Steven Lamm MD

Circulation

Pycnogenol® warrants good blood flow to all organs

better kidney perfusion(colour Doppler duplex ultrasound)Stuard et al., 2010

better skin micro-circulation

(Laser Doppler flowmetry)Cesarone et al., 2006

higher transdermal O2 less CO2

(partial pressure combisensor)Belcaro et al., 2006

greater retinal (eye)perfusion(colour Doppler duplex ultrasound)Steigerwald et al., 2009

greater artery dilatation (high resolution ultrasound)

Enseleit et al., 2012

greater heart ejection fraction(echocardiography)Belcaro et al., 2010

better cochlear (ear) perfusion

(colour-Duplex ultra-sonography)Grossi et al., 2010

improved endothelial function

(strain gauge plethysmography)Nishioka et al., 2007

thrombosis prevention(ultrasound)Belcaro et al., 2004

venous insufficiency(strain gauge plethysmography)Cesarone et al., 2010

placebo

Pycn

ogenol®

7.1%

4.7%

5.4%

5.1%

Pycnogenol® significantly improves artery dilatation

Enseleit et al., Eur Heart Journal, 2012

Patients with previous heart attack are under excellent control for blood pressure, blood lipids and glucose and thrombosis protection

Taking Pycnogenol restores natural arterial function

Flow mediated dilatation

8 weeks treatment

Constricted arteries limit blood flow and nutrient supply

O2CO2

smooth muscle constricts artery, causing low transport of oxygen and nutrients

Cesarone et al., Angiology 57: 431-436, 2006

Pycnogenol elevates nitric oxide to dilate vessels

N ON O

Nishioka et al., Hypertens Res 30: 775-780, 2007

CO2 O2

O2

O2

A relaxed artery transports more oxygen, nutrients and fluids to all organs

C

Se

E

more oxygenmore energy

more vitaminsmore minerals

Pycnogenol helps artery to dilate

Pycnogenol improves micro-circulation skin respiration

better blood flowSkin hydration (corneometry)

Belcaro et al., Clin Appl Thromb Hemost 12: 318-323, 2006

better oxygenation better nutrient supplBetter detoxificationy

CO2

32 mmHg

29 mmHg

O2

46 mmHg

55 mmHgmore oxygen present in the skin

Pycnogenol® significantly lowers cholesterol

Zibadi et al., Nutr Res28:315-320, 2008

Pycnogenol® improves veins, resolves swellings

Cesarone et al., Clin Appl Thromb Hemost 11(3): 289-294, 2005

Pycnogenol stregthens veins and reduces fluid release

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