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Agenda · 2013. 9. 9. ·...

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Page 1: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association
Page 2: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association

Agenda! 9:15%–%9:30! Registration%&%Networking%%%9:30%–%9:45! Introductory%Remarks%&%Introduction%of%Sponsors!!!9:45%–%11:00! Presenting%Companies%

C ScarX!Therapeutics!!C Aciex!Therapeutics!C Metabiomics!C Paradigm!Environmental!C IceCure!Medical!

!!11:00%–%11:15! Company%Breakouts%and%Networking%%%11:15%–%12:15! Panel:%Family,Offices:,Alternatives,5,Driver,of,Best,Returns%! !!12:15%–%12:25% Sponsor%Address:%Corbita%Maritime%!!!12:25%–%1:30! Luncheon%%%% Keynote:%Social,Impact,Investing,and,Multi5Generational,Planning,! Lisa!Gray!–!Founder!&!Managing!Member,!Graymatter!Strategies!!! Sponsor%Address:%Wainscott%Capital%Partners!%%1:30%–%2:45!!!!! Presenting%Companies%

C Molecular!Detection!C Persimmon!Technologies!C Bluestone!Medical!C Ischemix!C Technovax!

!!2:45%–%3:00! Company%Breakouts%and%Networking%%%3:00%–%3:45! Panel:%Venture,Capital,C,Investing,in,the,New,Wave%%%3:45%–%4:15% Company%Partnering!!%4:15% Reception%&%Door%Prize!

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Page 3: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association

Company(Summaries! Aciex&Therapeutics,&Inc.,&located!in!Boston,!Massachusetts,!is!developing!a!once4daily!asthma!treatment.!The!company!has! invented!ACX4FP,! a!novel! crystalline! form!of! fluticasone!propionate! (FP).!ACX4FP! is! a!Phase! 24ready!clinical! asset! that! is!being!developed! for!once4daily! treatment!of!asthma! (and!subsequently!COPD),!a!combined! $18! billion! annual! global! market.! The! intention! is! to! develop! ACX4FP! to! migrate! FP! respiratory!treatments!from!twice4daily!to!once!daily.!!!! ! ! ! ! ! !ACX4FP! has! unique! physical! attributes! compared! to! stock! FP,! which! is! already! approved! to! treat! asthma!(Flovent®!with! >! $1! billion! in! 2012!US! sales)! and! COPD! (Advair®!with! >! $5! billion! in! 2012!US! Sales).! ACX4FP!attributes! include:! (i)!defined!oriented!geometry,! (ii)!highly! stable,! compact!crystalline! structure,! (iii)!higher!melting!points!and!tap!densities,!(iv)!absence!of!inherent!impurities!found!in!stock!FP!powder,!and!(v)!slower!dissolution! rates.!physical! attributes! translate! into! significant!potential! therapeutic!benefits! including:! (i)! an!equal!or!better!efficacy!profile,!(ii)!less!frequent!dosing;!(iii)!overall!less!drug!exposure,!and!(iv)!fewer!related!side! effects.! These! attributes! apply! particularly!well! to! treat! pediatric! asthma,!which!may!be! fully! explored!following!adult!approval.!! ! !! !! !! ! !!ACX4FP!will!be!developed!using!an!accelerated! regulatory!pathway! (i.e.,! 505(b)2! in! the!US)!and!will!directly!enter! human! clinical! studies.!Milestones! include!GMP!drug! product,! regulatory! submission! and! first! human!clinical!data.! The! company! intends! to! license! global! rights! (with! full! rights! to! sublicense)! to! develop! and!commercialize!ACX4FP!for!all!respiratory!indications!(i.e.,!asthma,!COPD,!etc.)!The!ACX4FP!asthma!program!will!be!led!by!experienced!scientific!and!business!professionals.!The!company’s!Founder/CEO!has!20!years!raising!capital! and! managing! privately! funded! businesses.! Its! CSO! has! 25! years! pharma! experience! in! respiratory!diseases,!including!significant!contributions!to!product!discovery!and!development!at!GSK!and!Novartis.!!!Bluestone& Medical& Inc.,! located! in! Ridgefield,! Connecticut,! has! a! disruptive! business! model,! leveraging!technology!to!create!best4of4!breed!service!solutions!for!domestic!and!international!specialty!waste!markets.!Bluestone!core! target!market! is! regulated!medical!waste! (“RMW”),!a!highly! fragmented!$3!billion!domestic!industry.! Bluestone! has! secured! the! opportunity! to! acquire!multiple! technologies! that! can! be! bundled! in! a!unique!service!model.!According!to!the!company,!Bluestone!will!be!highly!differentiated!and!advantaged!by!its! industry! leadership! and! by! the! company’s! unique! model! for! gaining! market! share,! financing! business!growth,!circumventing!existing!market!barriers!to!entry!and!expanded!marketing!capabilities.!!!The!company!intends!to!reach!the!following!investment!objectives:!achieving!a!superior!internal!rate!of!return!on! invested! capital,! executing!a!disruptive!best4of4breed!business!model!with!multiple! streams!of! recurring!revenue,! targeting! investment! in! large/expanding! industry! ($3!Billion!domestic!RMW!market),! developing! a!growth! strategy! that! integrates! a! highly! fragmented! industry! with! one! major! competitor! and! developing!technologies!and!service!solutions!for!domestic!and!international!markets!!The! company’s! technologies! and/or! service!models!will! be! permitted! in! all! 50! states,! approved! for! federal!government!(GSA)!contracts!and!by!major!hospital!industry!group!purchasing!organizations!(GPO).!Bluestone!will!target!other!non4healthcare!domestic!sectors!requiring!RMW!sterilization,!including!the!animal!agriculture!and!international!transportation!industries!(APHIS!waste!at!airports,!seaports!and!border!crossings),!as!well!as!a!number!of!government!agencies!(U.S.!Military,!GSA,!FEEMA,!Homeland!Security)!managing!medical!services!domestically!and!internationally.!Bluestone!will!also!target!emerging!global!RMW!processing!markets.!!!IceCure&Medical,&Ltd.,&based!in!Caesarea,!Israel!and!Cleveland,!Ohio,!!develops!and!markets!minimally!invasive!cryoablation! therapies! for!women’s!health.! ! IceCure!has!developed!and!markets! ! IceSense3TM,!a!patented,!office4based,! minimally4invasive,! cryoablation! system! for! the! treatment! of! tumors! associated! with! breast!disease4fibroadenomas,!and!small!breast!cancer! tumors,!both! large!markets.! IceSense3TM! is!demonstrating!consistent! quarter! over! quarter! revenue! and! procedure! growth,! as! well! as! growing! traction! on!reimbursement,! for! treating!breast! fibroadenomas.!While! the! available! treatments! (surgical/biopsy! excision!

Page 4: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association

and!watchful!waiting)!are!associated!with!potential!complications,!patient’s!discomfort!and!tumor!recurrence,!IceCure’s! in4office!procedure!allows!removal!of!the!fibroadenoma!with!high!efficiency,!minimal!scar,!no!pain!and!no!deformation!of! the!breast.! ! IceSense3TM! is! FDA! (510K)! and!CE! approved,! and! reimbursable! (with! a!dedicated!CPT!code!19105).!!!For! breast! cancer,! IceSense3TM! has! been! successfully! used! in! a! pioneering! clinical! trial! in! breast! cancer!patients!in!Japan.!!Initial!results!from!22!patients!show!no!recurrence!or!metastases!and!a!!US!clinical!trial! in!breast! cancer!patients! is! now!under!way.! IceSense3TM!also!has!potential! high4value! applications! in! uterine!fibroids!and!atrial!fibrillation.!!!IceCure! is! raising! funds! in! two! milestone4based! tranches! to! be! used! to! execute! its! US! sales! &! marketing!strategy,! increase! penetration! to! radiology! and! breast! centers,! expand! private! payor! reimbursement!coverage,!and!continue!clinical!trials!of!the!breast!cancer!application.!The!company!has!been!public!since!2011!(TASE:ICCM).!!www.icecure4medical.com!!Ischemix,& headquartered! in! Maynard,! Massachusetts,! is! a! privately4held,! clinical4phase! pharmaceutical!company! developing! a! portfolio! of! novel! cytoprotective! compounds! for! the! prevention! and! treatment! of!serious! diseases! and! conditions.! ! Cytoprotective! compounds! have! broad! potential! therapeutic! utility! in!multiple!organ!systems!and!disease!states.!The!company’s!lead!product!candidate,!CMX42043,!is!a!chemically4modified!natural!compound!with!an!excellent!safety!profile.! Ischemix!believes!that! the!use!of! the!naturally4occurring!compound!as!the!base!of!the!chemical!scaffold!for!the!drug!increases!the!likelihood!of!a!favorable!safety!and!efficacy!profile!of!CMX42043.!!!!In!a!1424patient!international!Phase!2a!trial,!Ischemix!demonstrated!the!ability!of!CMX42043!to!prevent!cardiac!injury! in! percutaneous! coronary! intervention! (PCI)! patients.! The! company! intends! to! initiate! an! additional!Phase! 2! trial! of! CMX42043! in! early! 2014! to! study! prevention! of! acute! kidney! injury/contrast4induced!nephropathy!(AKI4CIN)!and!collect!additional!data!regarding!cardiac!injury!prevention.!Ischemix!believes!that!there!is!a!significant!unmet!opportunity!to!address!AKI4CIN!and!other!forms!of!acute!kidney!injury.!CMX42043!and! second! generation! compounds! also! address! additional! indications,! including! post4event! treatment! of!renal!and!cardiac!injury!as!well!as!treatment!of!injury!to!the!liver.!!!Ischemix!expects!that,!if!approved,!CMX42043!can!produce!net!cost!savings!to!the!health!care!system.!!Given!the!numerous!significant!segments!that!the!lead!compound!addresses,!the!Company!believes!that!there!is!a!multi4billion!dollar!market!opportunity!in!aggregate.!More!about!the!company!can!be!found!at!!www.ischemix.com!&Metabiomics& is! an! early! stage!molecular! diagnostics! company,! headquartered! in!Manassas,! Virginia!whose!focus! is! developing! a! game4changing! non4invasive! screening! test! for! early! detection! of! colon! polyps! and!colorectal!cancer!based!on!human!microbiome!biomarkers!and!next4generation!DNA!sequencing.!!Colorectal! cancer,!often! referred! to!as!one!of! the!most!preventable!yet! least!prevented!cancers,! is! the!2nd!greatest!cancer!killer!after!lung!cancer.!!According!to!the!company,47%!of!Americans!neglect!AMA!screening!recommendations,! and! colonoscopies! often! miss! small! polyps.! This! results! in! 60%! of! cancers! not! being!detected! until! Stages! 344,! 55k! US! deaths,! and! $14B! in! US! costs! annually.! ! Currently,! 14.5M! patients! are!screened! annually! in! the! US,! including! 4.3M! colonoscopies! and! 10.2M! FOBT/FIT! tests,! out! of! the! 90M!recommended!for!screening!by!the!AMA.!The!market!for!CRC!screening!is!estimated!to!be!greater!than!$7.5!Billion/year!globally.!!The!Metabiomics!assay!aims!to!meet! the!need! for!a!highly!sensitive,!yet!non4invasive!method!for!screening!patients!for!colon!polyps!and!cancer!and!guiding!the!decision!to!order!a!colonoscopy/polypectamy.!Removing!polyps!has!been!demonstrated!to!halt!the!~10!year!progression!to!cancer.!!Existing!screening!methods!require!extensive! colon! prep! and! are! not! sufficiently! sensitive! to! small! adenomas.! Metabiomics! advanced!interrogation!of!the!microbiome!can!detect!small!colon!polyps!and!early!stage!colorectal!cancer!because!of!a!

Page 5: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association

"functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the!microbiome! changes! dramatically! in! association! with! inflammation,! polyps,! and! cancer! and! we! are!characterizing!and!quantifying!this!disruption!of!the!microbial!ecosystem.!!The!company!has!achieved!strong!preliminary!results!demonstrating!sensitivity!and!specificity!for!colon!polyps!and!colorectal!cancer!in!excess!of!96%.!!the!company!has!developed!its!IP!portfolio!and!sampling!and!testing!approach! over! the! last! 10! years! and! analyzed! over! 4,600! samples! across! several! different! gastrointestinal!diseases.! !Metabiomics! is! currently! raising! funding! to! support! two! concurrent! clinical! studies! in! the!United!States!and!China!that!will!be!launched!in!4Q13.!!Management!believes!that!these!studies!will!represent!a!major!risk! reduction!milestone! for! early! investors! that!will! result! in! a! significant! increase! in! valuation! and! set! the!stage! for! early! exit! opportunities.! ! The! primary! exit! strategy! is! through! strategic! alliances,! merger! and!acquisition!with!global!molecular!diagnostic!or! therapeutic! firms!such!as! Illumina,!Life!Technologies,!Roche,!Qiagen,!LabCorp,!Quest,!or!Exact!Sciences.!Discover!more!at!www.metabiomics.com!&Molecular& Detection,& Inc.& is! a! privately4held! commercial4stage! diagnostics! company! located! in! Wayne,!Pennsylvania,! that! has! developed! and! commercialized! a! series! of! performance4leading,! highly4multiplexed,!rapid! and! highly4accurate! molecular! diagnostic! assay! kits.! MDI’s! initial! commercial! focus! is! on! the! rapid!detection! of!multiple! hospital! acquired! infections! (HAIs)! and! infectious! diseases! using! commonly! available!real4time!PCR!(rt4PCR)!instruments.!MDI’s!core!strategy!is!the!commercialization!of!highly4multiplexed,!rapid,!single4tube!“panels”!(pre4determined!groups!of!diagnostic!tests!focused!on!multiple!disease4causing!agents)!to!replace!multiple!complex!and!time4consuming!tests!(such!as!microbiology4!based!bacterial!culture!tests!and!culture4based!rt4PCR!products)!required!to!be!performed!in!clinical!laboratories.!Detect4Ready!panels!require!only!one!patient!sample!to!be!run!in!a!single!test,!allowing!for!more!efficient!clinical!laboratory!workflows!and!processes! and! ultimately! providing! a! greater! number! of! timely! actionable! results! to! clinicians.! MDI! has!commercialized!its!Detect4Ready®!MRSA!Panel!for!the!rapid!detection!of!Methicillin4Resistant!Staphylococcus!aureus! (MRSA),! Methicillin4Sensitive! Staphylococcus! aureus! (MSSA)! and! Methicillin4Resistant! Coagulase!Negative!Staphylococci!(MRCNS).!!!Notably,!MDI! is! finalizing! the!development!of! its!Detect4Ready!Whole!Blood!Sepsis!Panel,!which!will!be! the!first! molecular! diagnostic! test! to! provide! timely,! accurate! identification! of! key! antibiotic! resistance!determinants!and!pathogens!within!3!hours.!This!panel!has!the!prospect!of!replacing!blood!cultures!as!the!go4to! test! for! blood! infections! in! critically! ill! patients.! The!Detect4Ready! Sepsis! Panel! can! give! yield! a! result! in!hours!rather!than!days.!If!proven!accurate!and!sensitive!in!large4scale!trials,!and!validated!against!the!standard!of! care! blood! culture! tests,! this! assay! could! save! many! lives! and! become! a! key! laboratory! test! in! clinical!practice.!MDI! is!also! in!advanced!development!of! the!Detect4Ready!Gastro!Panel,! for! the!rapid!detection!of!diarrhea4causing!bacteria.!!!! ! ! ! ! !MDI’s! Detect4Ready! Panels! are! based! on! four! key! novel! industry4leading! proprietary! and! patented!technologies!that!underlie!the!entire!Detect4Ready!product!line.!MDI’s!proprietary!technology!platform!offers!significant! opportunities! and! advantages! for! oncology,! personalized! medicine! and! drug4diagnostic!combinations,!with!out4licensing!opportunities.!!Learn!more!about!MDI!at!www.detect4ready.com!!Paradigm&Environmental&Technologies,& Inc.! is!an!early!commercial!stage!waste4to4energy!company!based!in!Vancouver,!BC.!Paradigm’s!patented!MicroSludge®!technology!is!used!at!industrial!and!municipal!wastewater!treatment!plants!to!reduce!capital!costs!(fewer!digesters),! increase!revenue!(more!biogas),! lower!operating!costs!(fewer!chemicals,!less!power,!lower!disposal!costs),!and!reduce!GHG!emissions.!!!!Paradigm’s!field4proven!technology!turns!the!thick,!viscous!bacterial!sludge!byproduct!of!aerobic!wastewater!treatment! into!an!easily4digested,!easily4pumped!form!by!smashing!the!tough!cell!walls!of!the!bacteria!with!precise!application!of!hydraulic! impact!and!shear!forces.!The!company!has!been!operating!a!successful!$6m!demonstration! at! a! major! Canadian! pulp! &! paper! mill! for! over! 18! months,! with! progression! to! full! scale!expected! in! 2014.! ! It! has! also! secured! a! $3.2m!municipal! order!with!Metro! Vancouver,! starting! in! Q4! 2013.!Paradigm! is! in! discussions! with! prospective! municipal! and! industrial! customers! in! the! UK,! Asia! and! North!

Page 6: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association

America.! Microsludge! is! patented! in! USA,! Canada,! UK/Europe,! China! and! India,! with! additional! patents!pending.!!!!According! to! the! company,!Paradigm’s! addressable!municipal! and! industrial!market! in!North!America!alone!exceeds! $4bn,!driven!by! rising!energy! costs,! escalating! sludge!disposal! costs,! and!government!policies! that!limit!waste!disposal!options.! !The!ideal!acquirer! is!a! large!wastewater!equipment!or!services!provider!with!a!global!sales!channel!capable!of!accessing!the!$40B!worldwide!market!for!this!product.!!Find!out!more!about!the!company!at!www.microsludge.com!!Persimmon& Technologies,! headquartered! is! a! technology! company! focused! on! the! Semiconductor! Vacuum!Robotics!and!Hybrid4Field!Electric!Motors!markets.!!Persimmon!has!a!proven!management!team!with!a!track!record!of!success.!The!company’s!CEO!is!the!former!President! of! an! industry! leading! global! provider! of! automation,! vacuum! and! instrumentation! solutions! for!multiple!markets!and!a! leader!of! the!team!that! took!that!company!public! in! 1995,! raising!$600M! in!5!public!offerings.! The! company! has! 30! patents! pending.! According! to! the! company,! its! Semiconductor! Vacuum!Robotics!are!70%!more!repeatable!(accurate)!than!the!current!state!of!the!art!products!in!the!market!today.!Repeatability! is! critical! for! improving! yield! in! advanced! semiconductor! factories! and! the! key! reason! Intel!became!the!lead!investor!in!Persimmon!in!December!of!2012.!Persimmon!robots!also!have!50%!greater!torque,!20%!fewer!parts!and!are!lower!cost!than!the!industry!leader.!They!are!drop4in!compatible!for!the!10,000!unit!installed!base.!according!to!the!company,!the!market!for!semiconductor!vacuum!robotics!was!approximately!$300M!in!2012.!!!Persimmon’s! second! product! focus! is! based! on! a! new! way! to! manufacture! electric! motors.! Its! patented!Hybrid4Field!technology!changes!the!way!motor!stators!are!manufactured!and!uses!technology!based!on! its!experience! in! the! semiconductor! market.! Persimmon! has! received! 3! grants! from! the! National! Science!Foundation!to!fund!the!core!development!of!this!technology.!Hybrid4Field!motors!are!targeted!to!cost!25%!less!than!traditional! laminated!motors!and!will!have! 15%!greater!output.!The!Hybrid4Field! technology!enables!3D!motor!stators!which!offers!the!possibility!to!fundamentally!change!the!way!electric!motors!are!manufactured.!The!Low!Voltage!motor!market!is!greater!than!$10B!annually.!!!Persimmon’s!lead!investor!is!Intel!Capital.!Nidec!Sankyo!(NJ!NYSE),!an!$8!bn!Japanese!motor!company,!is!its!other! strategic! investor.! The! company! expects! to! have!multiple! exit! opportunities.! Nidec! has! a! long! track!record! of! acquisitions! and! recently! acquired! Emerson! Electric’s! motor! business.! Competitors! like! Brooks!Automation! have! also! made! many! acquisitions.! Related! semiconductor! sub! system! suppliers! like! MKS!Instruments,!Advanced!Energy!and!Edwards!High!Vacuum!are!also!potential!acquirers.!However,!if!the!Hybrid4Field!motor!technology!penetrates!broad!segments!of!the!electric!motor!market,!large!motor!companies!like!ABB,!Bosch,!Rockwell,!Moog!and!others!would!be!potential!acquirers.!!Discover!more!about!the!company!at!www.persimmontech.com!!ScarX& Therapeutics,& located! in! Toronto,! Ontario,! is! developing! the! world's! first! prescription! anti4scarring!medication,!a! $10!billion!market!opportunity.!SCX4001! is! a! small!molecule! therapeutic! that,! according! to! the!company,!has!with!a!clear!path!to!exit!to!pharma!driven!by!Phase!II!data!within!3!years.!!!The! discovery! of! nefopam! as! an! anti4scarring! agent! is! the! culmination! of! over! 15! years! of! research! by! Dr.!Benjamin! Alman,! Senior! Scientist! and! Head! of! Orthopedic! Surgery! at! Toronto’s! Hospital! for! Sick! Children!(SickKids).!Screening!a!library!of!known!drugs,!with!a!minimum!of!Phase!I!human!safety!data,!resulted!in!the!identification!of!nefopam!as!a!potent!inhibitor!of!β4catenin!protein!synthesis.!!β4catenin!is!a!protein!known!to!be!an!important!controller!of!fibrosis/scarring!of!the!skin!following!injury.!Nefopam!has!been!formulated!into!a! topical! cream.! Non4clinical! in4vivo! studies! demonstrate! that! nefopam! applied! topically! to! a! wound!significantly!reduces!scarring.!!!ScarX! plans! to! commercialize! both! the! reimbursed! and! private4pay! markets,! starting! with! the! cash4paying!cosmetic! and! reconstructive! plastic! surgery! segments.! Combined! these! two! surgery! groups! represent!

Page 7: Agenda · 2013. 9. 9. · "functional!link!between!bacterial!dysbiosis!and!carcinogenesis!in!chronic!inflammation".!!In!other!words,!the! microbiome! changes! dramatically! in! association

approximately!7.2M!procedures!in!the!US!annually.!In!the!skin!market!private4pay!for!cosmetic,!reconstructive,!and!aesthetic!procedures!is!well!established.!It!is!anticipated!that!opportunities!for!reimbursed!will!also!exist!where! there! is! serious!medical! need,!given! there!are!no! therapeutic!options.! The! company!aims! to!partner!with! large! or! specialty! pharmaceutical! companies! (with! an! established! dermatology! franchise)! following!successful! completion! of! Phase! II! as! a! strategy! to!most! effectively! complete! Phase! III! trials! and! ultimately!commercialize!SCX4001!in!international!markets!(patent!protection:!US,!EU,!Canada,!Japan,!China,!Korea,!and!Brazil).!More!about!ScarX!Therapeutics!at!www.scarxtherapeutics.com!&Technovax,&Inc.&is!a!privately!held,!near4clinical4stage!biotechnology!company!based!in!Tarrytown,!NY!specializing!in!viral!vaccine!development.!The!company’s!mission!is!to!create!and!advance!towards!the!market!unique!and!novel!vaccine!technologies!with!no!current!alternatives.!TechnoVax!was!founded!in!2004!by!an!expert!and!well!respected!scientist!in!the!field!of!virology,!who!pioneered!the!influenza!Virus4Like!Particle!(VLP)!vaccine!technology!and!by!a!Scientist!Emeritus!at!the!NIH!and!former!Sr.!VP!for!Scientific!Affairs!of!Fibrogen,!Inc.!!TechnoVax!has!developed!a!next4generation!technology4platform!based!on!Virus4Like!Particles!(VLP)!that,!according!to!the!company,!greatly!enhances!and!facilitates!the!development!and!production!of!a!limitless!range!of!vaccines!targeting!the!prevention!of!respiratory!diseases!as!well!as!hemorrhagic!fevers,!immunodeficiency!and!cancers.!The!industry!strongly!believes!that!VLP!based!vaccines!is!the!technology!of!the!future!!Its!vaccines!pipeline!has!been!rapidly!approaching!the!clinical!phases!with!3!main!candidates:!A!Universal!flu!vaccine!that!will!eliminate!the!need!for!annual!flu!vaccination!and!could!faster!and!better!protect!against!future!pandemic!strains;!an!Inhaled!Powder!flu!vaccine!that!eliminates!the!need!for!cold!chain!storage!and!distribution!and!could!be!self4administered:!a!greatly!needed!solution!for!the!developing!world;!and!an!RSV!vaccine!to!protect!against!one!of!the!leading!causes!of!infant!and!elderly!hospitalizations!and!often!results!in!fatalities!with!the!elderly.!!TechnoVax!has!a!strong!network!of!industry,!governmental!agencies!and!academic!collaborators.!According!to!the!company,!its!portfolio!of!vaccine!candidates!has!a!prospective!addressable!market!of!over!US$5!billion!in!annual!worldwide!sales.!TechnoVax!IP!is!strong!and!protected!by!multiple!domestic!and!international!patent!applications.!The!company!is!actively!pursuing!strategic!alliances,!licensing!arrangements!and/or!research!collaborations!in!order!to!bring!its!products!closer!to!the!market.!TechnoVax!is!seeking!funding!to!bring!1!to!3!vaccine!candidates!from!pre4IND!enabling!studies!to!post!clinical!Ph.!I/II!studies.!This!strategy!will!allow!TechnoVax!to!position!its!candidates!for!out4licensing,!divestiture!or!Ph.!II/III!partnerships.!Learn!more!about!the!company!at!www.technovax.com!&&&&&&&&&&&&&&&&&*"Information contained in the above summaries is provided by each presenting company. The presenting company, and not Landmark Angels, Inc., is solely responsible for its content.

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Participant)Biographies! Keynote)Social)Impact)Investing)and)Multi:Generational)Planning))As! the!Echo/Millennial! generation!moves! to! adulthood,! they! are! changing! the!way!we!do!philanthropy!and!also! investing.!Family!Office!Consultant!Lisa!Gray!will!guide!us! in!exploring!the!nature!of!this!upBandBcoming!generation,!the!impetus!behind!the!social!impact!investment!trend,!what!authentic!sustainability!looks!like!for!families!now,!and!how!the!wealth!management!process!will!be!different!in!the!future.))Lisa%Gray%Founder(&(Managing(Partner,(graymatter(Strategies((Lisa’s!experience!in!the!wealth!management! industry!began!in!1988!as!a!financial!advisor!for!Union!Planters!IBG,! then! Morgan! Keegan! &! Co.! (now! Raymond! James),! and! PaineWebber! (now! UBS).! She! is! a! regular!contributor!to!the!Journal!of!Wealth!Management,!is!a!member!of!its!Editorial!Board,!and!is!a!member!of!the!CFA! Institute’s! Approved! Speaker! List.! She! has! written! two! bestBselling! books,! The! New! Family! Office!(Euromoney!Books!2004)!and!Generational!Wealth!Management:!A!Guide!for!Fostering!Global!Family!Wealth!(Euromoney! Books! 2010).! She! created! a! new! approach! to! wealth! management,! the! Generational! Wealth!Management!Continuum℠,!which!redefines!the!intellectual,!human,!and!social!capacities!of!family!members!as!assets!to!be!managed!along!with!material!and!financial!assets!within!a!consummately!integrated!process.!!A! soughtBafter! speaker,! educator,! panelist,! author,! and! media! resource! on! family! office! and! wealth!management!topics,!Lisa’s!work!has!been!cited!by!the!Capgemini!Merrill!Lynch!World!Wealth!Report!(2005),!Barclay’s!(2007),!and!the!Wharton!Global!Family!Wealth!Alliance!(2008).!!Panel)Discussion)Family)Offices:)Alternatives):)Driver)of)Best)Returns)(This!panel!will! examine!alternative! class! investing.! The!discussion!will! focus!on! identifying! the!best!deals! in!M&A,!private!equity,!venture,!real!estate,!art!and!commodities.!!!Topics!to!be!explored!include:!finding!"best!of!breed"!deals,! creating!diversification!within! the! class,!maximizing! returns!while!minimizing! risk,! indexing!and!fund!vs.!direct!investing.!!Eugene%Braigen%Business(Development,(Savile(Finance(Group((Eugene!Braigen!manages!the!business!development!and!investor!relations!effort!at!Savile!Finance!Group.!Mr.!Braigen!has!been!involved!in!marketing!of!alternative!investments!and!hedge!funds!since!1998.!!From!2002!to!2006,! Mr.! Braigen! was! head! of! marketing! and! investor! relations! for! the! investment! program! for! Maple!Commercial! Finance! Group! where! he! was! part! of! the! group! that! employed! J.! Pablo! Mariño! and! Aurelio!Almonte.! ! From! 1999! to! 2002,! Mr.! Braigen! was! head! of! marketing! and! investor! relations! at! IIG! Trade!Opportunity!Finance!Group,!an!alternative! investment!asset!management!group!specializing! in!Asset!Based!Lending.!J.!Pablo!Mariño!was!a!senior!portfolio!manager!of!IIG!at!that!time.!In!early,!2002,!Pablo!and!Eugene!were!recruited!by!Maple!Finance!Group!to!establish!Maple!Commercial!Finance!Group!to!pursue!trade!finance!and!ABL!strategies.!!!!In!addition!to!his!activities!at!Savile!Finance!Group!between!2005!and!2008,!Eugene!was!active! in!advising!a!number! of! exBMaple! Commercial! Finance! Group! colleague! in! establishing! and!marketing! fund! in! the! trade!finance!and!asset!based!lending!space.!Among!these!was!an!Australian!private!debt!fund!and!a!Latin!American!trade!finance!fund.!Eugene!also!had!a!number!of!consulting!relationships!with!hedge!funds!and!fund!of!funds.!!He!has!a!B.A.!in!Economics!from!New!York!University!and!is!fluent!in!Russian.!

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Adam%Luysterborghs%Founding(Principal,(AVANT(Capital(Partners((Adam!Luysterborghs!has!fourteen!years!of!experience!in!commercial!real!estate!and!investment!banking.!He!is!a!Founding!Principal!of!AVANT!Capital!Partners,!a!Greenwich!CT!based!commercial!real!estate!lending!and!capital!advisory!firm.!!The!company!offers!loans!as!a!correspondent!lender,!provides!capital!advisory!services!and!has! recently!originated!nine!separate! investments! for!a!NYBbased!single! family!office! investor.! !Prior! to!founding! AVANT! in! 2007,! he!was! a! Director! at! a! leading! NYCBbased! CMBS! &! bridge! lender,! where! he!was!responsible!for!developing!capital!partnerships!and!expanding!the!company’s!team!of!originators.!The!team!he!managed!successfully!met!the!origination!targets!set!out!by!the!company’s!capital!partner,!a!multiBstrategy!hedge!fund!with!over!$3.0!billion!in!assets.!!!Mr.! Luysterborghs! received! a! Bachelor’s! Degree! in! Economic! Theory! from! The! American! University! in!Washington!DC!and!is!a!registered!principal!broker!in!the!State!of!New!York.!!In!2012,!he!was!the!recipient!of!the!Fairfield!County!Business!Journal’s!“40!under!40!award.”!!Mr.!Luysterborghs!and!his!wife!Silvia!have!two!children! and! live! in! Greenwich,! CT.! ! His! responsibilities! as! Managing! Director! at! AVANT! include! corporate!development,!originations,!investor!relations!and!he!is!a!member!of!the!Investment!Committee.!!David%Teten%Partner,(ff(Venture(Capital(Chair,(Harvard(Business(School(Alumni(Angels(of(Greater(New(York((David! is!a!Partner!with!ff!Venture!Capital!and!the!founder!and!chair!of!Harvard!Business!School!Angels!New!York.! !He! is! the!coBfounder!and!Chairman!of!Navon!Partners,!a!data!mining!and!research!analytics!company!focused!on!analyzing!private!company!data.!He!is!a!Mentor!with!Founder!Institute!in!New!York!and!Singapore,!Dreamit! Ventures,! Entrepreneurs! Roundtable! Accelerator,! Lean! Startup! Machine,! and! Startup! Leadership!Program.!David!was! formerly!Acting!CEO!of!Vertical!Key,!a!webBbased!software!service! for!managing! largeBscale!events.!!!He! was! previously! a! Managing! Director! with! Evalueserve,! a! 2,500Bperson! global! research! and! analytics!company,! and! Founder! and!CEO!of! Circle!of! Experts,! an! investment! research! firm!acquired!by! Evalueserve.!David!led!the!firstBever!study!of!best!practices!of!venture!capital!and!private!equity!funds!in!originating!new!deals,!published!in!Harvard!Business!Review,!Institutional!Investor,!and!the!Journal!of!Private!Equity.!He!is!the!lead!author!of!The!Virtual!Handshake:!Opening!Doors!and!Closing!Deals!Online,!with!Scott!Allen.!!Rosario%Saglimbeni%%Former(Director(of(Investments(&(Real(Estate(Acquisitions,(Schneider(&(Schneider,(Inc.((Rosario! Saglimbeni,! in! his! role! as! a! Family! Office! Executive,! was! responsible! for! sourcing! opportunities! in!private!equity,!direct!and!alternative!investing,!alongside!other!traditional!investment!vehicles.!While!Director!of!Acquisitions!&!Investments!at!Schneider!&!Schneider,!Inc.!(“S&S”),!Rosario!led!a!team!of!professionals!that!evaluated!and!underwrote!potential!acquisitions,!dispositions!and!repositioning!of!assets! for! the!ownership!and!its!investors/partners,!creating!new!global!business!opportunities!for!the!family!and!developing!important!relationships!with!major!brokerage!houses,!private!equity!funds!and!family!offices,!and!investors.!Rosario!has!particular! expertise! in! the!medical! and! technology! fields,! alternative! and! renewable! energy,! green! housing!construction,!digital!media,!mobile!applications,!and!socialBimpact!investing.!!!For! the!past! 15!years!Rosario!has!been!predominantly! involved! in! the!Real!Estate!arena.! In! this! role,!he!has!provided! advisory! services! to! and! closed! transactions!with! a!wide! array! of! private,! public! and! institutional!clients!both!domestic!and!international.!As!Commercial!&!Investment!Properties!Director!at!The!Rudd!Group,!Ltd.,!Rosario!headed!a!department! that! in! the! first!decade!of! the!21st! century!generated! sales! in!excess!of!$500.0M!in!diverse!sectors!of!the!industry.!!!

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A!graduate!of!Rutgers!University,!Rosario!is!a!member!of!REBNY!and!BOMA!and!an!active!panelist!for!PAM,!NELV,!FWR!and!IvyFON.!!Lester%Wigler%(Moderator)%Senior(Portfolio(Manager(|(Financial(Advisor,(Morgan(Stanley(Wealth(Management((Lester!Wigler,!CFP®,!joined!Morgan!Stanley!in!2004!and!focuses!on!guiding!families,!executives,!professionals!and! business! owners! in! achieving! their! financial! goals! and! objectives.! Lester! develops! and! implements!comprehensive! personalized! strategies! that! are! centered! on! detailed! estate,! tax! and! liquidity! planning.!Through! his! trademarked! process,! WealthCase®,! he! advises! his! clients! on! the! optimal! balance! of! short,!intermediate! and! longB! term! approaches! to! their! financial! security.! Prior! to! joining! Morgan! Stanley! Smith!Barney,!Lester!served!as!founder!and!president!of!an!institutional!investment!consulting!firm.!In!this!role,!he!worked!with!corporations,!banks!and!monetary!authorities! in!the!areas!of!capital!management,!customized!portfolios! and! financial! technology.! Before! launching! his! firm,! Lester! managed! financial! risk! management!activities!at!Accenture,!directing!engagements!with!international!financial!institutions.!!!Lester!has!written!and!lectured!on!the!strategic!and!tactical!implications!of!financial!innovation!and!formerly!instructed!the!corporate!finance!course!at!the!New!York!Institute!of!Finance.!He!is!a!member!of!the!New!York!State! Society! of! CPA’s! Family! Office! Committee,! Estate! Planning! Committee! and! chairs! the! education! subBcommittee!of!the!Investment!Management!Committee.!Lester!currently!serves!as!Vice!President!on!the!board!of! Columbia!University’s! Graduate! School! of! Arts! and! Sciences! Alumni! Association! and! is! a!member! of! the!Estate!Planning!Council!of!New!York!City.!Lester!earned!a!Master!of!Business!Administration!in!international!finance! from!New!York!University,! a!Master! of! Arts! from!Columbia!University! and! a! Bachelor! of! Arts! from!Queens!College,!CUNY.!!Panel)Discussion)Venture)Capital):)Investing)in)the)New)Wave)(This! panel!will! explore! the! state! of! venture! capital! investing.! ! A! retrospective! examination!will! explore! the!pitfalls!of!the!old!paradigm,!including!the!inability!of!the!sector!to!maximize!value!for!their!LPs.!!Looking!to!the!future,!the!panel!will!discuss!portfolio!diversification,!the!importance!of!syndicates!and!the!components!and!strategies!of!"new!wave"!venture!investing.!!John%Frankel%Partner,(ff(Venture(Capital((John!Frankel!is!the!founding!partner!of!ff!Venture!Capital,!an!earlyBstage!venture!capital!firm!in!New!York!City,!and!has!been!an!earlyBstage!investor!since!1999.!John!was!one!of!the!earliest!investors!in!Quigo!Technologies,!which!was!purchased!by!AOL!in!December!2007,!and! in!Cornerstone!OnDemand!(CSOD!on!NASDAQ),!which!had!a!successful!IPO!in!March!2011.!!John!currently!serves!on!the!boards!of!500px,!Appy!Couple,!Bottlenose,!Centzy,!ClearPath! Immigration,!Distil!Networks,!Estify,!Headliner,!Gobbler,! InteraXon,!Moveline,!Phone.com,!SkyCatch,! Tackk,! VolunteerSpot,! and! Voxy.! ! John! is! also! a! Mentor! with! the! Entrepreneurs! Roundtable!Accelerator!program.!!Prior!to!founding!ffVC!in!2008,!John!worked!at!Goldman!Sachs!for!21!years!in!a!variety!of!roles!that!involved!technology!development,! reengineering,!and!capital!markets.!He!started!his!business!career! in!London!with!Arthur!Anderson!in!the!audit!and!insolvency!divisions.!John!earned!a!Master!of!Arts!from!New!College,!Oxford!where!he!studied!Mathematics,!Philosophy!and!Logic,!and!is!a!Fellow!Chartered!Accountant!of!the!Institute!of!Chartered!Accountants!in!England!and!Wales.!John!is!a!frequent!keynote!speaker!and!has!appeared!in!leading!publications! such! as! BBC,! Bloomberg! BusinessWeek,! Business! Insider,! CNBC,! GigOM,! The! San! Francisco!Chronicle,!TechCrunch,!USA!Today,!The!Wall!Street!Journal!and!Xconomy.!!!

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Joe%Gensheimer%President,(Crosswind(Partners,(LLC.((Chairman,(River(Valley(Investors((Joe! Gensheimer! is! an! angel! investor,! president! of! Crosswind! Partners! LLC,! a! business! consulting! firm,! and!chairman!of!River!Valley! Investors,!an!angel!group!based! in!Springfield,!MA.! !He!was!a! founder!and!COO!of!Movida! Communications,! Inc.,! the! first! !MVNO! targeted! at! Hispanics! in! the! US.! Previously! he!was! COO! of!Cometa!Networks!in!San!Francisco.!!!Joe!was!one!of!the!first!20!employees!of!Sprint!PCS!where!he!served!as!General!Counsel!from!1995!through!2002,!and!Senior!Vice!President!of!Sprint!from!1999B2002.!!!Prior!to!Sprint!PCS!Joe!held!executive!positions!at!large!companies!such!as!IBM!and!GTE,!and!startups.!!He!started!his!career!as!an!engineer!for!GE!installing!large!gas!turbines!for!power!generation.!!His!interests!included!flying,!tennis,!and!writing!about!antique!employee!time!recorders.!!Bill%Podd%(Moderator)%Executive(Director,(Landmark(Angels(|!President(&(CEO,(Landmark(Capital(!William!S.!Podd!is!the!President!&!Executive!Director!of!Landmark!Angels,!Inc.!a!private!angel!group!located!in!Greenwich,!Connecticut!and!President!&!CEO!of!Landmark!Capital!Corporation,!a!boutique! investment!bank!which!he!founded!in!1993.!Prior!to!founding!Landmark!Capital,!Bill!completed!more!than!$3!billion!in!financings!as!a!corporate!finance!banker!and!a!lawyer.!!While!a!partner!at!the!law!firm!of!Kramer,!Levin,!he!led!the!debt!analysis! group! that! helped! structure! Hurwitz’s! acquisition! of! Kaiser! Aluminum! and! at! Lehman! Brothers!specialized!in!both!municipal!and!corporate!finance.!He!also!served!as!president!of!an!early!stage!enterprise!software!company!whose!technology!was!developed!at!The!Draper!Laboratory!at!the!Massachusetts!Institute!of!Technology.!Bill!is!a!frequent!speaker!and!panelist!on!angel!investing!and!venture!capital.!A!Phi!Beta!Kappa,!summa!cum!laude!graduate!of!The!University!of!Notre!Dame,!he!received!his!J.D.!degree!from!the!University!of!Virginia!School!of!Law.!!Stacey%Seltzer%Principal,(Aisling(Capital((Ms.!Seltzer!serves!as!a!Principal!of!Aisling!Capital.!Previously,!Ms.!Seltzer!was!at!ScheringBPlough,!where!she!held! roles! in! business! development,!marketing! and! sales,!most! recently! serving! as! the!US! ScheringBPlough!Brand! Lead! for! Zetia.! While! in! business! development,! Ms.! Seltzer! was! involved! in! the! structuring! and!negotiation!of!several!deals!with!an!aggregate!value! in!the!billions,! ranging!from! inBlicensing!deals!to!broad!development! and! commercialization! alliances.! Prior! to! ScheringBPlough,! Ms.! Seltzer! was! the! Director! of!Business! Development! for! Akceli,! a! biotechnology! company! developing! cellBbased!microarrays.!Ms.! Seltzer!began!her!career!as!a!management!consultant!for!McKinsey!&!Company.!!Ms.! Seltzer! serves! as! a! director! of! Miramar! Labs,! acts! as! the! Aisling! representative! for! its! investment! in!Precision!Dermatology!and! serves!as!a!board!observer! for!Durata!Therapeutics!and!Agile!Therapeutics.! She!was!previously!a!board!observer!for!Zeltiq!Aesthetics!(NASDAQ:!ZLTQ).!Ms.!Seltzer!received!her!M.B.A.!from!The!Wharton!School!at!the!University!of!Pennsylvania,!where!she!was!a!Palmer!Scholar.!She!received!her!M.S.!and!B.S.!from!Yale!University,!awarded!cum!laude!in!Molecular!Biophysics!and!Biochemistry!!Sponsor):)Corbita)Maritime))!Michael%W.%Davis%%Institutional(Sales(Director,(Behringer(Harvard((Michael!W.!Davis!CPA,!CFA!is!institutional!sales!director!at!Behringer!Harvard.!In!this!capacity,!he!is!responsible!for! building! and! maintaining! strategic! relationships! to! strengthen! the! company’s! institutional! distribution!channel! in!the!U.S.!With!a!career!spanning!more!than!20!years,!Mr.!Davis!brings!broad!expertise! in!portfolio!

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management! and! investor! relations! as! well! as,! private! equity,! hedge! fund! and! real! estate! investment!experience.!!Prior!to!joining!Behringer!Harvard!in!June!2012,!Mr.!Davis!worked!at!Gorelick!Brothers!Capital!a!Family!Office!in!Charlotte,! North! Carolina,! where! he! managed! new! business! development! in! the! family! office,! registered!investment!advisor,! and! foundation!and!endowment! space! (2008–2012).! From!2005! to!2008,!Mr.!Davis!was!managing!director!and!head!trader!of!debt!capital!markets!at!National!City!Bank!in!Cleveland,!Ohio.!Mr.!Davis!served! from! 2002! to! 2005! as! a! trader! and! director! of! portfolio! risk! management! at! JP! Morgan/Bank! One!Capital! Markets! in! Chicago,! Illinois.! From! 2000! to! 2002,! Mr.! Davis! served! as! senior! credit! analyst! and! vice!president! at!Deerfield!Capital!Management! in! Chicago.! From! 1995! to! 2000,!Mr.!Davis! coBmanaged!a! $3! real!estate! securities! portfolio! at! PPM! America.! ! During! the! period! of! 1989–1995,! he! held! various! leadership!positions!within! real! estate! firms! and! creditBrating! agencies! in! Chicago.! !Mr.! Davis! earned! a! BBA! from! the!University!of!Michigan!at!Ann!Arbor.!He!also!received!an!MBA!from!the!University!of!Chicago.!Mr.!Davis! is!a!Chartered!Financial!Analyst!and!a!Certified!Public!Accountant.!!Sponsor):)Wainscott)Capital)Partners))!Thomas%S.%Gilbert%%Founder(&(Lead(Portfolio(Manager,(Wainscott(Capital(Partners((Thomas!S.!Gilbert! founded!Wainscott!Capital!Partners!Fund,!LP! in!2011,!and! is! the!Managing!Member!of!the!General!Partnership,!Wainscott!Capital!Partners,!LLC!and!is!President!of!Wainscott!Capital!Management,!LLC,!the!management!company.!A!graduate!of!Princeton!and!Harvard!Business!School,!Mr.!Gilbert!has!extensive!knowledge! of! the! alternative! investment! space! having! spent! 40! years! on!Wall! Street!with! direct! investing!experience!in!the!stock!market,!as!well!as!private!equity,!real!estate,!and!the!fixed!income!market.!Previously,!Mr.!Gilbert!was!a!CoBFounder!of!Syzygy!Therapeutics,!a!private!equity!biotech!asset!acquisition! fund,!which!focused! on! identifying! and! investing! in! lateBstage! biotech! drug! candidates,! with! potential! for! billion! dollar!markets.!Mr.!Gilbert! left!Syzygy! in!April!2011!to!form!Wainscott!Capital!Partners.!Mr.Gilbert!founded!and!ran!Knowledge! Delivery! Systems,! Inc.! as! Chairman! and! CEO! from! 2000! through!May,! 2009,! Chairman! through!December,! 2010,! and! is! currently!a!Director!of!KDS.!He! is! a! former!Managing!Director!of!Venture!Capital! at!Loeb! Partners! Corporation,! where! he!was! responsible! for! originating,! structuring,! and!monitoring! a! broad!spectrum! of! private! equity! portfolio! investments.! Mr.! Gilbert! is! also! currently! a! Director! of! North! Atlantic!Holding!Company,!Inc.!!

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!

!!!

!!!!!

EXTENDS!A!SPECIAL!THANKS!TO!OUR!!

KEYNOTE!SPEAKER,!PANELISTS!!!

AND!!

SPONSORS!FOR!THEIR!SUPPORT!AND!PARTICIPATION!!

! !!!!!!!!!!!!!!!!!!!!!!!!!!!

!!!

!

LANDMARK ANGELS


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