1. The Opioid Class of Analgesics
2. Legal Terms and Conditions
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 1
3. Opioid Class of Analgesics: Slide 3
4. Legal Terms and Conditions (cont’d.)
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 2
5. Program Objectives
6. Definitions
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 3
7. Opioids
8. Opioids & Receptor Activity
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 4
9. Mu (µ) Receptor Activation
10. Dose-response Curves
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 5
11. How does this correlate to clinical pain management?
12. Opioid Agonists: Structural Pharmacology
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 6
13. Opioid Rotation (OR)
14. Codeine
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 7
15. Codeine
16. Morphine
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 8
17. Morphine
18. M-3-G (morphine-3-glucuronide)
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 9
19. M-6-G (morphine-6-glucuronide)
20. M-6-G and M-3-G (continued)
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 10
21. Renal Dysfunction and Morphine
22. Hepatic Dysfunction and Morphine
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 11
23. Pruritus and Morphine
24. Oxycodone
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 12
25. Oxycodone
26. Oxycodone
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 13
27. Hydrocodone
28. Hydromorphone (HM)
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 14
29. Biotransformation of HM
30. Metabolite Profile of Hydromorphone
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 15
31. Potential Role of HM Metabolites
32. Methadone
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 16
33. Methadone
34. Methadone
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 17
35. Propoxyphene
36. Meperidine
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 18
37. Normeperidine
38. Fentanyl
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 19
39. Levorphanol and Congeners
40. Buprenorphine
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 20
41. Agonist-antagonists
42. Opioid Antagonists
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 21
43. Summary
Tufts OpenCourseWare © 2007 Tufts University
Opioid Class of Analgesics
OCW: Introduction to Clinical Pain Problems (J. Haddox) Page - 22
