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StimulantsStimulantsPHSPHS
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StimulantsStimulants
StimulantsStimulants are chemical substances that are chemical substances that enhance the activity of the brain and the enhance the activity of the brain and the central nervous system. central nervous system.
They cause increased alertness and They cause increased alertness and wakefulness. In many cases they also act wakefulness. In many cases they also act to decrease appetite.to decrease appetite.
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Sympathomimetic Sympathomimetic DrugsDrugs
Sympathomimetic drugsSympathomimetic drugs are chemical are chemical substances that mimic the effects of the substances that mimic the effects of the hormone, adrenalin.hormone, adrenalin.
Generally they cause constriction of the Generally they cause constriction of the arteries and increase metabolism.arteries and increase metabolism.
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NeurotransmittersNeurotransmitters Neurotransmitters Neurotransmitters work work
to transmit electrical to transmit electrical neuro-impulses across neuro-impulses across a synapse.a synapse.
Many stimulants Many stimulants enhance the neuro-enhance the neuro-impulse transmission impulse transmission systemssystems..
L dopamine
Serotonin
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StimulantsStimulants The structures of The structures of
many stimulants many stimulants mimic chemical mimic chemical structures and are structures and are closely related to the closely related to the neurotransmitters neurotransmitters found in the body.found in the body.
L Dopamine
Serotonin
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Amphetamines - Amphetamines - Historical DevelopmentHistorical Development
Amphetamines were initially developed as a Amphetamines were initially developed as a cure-all for helping long haul truckers stay cure-all for helping long haul truckers stay awakeawake
They were also used for weight control, to They were also used for weight control, to help athletes to perform better and train help athletes to perform better and train longerlonger
As amphetamine abuse became more As amphetamine abuse became more common, it became evident that the dangers common, it became evident that the dangers of abuse far outweighed therapeutic uses. of abuse far outweighed therapeutic uses.
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AmphetaminesAmphetamines Amphetamine Amphetamine was first marketed in the was first marketed in the
1930s as Benzedrine, an over-the-counter 1930s as Benzedrine, an over-the-counter inhaler to treat nasal congestion. inhaler to treat nasal congestion.
It was also used in the treatment of the It was also used in the treatment of the sleeping disorder, narcolepsy, and the sleeping disorder, narcolepsy, and the behavioral syndrome called minimal brain behavioral syndrome called minimal brain dysfunction (MBD), which today is called dysfunction (MBD), which today is called attention deficit hyperactivity disorder attention deficit hyperactivity disorder (ADHD).(ADHD).
During World War II, amphetamines were During World War II, amphetamines were used to keep the fighting men going used to keep the fighting men going especially under intense battle conditions. especially under intense battle conditions.
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AmphetaminesAmphetamines
Amphetamines Amphetamines closely mimic the closely mimic the chemical structure chemical structure of adrenalin.of adrenalin.
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AmphetaminesAmphetamines
Amphetamines act byAmphetamines act by constricting arteries, increasing perspiration constricting arteries, increasing perspiration
activity and stimulating brain activity. activity and stimulating brain activity. increasing heart rate and blood pressure, increasing heart rate and blood pressure, increasing wakefulness, restlessness, agitation increasing wakefulness, restlessness, agitation
and insomnia. and insomnia.
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Amphetamines --Harmful Amphetamines --Harmful EffectsEffects
Highly addictive and toxicHighly addictive and toxic Long term use leads to deterioration of a Long term use leads to deterioration of a
number of body systems.number of body systems. Chronic abuse produces a psychosis that Chronic abuse produces a psychosis that
resembles schizophrenia and is characterized resembles schizophrenia and is characterized by paranoia, picking at the skin, by paranoia, picking at the skin, preoccupation with one's own thoughts, and preoccupation with one's own thoughts, and auditory and visual hallucinations. auditory and visual hallucinations.
Severe depression and violent or erratic Severe depression and violent or erratic behavior are also common among meth behavior are also common among meth addicts. addicts.
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EcstasyEcstasy Ecstasy is a powerful Ecstasy is a powerful
stimulant that has stimulant that has some characteristics some characteristics in common with in common with adrenalin and L-adrenalin and L-dopamine as well.dopamine as well.
Repeated use of Ecstasy ultimately may damage the cells that produce serotonin, which has an important role in the regulation of mood, appetite, pain, learning and memory.
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Ecstasy - EffectsEcstasy - Effects Because it mimics L-Because it mimics L-
Dopamine, it has been Dopamine, it has been used to relieve used to relieve symptoms of symptoms of Parkinson’s Disease.Parkinson’s Disease.
Results in mental Results in mental relaxation, increased relaxation, increased sensitivity to stimuli and sensitivity to stimuli and hallucinations.hallucinations.
It can be produce fatal It can be produce fatal effects even from a effects even from a single exposuresingle exposure
Attempts to synthesize new amphetamines led to so called designer drugs, all of which are highly dangerous.
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NicotineNicotine NicotineNicotine is an is an
alkaloidalkaloid found in found in the the nightshade family of plants (family of plants (Solanaceae) )
It constitutes It constitutes approximately approximately 0.6–3.0% of dry 0.6–3.0% of dry weight of weight of tobaccotobacco
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Nicotine -Short TermNicotine -Short Term SympathomimetiSympathomimeti
cc Increases Increases
concentration concentration and relieves and relieves tensiontension
Increased heart Increased heart raterate
Increased blood Increased blood pressurepressure
Reduction in Reduction in urine output urine output
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Nicotine – Long TermNicotine – Long Term Highly addictiveHighly addictive Increased risk of Increased risk of
heart disease and heart disease and coronary thrombosiscoronary thrombosis
Increased stomach Increased stomach acid and risk of acid and risk of peptic ulcerspeptic ulcers
Chronic lung Chronic lung diseasedisease
Increased risk of Increased risk of cancercancer
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Highly addictiveHighly addictive Cessation of Cessation of
smoking difficultsmoking difficult Cravings Cravings Nausea, weight Nausea, weight
gain, insomnia, gain, insomnia, irritability, and irritability, and depressiondepression
Nicotine -- Addiction Nicotine -- Addiction and Withdrawaland Withdrawal
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AlkaloidAlkaloid Widely used stimulant Widely used stimulant
found in coffee and found in coffee and tea.tea.
Added to some pain Added to some pain killers to speed up killers to speed up their effects. their effects.
Not addictive in usual Not addictive in usual sense but mild sense but mild withdrawal symptoms withdrawal symptoms observed in some observed in some casescases
Caffeine CharacteristicsCaffeine Characteristics
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Increases Increases alertness, alertness, concentration, concentration, and restlessnessand restlessness
DiureticDiuretic Potential Potential
dependencedependence
Caffeine EffectsCaffeine Effects
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Found in chocolateFound in chocolate Effects similar to Effects similar to
caffeine.caffeine. Structure is similar Structure is similar
to that of caffeine to that of caffeine but the methyl but the methyl group on the group on the nitrogen between nitrogen between the two carbonyl the two carbonyl groups is missinggroups is missing
Theobromine Theobromine
Theobromine
Caffeine
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Although theobromine Although theobromine does not cause harmful does not cause harmful effects with humans, it effects with humans, it is highly toxic to some is highly toxic to some domestic animals, domestic animals, including dogs and including dogs and horses.horses.
With the animals, With the animals, theobromine can lead to theobromine can lead to cardiac arrhythmias and cardiac arrhythmias and seizures.seizures.
Theobromine Theobromine
Theobromine
Caffeine
Theobromine has a bitter Theobromine has a bitter flavor, which gives dark flavor, which gives dark chocolate its typical bitter chocolate its typical bitter taste.taste.