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DEFINITIONS NAME THAT ANTIGEN

DISEASE ASSOCIATION

KELL SYSTEM ENZYMES

This is the ability of an antigen to stimulate an antibody

response.

Immunogenicity

This is the term for antigens that are present in

less than 10% of the general population.

Low prevalence

Low frequency

Low incidence

Familial

Private

DAILY DOUBLE

This is a known failure of an antigen-antibody reaction to

yield a positive test result as a consequence of antibody excess.

Prozone

This is the term for a reaction in which one cell population is agglutinated,

but a second cell population remains free.

Mixed-field

What term has been used to denote those antibodies which react weakly both

when diluted or undiluted, but are present in high

concentration.

HTLA

(High Titer, Low Avidity)

After the ABO and Rh antigens, this antigen is the

most immunogenic.

Kell

Name an antigen in the Kell system that is high prevalence.

k (Cellano)

Kpb ( Rautenberg)

Jsb (Matthews)

This antigen is formed by a non-secretor who has

inherited the genes lele.

Lec

Anti-Tja is associated with this blood group system.

P

Name one antigen that is part of the C4 molecule of complement,

and therefore not an intrinsic part of the RBC membrane.

(An example of an HTLA antibody)

Chido or Rodgers

This relatively uncommon antibody is found in up to 80% of

patients with infectious mononucleosis.

Anti-i

This antigen, related to the Kell system, is associated with Chronic Granulomatous

Disease.

Kx

The erythrocytes of individuals with this

phenotype appear to resist invasion by

Plasmodium vivax.

Fy (a-b-)

The Donath-Landsteiner antibody that is present in the

serum of patients with paroxysmal cold

hemoglobinuria (PCH) has this specificity.

Anti-P

A patient with a Mycoplasma pneumoniae infection will most

likely develop a cold autoantibody with this specificity.

Anti-I

Antibodies of the Kell system generally react at this phase of

testing.

AHG

Give two reasons a patient who had anti-K two years ago now appears to be compatible with two random donor units

of red blood cells.

1.Both units are K negative.

2.The anti-K titer is too low to be detected.

Name three pairs of antithetical antigens at the Kell locus.

1.K and k (Kell and Cellano)

2.Kpa and Kpb (Penny and Rautenberg)

3.Jsa and Jsb (Sutter and Matthews)

Individuals of the Kell null phenotype may only be

transfused with RBCs from other Kell null individuals

because their plasma contains this antibody.

Anti-Ku

A person with anti-K will be compatible with approximately this many random donors out of

ten.

9

This enzyme is the most commonly used in routine Blood

Banking.

Ficin

Papain is derived from this plant.

Papaya

Name 5 blood group antigens that are enhanced by enzymes.

Kidd, Lewis , Rh, Ii, P, ABO

(Kidd Lewis has Ripples In his Pecs and Abs.)

DAILY DOUBLE

Name 5 blood group antigens that are adversely affected by proteolytic substances.

MNS, Fy, Xga

(Many New Soldiers are destroyed in the Field by eXplosions.)

Note: Sometimes Kell (Many New Soldiers are Killed in the Field by

eXplosions)

These antigens of the Duffy system are enzyme

resistant.

Fy3, Fy5 (and Fy4)