+ All Categories
Home > Documents > 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong...

200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong...

Date post: 08-Oct-2020
Category:
Upload: others
View: 8 times
Download: 0 times
Share this document with a friend
Embed Size (px)
of 7 /7
Chinese Journal of Tissue Engineering Research :2095-4344(2018)02-00303-07 303 www.CRTER.org 1974 2001 :R318 :A 2017-08-22 Zhang Xiao-dong, Ph.D., Associate professor, Intellectual Property Research Center, East China University of Science and Technology, Shanghai 200237, China ( 200237 200092) DOI:10.3969/j.issn.2095-4344.0022 ORCID: 0000-0001-7038-9291() Orbit FAMPAT 3 A patent analysis of biodegradable vascular scaffolds Zhang Xiao-dong , Sun Jing ( Intellectual Property Research Center, East China University of Science and Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) Abstract BACKGROUND: Biodegradable vascular stents show great commercial potential as the third generation of stents in the treatment of vascular stenosis, and there is naturally an intense competition in patents. OBJECTIVE: To analyze the patent information of biodegradable vascular scaffolds, which is helpful for better understanding of the development of biodegradable vascular scaffold technology, and provides reference for patent early warning. METHODS: Based on the Orbit patent database, through the manual screening, we conducted an analysis with FAMPAT patent family as analysis object from three aspects—the application trend, patent layout and competitor analysis. In combination with the development of technology and industrialization, important Chinese patent list was also screened. Questel Orbit (1) (2) (1) orbit FAMPAT (2) (1) (2) (3)
Transcript
Page 1: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

�������� Chinese Journal of Tissue Engineering Research

����:2095-4344(2018)02-00303-07

303

����

www.CRTER.org

������1974���

��� ����2001

�����������

�������� !�

"#$%�&'()*+

,-./01�2345

��6

�����:R318

���:A

�����2017-08-22

Zhang Xiao-dong, Ph.D.,

Associate professor,

Intellectual Property

Research Center, East China

University of Science and

Technology, Shanghai

200237, China

��

���������� �

��

���

��� �

��(

����������� ����� 200237�

�������������������� 200092)�

DOI:10.3969/j.issn.2095-4344.0022 ORCID: 0000-0001-7038-9291(���)

�������

�����

����� ������� ����������������� ��� �!"#�$%

�&'�()*#��+,��-.� �/012�34567��89:;<=>?2@ABCD�E

FGH� +I���JK� LMNO2� PBQR�STUVW�XY��N��Z[\]3#

^_67`a�b#���c(defghi'�[*jk1lmno

������������ ���� pqrs�tuv)wO��xy-.z{|}~���'~

06r���pq����������v)���+��8o���� ��~� ���hy����

�������o

��

���H7�-.#�� �� ¡$8a¢�#�� �8£¤#�¥¦rs(§¨�©ª«¬�­®v

)¯°±²o

� �³´H7�-.#�� µ¶v)·¸�(¹*lº»H7�-.#�� �¼½a¢¾v)D¿À

ÁÂÃo

���ÄÅ» Orbit ÆÇÈlÆÇ�É�ÊOËÌÍÌÎÏ�Ä FAMPAT v)Ðltu³´yÑ�ÒÓÔ

ÕÖ³´~v)��³´~¯°yͳ´ 3×rs>?³´�ØÙÚ¼½a¢+��GÛXa¢ÜÝ�ÎÞ

b8º»���+�v)o

���� �ß»8൶=*v)��µáâã�º»a¢äz�åæ�a�v)��+�lçè� é

pq���oê*º»�v)��ëì�íî൶ï³tuv)wO��º»ðñÛ�a¾GÛXò�

�>?v)����óÏo

!"#�

�������������� ������ ����������

$�#�

������

A patent analysis of biodegradable vascular scaffolds

Zhang Xiao-dong

�, Sun Jing

� (

�Intellectual Property Research Center, East China University of Science and

Technology, Shanghai 200237, China;

�Xinhua Hospital, Shanghai Jiao Tong University Medical School,

Shanghai 200092, China)

Abstract

BACKGROUND: Biodegradable vascular stents show great commercial potential as the third generation of

stents in the treatment of vascular stenosis, and there is naturally an intense competition in patents.

OBJECTIVE: To analyze the patent information of biodegradable vascular scaffolds, which is helpful for better

understanding of the development of biodegradable vascular scaffold technology, and provides reference for

patent early warning.

METHODS: Based on the Orbit patent database, through the manual screening, we conducted an analysis

with FAMPAT patent family as analysis object from three aspects—the application trend, patent layout and

competitor analysis. In combination with the development of technology and industrialization, important

Chinese patent list was also screened.

���������� ��

�����

� � � �

Questel��

���

����

� Orbit��

��

�����

(1)����������

� !" # $%&'

()*+,-./

(2)*�0123�4�5

6789:;#.<=

>?@AB789CD

-.EFGH���

�����

(1)5 orbit ���

FAMPAT��I<=>�

��JK�LM��NO

PQ�� ��RS�

� TUJ���/

(2)VWXYZ[\]

^_`Zab��c

d[\���

���

(1)e� fghij��RSg

klm�n�Zo�/

(2)pqr]��RS[\<s

t-.#.uvwx/

(3)yjn���RSz{�|

}fgh~�=>������

n���_r�^_`���

LM���������

Page 2: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

������. ���� �������[J].

���������2018�22(2):303-309. DOI:10.3969/j.issn.2095-4344.0022

ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH

304

RESULTS AND CONCLUSION: USA is in a leading position in this field, and China develops quickly. There are still a lot of research and

patent layout space in the improvement of stent materials. Although some of basic patents have expired, patent infringement risks in China

still needs to be investigated due to the intensive patent layout when Chinese enterprises develop their industrialization.

Subject headings: Patents; Tissue Engineering

0 �� Introduction

������������ ������

��������������� !��"#$%&

��'��(�)*�+�,-./01234�5

���6����� !��789�:;<=��

���01>?@A4B�C���D;�����,

$E7FGHIJKLMN�OP�QRSTKL�

D;���UV;��WXYZ[\]^_

[1]

`aRb

@cdefg�Hh2006ij�>kl*��mn�

��job@��pqrs`��bt����>k"

6uvcwx�by3uzST{|}~����H�4

bt3uz\���{���������`Rb��

���D;�����\]`

��� !�����D;�������6��

P

[2]

z��� !�������f����� ¡¢

£4��/¤¥o�¦§��,¨¥©ª��«#��

�¬­4������®¯°G�±²³:;4�$´

�µ¶·m¸G¹º�»¼��½@D��¬¾�f�

¿À4ÁÂ[ÃG����ÄÅ�ÆÇÈÉÊ !ËÌ4

��[��Í*Îϱ�ÐÑ:;ÒN�Ó�¢£4�

�ÔÕÖ×�ت4*#ÙÚ°7ÛÜ`ÝD;���

��Þ�$�ßàk�á�âãäÀ�åæqç{��

��èéêë{ìí�î~�ï{��tðËñoò¿

À`

"#D;��������¼�óô�õö÷ø

Xùúû�¤Ò[øüKL{Mýþ­öHh����

�MN���Rb���MN޷#��N�`�

��~Mý�D;����� ������UV;

��ö��� !��`W�(í01Mý�D;�

������æ�

��

�1��

[2-3]

�QR��ST�Abbott

BVSYZ[\]^_4Rb��{���uvc�@A

,$01�����y�u��������@AÞ

����,$��R`

HIJ@c� !«"#$%&'(�@c�

kYZHIJ�¸)*^�àk+,�01��-

.�MN/���0 1�(`MNþ­àk23�

4�Mýâã!«56���¬§MN�7àk !

«K�{89{56Çem¸:;<=Mý�m¸!

«¼>`

a@c�(g�D;�������?@·#\

A��BB���@A\]�CDGuvc,·#0

1��01��R�EFGH�IJ� K?@!«

�LMMýÞN�¬k`O Pò

[6]

m¸[K?@C

D � R b ! « � Q Ç L M � R S T & U 7

2014�08�21��VLM[!«WXK�-üöYZ�

¬P�4|b{[\{]^_`Ca!«bU`�d

e�btvcLM[\�{��{c]3a@cËbU

`de�¼VK?@!«WXüdm�e²�4fP

[7]

gh�M[RbC�������vc!«,

6�RST&2015i6i� Rb56�jk�hk

�al�!«dem¸[ghmn4o pò

[8]

LM

[���qöqV ����Rb!«QÇ�RST

&U72015�12�08�LM[WXü{89üYZ�r

Ó[WXüstu��vhk�!«WX/89rw�

x7��89üWm�yz��!«âãÓQ[{| ̀

Q�Mýwp���������!«LM!#@

cN��4P�}�Rb$K?@~(�MN��

&{@c��&���`"#�������)7�C

���?@��âã���CE��!«EF�Z�'

GH�Rbvc��&(�vøHh��Mþ­Þ��

º�MN��;��m¸!«d�Mý���k,���

�à !«56���LM� MNOPm¸���

Rb56�¬P!«m¸w����# Rb�MNþ

­wxMN�¼>LM��`

1���������Data and methods

1.1 ���������� RS�bQuestelKL

�N�!«$�RSLMOrbit-.��K-.���

105abuö_`�!«-.�51abu���Ç��

22abu�Ò*�/Ò*-.`RS-.?Q7orbit

�¸�N�FAMPAT!«�U�-.���a!«�$

RS�(\�71a-.�$��������-.

¬§�ÝLMÃ�R�6�K!«�`

�ࡢi���D;��������(�

mnª£��7�¸c!u¤£RS>À¥ö´¦¥�

§VIPCL�¨��éªRS§­«�RS¬�6"

­®ü¯C`RS¬æ�

��

�2��`RST&U�7

2016�12��6�Ölb°FAMAT!«u�-2 162a`

1.2 ���� X±²³è�¯�s´{µ�{¶{

·¸T¹{º»'Dò���'X-¼ ¡�½Â6�

��� !¶�789w(¾¯���¿©����

�øü!«�ÀÁ622a23��FAMAT!«u��m

¸��LM`"#!«WXNK���ÂÃo�LM-

.R2015N2016i�-.Äx��`

1.3 �� � 6orbit-.��FAMPAT!«�78

9LM Å�m¸!«WXYZLM{!«56LM{

EF ±LM�7§VâãN¬P�@cËNd

e���Ó¬P!«`��R�¬P!«�Æ MN

�¼>�¬k��úû�!«`�����orbit!«

-.��!«u�56{Ò*�/Ò*-.de{!

«9l¬kª{��Ç�ò��Ãl² ¡���f

��`

Page 3: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

Zhang XD, Sun J. A patent analysis of biodegradable vascular scaffolds. Zhongguo Zuzhi Gongcheng Yanjiu. 2018;22(2):303-309.

DOI:10.3969/j.issn.2095-4344.0022.

P.O. Box 10002, Shenyang 110180 www.CRTER.org

305

2������Results �

2.1 �������������� ��

2.1.1 âãNYZö56LM 1985N2016iÂD

;�������!«��WXüÇÈÉ�Ê9i�

YZæ�

��

�1��`�6gÓ��1985N1996i!«WX

ü~Ë�·#Kâã�ÌÍ�41996N2001i�β

�4�2001N2014iÏ�¶Ë�Ý8�Ð:$~(Ñ

y`q�K?@�ҷ#MN���`}�YZ���

���ø(�01�*ö7� Çj@D��ó7N

Ó23�� 1̀987i��aDÔÕÖ !��E×*#

l?o� !��Ø°ÆÙµÚ �ÛÜ�J��ÏÝ

(LÞ��W�ßà�Ý�î~ö��²ª�®lá�

7�Ø01�44ÝB�ão� !��t�ND'

��7[�Ë'��ÇoN[âþ;¿©{(LÞ

¿©{ã䪿©{¯:¿©òGå¿©�¯: !�

��$JÃ�R�¯:¿© !��-.E701�*

>?�Ý'��¿À{´�·ä6æ*Ga��ò¿

À���C�á�}çæMý $´�èé°7êë�

�������

� 10 ��

������

�����

20 ����

����

� 4 ���

����

�� ���

�����

30�

� 1 1985

� 2016 ��

�����

���

�����

���

� 3 1985 �

2016 ����

����

������

!����

"#�

� 7 1985�

2016 ���

���$%�

����

���� !

����"#

& 1 �������'()*+,-./0

�� ���� �� �� ���

����� Abbott BVS Abbott

Vascular

� ��CE���2016

�FDA����

����� Igaki-Tamai Kyoto

Medical

! "�#$�%&'(

)*+,-./�0

1$�%&23

4�5�6�� ReZolve Reva

Medical

� 789:;

<=����� DESolve Elixir � 789:;

4����� Ideal Xenogenics

Corp

� 789:;

����� Amaranth Amaranth

Medical

� >?9:;

����� Acute OrbusNeich � >?9:;

����� FADES Zorion

Medical

� >?9:;

����� MeRes Meril @� >?9:;

ABC�� DREAMS Biotronik D 789:;

�����EF

G6H���

XINSORB �IJKL

?MN

; 789:;

���

����� Neovas OP (QR )

S/TU

; 789:;�2016�

12VW$�X; Y

ZS/TUK�[�

\](9^)_^`a

[�

���

� 5 ���

����

�� �

�����

�12"3

� 2 1985�2016�������������45 !67

� 6 1997

� 2016 ��

����8

9��

�����

� !��

��"#�

bcdef�

g

hidef�

jklmno

hidef�

����

���

����

��

��

hidef�

����

Page 4: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

������. ���� �������[J].

���������2018�22(2):303-309. DOI:10.3969/j.issn.2095-4344.0022

ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH

306

������������ �������

��

�2���1985�2016���������

��� !"#$%&'()&*+�,��-.)�

/0�1223��45678�� !$%&��9

:;<=>�$%?@����A�BCDE&F�G

HC 8I�J&GHK38�LMNOP@Q:�12

RS��456208���(T&�UVWX;<YZ

&�T[*+��\]E&^OPG6�LMNJ&^

Q:^_`a^ba�cd�efNghijA\�E

&kNlHC ?8�J&�����AmlHnop

�8I�qNrs���T[&�

��

�3���t,uv�� !&'� !�wx*

+�1Jyz�a{���"#�/|�yz}a�"

#/|}a�g1J�~\]�E&�1985����Y

BCDJ���g2001��F�"#/|3��q�

2014���lHp8�J&g2002����W��"

#��Y2008�MF�"#|3�q��Yno�p�

8I�Q: �̂&@O���mW�,�����"#�

����"#|�no����s�]�N�12@13

J]��WO�/0�PCT"#/0��U$�He�

&��e�������

2.1.2 �s ¡¢�� Y�����622iFAMAT

& 2 �������:;<

pq rst jklmou

v ( � � OR w x OR y z K OR STENT+ OR SCAFFOLD+ OR PROSTHE+ OR ENDOPROSTHE+ OR HEART

VALVE)/TI/AB/IW/CLMS OR (A61F-002)/IPC)

1 014 790{

| (}~ OR �� OR ABSORB+ OR BIOABSORB+ OR BIORESORB+ OR BIODEGRAD+ OR BIOCOMPAT+ OR BIOLOGICAL

COMPAT+)/TI/AB/IW/CLMS

1 713 442{

� ()* OR >3 OR �3 OR ARTER+ OR VEIN OR VASCULAR OR VESSEL)/TI/AB/IW/CLMS 1 241 148{

� (A OR � OR MAGNESIUM OR FERRUM OR IRON+)/TI/AB/IW/CLMS 1 158 834{

� v and | and � and � 591{

� (��� OR POLYLACTIC ACID OR POLYLACTICACID OR POLY LACTIC ACID OR �FG6 OR POLYLACTIDE OR PLA OR �

<=�� OR �<�� OR POLY-L-LACTIC ACID OR PLLA OR ��������H�? OR POLY LACTIC-CO-GLYCOLIC ACID

OR PLGA OR ��G6�FG6 OR PGLA OR ����� OR POLYGLYCOLIC ACID OR POLY GLYCOLIC ACID OR PGA OR �

E�F6 OR �E�6 OR POLY-CAPROLACTONE OR PCL OR ������6 OR �������H�6 OR

POLYHYDROXYLBUTYRATE VALERATE OR POLY HYDROXYL BUTYRATE VALERATE OR PHBV OR ������ OR

POLYACETYLGLUTAMIC ACID OR POLY ACETYL GLUTAMIC ACID OR PAGA OR ��6 OR POLYORTHOESTERS OR POE

OR �����/���H�? OR POLYETHLENE OXIDE/POLYBUTYLENE TEREPHTHALATE OR PEO/PBTP OR �����E�

OR ����E� OR POLY P-DIOXANONE OR POLY 1,4-DIOXAN-2-ONE OR DIOXANONE OR PPDO OR PDO OR

PDS)/TI/AB/IW/CLMS

98 798{

� (��� OR � OR �� OR �� OR STEEL OR TANTALUM OR NICKEL+ OR COBALT+)/TI/AB/IW/CLMS 745 432{

  (v AND | AND � AND �) NOT � 1 648{

¡ � OR   2 162{

& 3 =>����89?@ ��AB

��¢£ bc¤¥ ¦§�� ¨©¤¥ª/jkfª «¬­®

A�BC 2010�03�25 ¯L?}~°ABC±�+²-?³´L?}~°ABC

"±µ²-?;+%¶

(CN102762235)·4¸¹º 2014�06�11»f

A�BC 2013�03�29 L?¼}~Mg-Gd-Zn-Ag-Zr½ABC´¾±¿À« (CN103184379B)ÁÂÃÄS/Å¿ÆÇÈ ÉRÊ

\ËÌ

2015�10�07»f

A�BC 2008�12�23 Íμ}~Mg-Zn-ZrBC)*���´¾ÏBÐÑÊÒ (CN101485900B)ÓÔÑÊÕË 2012�08�29»f

A�BC 2013�05�16 �B? TiO�Ö×*ØÙ+¼��ABC��´¾±¿À« (CN103272290B)Ú¨ÑÊÕË 2015�04�08»f

A�BC 2013�12�27 ÛÜÝ�ÞS%Mg-Zn-Ce-Ca-MnBC´¾±¿À« (CN103757511B)ÉßàIÕËIáâãIÊ\äåÌ 2016�09�07»f

A�BC 2014�05�13 }æ¼h}~ABC)*��}~çè+éêØÙ±¿À« (CN104189963B)ÁÂëìS/TUÆÇ 2017�01�04»f

A�BC 2011�12�26 ÍÎíƼL?}~+AîBC¢£´¾±¿À« (CN102505089B)QRïðïÓÕË 2016�02�17»fñòó

A�BC 2013�07�03 L?S%¼}~ôõöMg-Zn-ZrBC´±¿À« (CN103343273B)QR÷MÕË 2016�01�20»f

A�BC 2009�08�20 ÍÎ%&ABC)*���éê+ø°À« (CN101632842B)ùÉÑÊÕË 2012�08�22»f

A�BC 2013�06�20 ABCú¾LûÀ«´¾%¶ (CN104284993)·4¸¹º 2015�07�22üý[þ

A�BC 2013�06�24 ABCú¾±µÀ«´¾%¶ (CN104245983)·4¸¹º 2015�07�29üý[þ

A�BC 2013�06�24 ABCú¾±µÀ«´¾%¶ (CN104302798)·4¸¹º 2015�07�29üý[þ

A�BC 2014�06�09 ÍÎ4ÙABC�)*��(ü%ZÞ) (CN204133648U)��� 2015�02�04»f

A�BC 2014�03�19 ÍΪx¼��+ôö�Ý��ABC²-¢£ (CN104587532A)�D��S/÷MÆÇ 2015�05�27üý[þ

��BC 2012�04�12 L?¼��+S/TUi (CN202821735U)e�÷M(��)ÆÇ 2013�03�27»f

��BC 2009�05�05 ÍΪx¼��+)*��´¾±�À« (CN101549170B)e�÷M(��)ÆÇ 2013�06�12»f

��BC 2013�10�31 ¼����BC�� (CN105636617A)e�÷M(��)ÆÇ 2016�06�29üý[þ

��BC 2010�12�21 Íμ����BC�� (CN105636618A)e�÷M(��)ÆÇ 2016�06�29üý[þ

��BC 2010�12�21 ¼��+)*�� (CN201968866U)e�÷M(��)ÆÇ 2011�09�14»f

Page 5: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

Zhang XD, Sun J. A patent analysis of biodegradable vascular scaffolds. Zhongguo Zuzhi Gongcheng Yanjiu. 2018;22(2):303-309.

DOI:10.3969/j.issn.2095-4344.0022.

P.O. Box 10002, Shenyang 110180 www.CRTER.org

307

������������ ���30�����

��

��

�4��������5����������� !�

Advanced Cardiovascular System�Ethicon"#$%�

&'#()*+�(�,- .(Microport)��/10�0

�(1!234567�89:;<!�=> 2��(

1!2?!567�@ABC1D�EF .�>GHI

<!JK��/14�16�17�22�25��27�29�+

8LMNOPQ��)*R���STUVW�

��

�57������)*X�YZ[\]��̂ 45�_

ST�`a������� !�bcde��f]

�ghij+�(kflmno�STW�+�(p

q����rs� 8^t�kf"56uvw�

30 �x�(y����z{X�y|�}<~J�

��(z{����^������(�������

�����(��z{�B�,- .��^4��

������1�#(�����1��(�����1

�����+

2.2 ���������� ��� �����

I����622�������n���34�� ¡

FAMPAT����¢100��£¤[B�¥"[B�(

� 4 ��������� �������

������ ��� �� � ����/���� ����

���+����� !" 2015�09�21 #$%&'(���)*+,-�./0 (CN105214144)123456 2016�02�03789:

�������;<�=>?

*!�?!"

2015�02�16 %@A��)*+,-� (CN104586548)B3CDEFGH(I

J)KLMN

2015�05�27789:

���+OPQ�R�;+S

T;OU!�>

2014�12�29 #$VWX>%&'YZ[\(��)*+,-� (CN104511058)]^56 2015�08�19789:

����� 2014�10�23 #$\(��)*+,-� (CN104353129)B3_`aX>bcK

LMN

2015�03�25789:

���+X>%@ATde

!"

2012�10�09 fg���%@A��)*+,-� (CN103709386B)B3CDEFGH(I

J)KLMN

2016�03�30h�

������ijkl 2012�07�24 mX>%n&'o��o+p1q0rseft�=>

g8

(CN104487104)uv`\(wxMN 2015�08�19789:

���+yz{|}�o~

���

2011�12�22 #$X>%@A�=>]=��)*+,-� (CN102585463B)��(��)EFGH�

�KLMN

2013�09�11h�

�����-kl��+ 2011�11�22 #$�t�o�=>(�.�*+,oVW%X>@A

�=>��

(CN102499999B)������X>E

F��KLMN

2014�06�18h�

�����+� 2011�09�30 X>%&'o��� (CN104023758)������ ICMN 2014�10�08789:

���+�g~��[ 2011�08�02 #$�� oX>%@A��)*+,-� (CN102379762B)CDEFGH(B3)K

LMN

2015�03�25h�

�������+kl� 2011�06�30 %X>@Ao�¡��)*+p-� (CN103764076)¢£E¤MN 2014�06�04789:

���+¥p¦e 2011�04�29 #$%§¨oX>@A�=>��o+,-� (CN102755670B)©ª«; Y¬ 2014�04�09h�

���+­�® 2011�01�19 ¯°k±o(²��)*+,-� (CN102599995)��³´µX>¶bK

LMN

2014�01�08789:

���+�(·�¸¹º»¼

½)

2010�09�22 %X>&'o�=>¾=>¿À�-�)�ÁÂÃoE

FÄ¡

(CN1013119100)ÅƵMN 2013�10�30789:

���+�g�[ 2010�08�17 #$X>%@A�� (CN102371006B)B3CDEFGH(I

J)KLMN

2014�08�20h�

����� 2009�07�21 @AÇÈ%Éo�(L�ÊT;)��o+p-� (CN102892442)˳Ì`\(wxMN 2015�06�10h�

���+�S¸Í 2006�04�12 q�=>��yzÎÏ.ÐÑyzÒÓÔX>6ÕgÖ

×ofØ-�

(CN101437471)ÙÚnpbc��KL

MN

2011�08�31h�

����� 2004�04�02 �Û�=>o��Ä¡ (CN1960684)ÙÚnÜbcMN 2013�11�06h�

�����?���)*!

�>

1999�09�08 Ú(0�ÝÌÞßà (CN1271979C)áâãäÅåEFæç 2015�10�28h��èé

�; 2014�06�03 X>%@A¤>êë��)*+ì-� (CN104524646)íîïïðBEF¶b

KLMN

2016�10�12789:

�R�; 2014�05�28 ñòó¯­ôU»õ£�JoR�;�=>)*/0 (CN104031248B)³öX>E¤(÷ø)�

�KLMN

2016�09�07h�

ùúû��üýYZ[ 2013�11�27 #$��%@Ao��üýYZ[þÚ��wx)*+

,-�

(CN104667356)�íöa�EFbcK

LMN

2015�07�01789:

��; 2012�12�27 ��;��)*+,-� (CN103897133)���Øbc��� 2015�11�18789:

�R�; 2010�08�27 #$%X>@A�¤YZ[����)*+,-� (CN101947333B)a�¶b��KLM

N;

2014�06�25h�

ùúû��üýYZ[ 2009�05�22 X>@Ao��üý(�����o+,-�.q0-

(CN101554488B)ÆT56 2012�10�03h�

ùúû��üýYZ[ 2005�11�28 (�¾���Go �-� (CN101443055)üý¶6KLMN 2013�05�08h�

ùúû��üýYZ[ 2003�06�16 �=>��.*+p-� (CN1812754)4��56 2009�11�11h�

Page 6: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

������. ���� �������[J].

���������2018�22(2):303-309. DOI:10.3969/j.issn.2095-4344.0022

ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH

308

�¦§���

��

�67��#("�(��J ���5

¨©ª«¬����(�5¨©ª«­¬�®��2008

¯2014¥R+

���34 ¡MN°±²³´ ¡"µ³´ 

¡+���Jz¶·J¸�¹���ºs��5�J

K��12347(6�)�Biotronik(5�)�@ABC(5

�)�89:;<!(5�)���(3�)+x¹»¼���

�º�Biotronik(½t%)¾Z¿���5����z{�

(�ÀÁ°±US�DE�JP�AU�AT�CN�SG�KR�

BR�HK�IN�RUÂ��)*�ÃZ²³´ ¡�ÄÅ

wÆÇÈÉÊË0�(����34 ¡ÌÍ�5¨

ÎÏMN®��34 ¡�ÐÑvÎ�ÐÑÒÓÌÍ�

�ÔÕ=�²³Ö3�µ³ÐÑ�×ØYHÂ�}<~

J�(�����((��+��@ABC1D�D

Ú®��µ³ ¡8�^1���^t(z{+

²³´ ¡ÛT�Ü�ÝN�Þ�MNßà��

�á«âãÄäÓ<�åÓæçè%·é�Ü����

DÚêmëì�Þ8Lßà+Biotronik(½t%)��(

z{�4�²Ö3���1�í��î3�&�ï���

ðñò²�ó�ô�¶��Ü��)*�/õö²³ ¡

��÷RÅøù¯6�ú+µ³´ ¡�%!Óè��

�áûÂÜ��ü^ýò�ÆÇÈÉ�Nþ+�ZÖ3

�J���Ì��34ÐÑYH�Ò�]·<��§

�����56^·<�R�x�fê^·��

+�

��

�3'��n��N�(����+

2.3 � ���������� ���� ����

��Ö� ¡�Ü������ ¡�f?M´Ì+

������:����Ù�Å_#(FDA���'�

w´����ÐÑ����'M´�¡TZv� ¡

��Ð+gU�522�FAMAT����£¤[B�¥"

[B�(�¦§���

��

�77��#(��J ���

5¨©ª«X�·d('¬��� �!�"+�I

��#$��%3�Ì'ÝN�(5¨uv�&UÃ'

2.3.1  ¡(´ÐÑ�) �� ¡*T����¡

ÐÑ�³+��Ü�ü^^,�(��+2015¥10ú-

m.¥/01���CN1271979C'23��(í�

�������Å)¼4���ñ�gU¢�����

�� ¡y567çÎ� ¡8Í�9:� ¡8Ý;

<X=>?`ÂDÚÌ@�AÄ���BC�­2��

��DE8�¬JF�Ö� ¡��GHò1990¥��

� US 5163952�I¯J2� 1987¥��� US

4820298�-K�*T���ñ�L�Ö�¢���'

³+�¡vÎ�� ¡ÐÑM��èÓC<+

NO���������� ¡�����'�

¡ÐÑ����(�gU��MNðñ�¡ÐÑvÎ�

 ¡�çP§";:��Ní���'CN10289

2442B+�(wÆÇÈÉ�EFNeovas������

¡+EF�gU��MNðñ ¡�¡�QÖÐÑYH

(í���'CN102585463B)ñ ¡8ÍRSYH;:

(��'102824236B)+

x�Z��áûT��U VW«ÂßàêCè

XYZ�����¡ÐÑ�[´vÎ�\�Ò��

-K����c�d¬JF�¢�]c^_`FÂ�¢

�Â��(^·t������*TbLab�Ö��

cd%^�èvÎM�+î��e4����'M´�

�¡���d����¬���¡�fOUÃ����

g��]¢����çh`i¬JF��� ¡+UZ

çh`i¬JF��� ¡�³+��(US5670161,

1996)Ü���(ü^z{�xjk¼¨�ÔÕabl

Ì�çh`i¬JF^�b�z{+�

��

�4'��n��

N�(����+

2.3.2  ¡ÎmÌn�)ñ ¡�çP§ ;â��

��Jo��¨o ¡ÎmÌn°±pqrs�tuÎ

m�vwx5�3Dyi�z{ÎmÂ�x|Ö�}cd�

�X~pqrsÎm�If8�s���­'[�Ì

@���ÖZ34 ¡���ÖZ¬JF ¡��s�

T«¬��çP§�R<��«�ZT���Iá«ã+

*Ttu�z{�3DyiÂ�dÌn��35¨ÊË�

èü^UV�x�wÆÇÊË�è�ÍÆ·<���

C�Z�w·t5¨�%+

�Ö� ¡�U V%"�����ßàÜ��

C��H��e4;â ¡�¡ÐÑÒ����¡(�

��Ó��Ü�<tº���&�ZP§C�� ¡�

ç�;â%!|v�æ?��W VW«�����%+

2.3.3  ¡;: ���¬JF�Ö� ¡;:�U

�&�Z7;:��;:��]�;´;:Ìn+Ü�

ÆÇ� ­¡�:��¢£¤¥�¦¥�§¨©Â�^

ªÈ+;:��^<s����°±�«¬34 ¡8

�;:���&�TZ�Ö� ¡8Í+;:ÌnÌÍ

�^­´���yÍ���y/®Í¯]S;:ÂC�D

� 5 ��������� ���������

�¦�� ��� �� � ����/���� ����

���¦� 2014�04�14 #$VW%@A�� (CN203841857U)B3CÌX>bcKLMN 2014�09�24h�

�¦�¿¥3Í�·�e�¦ 2013�02�22 #$%�¦oVW%@A��)*+,-� (CN103169556B)������X>EF��KLMN 2015�04�15h�

X���¦e���¦ 2011�01-11 #$��%@A\(��o+,-� (CN102048602B)��56 2016�03�02h��èé

¥�¦ 2008�09�27 #$�¦g��;o+,-� (CN101392048B)��56 2011�04�27 h�

­�®�¦ 2011�01�19 ¯°k±o(²��)*+,-� (CN102599995B)��³´µX>¶bKLMN 2016�08�03 h�

s��>8�¦ 2012�10�25 0ÛX>%n&'��o s��o!"> (CN104918585)ÙÚnpbc��KLMN 2016�10�12h�

Page 7: 200237 ˘ˇˆ ORCID · Technology, Shanghai 200237, China; Xinhua Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200092, China) bs trac BACKGROUND: Biodegradable

Zhang XD, Sun J. A patent analysis of biodegradable vascular scaffolds. Zhongguo Zuzhi Gongcheng Yanjiu. 2018;22(2):303-309.

DOI:10.3969/j.issn.2095-4344.0022.

P.O. Box 10002, Shenyang 110180 www.CRTER.org

309

Ú��(,-�EF°^±M�;:Ìn���ÄÛT

Z�ÆÇ�}�+�~J4Z·'β�DÚ���s

·<�pq³´��³(Åâ3�x5¨÷êÝN�

·'µ¶���+

2.3.4  ¡�· �Z���¬JF�Ö� ¡(�

C�X=>%�·�-K��¸¹j�Úâº��»¼

ÓÎ'½¾�Þ�ßà+Ü�·'F¿��� ¡ÀÁ

|Ö��·�345]� ¡ÀÁPSÂ�834Ð

Ñ��^�Õ�ÃÄÅ�·Æ��� ¡�~�]ÃÄ

Å�·ÆÇPZ ¡ÀÁ�SÙ(@AÈÉÊË�DÚ

ÅNO�(���)��ñ*TÌ�Íη+�

��

�5'��

n��N�(����+

3������Discussion �

;â8L�������� ¡������Ï

\���z{cd�OP���Jo�|Ö���DÚ

¨»�&"�f¨»cd��I���N��5$�

�m�����"�f?Ы��Ñ(kÒfy��-

=5¨�øn�%Ó&ÔÕÖ'����34�� ¡

5¨ÌÍ�kf��<cÑ(15uv� 2��!5

����c�1234567�89:;<!�H

×"DØÌÍÅ^gÛÙÚ�y�Ö���3�ÐÑv

Î"ÒÓÌÍNOÛÜ��÷ÝÞJÖßòÆÇ�Ý

N0�����Ö��� ¡5¨ÌÍ����ê��

&Öß�³´�¡�x��Öß�d��Ö�³´+�

Ö��JvÎ��Ö���áû��Ö� V�ÓÌÍ

�Ò�³´OP%�;â·<¬z�ÈÉ��NOJ

^OP%� ¡³´ÐÑ�bà�ÆÇ8�èc(�k

fáâ+î��ã�C���ä���Î"åæ��

��ÛÓ��JÒæ0UZbÌÍ��c^�b56

�É�uv��Qç<!�è><!�=> 2Â�

Ö�0� ¡�t�P§�T��Ö���áû�t�

;:é:ÌÍ� òUÃ�Å^�L��z{�ÝN

�����M�êë���ìíM�êë0�;:�

����(����z{·t����� ¡8Í;:

÷ÛÞJÖß�îï���M�êë0ð ¡�ç%!

|vP§�Òñ V�Ó"òóÓÌÍê^øù��

R0�·ÌnÛ¬ìdÅ^��+

r´Aô�������� ¡���f¨»õY

Z8ù3�ö÷ø%ù<�DÚ8êï�úkÒ�Ý

þ+ã������DÚûüßà��ýkfc56u

v¼»@w��!5Ö���3NOÛÜ��÷��N

�ÛÜÓDÚÃ���þ��sñt(z{+�Z��

�®«¬�������Jo56êÛúk���ì

ím�ù<���M�êë+

��������������� ���������

������������ !"#$"%�&'($����

)���*+,-

�����.�/�01234567,-

�������� 89�:;<�=>?,-

�����#@ABCDEFG�HIJKLMN�O

P��QRSTU(PRISMAVW),

������XYZ[4\ CNKI ]^_`abKL&' 3

cde,

������4fgh 'i*�jkli*�mnopqr

st,-

�����uv�����w(x�@A#"yX�#z{'

|}~�2,"y��#�������������������

��o[���<S����������901�d,-

������XYZ��[B����� ¡¢£Y ;<

¤¥,-

������¦§¨v©ª«¬­��®�J¯°��±9¤

¥U²£³�´µ¶·¸¹�; º»��3.0¼½¾�¿nÀÁ¹#Â

�Ã�ıšƴµ¶·Ç#ÈÉ�gÊCD�ËÌ�ÍÎ�

Ïı23¹ÐÑÒ�ÃÓ�ÔÕ�Ö×�ØÙ�aÚ�ÛÜÝ0.

`�Þ|ßàáÚÁ�¹�âã#äå��æçè23né¹ê,-

-

4 ���� References

[1] ²ëìAbsorbTM¼¬ífîïðïñÀòóô[EB/OL].

[2016-10-17].

http://cardio.elseviermed.cn/news/detail/E362036.

[2] õö÷,øùú.ûü9ýþ����6�#(x&Î[J].i�(

xBú��,2014,3(4):267-274.

[3] �¶�,ø�.ûü9ýþ�ñ6�#(x&Î[J].yfûü

����,2016,22(3):254-257.

[4] ��v���ûü9ýþ6��j�[EB/OL].[2016-06-17].

http://mt.sohu.com/20160617/n454974337.shtml.

[5] ���:<É�ýþ�nüÈ�ðü(����)��6�KL

�\�ú� !"#*ó*�#$R[EB/OL].[2016-12-07].

http://newstock.cfi.cn/p20161207001810.html.

[6] %&�,'(,)*.9ýþ�ñ6�������[J].yfq+B

��,2015,12(11):69-75.

[7] ,��,-.,��/.�ýþ�ñ6�0¶��1òþ�[J].�

23,2015,28(11):29-30.

[8] 4&5,-66.Æ����789:��ûü9ýþ;�;n

&�ñ6�#��[J].yf<=��(x,2016,20(43):

6507-6513.


Recommended