Malaria - History

Patrick MansonSir Alphonse Laveran

Sir Ronald Ross Giovanni Grassi

Malaria – Geographic distribution

Malaria – United States

Malaria transmission 1957-1994

Malaria – Life cycle

Malaria - Vectors

Anopheles freeborni

Malaria – Vectors (cont.)

Anopheles balabacensis

A. freeborni

A. gambiae

A. stephensi

Malaria – Vectors (cont.)

Malaria - Sporogony

Malaria - Sporogony

Plasmodium falciparumSporozoites and liver schizonts

Malaria - Merozoite

Malaria – Red blood cell invasion

Malaria – Red blood cell invasion

P. falciparum – Blood stages

Uninfected RBC

2 hr.

4 hr.

12 hr.

Malaria – Blood stages (cont.)

Malaria – Blood stages (cont.)

Malaria - Cytoadherence

Malaria and Sickle cell anemia

Malaria

Malaria - Immunity

Malaria – Immunity (cont.)

Malaria - Vaccination

Malaria - Diagnosis

Malaria – Diagnosis (cont.)

PvPm

Pf

Po

Immunofluorescent antibody

Malaria PCR

Malaria - Treatment

Artemisinin

Malaria - Prevention