1,000,000,0007,000,874

6587423

81

US $ investmenthours of workexperimentsresearchersyearsdrug

Pharma is experience challenges

Pharma R&D is adapting for the future

Focus is on:

•Productivity, ROI

•Externalization & Collaboration

•Diversification

•Personalized Medicine

We want to contribute

• Dedicated Science, Medical Information company• 7,000 Employees• PhD scientists, information

scientists, publishers

• Extensive scientific network• 600,000 authors• 300,000 reviewers• 70,000 journal editors and

board members

• Publish• 300,000 articles/yr• 2,000 journals• 20,000 books• Leading titles (e.g. Cell, The

Lancet)

• Global STM coverage• 18,000 titles used in

abstracting, indexing• Extensive patent coverage

(USTPO, EPO, WPO)

Our information spans Pharma’s value chain

TargetValidation

Lead ID

LeadValidation PoCPhase

IPhaseII

PhaseIII

PhaseIVToxicity Safety Post

LaunchTargetFinding

Trusted External R&D

Evolving with Pharma R&D

I. Identify relevant knowledge that drives R&D

II. Disseminate content to scientists, R&D decision makers

III. Make content interactive and actionable

Creating Insight

Identify relevant content that drives R&D

... the past... the present

... the past

Disseminate Content to Scientists, R&D decision makers

... the present

... The past

Make Content Interactive and Actionable

... The present

Why is Elsevier here?

Novartis announces USD 1 billion investment to build largest pharmaceutical R&D institute in China Press Release November 2009

Because our customers have come here....

... And our new customers are here

What is Reaxys?

A workflow solution for researchers in chemistry, drug discovery and related scientific areas

Using Reaxys researchers can

• Easily access validated reaction and substance data, ranking and filtering for relevant results

• Source available chemicals• Plan and optimize synthetic route• Export and share results for immediate action in the lab

An extensive repository of reaction and substance property data, Reaxys includes:

• Organic, inorganic, organometallic chemistry from 400 journals

• Coverage from 1771 - present• World Patent Office, European Patent Office and US English

language patents from the major chemistry patent classes

Reaxys extracts valuable chemical properties and reaction details from journals and patents.

1H NMR

300 MHZ

Five good reasons to use Reaxys

1. The wealth of experimentally validated data which can be searched, filtered and ranked to find the most relevant answer to a specific question quickly.

2. Functionality beyond data searching: synthesis planner, results management, smart analysis tools for fast evaluation.

3. No user or usage limits: flat-rate for institution-wide access at any time.

4. The intuitive interface and online educational material help reduce your training efforts.

5. Interoperable: linking to SciVerse Scopus, full-texts at publishers and patent offices. Access to your own library settings via OpenURL resolver is possible.

Professor Peter Johnson, University of Leeds

What our customers say:

Peter Johnson, University of Leeds

Reaxys is used by 24 of the Top-25* ranked academic chemistry research programs

Src: 2011 www.arwu.org

Reaxys Case Study:

Finding coumarin glycosides

What we will do

• Search by structure

• Filter By substructure, spectra, and bioactivity

• Export to a spreadsheet

• Create a Synthesis Plan

• Use the Form-based and Advanced Search Tabs

• Search by Keyword

17

HO

O

Examples:Isolate the substances that

have NMR data and antibacterial activity

Find coumarin glycosides

O

O

O

O

O

O

coumarin

glucopyranose

5

*bac*

antibacbacterio

catalyst

*’

palladium

Reaction type

hydrogenation

Coumarin NEXT glycosideC*marin* NEXT glycosid*

What you have seen

• Search by structure

• Filter By substructure, spectra, and bioactivity

• Export to a spreadsheet

• Create a Synthesis Plan

• Use the Form-based and Advanced Search Tabs

• Search by Keyword

47

Thank You

• Reaxys training materials can be found at www.reaxys.com/info

• Contact Reaxys Customer Support at: Usinfo@reaxys.com if you would like to schedule a Reaxys Advanced Training webinar

Thank you

• Questions?