1

Why is Photostability Important?

2

Biggest Innovation in UVA Protection has Biggest Innovation in UVA Protection has Been the Invention of AvobenzoneBeen the Invention of Avobenzone

• Avobenzone provides broad spectrum beyond 370 nm

290

Wavelength (nm)

2.5

1.5

1

0.5

0

2

310 330 350 370 390

Ab

sorb

ance

With avobenzone

With oxybenzone

Data on file, Johnson & Johnson Neutrogena.

3

An Example of Avobenzone Photoinstability An Example of Avobenzone Photoinstability in a Sunscreen Formulationin a Sunscreen Formulation

Wavelength (nm)

Ab

sorb

ance

290 310 330 350 370 390

Static SPF

10 J

20 J

50 J

2.0

1.8

1.6

1.4

1.2

1.0

0.6

0.4

0.2

0

0.8

Data on file, Johnson & Johnson Neutrogena.

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Why is Photostability Important?Why is Photostability Important?

Photostable and non-photostable spf products have the same protection up to their SPF value, but protection after first MED is very different

0

10

20

30

40

50

0 10 20 30 40

UV exposure (MEDs)

Ins

tan

t S

PF

Photostable SPF 15

Non-Photostable SPF 15

1 MED2 MED

15

5

How Can You Tell Which How Can You Tell Which Ones Are Photostable?Ones Are Photostable?

• Currently, there is no uniform test method or communication device on products to indicate photostability of products or extent of UVA protection

6

HelioplexHelioplex™™ Technology Technology

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What Comprises What Comprises HelioplexHelioplex™™ Technology? Technology?

• Photostable UVA– Contains avobenzone—provides broad UVA

protection – Contains diethylhexyl 2,6-naphthalate (DEHN)—

an avobenzone stabilizer – Contains benzophenone (oxybenzone,

sulisobenzone, or dioxybenzone)—stabilizes avobenzone and adds UVA protection

• Added SPF drivers– Conventional UV filters to build SPF

Data on file, Johnson & Johnson Neutrogena.

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Mechanism of Action of HelioplexMechanism of Action of Helioplex™™

UVUV

UV UV

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Mechanism of Action of HelioplexMechanism of Action of Helioplex™™

UV

DEHN

UV

DEHN DEHN

UV

DEHN

UV UV

DEHN

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Ultraviolet Photography demonstrates Ultraviolet Photography demonstrates the red fluorescence of Helioplexthe red fluorescence of Helioplex®®

Photograph courtesy of Darrell Rigel, MD

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Neutrogena Now Offers Broad-Spectrum Neutrogena Now Offers Broad-Spectrum Protection That Is PhotostableProtection That Is Photostable

Wavelength (nm)

Neutrogena Ultra Sheer SPF 50+With Helioplex™

1.8

Ab

sorb

ance

290 310 330 350 370 390

1.6

1.4

1.2

1.0

0.8

0.6

0.4

0.2

0

290 310 330 350 370 390

1.8

1.6

1.4

1.0

1.2

0.8

0.6

0.4

0

0.2

0 J

10 J

20 J

30 J

50 J

Nonphotostable Sunscreen

Data on file, Johnson & Johnson Neutrogena.

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Photostable in Real SunlightPhotostable in Real Sunlight

Neutrogena Ultra Sheer SPF 50+ holds up under sunlight

Baseline

1.5 hours of sun

0

0.5

1.0

1.5

2.0

290 310 330 350 370 390

Wavelength (nm)

Ab

sorb

ance

Data on file, Johnson & Johnson Neutrogena.

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Photostable in Real SunlightPhotostable in Real Sunlight

Neutrogena Ultra SheerSPF 50+: PFA 12.1

20% ZnOSPF 4: PFA 4

9% TiO2

SPF 30: PFA 4.5

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

1.8

2

290 310 330 350 370 390

Wavelength (nm)

Ab

sorb

ance

Data on file, Johnson & Johnson Neutrogena.

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Photostability of HelioplexPhotostability of Helioplex™™ Compared Compared With Anthelios SPF 60+ With MexorylWith Anthelios SPF 60+ With Mexoryl®®

Data on file, Johnson & Johnson Neutrogena.

COLIPA n = 5 avg

In Vitro Photostability (COLIPA Method)% Loss After 50 J Simulated Exposure

40

20

0

Anthelios XL 60+

–15% –39%

Neutrogena Ultra Sheer SPF 50+ With Helioplex™

% L

oss

15

Photostable Even Under Direct Photostable Even Under Direct Tropical Sun Exposure*Tropical Sun Exposure*

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HelioplexHelioplex™™ technology offers technology offers a step change in protectiona step change in protection

• Helioplex™ technology offers exceptional and photostable UVA protection – PA +++!– PFA protection values for Helioplex products exceed

20 (PA+++ only requires PFA = 8)

• Comparable protection to Mexoryl Anthelios XL 60 technology with better photostability

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PLE Protection by Ultra Sheer PLE Protection by Ultra Sheer SPF 50+ With HelioplexSPF 50+ With Helioplex™™: Results: Results

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PLE Protection by Ultra Sheer PLE Protection by Ultra Sheer SPF 50+ With HelioplexSPF 50+ With Helioplex™™: Conclusions: Conclusions

Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64th Annual Meeting; March 3-7, 2006; San Francisco, Calif.

Percent Agreement

Subject Self-PerceptionEfficacy and Aesthetics

75 80 85 90 95 100

Lengthens time outdoors

Weightless feeling

Is not greasy/oily/tacky

Absorbs quickly/evenly

Does not sting

Is gentle

Overall rating (excellent-good)

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PLE Protection by Ultra Sheer PLE Protection by Ultra Sheer SPF 50+ With HelioplexSPF 50+ With Helioplex™™: Conclusions: Conclusions

• Complete inhibition of PLE by Ultra Sheer SPF 50+ with Helioplex™

• The aesthetics of Ultra Sheer SPF 50+ with Helioplex™ was favorably rated by users with PLE; this may enhance compliance with use

Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64th Annual Meeting; March 3-7, 2006; San Francisco, Calif.

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Neutrogena Helioplex SunscreensNeutrogena Helioplex Sunscreens

• Does not leave a film/residue

• Is not tacky

• Is not sticky

• Is not greasy

• Leaves a velvety skin feel

• Leaves the skin feeling nourished

Data on file, Johnson & Johnson Neutrogena.

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Sunscreen With HelioplexSunscreen With Helioplex™™: : Ultra Sheer AestheticsUltra Sheer Aesthetics

• Unsurpassed Protection

• Superior Aesthetics and Skinfeel

• Outstanding Value

• Dermatologists Preferred for themselves and their families