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THE COMPANY

Founded 1988 in Linz, Austria; privately owned

Leading supplier of high quality cell culture products

Third largest FBS processor world-wide

Products manufactured in Europe, North America and Australia

Present in 50+ countries through own operations, exclusive distributors and OEM customers

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NOW AND THEN

7 years average sales growth p.a.: >35%

2005 sales (b): US$ 35 million

2006 sales (e): US$ 50 million

~120 people employed

99% of all products sold outside Austria

THE „OLD“ GROUP

over 40 Distributorsworld-wide

PAA Austria, PaschingManufacturing

Distributor Sales

PAA Germany, CölbeSales in Germany

Marketing world-wide

PAA France, ParisSales in France

PAA UK, YeovilSales in UK

THE „NEW“ GROUP

PAA EuropeA, GER, F, UK

Manufacturing & Marketing

PAA North AmericaToronto

Manufacturing

PAA AustraliaBrisbane

Manufacturing

Terracell

Cansera

PAA

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PAA Laboratories: The Group

Board of Directors:Rainer C. BurianAndreas MladekHarry BrackRainer Waldmann

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THE CUSTOMERS

Cell culture academic research & industry, clinics and hospitals

Cell culture departments of the molecular biology research

Diagnostic industry

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THE PRODUCTS

All types of animal sera

Human sera

Basal and special liquid media

Components and additives

Custom made fillings and formulations

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ANIMAL SERUM

Foetal Bovine Serum (FBS) Regular grade FBS FBS „Gold“ “EMEA tested” FBS

Bovine derived Serum Newborn Calf Calf Adult Bovine

Other Animal Serum all species available

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FOETAL BOVINE SERUM

Third largest processor world-wide

Largest processor in Europe

Raw material from USDA and EU accepted origins

Extensive documentation enables full traceability: PAA batch release protocol EDQM certificate of suitability PAA Quality Manual

Wide variety of origins, specifications and treatments available

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HUMAN SERUM

many different grades available

sterile filtered off the clot for cell culture use

converted grade for diagnostic application

stringent testing according to prevailing FDA regulations

full documentation on donors and collection procedures on file

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LIQUID MEDIA

Standard basal media Cell-type specific media for the academic market:

“Quantum” serum-free media, cell-type specific „SerEx!” Serum Additive for serum-free culture

Cell-type specific media for the industry: „Express“ ADC-free media

MDCK Express for cultivation of MDCK cells Vero Express HEK 293 Express CHO Express BHK Express

Serum Substitute „Lipumin™“

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COMPONENTS & ADDITIVES Detachment and attachment factors:

native and recombinant Trypsin, Collagenase

Accutase™, AccuMax™

human Fibronectin

Antibiotics and selection-antibiotics for transfection G-418 sulphate

Hygromycin, Blasticidin & Other

Mycoplasma specific Antibiotic „Mycokill“

Hybridoma Cloning Factor

Buffers, vitamins, salt solutions

Bovine serum albumin and bovine serum fractions

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Filling of a wide variety of substances under cGMP conditions

All products manufactured according to customer's requirements

Products can be filled in PET bottles or pharmaceutical-grade plastic bags

Different lock and coupling systems offered

CUSTOMIZED FILLINGS

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REFERENCES

Baxter, Austria

Boehringer Ingelheim, Austria

Roche Diagnostics, Germany

Merial, France

Aventis, France

Bio-Mérieux, France

Novartis, UK

Astra-Zeneca, UK

Bayer, Germany

Japan Tobacco, Japan

Kirin Breweries, Japan

Olympus Diagnostics, Ireland

Glaxo Smith Kline ( UK + Belgium)

Serum Institute of Indiaetc.

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5.000 m² (50,000 sqft) under roof

Completion in October 2003

Investment US$ 15 million

GENERAL INFORMATION

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Compliance with FDA, EMEA and EP guidelines

cGMP pharmaceutical license granted by Ministry

Validation according to ICH Q7A guideline “manufacturing API’s”

THE STANDARD

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Lab

elin

g

Pac

kin

g

THE HVAC SYSTEM

Pool 1Fill 1

Fill 2

Wash Dry

We

igh

Spare

Spare

Chrom.UF

Prod.Storage

Prod.Storage

+ 4°C

Empty bottles

Blank labels

Archive

WaterBaths

Thaw

Ch

emic

als

Pack-aging

Pool 2P

re-

pa

rati

on

Four different air zones from controlled into D into C into A

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WFI in 6,000 L tank according to FDA standard

Clean-in-Place (CIP) and Steam-in-Place (SIP) System for all fill lines

WFI, CIP & SIP

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12.000 m³ room temperature, cooler and freezer areas

Raw material sepa-rated from final frozen products

THE WAREHOUSE

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Two 2,500 L and one 3,000 L pooling tank in place

Filling done by 2.500 L „true pool“ lots

POOLING

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Three separate fill lines (one from it fully automated)

Max. fill capacity 15,000 L / day

Media and sera fills at separate lines

STERILE FILL

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Full-automatic bar-coding, labeling, sleeving system

LABELING

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One full-automatic packing line for liquid media

PACKING

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Certificate of Analysis according to EP and 9CFR

Full “EMEA testing” for Australian FBS

QUALITY CONTROL

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Material filled in validated NALGE or PET-Power bottles of different sizes

THE END-PRODUCT

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SHIPPING

Products shipped to >5,000 customers in >50 countries

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“Upper Austria’s Leading Company” 2003

“Austria’s Leading Mid-Sized Company” 2004

“Golden Pegasus” Prize Winner 2004