridian Resort & Spa lake Buena Vista, FloridaFor more information, email Katherine Siler: [email protected] four day course will focus on awareness among anesthesia providers concerning the function, use and limitations of new technologies and medications currently being used in the operating suites.
