2 pt
3 pt
4 pt
5pt
1 pt
2 pt
3 pt
4 pt
5 pt
1 pt
2pt
3 pt
4pt
5 pt
1pt
2pt
3 pt
4 pt
5 pt
1 pt
2 pt
3 pt
4pt
5 pt
1pt
REACTIVITYNAME THAT ANTIBODY COLDS GENETICS
MNSs SYSTEM
Antigens and antibodies of the Kidd blood group system can be detected in this phase of testing.
AHG
When this antibody reacts with the target antigen, the
reaction appears to be mixed-field, and the
agglutinates appear to sparkle when examined
microscopically.
Anti-Sda
This tapeworm by-product can be used to neutralize
anti-P1.
Hydatid cyst fluid
Although the Sda antigen is found in most body fluids, it will be found in the greatest
concentration here.
Urine
This IgG antibody may bind complement, then dissociate from the RBC, leaving the
complement behind. (i.e. It is a complement- dependant
antibody.)
Anti-Jka
This antibody accounts for two-thirds of all non-Rh
immune antibodies.
Anti-K
This usually cold reacting antibody will sometimes
react at 37C, causing hemolysis.
Anti-Lea or –Leb
or
anti-P1
The antibodies in this system are notorious for
causing delayed hemolytic transfusion reactions.
Kidd
DAILY DOUBLE
This antibody rarely causes hemolytic transfusion
reactions because it can be neutralized by antigens found
in the plasma.
Lewis
Parasitic infections, early abortions, and PCH have all
been associated with antibodies in this blood group.
P
Antibodies in these blood group systems generally react
at room temperature and below.
Lewis
Lua
Ii
MN
P1
(LIMP)
This system’s antigens are not true red blood cell antigens, but are absorbed from the
plasma.
Lewis
This antigen is found almost exclusively on red blood cells
from cord blood.
i
When antigens and antibodies in this system react, the agglutinates are
said to be fragile, and appear to look like clusters
of grapes.
Lewis
This autoantibody reacts with all antibody screen and panel cells, and is commonly found
in the serum of Group A1 individuals.
Anti-H
(or anti-IH)
This is the most common form of inheritance for blood group antigens.
Codominant
Inheritance of this gene results in the absence of
Kidd antigens on the RBCs.
In(Jk)
[or Jk if inherited homozygously]
This Duffy phenotype is found in 68% of the black
population, but is NOT found in the white population.
Fy (a-b-)
The genes that control expression of this blood
group system are located on chromosome 1.
Duffy
or
Rh
If a patient has homozygous inheritance of
Le, se, H and O genes, these antigens will be present in his saliva.
Lea only
Anti-M will sometimes react stronger with an RBC that has
homozygous antigen expression rather than a cell with
heterozygous antigen expression.
This is the term that describes that characteristic.
Dosage
Because MN antigens are well developed at birth, in
the past they have been useful in determining this.
Paternity
Patients undergoing renal dialysis may develop this
antibody.
Anti-N
Typing a patient’s RBCs for this antigen may not be possible. By proving the RBCs are S-s-, one
can establish the probability they are also negative for this
antigen.
U
This antibody has examples that react best at
a pH of 6.5.
Anti-M