CHAPTER 01

1-1

1-2

1-3

1-4

1-5

1-6

2

1.

2.

3.

4.

1-1

(Cosmeceuticals) (cosmetics)

(pharmaceuticals)

(biologically active ingredients)

3

01

(cosmetics) (drugs)

(alkaloids) (saponins)

4

(tannins) (glycosides) (resins) (volatile oils)

1-1

1. (tannic acids) (poly-phenolic

compounds)

-OH

(astringent effect)

reactive oxygen species; ROS

(anti-oxidation)

(anti-aging)

2.

(antibiotics) (aminoglycosides)

C(L-ascorbic acid) C

AA-2G(Ascorbic acid-2

glycoside) C

3.

(isoprene)

1-1

5

01

(tetra

cycline) (erythromycin) (Clostridium Botulinum)

(botoxine)

1-2

1.

6

2.

3.

1-2

(receptors)

1-2

7

01

酶(tyrosinase)

C C

C (scurvy)

C

8

1-3

9

01

(1)

(2)

1.

2.

3.

10

0.5~2.0

(ml)

1-4

(microsomes)

P-450(cytochrome P-450)

P-450

11

01

�(glutathione)

(glucuronic acid) (conjugation)

(1) (2)

(3) (normal flora)

(1)

(2) (-

C=O) (C=C) (3)

(4) (glycine) �

(methylation)

(bioavailability)

A (all trans retinoic acid)

13- - A (13-cis retinoic acid) A

12

(benzoyl peroxide)

(benzoic acid)

1-5

(therapeutic index; TI)

(LD50) (ED50)

TI(therapeutic index)50

50

LD=

ED

LD50

50% LD50 ED50

50% ED50

LD50 ED50 LD50 ED50

13

01

1-6

(1) (2) (3) (4)

(code name)

RU486 RU486 mifepristone

(RU486) RU Roussel 486

(chemical name)

(asprin)

(acetyl-salicylic acid)

14

(generic name or official name)

(official name)

(generic name)

RU486 mifepristone

(brand name)

®

A (retinoic acid)

Relief ® Retin-A®

Antiacne®

15

01

1. (Cosmeceuticals) (cosmetics) (pharmaceuticals)

2.

3. (tannic acids) (glycosides) (volatile oils)

4.

5.

6. (1)

(2)

7.

(microsomes) P-450

8. LD50 ED50

16

1. (A) (B)

(C) (D)

2. (tannic acids) (A) (B)

(C) (D)

3. C

(A)C-1 (B)C-2 (C)C-3 (D)C-4

4. (A) C (B)

(C) (D)

5. (A) (B)

(C) (D)

6. (A)0.5~2.0

(B)2.5~3.0 (C)3.5~4.0 (D)4.5~5.0

7. (A)

(B) (C) (D)

8. (A) (B) (C)

(D)

9. (A) 酶

(B) 酶 (C) P-450 (D) 酶

10. (TI) (A)TI LD50 ED50 (B)TI

LD50 ED50 (C)TI LD50/ED50 (D)TI ED50/LD50

11. (A)

(B) (C) (D)

BDBCC ACBCC A

CHAPTER 02

2-1

2-2

2-3

2-4

18

1.

2.

3.

4.

2-1

(ultraviolet; UV)

19

02

UVA

320~400nm UVB 280~320nm

UVC 100~280nm

UVB

UVA

UVC

UVC

UVA UVB

UVC

300nm

(collagen)

20

1. (melanosomes)

2. (UVA, UVB, UVC)

(photoaging)

(elastic fibers)

(ultraviolet index; UVI)

(UV)

0~15 0~2 3~4 5~6

7~9 10~15

10 2