Make sure you’re protected from hepatitis A & B 1

Immunisation against hepatitis A & B is strongly recommended for the following groups by the NZ Ministry of Health and the World Health Organization: 1

holidayhealth.co.nz

Travelling from A to B?

Twinrix®: the only combination vaccine for both hepatitis A & B.2

Who should be immunised?

Twinrix ® (inactivated hepatitis A and recombinant DNA hepatitis B vaccine) is available as an injection of 1.0mL, containing 720 units of inactivated hepatitis A virus and 20mcg of hepatitis B protein; Twinrix Junior ® is available as an 0.5mL dose, containing 360 ELISA units of inactivated hepatitis A virus, and 10mcg of hepatitis B protein. Twinrix is a private-purchase prescription medicine for immunisation against hepatitis A and hepatitis B virus infection. You will need to pay for this medicine. Use strictly as directed. Twinrix has risks and benefits. Twinrix should not be administered if you are sensitive to components of the vaccine or other hepatitis A or hepatitis B vaccines. Tell your doctor if you have a fever, are on dialysis, or are pregnant. Common side effects: headache, fatigue, fever, malaise, diarrhoea, nausea or vomiting, irritability, drowsiness, and pain, redness or swelling at injection site. Rare side effects, such as rash, anaphylaxis, and allergic reactions, have also been reported. If you have side effects, see your doctor, pharmacist or health professional. Additional Consumer Medicine Information for Twinrix is available at www.medsafe.govt.nz. Normal doctor's office visit fees apply. Ask your doctor or travel medicine specialist if Twinrix is right for you. Twinrix is a registered trade mark of the GlaxoSmithKline group of companies. Marketed by GlaxoSmithKline NZ Limited, Auckland. TAPS NA 8564/16SE/TWI/0005/16 GSK00345.

People travelling to countries where hepatitis A & B are

common.1,4,12

Anybody who has emigrated to NZ

from a hepatitis A & B endemic region. Especially when

travelling to visit family and friends in their country of birth.1,4,12

Those in certain occupations who are at an

increased risk of exposure to hepatitis e.g. those exposed

to human waste, bodily fluids or contaminated food or water, or those who may infect susceptible contacts such as healthcare workers

or carers.1

New Zealanders over the age of 28 (who

were born before routine immunisation

against hepatitis B began in 1988).1

1. Ministry of Health. 2014. Immunisation Handbook 2014. Wellington: Ministry of Health. 2. Twinrix. Data Sheet, GSK New Zealand; November 2011. Available from www.medsafe.govt.nz April 2014. 3. World Health Organization. Hepatitis A, countries or areas at risk. Available at: http://gamapserver.who.int/mapLibrary /Files/Maps/Global_HepA_ITHRiskMap.png?ua=1. Accessed March 2016. 4. Centers for Disease Control and Prevention (CDC). Traveler’s Health. Yellow Book. Chapter 3: Infectious Diseases Related to Travel. Hepatitis B. Available at: http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related- to-travel/hepatitis-b. Accessed March 2016. 5. Shaw M. Hepatitis A and B. The case for Immunisation, In: Travel Medicine Guide. 9th Ed. Auckland:UBM Medica; 2015:27-34. 6. Yung A et al. Manual of Travel Medicine, 3rd edition. IP Communications, Melbourne, 2011. 7. Noele P. Nelson et al. Chapter3-Infectious Disease Related to Travel. Hepatitis A. In: Traveler’s Health-Yellow Book, Atlanta: Centers for Disease Control and Prevention; 2016. Available from http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related -to-travel/hepatitis-a Accessed August 2016. 8. Shaw M. Food and Water Safety. A practical guide for travelers. In Travel Medicine Guide. 8th Ed. Auckland:UBM Medica; 2016:37-45. 9. Averhoff F. Chapter3-Infectious Diseases Related to Travel. Hepatitis B. In Travelers Health-Yellow Book, Atlanta: Centers for Disease Control and Prevention; 2016. Available from http://wwwnc.cdc.gov/travel/yellowbook/2016/ infectious-diseases-related-to-travel/hepatitis-b Accessed August 2016. 10. World Health Organization. WHO/CDS/CSR/LYO/2002.2: Hepatitis B. Available at: www.who. int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf. Accessed March 2016. 11. World Health Organization (WHO) Fact Sheet: Hepatitis B. Available at: www.who.int/mediacentre/factsheets/fs204/en/. Accessed March 2016. 12. World Health Organization. International travel and health. Hepatitis B. Available at: http://www.who.int/ith/vaccines/hepatitisB/en/. Accessed March 2016.

Adverse events involving GSK products should be reported to GSK Medical Information on 0800 808 500

Hepatitis B can be contracted through the

mucous membranes (mouth, eyes, nose) or by open skin breaks coming into contact

with the virus on inanimate objects or

surfaces.10

The hepatitis A virus is contracted by consuming water and food that has been contaminated by infected human faeces. This can include

• water based drinks• ice cubes• even brushing your teeth.5,8

The hepatitis B virus is spread through contact with blood or bodily fluids. This can happen through

• any form of injury (e.g. water sports, scooter hire)• sexual contact with a new partner• a tattoo or piercing or simply getting an injection or even dental.9

Hepatitis A & B at-risk destinations are closer than you think 3,4

90% of people globally with

chronic hepatitis B live in the Asia-Pacific

region - a common destination for New Zealand travellers. 1

Areas where there is a moderate to high risk of hepatitis A & B:

THE PACIFIC ISLANDS • EAST, SOUTH EAST & CENTRAL ASIA • THE INDIAN SUB-CONTINENT • SOUTH AMERICA • AFRICA • EASTERN EUROPE

Everyday travel activities could put you at risk

Hepatitis can be a serious disease

If you work in a job that puts you in contact with blood, bodily fluids, potentially contaminated water or human waste you should talk to your Health & Safety O�cer at work or ask your GP about how you can be protected against both hepatitis A & B.1,2

You don’t have to travel overseas to be at risk.

Hepatitis A is the second most common

vaccine-preventable disease amongst

travellers.6,7

Hepatitis B is about 100 times more infectious than HIV.10

Hepatitis B virus is the

second leading carcinogen

worldwide after tobacco.10

Twinrix ® is the only vaccine that can help protect against both hepatitis A & B.

Ask your healthcare professional if Twinrix is right for you.

Check the destination, get the vaccination.

Twinrix

Twinrix

Countries/areas withrisk of both hepatitis A & B

Countries/areas with risk of hepatitis B

Countries/areas with risk of hepatitis A

The virus is capable of

surviving outside the body

for at least 7 days.11

† Map adapted from World Health Organization, Interactive disease distribution map of Hepatitis A3 and Centers for Disease Control and Prevention, Yellow Book, 20164

* Risk: ≥2% prevalence of hepatitis B4 ; moderate to high risk hepatitis A3

Map adapted - refer †