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2003-2004Review of Anticoagulants,
Thrombolytics and Anti-platelet Drugs
April 20, 202306:30 AM
Abciximab
Antiplatelet
Anti-GPIIb/IIIa receptor antibody
Adalimumab
TNF inhibitor
Anti-TNF antibodyUsed in rheumatoid arthritis
Allopurinol
AntigoutAntineoplastic (supporting
agent)
Folic acid analogueXanthine oxidase inhibitor
Aminocaproic acid (EACA)
Procoagulant
Inhibitor of plasminogen activation
(decreases fibrinolysis)
Anistreplase
Thrombolytic
Streptokinase + plasminogen
Aprotinin
Procoagulant
Fibrinolytic inhibitorSerine protease inhibitor
(“serpin”)Streptokinase inhibitor
Argatroban
Anticoagulant
Direct thrombin inhibitor
Aspirin(Acetylsalicylic acid, ASA)
NSAID (acetylsalicylate)Analgesic, Anti-inflammatory
Antipyretic, Antiplatelet
Irreversible cyclooxygenase inhibitor
Atorvastatin
Antihyperlipidemic
HMG-CoA reductase inhibitor
Auranofin
Disease modifyinganti-rheumatic drug (DMARD)
Gold saltOral
Aurothioglucose
Disease modifyinganti-rheumatic drug (DMARD)
Gold saltParenteral
Balsalazide
NSAID (salicylate)
Treatment of IBD
Beclomethasone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidInhaled
Betamethasone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidNot by inhalation
Bivalirudin
Anticoagulant
Direct thrombin inhibitor
Bradykinin
Inflammatory mediator
Plasma, hypotension, pain
Budesonide
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidInhaled OR treatment of IBD
C3a, C5a
Inflammatory mediators
Anaphylatoxins Low molecular weight
complement cleavage products
Celecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
Cholestyramine
Antihyperlipidemic
Bile acid binding resin (BABR)
Clofibrate
Antihyperlipidemic
Lipoprotein lipase activator
Clopidogrel
Antiplatelet
ADP receptor antagonist
Colchicine
Antigout onlyAnti-inflammatory
Microtubule inhibitor
Colestipol
Antihyperlipidemic
Bile acid binding resin (BABR)
Cortisol (Hydrocortisone)
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroid
Cromolyn sodium
Mast cell stabilizer
Inhibits release ofmast cell mediators
Used prophylactically in asthma
Dalteparin
Anticoagulant
LMW HeparinATIII activator
Dexamethasone
AdrenocorticosteroidGlucocorticoidAntineoplastic
Antiemetic
Anti-inflammatory steroidNot by inhalation
Diflunisal
NSAIDAnalgesic, Anti-inflammatory
Antipyretic
Cyclooxygenase inhibitor
Dipyridamole
Antiplatelet
Phosphodiesterase inhibitor(increases cAMP)
Drotrecogin alfa(Activated Protein C)
Anticoagulant
Many actionsTreatment for septic shock
Enoxaparin
Anticoagulant
LMW HeparinATIII activator
Eptifibatide
Antiplatelet
GPIIb/IIIa antagonist
Erythropoietin (EPO)
Cytokine
Primary regulator of RBC synthesis
Etanercept
TNF inhibitor
Tumor necrosis factor receptor+ Fc portion of IgG
Used in rheumatoid arthritis
Ezitimibe
Antihyperlipidemic
Cholesterol absorption inhibitor
Fenofibrate
Antihyperlipidemic
Lipoprotein lipase activator
Flunisolide
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidInhaled
Fluticasone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidInhaled
Fluvastatin
Antihyperlipidemic
HMG-CoA Reductase Inhibitor
Gemfibrozil
Antihyperlipidemic
Lipoprotein lipase activator
Gold salts
Disease modifying anti-rheumatic drugs (DMARD)
auranofin, aurothioglucose
Granulocyte-Colony Stimulating Factor (G-
CSF)
Cytokine
Granulocyte synthesis stimulator
Granulocyte/Monocyte-Colony Stimulating Factor
(GM-CSF)
Cytokine
WBC (granulocytes and monocyte) synthesis stimulator
Heparin
Anticoagulant
ATIII activator
Hirudin
Anticoagulant
Direct thrombin inhibitor(DTI)
Histamine
Inflammatory mediator
Stored in mast cells and basophils
Hydrocortisone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroid
Hydroxychloroquine
Disease modifyinganti-rheumatic drug (DMARD)
4-Hydroxycoumarin
Oral anticoagulant
Vitamin K synthesis inhibitor
Ibuprofen
NSAIDAnalgesic, Anti-inflammatory
Antipyretic
Reversible cyclooxygenase inhibitor
Indomethacin
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitorTocolytic
Uterine relaxant
Infliximab
TNF inhibitor
Anti-TNF monoclonal antibodyTreatment of IBD
Interferon alpha
Antiviral for hepatitisAntineoplastic
Cytokine
Anti-angiogenesis
Interleukin 2
Cytokine Antineoplastic
Interleukin 11
Cytokine Antineoplastic (supporting
agent)
Kallidin
Inflammatory mediator
Plasma, hypotension, pain
Ketoprofen
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Lepirudin
Anticoagulant
Direct thrombin inhibitor (DTI)
Leukotriene B4 (LTB4)
Inflammatory mediator
Lipoxygenase productof arachidonate metabolism
Chemotactic
Leukotrienes C4, D4, E4
(LTC4, LTD4, LTE4)
Inflammatory mediators
Cysteinyl leukotrienesPeptidyl leukotrienes
SRS-ALipoxygenase products ofarachidonate metabolism
Lovastatin
Antihyperlipidemic
HMG-CoA reductase inhibitor
Meclofenamate
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Mesalamine(5-ASA)
NSAID (salicylate)
Treatment of IBD
Methylprednisolone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidNot by inhalation
Montelukast
Leukotriene inhibitor
LTR1 and LTD4 antagonistAsthma treatment
Naproxen
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Nedocromil
Mast cell stabilizer
Inhibits release of mast cell mediators
Used prophylactically in asthma
Nicotinic acid
Antihyperlipidemic
Inhibition of VLDL secretion (?)
Non-steroidalAnti-inflammatory Drugs
(NSAIDs)
Analgesic, Anti-inflammatory, Antipyretic
Cyclooxygenase inhibitors
Olsalazine
NSAID (salicylate)
Treatment of IBD
Phytonadione
Vitamin K
Warfarin antagonist
Piroxicam
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Platelet Activating Factor (PAF)
Inflammatory mediator
LipidHypotensive
Pravastatin
Antihyperlipidemic
HMG-CoA reductase inhibitor
Prednisone
AdrenocorticosteroidGlucocorticoid Antineoplastic
Anti-inflammatoryNot by inhalation
Probenecid
Uricosuric
Adjunct in penicillin therapy
Probucol
Antihyperlipidemic
LDL oxidation inhibitor
Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)
Oxytocic prostaglandinInflammatory mediator
Cyclooxygenase product of arachidonate metabolism
Uterine stimulantCervical ripener
Prostaglandin F2 (PGF2)
Inflammatory mediator
Cyclooxygenase product of arachidonate metabolism
Prostaglandin I2 (PGI2)
Inflammatory mediator
Inhibits platelet aggregation
Cyclooxygenase product of arachidonate metabolism
Prostacyclin
Protamine Sulfate
Heparin antagonist
Rofecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
Simvastatin
Antihyperlipidemic
HMG-CoA reductase inhibitor
Streptokinase
Thrombolytic
Rofecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
Sulfasalazine
Disease modifyinganti-rheumatic drug (DMARD)
Metabolized to sulfonamide+ salicylate (NSAID)
Treatment of IBD
Sulfinpyrazone
Uricosuric
Anti-gout
Sulindac
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Thrombopoietin
Cytokine
Platelet synthesis stimulator
Thromboxane A2 (TXA2)
Autacoid
Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism
Ticlopidine
Antiplatelet
ADP receptor antagonist
Tissue plasminogen activators
Thrombolytics
alteplase, reteplase, tenecteplase
Triamcinolone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidInhaled
Tumor necrosis factor
CytokineAntineoplastic
Urokinase
Thrombolytic
Warfarin
Anticoagulant
Vitamin K synthesis inhibitor
Zafirlukast
Leukotriene inhibitor
LTR1 and LTD4 antagonistAsthma treatment
Zileuton
Leukotriene inhibitor
5-lipoxygenase inhibitorUsed in asthma