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Effect of a community dance program on the rate of preeclampsia in pregnancy Ann Cowlin, MA, Yale University Department of Athletics, New Haven, Connecticut, USA; Robyn Brancato Ovozek, CNM, MA; Brookdale Hospital, Brooklyn, New York, USA; Gil Mor, MD, PhD; Daniel Zelterman, PhD; Brian Karsif, MD, MPH, Yale University School of Medicine, New Haven, Connecticut, USA; Peggy DeZinno, RN, BSN, Yale-New Haven Hospital, New Haven, Connecticut, USA.
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Page 1: *1 Dance & Pe2

Effect of a community dance program on the rate of preeclampsia in pregnancy

Ann Cowlin, MA, Yale University Department of Athletics, New Haven, Connecticut, USA; Robyn Brancato Ovozek, CNM, MA; Brookdale Hospital, Brooklyn, New York, USA; Gil Mor, MD, PhD; Daniel Zelterman, PhD; Brian Karsif, MD, MPH, Yale University School of Medicine, New Haven, Connecticut, USA; Peggy DeZinno, RN, BSN, Yale-New Haven Hospital, New Haven, Connecticut, USA.

Page 2: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

Background– Preeclampsia (PE) described:

• Complex disorder of pregnancy & downstream CVD• BP > 140/90 after 20 weeks, with proteinuria• Characterized by endothelial dysfunction, affecting the

placenta• Causes include infection and metabolic disorder of

pregnancy, affecting placental function• Genetic predisposition • Immune, cardiovascular & metabolic dysfunction• Responsible for 15-40% of preterm birth (PTB: <37

weeks), low birth weight (LBW: <5.5 lbs) and - likely - adverse fetal programming (e.g. autism, CVD)

Page 3: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

BackgroundFrom Mor, G., Trophoblast as Immune Regulators in Immunology of Pregnancy, Chapter 19, 2006

0

100

200

300

400

500

600

1st 2nd 3rd

Trimester (normal pregnancy)

Concentration (ng/ml) *except Leptin

(pg/ml)

G-CSF (pg/ml)IL-8 (pg/ml)MCP-1 (pg/ml)VEGF (pg/ml)EGF (pg/ml)Leptin (ng/ml)

Page 4: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

Background– Evidence for a beneficial effect of PA

• Lombardi, 1999 (military study)• Sorenson, 2003 (PA & risk of PE)• Saftlas, 2004 (leisure activity)• Rudra, 2005 (RPE & prepregnancy PA)

– Methods: largely recall of varying modalities– Difficulties

• Standardization• Translation for public health enhancement

Page 5: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

Purpose of This Project– To determine rates of 1) PE, and

2) PTB & LBW, in a community prenatal dance program versus the larger pregnant community.

Secondary Purpose– To determine if a community

prenatal dance program that is standardized, quality controlled, and culturally sensitive can reproduce the finding of reduced risk for PE consistent with other exercise studies.

Page 6: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk Method

– Retrospective– Control Group

• PE Control Group: 9,949 women delivering at a major U.S. teaching hospital in 2004-2005

• PTB & LBW Control Group: 4,053 subset of community residents who delivered at the hospital 2004-2005

– Experimental Group 119 women…• Self-selecting Subgroup: 88 program compliant women• High-risk, assigned Subgroup: 31 women in a controlled environment

– Outcome Measures • PE • PTB & LBW

Page 7: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk Design

– Community-Based Prenatal Dance program• Standardized, proprietary program • In existence for 30 years• Excellent compliance record among diverse

groups • Able to easily track progress and compliance• Allows us to account for group support• Reduces standardization & translational issues

Page 8: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk Design

– Program Components• Centering floorwork (neutral

posture, slow breathing, TrA activation)

• Graham/Hawkins, Feldenkrais, Alexander, Ideokinesis, Belly Dance, Pilates & Yoga

• Relaxation Response (as per Benson)• Strength work based on needs of prenatal

posture• Special birth preparation exercises• Aerobic Dancing 20-30 minutes 2 X/week• Opportunity for socialization and support

Page 9: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

NOTES:

• In Dance group, 5 cases of elevated BP and 4 cases of proteinuria >20 weeks, not progressing to PE.

• Both cases of PE diagnosed in final month.

PE Rate - Dance vs. Control

1.68

7.85

0

1

2

3

4

5

6

7

8

9

Dance Control

%

Page 10: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

Power Table

Number of pre-eclampsia cases 11 14 20 25 31

Critical value 2/9 3/11 5/15 7/18 10/21

2-tail p-value .065 .057 .041 .043 .071

Power against:

2:1 odds .23 .26 .30 .37 .53

3:1 odds .46 .52 .62 .73 .87

4:1 odds .62 .70 .80 .89 .97

Page 11: *1 Dance & Pe2

Effect of Prenatal Dance on PE RiskPTB - Dance vs. Control

5.04

12.5

0

2

4

6

8

10

12

14

Dance Control

%

Notes: 6 PTB infants, none with LBW or belonging to PE mothers.

Page 12: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

LBW - Dance vs. Controls

0.84

11.1

0

2

4

6

8

10

12

Dance Control

%

Page 13: *1 Dance & Pe2

Effect of Prenatal Dance on PE RiskFig. 4. PA Group2 Gestational Age

0

2

4

6

8

10

12

14

16

number of women

35 weeks36 weeks37 weeks38 weeks39 weeks40 weeks41 weeks42 weeks43 weeks

Fig. 5. PA Group2 Birth Weight - lbs

0

1

2

3

4

5

6

7

8

9

10

0 5 10 15 20 25 30 35 40

participant number

lbs

Fig. 3. PA group Birth Weight - lbs

0

1

2

3

4

5

6

7

8

9

10

0 20 40 60 80 100

participant number

lbs

Fig. 2. PA group Gestational age

0

5

10

15

20

25

30

number of women

35 weeks36 weeks37 weeks38 weeks39 weeks40 weeks41 weeks42 weeks

Page 14: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

Conclusions– Findings support the hypothesis that a standardized

community-based prenatal dance program results in

low rates of 1) PE and 2) PTB & LBW. – Participating in such a program may help dance

professionals, serious amateurs, and general population participants remain healthy in this critical period, thereby promoting long-term health.

Page 15: *1 Dance & Pe2

Effect of Prenatal Dance on PE Risk

The “Take-Home” Messages – There may be an ideal physical activity form for a

healthy pregnancy, birth and recovery: Group Dance with intentional choreography that maximizes benefits.

– Efficacious Prenatal Dance forms are untapped resources for our discipline…both as a benefit for our artists and as a way to engage the public in meaningful dance experiences within the community.

Page 16: *1 Dance & Pe2

Our research team

       

Ann Cowlin, MA, Yale University Department of Athletics, New Haven, Connecticut, USA. Movement Specialist. Consultant, School of Medicine. <[email protected]>

Robyn Brancato Ovozek, CNM, MA; Obstetrics, Brookdale Hospital, Brooklyn, New York, USA. Certified Nurse Midwife.

Gil Mor, MD, PhD, Yale University School of Medicine, New Haven, Connecticut,

USA. Director, Reproductive Immunology Unit, Department of Obstetrics, Gynecology and Reproductive Sciences.

Daniel Zelterman, PhD, Yale University School of Medicine, New Haven, Connecticut, USA. Professor of Biostatistics, Department of Epidemiology and Public Health.

Brian Karsif, MD, MPH, Yale University School of Medicine, New Haven, Connecticut, USA. Assistant Clinical Professor, Department of Obstetrics, Gynecology and Reproductive Sciences. Coordinator, Maternal/Child Health, Connecticut State Medical Society and Dept. of Public Health.

Peggy DeZinno, RN, BSN, Yale-New Haven Hospital, New Haven, Connecticut, USA. Coordinator, WELL/A Mother’s Place at YNHH.

Page 17: *1 Dance & Pe2

Thank you for your attention.References 1

1. Clapp, JF 3rd. (2002). Exercising Through Your Pregnancy. Addicus Books. 2. Dempsey, J. C., Butler, C. L., Sorensen, T. K., Lee, I. M., Thompson, M. L., & Miller, R. S. et al. (2004). A case-

control study of maternal recreational physical activity and risk of gestational diabetes mellitus. Diabetes Research and Clinical Practice, 66(2), 203-215.

3. Enquobahrie, D. A., Williams, M. A., Butler, C. L., Frederick, I. O., Miller, R. S., & Luthy, D. A. (2004). Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. American Journal of Hypertension : Journal of the American Society of Hypertension, 17(7), 574-581.

4. Ning, Y., Williams, M. A., Butler, C. L., Muy-Rivera, M., Frederick, I. O., & Sorensen, T. K. (2005). Maternal recreational physical activity is associated with plasma leptin concentrations in early pregnancy. Human Reproduction (Oxford, England), 20(2), 382-389.

5. Dempsey, J. C., Butler, C. L., & Williams, M. A. (2005). No need for a pregnant pause: Physical activity may reduce the occurrence of gestational diabetes mellitus & preeclampsia. Exercise and Sport Sciences Reviews, 33(3), 141-149.

6. Saftlas, A. F., Logsden-Sackett, N., Wang, W., Woolson, R., & Bracken, M. B. (2004). Work, leisure-time physical activity, and risk of preeclampsia and gestational hypertension. American Journal of Epidemiology, 160(8), 758-765.

7. Lombardi, W., Wilson, S., & Peniston, P. B. (1999). Wellness intervention with pregnant soldiers. Military Medicine, 164(1), 22-29.

8. Rudra CB, Williams MA, Lee IM, Miller RS, Sorensen TK.(2005). Perceived exertion during prepregnancy physical activity and preeclampsia risk. Medicine & Science in Sports & Exercise, 37(11), 1836-41.

9. Mor, G. (2006). Trophoblast as Immune Regulator, Immunology of Pregnancy, ch. 19. 10. Parnell, M. M., Holst, D. P., & Kaye, D. M. (2005). Augmentation of endothelial function following exercise

training is associated with increased L-arginine transport in human heart failure. Clinical Science 109(6), 523-530.

Page 18: *1 Dance & Pe2

Thank you for your attention.References 2

11. Rush, J. W., Denniss, S. G., & Graham, D. A. (2005). Vascular nitric oxide and oxidative stress: Determinants of endothelial adaptations to cardiovascular disease and to physical activity. Canadian Journal of Applied Physiology 30(4), 442-474.

12. DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., & Tanaka, H. et al. (2000). Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation, 102(12), 1351-1357.

13. Febbraio, M. A., & Pedersen, B. K. (2005). Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ? Exercise and Sport Sciences Reviews, 33(3), 114-119.

14. Petersen, A. M., & Pedersen, B. K. (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 98(4), 1154-1162.

15. Clapp JF III and Kiess W. (2000). Effects of pregnancy and exercise on concentrations of the metabolic markers tumor necrosis factor alpha and leptin. American Journal of Obstetrics and Gynecology 182(2):300-306.

16. Ischlander M, Zaldivar Jr. F, Eliakim A, Nussbaum E, Dunton G, Leu S, Cooper DM and Schneider, M. (2007). Physical activity, growth and inflammatory mediators in BMI-matched female adolescents, Medicine and Science in Sports and Exercise 39(7):1131-1138.

17. Cowlin, A. F. (2002). Women's Fitness Program Development. Champaign, Il: Human Kinetics. 18. Costanzo ES, Lutgendorf SK, Sood AK, Anderson B, Sorosky J and Lubaroff DM. (2005). Psychosocial

factors and interleukin-6 among women with advanced ovarian cancer, Cancer 104(2):305-313. 19. Hart, M. A. (1993). Self-care agency and prenatal care actions: Relationships to pregnancy outcomes.

Unpublished dissertation, Case Western Reserve University, Cleveland, OH.


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