2013 FASEB SCIENCE RESEARCH CONFERENCES ADVISORY … The... · Proposal #: 15-24 . 2013 FASEB...

Proposal #: 15-24

2013 FASEB SCIENCE RESEARCH CONFERENCES ADVISORY COMMITTEE MEETING

TOPIC FOR CONSIDERATION TOPIC NAME: Nutritional Immunology: Role in Health and Disease PREVIOUS TITLE: Nutritional Immunology: Role in Health and Disease SUBMITTED BY: Melinda Beck, University of North Carolina – Chapel Hill

Philip C. Calder, University of Southampton YEAR REQUESTED FOR SCHEDULING:

2015

SITE REQUESTS: 1. Lisbon, Portugal

2. Cambridge, England 3. Liverpool, England

DATE REQUESTS: 1. July 19-24, 2015

2. July 26-31, 2015 3. July 12-17, 2015

YEAR(S) CONFERENCE HAS BEEN HELD:

2003, 2007, 2011

NOTES: To the best of our knowledge, there is not a direct conflict with any other

FASEB SRC or other society or industry meeting.

FASEB SRC Proposal Instructions

Attached are the instructions and requirements for submitting a FASEB SRC proposal. Please complete sections 1-6 before submitting your information. Please submit your proposal by September 1, 2013. Your proposal will be reviewed by the FASEB Science Research Conference Advisory Committee in early November. Once your Conference is approved you will be assigned a Conference manager from the FASEB SRC Team who will provide you with detailed instructions on program management and timelines to help make your planning process successful and seamless.

Section 1: Organizer Responsibilities: By submitting a FASEB Science Research Conference proposal for consideration by the FASEB SRC Advisory Committee, the organizer (s) accepts the responsibility for producing a successful conference. Such responsibilities include: 1. Anything related to the scientific portion of your Conference. You will need to provide the Conference title and topics. The Conference title and topics should be timely and attractive. 2. Attendance to your conference is expected to be no less than 100 participants. 3. Contacting all speakers and session chairs to invite and confirm their participation. Speakers should be informed that their expenses will be reimbursed after the conference and only to the extent that funds are available. We recommend you do not commitment to a speaker a specific amount of funds prior to the conference. (Note: Invited speakers and session chairs are required to remain at the conference for a minimum of three full days and three full nights in order to be eligible for reimbursement of any conference related expenses.) 4. Reviewing and approving the submitted attendees. 6. Including a “Meet the Expert” session in your program. This session is aimed at encouraging the younger investigators an opportunity to network with the more established and senior PIs in your field. 7. Providing a final conference program to your Conference Manager three weeks prior to the conference. The program will include the speaker abstracts (in presentation order), poster abstracts, and a poster listing of the submitted abstracts. The Conference Manager will prepare the cover for the program, the participant list and have the final packet of materials reproduced and shipped to the venue. 8. Constant communication with your Conference Manager. By doing so, this will eliminate any miscommunication or understanding of the policies and procedures that will need to be followed.

Section 2: Conference Title & Organizer Information: Please insert the title of the conference as you would like it to be advertised in future publications. List the organizing committee below and complete contact information and attach a brief CVs (maximum 3 pages) in NIH format for each. Title of Conference: Nutritional Immunology: Role in Health and Disease # of EXPECTED ATTENDEES: 175 Preferred Primary Point of Contact for Proposal Questions: Name: Melinda A. Beck Full Address: Department of Nutrition, 2303 MHRB, CB #7461, University of NC at Chapel Hill, Chapel Hill, NC 27599-7461 Telephone: 919 966-6809 Email Address: [email protected] Science Categories (select up to 3) 1) Biochemistry 2) Biomedical Research 3) Cell Biology Organizing Committee: Organizer Chair: Melinda A. Beck Title: Professor Affiliation: University of North Carolina at Chapel Hill Full Address: Department of Nutrition, 2303 MHRB, CB #7461, University of NC at Chapel Hill, Chapel Hill, NC 27599-7461 Phone: 919 966-6809 Email: [email protected] Organizer Co-Chair: Philip C. Calder Title: Professor Affiliation: University of Southampton Full Address: Human Development & Health Academic Unit, Faculty of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UNITED KINGDOM Phone: +44 (0)2380 795250 Email: [email protected]

mailto:[email protected]

Section 3: Program Submission Requirements & Outline:

Please insert program details in day order as requested below. Session titles should be listed with session chairs and affiliations. Indicate the proposed tentative talk titles within each session and list up to at least 4 speakers per session (not including short talks selected from submitted abstracts). Please remember to also include the required “Meet the Expert” session. The FASEB SRC Advisory Committee requires all session chairs to be confirmed before the submission of the application. Be sure to indicate with a "C" if the session chair is confirmed, indicate with a “CS” if the speaker is confirmed, indicate with a "W" which session chairs and speakers are women, indicate with an "M" which session chairs and speakers are of a minority group and indicate with the word “NEW” which session chairs and speakers are new to the program. (Note: The committee defines new speakers as one that has NOT spoken at the last two (2) conferences.) Overview of Program Flow # of Days: 6 # of Sessions per day: 2 # of Speakers per day: 8 # of Session chairs per day: 2 # of Breakouts per day: 1 # of Abstracts per day: 4-6 Day One (1) Afternoon: Conference Registration Evening: FASEB SRC Welcome Reception & Dinner

KEYNOTE SPEAKER: Jenny Ting, University of North Carolina at Chapel Hill, USA CS, W, NEW Using nanoparticles to analyze the immune response Day Two Session 1 (Monday AM): Title of Session: Cutting Edge Research in Nutritional Immunology Session Chair: Simin Nikbin Meydani, Tufts University, Boston, USA C, W Speaker 1: Michael Muller, Wageningen University, The Netherlands CS, NEW Using omics approaches to understand nutrition-inflammation interactions

Speaker 2: Ajay Chawla, UCSF, USA CS NEW The immune system as a sensor of the metabolic state Speaker 3: Liza Makowski, University of North Carolina at Chapel Hill, USA CS, W, NEW

New understandings of macrophage biology

Speaker 4: Charles Serhan, Harvard University, Boston, USA NEW Pro-resolving mediators formed from omega-3 fatty acids

Number of short talks selected from abstracts: 3

Session 2 (Monday PM) Title of Session: Obesity, Inflammation and Immunity Chair: A. Catherine Ross, Penn State University, University Park, USA C, W Speaker 1: Melinda A. Beck, University of North Carolina at Chapel Hill, USA CS, W

Obesity impairs the immune response to infectious disease

Speaker 2: Giuseppe Matarese, IEOS-CNR, Naples, Italy CS NEW Immune profiling in metabolic disease

Speaker 3: Savierio Cinti, University of Ancona, Italy NEW

The role of white-brown adiopocyte plasticity in inflammation Speaker 4: Gema Fruhbeck, University of Navarra, Pamplona, Spain CS, W, NEW New insights into the role of adipokines Number of short talks selected from abstracts: 2 Day Three Session 3 (Tuesday AM) Title of Session: Nutrition, immunity and chronic age-related diseases Chair: Melinda A. Beck, University of North Carolina at Chapel Hill, USA C, W Speaker 1: Graham Pawelec, University of Tübingen, Germany CS, NEW

The ageing immune system: how can it be assessed?

Speaker 2: V. Hugh Perry, University of Southampton, UK CS, NEW Neuroinflammation and ageing Speaker 3: Graham Devereux, University of Aberdeen, UK CS, NEW Micronutrients and asthma Speaker 4: Martin Hewison, University of California, Los Angeles, USA NEW Vitamin D as a master regulator of immune function MEET THE EXPERTS SESSION DIRECTLY AFTER LUNCH Session 4: (Tuesday PM) Title of Session: Gut immunology and the diet-microbiota-immune axis Chair: Parveen Yaqoob, University of Reading, UK C, W, NEW Speaker 1: Nathalie Delzenne, Catholic University of Louvain, Brussels, Belgium CS, W, NEW

Gut microbiota as a regulator of inflammatory tone in metabolic disease

Speaker 2: Parveen Yaqoob, University of Reading, UK CS, W, NEW Probiotics and the ageing immune system – new insights

Speaker 3: Erika Isolauri, University of Turku, Finland CS, W, NEW Modifying gut microbiota can prevent allergic diseases

Speaker 4: Jerry Wells, Wageningen University, The Netherlands NEW How do probiotic organisms interact with the host?

Number of short talks selected from abstracts: 2 Day Four Session 5 (Wednesday AM) Title of Session: Early life nutritional influences on the immune system Chair: Andrew Prentice, London School of Hygiene & Tropical Medicine, UK C, NEW Speaker 1 Angel Gil, University of Granada, Spain CS, NEW

Immune maturation factors in human breast milk

Speaker 2: Susan Prescott, University of Western Australia, Perth, Australia W, NEW Early life programming of immune function alters later risk of non-communicable diseases Speaker 3: Thom McDade, Northwestern University, Evanston, USA CS, NEW Impact of early environment on later immune and inflammatory responses Speaker 4: Philip Calder, University of Southampton, UK C

Omega-3 fatty acids and immune programming Number of short talks selected from abstracts: 3 Session 6 (Wednesday PM) Title of Session: Nutrition and immune cell signaling Session Chair: Graham Pawelec, University of Tübingen, Germany C, NEW

Speaker 1: S. Raz Shaikh, University of East Carolina, Greenville, USA CS

Fatty acids, lipid rafts and antigen presentation

Speaker 2: Simin Nikbin Meydani, Tufts University, Boston, USA CS, W Vitamin E, ceramides and T cell signaling

Speaker 3: Susan Percival, University of Florida, Gainsville, USA CS, W Phytochemical influences on immune cells in humans

Speaker 4: A. Catherine Ross, Penn State University, University Park, USA CS, W

How vitamin A controls T cell differentiation and functionality Number of short talks selected from abstracts: 2 Day Five Session 7 (Thursday AM) Title of Session: Nutrient-gene interactions in the immune system Chair: S. Raz Shaikh, University of East Carolina, Greenville, USA C Speaker 1: Lothar Rink, Aachen University, Germany

Zinc regulation of gene expression within the immune system CS, NEW

Speaker 2: Margherita Cantorna, Penn State University, University Park, USA CS, W Vitamin D and immune mediated diseases

Speaker 3: Peter Hoffman, University of Honolulu, USA CS Selenium as a regulator of immune and inflammatory responses

Speaker 4: Helen Roche, University College Dublin, Ireland CS, W, NEW

Fatty acid interactions with the inflammasome Number of short talks selected from abstracts: 3 Session 8 (Thursday PM) Title of Session: The metabolic cost of infection and inflammation Chair: Philip Calder, University of Southampton, UK C Speaker 1: Jeff Rathmell, Duke University, Durham, USA CS, NEW

Metabolic regulation of T cells

Speaker 2: Andrew Prentice, London School of Hygiene & Tropical Medicine, UK CS, NEW Undernutrition, infection and growth impairment Speaker 3: Hongbo Chi, St. Jude, Memphis, US CS, NEW Lymphocyte metabolism and the role of mTOR Speaker 4: Erika Pearce, Washington University, St. Louis, USA CS, W, NEW Mitochondrial respiratory capacity as a critical regulator of T cell memory development

Number of short talks selected from abstracts: 2 Day Six Session 9 (Friday AM) Session title: Nutritional immunology – old challenges require new approaches Chair: Margherita Cantorna Penn State University, University Park, USA C, W Speaker 1: Harald Renz, Philipps University of Marburg, Germany CS, NEW The need to grasp new technologies

Speaker 2: Ben van Ommen, University of Wageningen, The Netherlands CS, NEW

The challenge of biomarkers Speaker 3: David Raubenheimer, Massey University, Auckland, New Zealand CS NEW Nutritional Immunology: A Multi-Dimensional Approach

Speaker 4: Panel Discussion END OF CONFERENCE

Section 4: Content Assessment:

Please complete the grid below which will assist the FASEB SRC Advisory Committee in assessing the requirements of the proposal. Positive reviews are given to proposals with confirmation of session chairs and invited speakers, new speakers to the program, a good representation of women, and a sufficient number of short talks from junior level investigators.

Indicate the number of session chairs that have confirmed their participation: 9 (100%) Indicated the number of women included with the entire program: 14 Indicate the number of session chairs/speakers of a minority group: 0 Indicate the number of “new” speakers to the conference: 28 Indicate the number of speakers that have confirmed their participation in the conference: 31 Indicated the number of talks set aside for junior level investigators to present their work: 7 Indicated the number of poster sessions that will be organized: 3 Please provide a brief description of how the poster sessions will be organized:

Based on previous experience, we will have poster sessions during the free time on Monday, Tuesday and Wednesday of the meeting, with authors required to be at their posters on Monday, and optional attendance on Tuesday and Wednesday. We will also provide a cash bar and snack foods during the poster session, which we found helped to provide a relaxed and congenial attendance at poster sessions. Indicate (if known) if there is a potential of a conflict with any other FASEB SRC or any other society or industry meeting. If yes, please explain the conflict in detail. None have been identified.

Section 5: Scheduling & Location Preferences:

Select three (3) choices of dates from that you wish to hold the Conference. Define the pattern flow, start date and end date of your Conference. Week 1: __July 19-24_________ Week 2: _July 26-31________ Week 3: __July12-17____ Select at least three (3) cities/venues for consideration. Venue #1 should be the most preferred. (Note: We will do our best to give you your first choice but it cannot be guaranteed.) Please circle the type of facility you would like to host the program. Hotel Conference Center University, Academic Setting (summer only)

Cites/venues: Preference Lisbon, Portugal 1 2 3 Cambridge, England 1 2 3 Liverpool, England 1 2 3

Contingent upon interest. Every effort will be given to the Organizer’s choice of venue and date choice. Due to limited availability and scheduling site and date preferences are not guaranteed. For each conference year, A minimum of 4 conference proposals must have interest in a potential venue in order for that venue to be used as a conference location.

Section 6: Justification:

The SRC Advisory Committee requires all proposals to include answers to the following eleven (11) questions. In a separate Microsoft word document, answer each individual question accordingly. Once completed, name the document the title of your conference and attach this file to your email when submitting the final proposal. 1. Explain why this topic is of high current interest to the scientific community. The primary focus of this meeting is to explore the relationship between nutritional status and immune function in its broadest context. The nutritional status of the host has recently become appreciated for its ability to influence obesity, asthma, diabetes, GI disorders, cardiovascular disease and autoimmunity, to name a few. On the other hand, these metabolic-nutritional disorders both involve cells of the immune system and can influence the immune response. Thus there are multidirectional interactions between nutrition, immunity, and non-communicable diseases. In addition, new appreciations for cutting edge immunological techniques can be brought to bear on understanding the role of nutrition on influencing the immune response. Sessions examining these key issues are a part of our meeting, including a keynote address to kick-off the meeting by Jenny Ting, who recently received the American Association of Immunologists career award for “outstanding research contributions to the field of immunology”. Dr. Ting will discuss the use of nanoparticles in probing the immune response. With the epidemic in obesity, diabetes and related metabolic disorders worldwide coupled with a growing understanding of the importance of the nutrient-gene-immune axis, this area is of high importance and high interest to the scientific community 2. Is this a rapidly growing field? Nutritional immunology is a rapidly growing field. In the last few years it has become of sufficient interest and growth that it is now a regular sub-section of the Journal of Nutrition, the American Journal of Clinical Nutrition and is a Research Interest Section (RIS) for the annual FASEB National meetings. Diet and health overall is an area of rapidly growing research and the effect of diet on immune function is particularly growing. 3. Have there been previous conferences on this topic? If so, where and when were the conferences held, how many participants attended? (Additionally, consider whether or not another similar conference/meeting is scheduled that might cause a conflict). In 2003 the first FASEB Summer Conference in nutritional immunology was held in Vermont. The title was “The Impact of Nutritional Status on Immune Function and Health”. It was the first such conference dealing with this topic to be held in the USA in many years. There were over 90 participants at that time who repeatedly expressed appreciation for the opportunity to meet each other (for the first time in some cases) and to share ideas and information. In 2007, we met for the 2nd time in Arizona with 126 participants. Again, participants expressed great enthusiasm for this meeting and we were able to attract new investigators to this second meeting who were not at the first meeting, demonstrating the growth of the field. In 2011, we met for the 3rd time in Carefree Arizona, and for this conference we invited a number of immunologists who worked in cutting edge areas and techniques in order to stimulate discussion on how these new areas could be used to move forward the field of nutritional immunology. At this meeting, attendance was down from the previous meeting (66 attendees), but in polling attendees, this was found to be due to the then-current state of the economy and not due to a lack of interest in the field. A number of attendees could not afford to send students or post-docs to attend and some scientists who did not attend stated that they could only afford one meeting a year and had already chosen the annual FASEB meeting. At this time, there is no

scheduled conflict with this proposed meeting on this topic. 4. How many participants do you expect to attend the conference? We anticipate increased participation over our previous meeting. We believe that holding the meeting in Europe and having half of the speakers from non-US countries, will greatly increase participation by active non-US nutritional immunologists. In addition, this will be a very attractive meeting for US attendees as they now have an opportunity to hear a number of speakers that they have not had an opportunity to interact with previously. We expect to have at least 150 attendees at this meeting. In October 2012 a Workshop on Immunonutrition in Palma, Spain attracted approximately 150 delegates, mainly European. 5. What percentage of women have participated in this conference in the past (if it had been previously held)? At the last conference, 50% of the attendees were women. 6. How will you recruit young investigators to attend and participate in the conference? Since this is, in fact, a growing field, many of the investigators are young (in their 30's and 40's). Thus, in 2011, 27% of our speakers were Assistant Professors. For the current program, we have identified a number of young scientists as speakers. We are also making an effort to invite postdoctoral students and graduate students by providing some travel support because they are especially vital to the future of this field. At the 2011 meeting, we were able to provide 4 travel awards to graduate students and post-docs. We hope to increase that number for the 2015 conference.

7. How will you recruit and select new speakers? Both co-chairs are highly active in the field. For the first time, a non-US Co-Chair, Philip Calder who is Professor of Nutritional Immunology at the University of Southampton, UK, was selected. This signals the international nature of the topic and provides an opportunity to recruit new speakers and new delegates. Suggestions for speakers were made at the business meeting from the 2011 conference as well. At the time of this submission, we have commitments from 100% of our speakers, of which 78% have never been invited to speak at this conference previously. 8. Who will attend this conference? (Provide specifics) This meeting by its very nature is interdisciplinary. The delegates will include nutritionists, immunologists, biochemists, cell biologists, allergists, geneticists, and clinicians cross-trained in these areas. The primary societies involved are ASN and AAI. We will also try to involve the (British) Nutrition Society and the British Society for Immunology. 9. From what sources and resources will you use to solicit funds for the conference (Provide specifics)? We were very successful at finding funds the last time since the topics are of interest to industry, foundations, and the NIH. We were able to cover all costs of all the speakers as well providing travel

grants for 4 graduate students and postdocs. We plan to apply to NIH for about a third of the needed funds. NCI, NIDDK and ODS have all expressed interests in this topic for all of our previous meetings and we expect that interest will continue. We also plan to approach Abbott Labs, Kraft, Shaklee, Proctor and Gamble, Quaker Oats, Solexa, Novartis, Dyets, Campbell Soup, Dannon, Minute Maid, Roche Vitamins, the Crohn’s Foundation, ACS, the Diabetes Foundation, Nestle, Danone, DSM, BASF, Unilever, Syral-Terreos, Beneo-Orafti among others for support. Many of these groups provided $2000 to $20,000 of support in 2011. 10. Where will you advertise the conference? What types of media will you use to advertise your conference? (Provide specifics). We will advertise the meeting in Science, Journal of Nutrition, American Journal of Clinical Nutrition, FASEB J., and the Journal of Immunology. Furthermore, to add to the international pool ads will also be placed in the British Journal of Nutrition, the European Journal of Immunology, the (British) Nutrition Society Gazette, and The British Society for Immunology’s Immunology News. A key route of information is the Nutritional-Immunology FASEB RIS Group. We have a large web mailing list for nutritional-immunology that includes international scientists. A general announcement can be sent out as soon as we know the venue and date of the meeting. In addition, the RIS sends out twitter messages, which will be used to advertise the conference. Additional announcements/reminders can be sent out a year ahead of the meeting. We can also use the RIS meeting at the upcoming FASEB meetings in 2014 and 2015, as well as hand out announcements at the AAI meeting. We will also ask ASN, AAI and other relevant societies to post the meeting on their web sites. In addition, both Beck and Calder will be attending workshops/conferences at which this meeting can be widely advertised.

11. What societies and disciplines will you attract to attend the conference? (provide specifics) Societies: American Society for Nutrition, American Association of Immunologists, Clinical Immunology Society, Society for Experimental Biology and Medicine, The Obesity Society, UK Nutrition Society, British Society for Immunology, various European Immunology Societies, International Forum for Immunonutrition Education and Research Disciplines: Nutrition, Immunology, Infectious Diseases, Cell Biology, Biochemistry REQUIRES COMPLETION 12. Are you planning on submitting a similar application to another organization for additional funding and sponsorship? If yes, please clarify. No

Program Director/Principal Investigator (Last, First, Middle): Beck, Melinda A.

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Beck, Melinda A

POSITION TITLE Professor and Associate Chair

eRA COMMONS USER NAME (credential, e.g., agency login) mabeck EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE (if applicable) MM/YY FIELD OF STUDY

University of California, Berkeley BA 1978 Zoology California Polytechnic State University, SLO

MS 1983 Biological Sciences

The Ohio State University, Columbus, OH Ph.D. 1987 Medical Microbiology and Immunology

Personal Statement: I am a Full Professor in the Department of Nutrition. I was the Co-Organizer for the previous SRC and successfully raised funds to support all of our speakers and to provide travel grants for students and post-docs. We have identified new speakers for this proposal, and by holding it in Europe, we can anticipate increased European investigator participation, along with Americans.

Positions and Honors Positions 3/87 - 6/89 Postdoctoral Research Associate, Department of Pathology and Microbiology, College of

Medicine, University of Nebraska Medical Center, Omaha, NE. 7/89 - 6/91 Instructor, Department of Pathology and Microbiology, College of Medicine, University of

Nebraska Medical Center, Omaha, NE. 7/91 - 9/91 Assistant Professor, Department of Pathology and Microbiology, College of Medicine,

University of Nebraska Medical Center, Omaha, NE. 10/91 - 9/92 Visiting Assistant Professor, Department of Pediatrics, School of Medicine, University of

North Carolina at Chapel Hill, Chapel Hill, NC. 9/92 - Present Assistant Professor, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill. 9/93-Present Fellow, Frank Porter Graham Child Development Center, University of North Carolina at Chapel Hill 9/96-4/98 Assistant Professor, Department of Nutrition, School of Medicine and School of Public Health, University of North Carolina at Chapel Hill 4/98-8/04 Associate Professor, Departments of Pediatrics and Nutrition, School of Medicine and

School of Public Health, University of North Carolina at Chapel Hill 9/04-3/05 Professor, Departments of Pediatrics and Nutrition, School of Medicine and

School of Public Health, University of North Carolina at Chapel Hill 4/04-present Professor, Department of Nutrition, School of Medicine and School of Public Health,

University of North Carolina at Chapel Hill 6/05-8/11 Director, Division of Nutritional Biochemistry, Department of Nutrition 6/09-present Associate Chair, Department of Nutrition Honors



American Society for Microbiology, Foundation for Microbiology Lectures Program. Speaker: July 1, 1995 - June 30, 1997. E.L.R. Stockstad Award, 2001. American Society for Nutritional Sciences Associate Editor, Experimental Biology and Medicine Instituto de Medicina Tropical “Pedro Kouri”, Havana, Cuba. Commeorativa Centenario del Natalicio de Pedro Kouri, medal given for outstanding contribution to science, 2/2003 Member: NIH Study Section- Integrated Nutrition and Metabolic Processes Ad Hoc member of several NIH study sections 15 Selected Peer-Reviewed Publications Beck, M.A., Shi, Q., Morris, V.C.,and Levander, O.A. Rapid genomic evolution of a non-virulent

coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nature Medicine 1: 433-436. PMID: 7585090

Cook, D.N., Beck, M.A., Coffman, T.M., Kirby, S.L., Sheridan, J.H., Pragnell, I.B., and Smithies, O. 1995. MIP-1α required for normal inflammatory response to viral infection. Science 269: 1583-1585. PMID: 7667639

Beck, M.A. and Levander, O.A. 1998. Dietary oxidative stress and the potentiation of viral infection. Ann. Rev. Nutr. 18:93-116. PMID: 9706220 McDade TW. Beck MA., Kuzawa C. and Adair LS. 2001. Prenatal undernutrition, postnatal environments, and antibody response to vaccination in adolescence. American Journal of Clinical Nutrition. 74:543-

8. PMID: 11566655 Beck, M.A., Nelson, H.K, Shi,.Q., Van Dael, P., Schriffrin E.J., Blum S., Barclay D. and Levander, O.A. 2001. Selenium deficiency increases the pathology of an influenza virus infection. FASEB J 15:1481-3. PMID:

11387264 Nelson, H.K, Shi,.Q., Van Dael, P., Schriffrin E.J., Blum S., Barclay D., Levander, O.A. and Beck, M.A. 2001. Host selenium status as a driving force for influenza virus mutations. FASEB J 15:1846-8. PMID:

11481250 McDade, T.W., Kuzawa, C., Adair, L.S., and Beck, MA. 2004. Prenatal and early postnatal environments are

significant predictors of IgE concentration in Filipino adolescents. Clin Exp Allergy 34:44-56. PMID: 14720261

Gay RT, Belisle S, Beck MA and Meydani SM. 2006 An aged host promotes the evolution of an avirulent coxsackievirus strain into a virulent strain. PNAS 103:13825-13830. PMID: 16950876

Li, W. and Beck, MA 2007. Selenium deficiency induced an altered immune response and increased survival following influenza A/PR8/34 infection. Exp boil Med 232:412-9. PMID: 17327475

Smith, AG, Sheridan PA, Harp JB, Beck MA. 2007. Increased mortality and altered immune response in obese mice infected with influenza virus. J. Nutr. 137(5):1236-43. PMID: 17449587

Smith, AG, Sheridan PA, Tseng, R., Sheridan, J, Beck MA. 2008. Selective impairment in dendritic cell function and altered antigen-specific CD8+ T cell responses in diet-induced obese mice infected with influenza virus. Immunol 126:268-79. PMID: 18754811 Karlsson, EA, Sheridan PA and Beck MA. 2010. Diet-induced obesity impairs the T cell memory response to

influenza virus infection. J. Immunol. 184:3127-33. Karlsson EA, Sheridan PA, Beck MA. 2010. Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. J Nutr 140:1691-1697 Karlsson EA, Beck MA. 2010. The burden of obesity on infectious disease. Exp Biol 235:1412-1424. Sheridan PA, Paich HA, Handy J, Karlsson EA, Hudgens MG, Sammon AB, Holland LA, Weir S, Noah TL and Beck MA. 2012. Int J Obesity Oct 25. doi: 10.1038/ijo.2011.208. [Epub ahead of print] Research Support Current RO1 AI078090 12/01/08-11/30/16 NIH/NIAID Role of influenza infection in a vaccinated obese population Study designed to determine if obesity can impact the immune response to influenza vaccination



Role: PI RO1 AI082298 4/01/10-3/31-13 (in a no-cost extension through 3/31/2014) NIH/NIAID Viral Adaptation to Host Selenium Status The goal of this study is to understand how host Se status can influence viral mutation rates. Role: PI 5P30 DK56350 (Zeisel) 09/30/99-09/20/15 NIH/NIDDK Clinical Nutrition Research Unit Core C: Molecular Biology and Nutritional Biochemistry The goal of the core is to provide services to the CNRU participants in the area of antioxidant biochemistry and molecular biology techniques Role: Director of Core Completed R01 AI055050 10/1/03-9/30/08 NIH/NIAID Nutrition, Viral Mutation and Host Defense Study designed to determine the mechanism involved in viral mutations induced by host nutritional stress. Role: PI RO1 EY12410 4/15/99-4/14/07 NIH/NEI The Role of Nutrition in Virus-Induced Optic Neuropathy This study was designed to understand how a nutritional deficiency in a Cuban population led to viral mutations and a new pathogenesis of coxsackievirus A9. Role: PI

Program Director/Principal Investigator (Last, First, Middle): Beck, Melinda

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Calder, Philip C.

POSITION TITLE Professor of Nutritional Immunology

eRA COMMONS USER NAME (credential, e.g., agency login) EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE (if applicable) MM/YY FIELD OF STUDY

Massey University, New Zealand BSc (Hons) 1980 Biochemistry University of Auckland, New Zealand PhD 1987 Biochemistry University of Oxford, UK DPhil 1995 Biochemistry

A. Personal Statement Calder holds a Personal Chair in Nutritional Immunology at the University of Southampton, UK. He is internationally recognized as an expert in the field with a specialism in the influence of fatty acids and their mechanisms of action. A strength of his work is its translational approach, with mechanistic molecular, cellular and animal studies, trials in healthy human subjects, and clinical trials in patients all running in parallel. Calder has published widely in the field including a number of highly cited primary research and review articles. He has co-edited two books on the topic of nutritional immunology and he has authored chapters on this topic in three important textbooks (Nutrition Society Textbook on Nutrition & Metabolism [2003; second edition 2011]; Present Knowledge in Nutrition, 10th edition [2012]; Modern Nutrition in Heath & Disease, 11th edition [2014]). He has lead important expert groups, workshops and position papers on the topic, particularly with regard to immune biomarkers in human studies. He has organized workshops and symposia in the area of nutritional immunology over a long period of time. He is a member of the i-FINER (International Forum on Immunonutrition: Education & Research), in-FLAME (Worldwide Universities Network International Inflammation Network) and NIH INSPIRE (Inflammation & Nutrition Science for Program/Policy and Interpretation of Research Evidence) groups. B. Positions and Honors Positions and Employment 1982-1987 Assistant Lecturer, Department of Biochemistry, University of Auckland, NZ 1987-1991 Nuffield Medical Fellow, Department of Biochemistry, University of Oxford, UK 1991-1995 Departmental Lecturer, Department of Biochemistry, University of Oxford, UK 1995-1998 Lecturer in Human Nutrition, University of Southampton, UK 1998-2002 Reader in Human Nutrition, University of Southampton, UK February 2002 – present Professor of Nutritional Immunology, University of Southampton, UK

Other Experience and Professional Memberships Member of The (UK) Nutrition Society, The (UK) Biochemical Society, The British Society for Immunology, European Society for Clinical Nutrition and Metabolism, International Society for the Study of Fatty Acids & Lipids, American Oil Chemists’ Society, American Society for Nutrition, and Developmental Origins of Health and Disease Society. Served on committees of the UK Nutrition Society, the British Society of Immunology, The British Association of Parenteral and Enteral Nutrition, and the European Society for Clinical Nutrition and Metabolism; Currently Chair of the Scientific Committee of the European Society for Clinical Nutrition and Metabolism; Serve on the Council of the British Nutrition Foundation. Served as a member of the Board of the International Society for the Study of Fatty Acids and Lipids (ISSFAL); Elected Vice President and President-Elect of ISSFAL from March 2006; President for three years from March 2009.



Editor-in-Chief of the British Journal of Nutrition December 2005-January 2013; Associate Editor of Clinical Science, of Lipids, and of Nutrition Research; Currently serve on the Editorial Boards of Annals of Nutrition and Metabolism, Biochimica et Biophysica Acta Molecular & Cell Biology of Lipids, Clinical Nutrition, European Journal of Nutrition, Nutrition, and Prostaglandins Leukotrienes and Essential Fatty Acids; Previously served on the Editorial Boards of Journal of Nutrition, International Journal of Biochemistry and Cell Biology, and Annual Review of Nutrition. Co-Editor of the Lipid Metabolism & Therapy section of Current Opinion of Clinical Nutrition and Metabolic Care. Served on the British Nutrition Foundation's Task Force on “Adverse Reactions to Foods” (reported in 2000) and on the ILSI Europe PASSCLAIM Task Group on “Gut health and immunity” (2001-2003). Chaired the ILSI Europe Workshops on “Nutrition and Immunity in Man” (2004), “Nutrition and Inflammation” (2006) and “Biomarkers of Inflammation” (2012); Chaired the ILSI Europe Expert Groups on “Nutrition and inflammation in metabolic syndrome” and on “Biomarkers of inflammation”. Served on the National Asthma Campaign’s Early Life Task Force. Honours 1987-1991 Oxford Nuffield Medical Fellowship 1995 Sir David Cuthbertson Medal, (UK) Nutrition Society 2000 Outstanding Paper, American Oil Chemists’ Society – Annual Meeting 2002 Senior author on a paper named by The Office of Dietary Supplements, NIH as among the top 25

papers published in 2001 2004 Senior author on a paper named by The Office of Dietary Supplements, NIH as among the top 25

papers published in 2003 2305 Belgian Danone Institute Chair 2005 Co-author on paper named as Best Paper published in Clinical Nutrition in 2004 2007 Nutricia International Award 2007 Nutrition, Diet & Chronic Disease Visiting Lectureship, Michigan State University 2008 Cuthbertson Award & Lecture, European Society for Clinical Nutrition & Metabolism 2008 “Inflammation at the Interfaces” Cluster Lecture, Germany 2009 Muriel Bell Lecture, Nutrition Society of New Zealand 2009 Listed on isiHighlyCited 2010 Appointed Member of the Faculty, European Society for Clinical Nutrition & Metabolism 2011 Elected Fellow of the Society of Biology 2012 Louisiana State University Chancellor’s Award in Neuroscience and Medicine 2012 Elected Fellow of the Association for Nutrition 2012 Normann Medal, German Society for Fat Research C. Selected Peer-reviewed Publications (Selected from 206 peer-reviewed research publications) 1. Grimble, Howell, O'Reilly, Turner, Markovic, Hirrell, East, Calder (2002) The ability of fish oil to

suppress tumor necrosis factor-a production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor a production. Am J Clin Nutr 76, 454-459.

2. Thies, Garry, Yaqoob, Rerkasem, Williams, Shearman, Gallagher, Calder, Grimble (2003) Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 361, 477-485.

3. Kew, Banerjee, Minihane, Finnegan, Williams, Calder (2003) Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25–72 y. Am J Clin Nutr 77, 1278-1286.

4. Kew, Banerjee, Minihane, Finnegan, Muggli, Albers, Williams, Calder (2003) Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. Am J Clin Nutr 77, 1287-1295.

5. Trebble, Wootton, Miles, Mullee, Arden, Ballinger, Stroud, Calder (2003) Prostaglandin E2 production and T-cell function after fish-oil supplementation: response to antioxidant co-supplementation. Am J Clin Nutr 78, 376-382.



6. Trebble, Arden, Wootton, Calder, Mullee, Fine, Stroud (2003) Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn's disease. Am J Clin Nutr 80, 1137-1144.

7. Tricon, Burdge, Kew, Banerjee, Russell, Grimble, Williams, Calder, Yaqoob (2004) Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am J Clin Nutr 80, 1626-1633.

8. Rees, Miles, Banerjee, Wells, Roynette, Wahle, Calder (2006) Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am J Clin Nutr 83, 331-42.

9. Thienprasert, Samuhaseneetoo, Popplestone, West, Miles, Calder (2009) Fish oil n-3 polyunsaturated fatty acids selectively affect plasma cytokines and decrease illness in Thai schoolchildren: a randomized, double-blind, placebo-controlled intervention trial. J Pediatr 154, 391-395.

10. Tull, Yates, Maskrey, O'Donnell, Madden, Grimble, Calder, Nash, Rainger (2009) Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biol 7, e1000177.

11. Barbosa, Miles, Calhau, Lafuente, Calder (2010) Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial. Crit Care, 14, 2010, R5.

12. Cawood, Ding, Napper, Young, Williams, Ward, Gudmundsen, Vige, Payne, Ye, Shearman, Gallagher, Grimble, Calder (2010) Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability. Atherosclerosis 212, 252-259.

13. van den Elsen, Noakes, van der Maarel, Kremmyda, Vlachava, Diaper, Miles, Eussen, Garssen, Willemsen, Wilson, Godfrey, Calder (2011) Salmon consumption by pregnant women reduces ex vivo umbilical cord endothelial cell activation. Am J Clin Nutr 94, 1418-1425.

14. Noakes, Vlachava, Kremmyda, Diaper, Miles, Erlewyn-Lajeunesse, Williams, Godfrey, Calder (2012) Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. Am J Clin Nutr 95, 395-404.

15. Browning, Walker, Mander, West, Madden, Gambell, Young, Wang, Jebb, Calder (2012) Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. Am J Clin Nutr 96, 748-758.

D. Research support

Ongoing Research Support Calder (Co-PI with CD Byrne) 1/1/13-12/31/15 National Institute of Health Research, UK “Synbiotics to treat non-alcoholic fatty liver disease” The goal of this project is to conduct a randomized control trial of a mix of pre and probiotics in patients with non-alcoholic fatty liver disease with the primary outcome being change in liver fat; secondary outcomes related to cardiometabolic risk factors.

Calder (PI) 3/1/10-2/28/15 European Commission, Brussels, Belgium “Omega-3 fatty acids and inflammation in normal weight and obese subjects” The goal of this project is to identify the acute and chronic effects of marine omega-3 fatty acids on biomarkers of inflammation in normal weight and obese persons. Calder (PI) 4/1/09-3/31/14 Vifor Pharma, Switzerland “Bioavailability of omega-3 fatty acids in humans”

http://www.ncbi.nlm.nih.gov/pubmed/19707265?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/19707265?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/20085628?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2http://www.ncbi.nlm.nih.gov/pubmed/20085628?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2http://www.ncbi.nlm.nih.gov/pubmed/20085628?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2http://www.ncbi.nlm.nih.gov/pubmed/20542512http://www.ncbi.nlm.nih.gov/pubmed/20542512http://www.ncbi.nlm.nih.gov/pubmed/20542512http://www.ncbi.nlm.nih.gov/pubmed?term=%22van%20den%20Elsen%20LW%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22van%20den%20Elsen%20LW%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22van%20der%20Maarel%20MA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22van%20der%20Maarel%20MA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Vlachava%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Vlachava%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Miles%20EA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Miles%20EA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Garssen%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Willemsen%20LE%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Willemsen%20LE%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Godfrey%20KM%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Godfrey%20KM%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/21849598##http://www.ncbi.nlm.nih.gov/pubmed/22218160http://www.ncbi.nlm.nih.gov/pubmed/22218160http://www.ncbi.nlm.nih.gov/pubmed/22932281http://www.ncbi.nlm.nih.gov/pubmed/22932281



The goal of this project is to identify whether different chemical formulations of marine omega-3 fatty acids are equally bioavailable in humans.

Calder (PI) 9/1/09-8/31/13 Beghin-Meiji, France “Prebiotics and immune function in elderly humans” The goal of this project is to identify the immunologic impact of a prebiotic (short chain fructooligosaccharides) on immune outcomes, including response to seasonal influenza vaccination, in elderly persons. Completed Research support 2010 to 2012

Calder (PI) 3/1/06-2/28/10 European Commission, Brussels, Belgium “Salmon in Pregnancy Study” The goal of this project was to identify whether increased consumption of salmon during pregnancy by women whose baby is at risk of allergic disease modifies immune outcomes in cord and infant blood and clinical outcomes at age 6 months

Calder (Co-PI with H. Inskip (PI) and six others) 2007-2010 Food Standards Agency, London, UK “Maternal, infant and childhood diet: influence on respiratory health and asthma in childhood” The goal of this project was to identify associations between intake and status of antioxidant nutrients and fatty acids in pregnant women and respiratory health and disease outcomes in their offspring aged 3 to 9 years.

Calder (Co-PI with A.M. Minihane (PI) and three others) 9/1/09-2/28/11 Food Standards Agency, London, UK “Response of cardiovascular risk factors to fish oil fatty acids” The goal of this project was to further explore samples and data from an earlier project that set out to identify genotype-omega-3 fatty acid interactions in the context of modified cardiovascular risk profiles

Calder (PI) 6/1/09-7/31/11 Abbott Nutrition, Spain “Nutrition and early life origins of bone and immune health” The goal of this project was to establish an animal model of stress during pregnancy leading to altered bone structure and immune function in the young offspring and then to examine the impact of nutritional strategies to reduce the long term impact of the maternal stress.

Calder (Co-PI with L. Michaelis (PI) and others) 1/1/10-12/31/12 BUPA, UK “Vitamin D and immune outcomes in cord blood” The goal of this was project was to measure immune markers in umbilical cord blood collected as part of a large RCT of vitamin D during pregnancy which is focusing on offspring bone health. Calder (Co-PI with CD Byrne) 1/1/09-12/31/12 National Institute of Health Research, UK “Prescription omega-3 fatty acids to treat non-alcoholic fatty liver disease” The goal of this project was to conduct a randomized control trial of a prescription omega-3 fatty acids in patients with non-alcoholic fatty liver disease with the primary outcome being change in liver fat; secondary outcomes related to cardiometabolic risk factors.

Course Evaluation 2011 Summer Research Conferences

Nutritional Immunology: Role in Health & Diseasepresented 07/10/2011

44 forms submitted

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Forms

Section 1 - Scientific Content

General Sessions

The most important areas of current active research were adequately discussed. 0.0

There was a sufficient amount of unpublished research presented. 0.0

The conference helped you generate new ideas for research. 4.2

There was adequate time provided for invited presentations and short talks selected from submitted abstracts. 4.5

The discussion periods were utilized effectively. 4.1

Poster Sessions

The time allocated for poster sessions was effective. 4.2

I am satisfied with the contribution of the poster sessions to the conference. 4.2

Scientific Content - Overall

Overall, I am satisfied with the scientific content. 4.3

What kinds of sessions would you like to see included at future conferences?

Dietary molecules and their influence on biochemical mechanism of T cell activation.

Translational research - more clinical studies.

Metabolic and Immune Interactions. Not just diet.

Shorter invited presentations, e.g. 25 minutes instead of 35

1) Perinatal nutrition and immune system development. 2) Pulmonary immunology

I am interested in development and would like more on the neonatal immune system.

More diversity of speakers, including international and rising stars (too many UNC and Tufts speakers . . . )

Global health session. Maternal health and fetal programming/epigenetics.

Nutrition, Immunology and Metabolism/Metabolic Disease

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This is an area that would benefit from infusion of scientists from other disciplines.

Broaden the scope of the topics and so embrace those dealing with the effects of bio-active food components on not only T cells but also special subsets of T cells such as Treg, other adaptive immune cells such as B cells, and innate immune cells such as natural killer cells.

Afferent neuron signaling, nutrition and inflammation

emphasis on malnutrition on immune function and susceptibility to infection

Helminth based teatment of immune pathology in animal and human studies.

Diet, malnutrition and immune responses, commercial development of nutritional immunology products

arthritis

Section 2 - Management

Program Management & Organization

How satisfied were you with the coordination and organization of the scientific program? 4.6

How satisfied were you the representation of international scientists in this field participating? 4.2

How satisfied were you with the conference materials provided? 4.5

Did you feel the length of conference sessions were too long, just about right, or too short? 2.2

Logistics Management & Organization

How satisfied were you with the registration and abstract submission process? 4.5

How satisfied were you with the information found on the FASEB SRC website and from emails sent by the FASEB SRC Office? 4.5

Overall Management & Organization

The conference was well organized. 4.7

Conference onsite staff member was helpful and courteous. 4.6

Overall, I was satisfied with the conference facilities. 4.5

Where would you like to see future SRCs take place?

Tuscany, Italy.

Tuscany, UK, Caribbean

Same place

Western Mass, other facilities in Vermont or New Hampshire, Woods Hole, MA

central united states, so easy for everyone to get there.



There are some very nice venues in Michigan, particularly northern Michigan. Or anywhere in the Midwestern USA.

The Carefree site worked very well. Although there were renovations going on they didn't affect the conference much. The food, proximity to major airport and AV assistance were positive factors.

Carefree Resort is showing its age. A more modern venue would be better, keeping in mind costs so that trainees and young faculty are able to afford to come.

Phoenix was too hot for a summer conference.

Italy

Tuscany, Italy. Colorado. Somewhere in the East Coast.

Some place cooler, but not in a dormatory.

Colorado, Montana

This was discussed during the conference. I think many wanted to have it in Italy.

Carefree in summer was not ideal - renovations in progress and too hot even in the morning.

in a cooler location with adequate number of centrally placed room. I was in aremote room which made travel to and from difficult!!!!!!!!!!!!!!!!!

Southern US

Overall, how would you rate the FASEB SRC Staffs' professionalism and responsiveness to your questions and concerns? 4.6

Comments:

Very helpful when I needed an extension to submit my payment.

FASEB staff were great. The AV staff was great! Some of the hotel staff were not nice or helpful.

Liked having the mornings free

People that arrived late to the conference lost their rooms and it was very difficult to solve the problem. I also heard that the hotel staff was not very helpful about this. It would have been helpful for FASEB to alert the hotel of late arrivals in advance.

wonderful responsive staff

Section 3 - General Information

Approximately how many conferences of this type do you attend annually?

1-2 per year: 30 (75%)

3-4 per year: 6 (15%)

More than 6 per year: 3 (7.5%)

Don't usually attend conferences: 1 (2.5%)

5-6 per year: 0 (0%)

Do you plan to attend this conference again in 2 or 3 years?



Yes: 37 (88.1%)

No: 5 (11.9%)

Would you recommend this conference to others?

Yes: 41 (93.2%)

No: 1 (2.3%)

Not Sure: 2 (4.5%)

How would you rate this conference compared to other conferences of this type that you have attended? 4.1

How did you learn of this conference?

By Invitation: 18 (41.9%)

Co-Worker: 12 (27.9%)

Internet: 4 (9.3%)

FASEB Emails: 4 (9.3%)

Other (please specify): 3 (7%)

Experimental Biology/Neuroscience/Cell Biology: 2 (4.7%)

FASEB Journal: 0 (0%)

FASEB Mailings: 0 (0%)

Please indicate your age group:

50's: 12 (27.3%)

40's: 11 (25%)

20's: 9 (20.5%)

60's: 6 (13.6%)

30's: 6 (13.6%)

70's: 0 (0%)

In what ways could this conference be improved?

I thought that the conference was too long. There were not many activities to participate in during the mornings. Could have been shortened by cutting some morning free time. Overall though, very satisfied with the conference and the scientific knowledge I gained from attending the meeting.

The poster presentation times could have been staggered so that the poster presenters had an opportunity to hear the other poster presentations.

Shorter invited presentations + more selected short talks

Being held in another location

It is just a tad bit long overall, by Wednesday evening, we're all a little burnt out. Then it continues until Friday morning.

I think it will have increasing registration due to word of mouth that this was a good meeting, and increasing interest in nutritional immunology in general.

More diversity of speakers and poster presenters.

I would have preferred morning sessions, instead of afternoon sessions. The 4-6 pm poster viewing sessions on Wednesday and Thursday could have been used for oral presentations, so



that night sessions could end earlier. For this conference and the number of posters, two days were adequate for poster sessions. Leaving the posters up all week is still a good idea.

have the sessions in the morning and evenings open

Maybe a little bit more variety on how materials were presented...instead of making it all PowerPoint presentations, there could be organized group discussions or other kind of activity to communicate our work.

First, I think it would be great to add a picture next to each person's contact information, and maybe a three sentence blurb. Also, ss someone who is lactose intolerant, the food choices were very limited.

make it shorter and invite more prominent speakers

Have the travel awards given out before the conference to postdocs, grad students, junior faculty because the travel award may make the difference as to whether the individual or other individuals in the lab could attend.

Location was difficult to reach - arizona in the middle of july is not hospitable.

Very good overall. Some late night sessions could have been brought forward by e.g. shortening poster session time by 30 min each day.

The topics were well selected. Nevertheless, if the organizers consider the balance between pre-clinical and clinical and thus plan the agenda accordingly, the information provided would be much more useful.

The total length of the conference made it difficult for all participants to stay the whole time (5.5 days). If possible, shortening the period to 4 days with more talks per day might facilitate keeping all participants there the entire time.

Different location. Less on T cells

shorter time, cooler location



FINAL REPORT FASEB Summer Research Conference, Carefree, Arizona

Nutritional Immunology: Role in Health and Disease July 10-15, 2011

Organizers: Melinda A. Beck Simin N. Meydani The 2011 meeting “Nutritional Immunology: Role in Health and Disease” was held at Carefree, Arizona, from July 10-15, 2011. The primary focus of this meeting was to explore the relationship of nutritional status and its impact on immune function. Research indicates thus far that obesity, diabetes, gastrointestinal disorders, cardiovascular and autoimmune diseases can all be influenced by the host’s nutritional status, human and animal. Further, these metabolic-nutritional disorders can also influence the immune response. This conference was unique in that it in addition to bringing in experts in the field of nutritional immunology, we also brought in experts from other fields in which to stimulate discussion on how these new areas could be used to move forward the field of nutritional immunology. For example, we had discussions on systems biology, metabolomics, next-generation massively parallel sequencing and evidence based practices applied to immunology. In addition, we also brought in cutting-edge experts in immunology who did not have nutritional research experience, both to stimulate new ideas for nutritional immunologists as well as to cross-fertilize by exposing immunologists to nutritional concepts for their studies. For instance, we had experts in the area of T cell memory, autophagy, and lipodomics, all of whom provided excellent talks on their area of expertise, which sparked interest in the audience as to how these areas/ideas could be brought to bear on the nutritional immunology field. An international group of researchers from North America and abroad chaired the sessions and spoke at the conference, which was attended by scientists, junior scientists, postdoctoral fellows and graduate students. A total of 31 speakers (including the organizers Drs. Beck and Meydani and the Keynote Speaker Dr. Ana Maria Cuervo) and 33 attendees participated in this conference. A program book delineating the conference program, the speaker abstracts in order of presentation, a listing of displayed posters and the respective poster abstracts was provided to all participants. Our meeting began on Sunday evening, July 10th with a Keynote presentation entitled ”Autophagy” by Ana Maria Cuervo from Albert Einstein College of Medicine, Bronx, NY, who addressed the participants for one hour followed by 15 minutes of questions. Over the next 4 days, the invited speakers presented full-length, 25 minute talks followed by questions and answers for an additional 5-10 minutes. The conference sessions were held in the afternoon and evening; except for the final day, July 15th, the mornings were free. The conference was organized into 9 formal sessions as follows: 1) Cutting Edge: What’s new and exciting?, Chair: Stephen Bunnell, Tufts University School of Medicine, Boston MA, 2) Obesity Induced Immune Dysfunction, Chair: Vishwa DIxit, Pennington Biomedical Center, Baton Rouge, LA, 3) Neuroinflammation: Role of Nutrition, Chair: Rodney Johnson, University of Illinois at Urbana-Champaign, Champaign, IL, 4) PUFA, Lipid Rafts and Immune Function, Chair: Robert Chapkin, Texas A&M University, College Station, TX, 5) Nutrient-Gene Interactions, Chair: Pam Fraker, Michigan State University, East Lansing, MI, 6) Specialized T cells, Inflammation and Nutrition, Chair: Joel Linden, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 7) Gut Immunology: Role of Bacteria and Nutrition, Chair: Kay Lund,

University of North Carolina, Chapel Hill, NC, 8) Host Nutritional Status and Immune Related Disease, Chair: Melinda Beck, University of North Carolina, Chapel Hill, NC, and 9) Nutritional Immunology: Where is the field headed?, chair: Simin Meydani, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. The nine sessions and keynote address covered a wide range of research areas within nutritional immunology, focusing on current findings in this continually growing field. Of note, 14 of the invited speakers including the Keynote speaker and 4 of the nine session chairs were women.

On Tuesday afternoon, July 12th, we held a “Meet the Expert” session in which all participants had the opportunity to speak to a designated group of invited speakers, who represented the areas within the larger field of nutritional immunology. The assigned Meet the Expert speakers included Melinda Beck, Simin Meydani, Robb Chapkin, Catherine Ross, and Ana Maria Cuervo. All speakers and participants were encouraged to attend and interact. For this meeting, we felt the Meet the Expert session was not needed, although the speakers made themselves available at the appointed time. Given that our meeting was less than 100 participants, interactions between speakers and participants were taking place throughout the meeting, both during breaks between sessions, at meals, and after the final session, many informal discussions took place at the hotel bar and outdoor seating areas. In order to showcase the work of attendees, we had 6 attendees present their work from submitted abstracts. These speakers were allowed 8 minutes to speak with 2 minutes of questions. This format worked very well and generated a lot of discussion from the attendees. These speakers included students, postdocs, and established investigators. The topics ranged from obesity effects on immunity to vitamin D levels and infection. In all, 22 Posters were submitted by participants. Given the number, we able to display all posters for the entire length of the conference, which allowed for optimal exposure. Four sessions for poster viewing were scheduled on four consecutive days, July 11-14th. On Tuesday, July 12th, the poster session was a formal gathering in which all first authors were required to be present at their posters to discuss their research with attendees. Refreshments were available at this formal session, giving the conference an intimate, relaxed and even festive atmosphere for the exchange of information. In order to provide travel awards to graduate students and postdocs, we selected 3 senior investigators from our speakers, who did not have students/postdocs presenting posters, judge each poster presentation from attendees who requested a travel award. From a group of 2 postdocs and 8 graduate students, the judges ranked the poster presentations from 1 (best) to 10. The top 4 poster presentations were then selected for a travel award of $570. Three graduate students and one postdoc received a travel award. On Thursday morning, July 14th, 3 FASEB-sponsored group activities were available as optional excursions for participants who wanted the chance to explore the area outside of the Carefree Resort, most specifically the spectacular Sonora Desert. Despite extreme temperatures above 100 degrees Fahrenheit this week, 5 attendees enjoyed the Southwest Jeep Tour, a land-based tour of the Sonora Desert in an open-air jeep driven by knowledgeable local guides and several participants visited Taliesin West, the famed personal winter home of architect Frank Lloyd Wright in Scottsdale, Arizona. We successfully obtained funds to support this conference from FASEB Summer Research Conferences, DSM Nutritional, Abbott Nutrition, Ocean Spray, Wakunaga of America, Nestlé S.A., General Mills, The Dannon Company, and grants from National Institutes of Health,

National Institute on Aging, and National Institute of Diabetes and Digestive and Kidney Diseases. The funds raised completely covered the registration fees and all travel expenses for the invited speakers. At the business meeting held during lunch on Wednesday, July 13th, which most participants attended, we discussed when and where the next meeting would be held. It was unanimous that the next meeting should be held at least 3 years, if not 4 years, from the current meeting (2014 or 2015). Italy was the most popular destination site, followed closely by the Bahamas. The Chairpersons elected for the next meeting were Melinda Beck, University of North Carolina, Chapel Hill, NC and Robert Chapkin, Texas A&M University, College Station, TX. The participants agreed that while the current meeting had covered many of the areas of importance in nutritional immunology, additional suggestions were made to include more sessions on functional foods for the next program. All participants were encouraged to suggest potential topics and speakers to elected Chairpersons. In addition, we also discussed fund raising for the future meeting and encouraged all participants to play a role in obtaining funds for the next meeting. In conclusion, the co-organizers felt that the 2011 conference was a great success and that the smaller number of attendees compared to the 2007 meeting in Tucson, Arizona was a barometer for the current economy and not a lack of interest in the field. Many attendees stated that they did not have the funds to bring their students/postdocs to the meeting, as they had for previous meetings. On a positive note, the smaller numbers of the 2011 meeting provided an intimate atmosphere for all to enjoy an exchange of information, both formal and informal.

Year# of

Applicants# of

Participants Private Government Total Raised2003 87 83 32,500.00$ 28,010.00$ 60,510.00$ 2007 88 82 25,000.00$ 34,000.00$ 59,000.00$ 2011 65 65 37,485.00$ 23,500.00$ 60,985.00$

ATTENDANCE FUNDING

NUTRITION & IMMUNE RESPONSE: MECHANISMS OF IMPACT ON HEALTH & DISEASEComparison of Previous Conferences

Year Name Affiliation

2003 Simin Nikbin MeydaniJM USDA Human Nutrition Research Center at Tufts Univ.

Pam Fraker Michigan State Univ.

2007 Pamela Fraker Michigan State Univ.

Simin Nikbin MeydaniJM USDA Human Nutrition Research Center at Tufts Univ.

2011 Simin Nikbin MeydaniJM USDA Human Nutrition Research Center at Tufts Univ.

Melinda BeckUniversity of North Carolina at Chapel Hill

2015 Melinda BeckUniversity of North Carolina at Chapel Hill

Philip C. CalderUniversity of Southampton, United Kingdom

NUTRITION & IMMUNE RESPONSE: MECHANISMS OF IMPACT ON HEALTH & DISEASE

Past Conference Organizers

Member Societies The American Physiological Society

American Society for Biochemistry and Molecular Biology

American Society for Pharmacology and Experimental Therapeutics

American Society for Investigative Pathology

American Society for Nutrition

The American Association of Immunologists

American Association of Anatomists

The Protein Society

Society for Developmental Biology

American Peptide Society

Association of Biomolecular Resource Facilities

The American Society for Bone and Mineral Research

American Society for Clinical Investigation

Society for the Study of Reproduction

Teratology Society

The Endocrine Society

The American Society of Human Genetics

Society for Gynecologic Investigation

Environmental Mutagen Society

International Society for Computational Biology

American College of Sports Medicine

Biomedical Engineering Society

_________________________

Guy Fogleman, Ph.D. Executive Director

Office of Scientific Meetings and Conferences Marcella Jackson, CMP Director

9650 Rockville Pike Bethesda, Maryland 20814-3998 Telephone 301-634-7010 FAX 301-634-7014 Email: [email protected] http://www.faseb.org/meetings/

Federation of American Societies for Experimental Biology — Quality Life Through Research —

November 30, 2009 Dr. Melinda Beck Univ. of North Carolina at Chapel Hill Dept. of Nutrition 2303 MHRB, CB #7461 Chapel Hill, NC, 27599-7461 Re Proposal #: 11-05 Dear Dr. Beck: We would like to thank you for submitting a proposal for the 2011 FASEB Summer Research Conference series. After careful consideration by the Advisory Committee, the proposal entitled, "Nutritional Immunology: Role in Health & Disease" has been approved. However the committee had the following suggestions:

• There are a relatively low number of slots available for students and post-docs to present their research. The committee would you like you to include more short talks for the students and post-docs.

• The committee suggests putting more effort into promotion and marketing

of the conference to substantially increase attendance. Attendance at both past conferences (2003-83, 2007-82) has not reached the required 100 participants FASEB considers to be acceptable.

The committee also requests that you make every effort to include young investigators (poster presentation or a short talk) as early as possible within the conference agenda. This will have an enormous impact on one’s experience at the conference. This will also allow other participants to learn early on about their work and will then greatly increase interaction. During the recent review of the submitted proposals, the members of the Summer Research Conferences Advisory Committee decided that beginning in 2011, all conferences are to incorporate a “Meet the Experts” session into the program. This will allow the young investigators the opportunity to interact and network with the experts they admire. Planning details will be shared with you as we get further into the organizing of your conference We will soon begin the process of developing the conference schedule and will let you know the location and date of your conference as soon as this has been decided. Please keep in mind, location and date preferences are not guaranteed however we do our best to give you your first choice. In February, an Organizer Manual will be posted at our website (http://src.faseb.org) to assist you in your conference planning efforts.

Dr. Beck Page 2 Please be aware that by agreeing to be an Organizer/Co-organizer of a FASEB Summer Research Conference, that should you decided to cancel the conference for any reason, you will be held responsible for any fees related to the cancellation (i.e., fees charged by the host location). The Summer Research Conferences have been very successful over the years due to the commitment and dedication of the Organizers. On behalf of the Federation and the Summer Research Conferences Advisory Committee, your efforts in contributing to the success of the program are sincerely appreciated. A copy of this letter has also been sent to your co-organizer(s). Please do not hesitate to contact me by telephone at (301) 634-7093 or via email [email protected] should you have any questions. We look forward to working with you on this project over the next few years. Sincerely, Julie Levin Conference Manager FASEB Summer Research Conferences

Member Societies The American Physiological Society

American Society for Biochemistry and Molecular Biology

American Society for Pharmacology and Experimental Therapeutics

American Society for Investigative Pathology

American Society for Nutrition

The American Association of Immunologists

American Association of Anatomists

The Protein Society

Society for Developmental Biology

American Peptide Society

Association of Biomolecular Resource Facilities

The American Society for Bone and Mineral Research

American Society for Clinical Investigation

Society for the Study of Reproduction

Teratology Society

The Endocrine Society

The American Society of Human Genetics

Society for Gynecologic Investigation

Environmental Mutagen Society

International Society for Computational Biology

American College of Sports Medicine

Biomedical Engineering Society

_________________________

Guy Fogleman, Ph.D. Executive Director

Office of Scientific Meetings and Conferences Marcella Jackson, CMP Director

9650 Rockville Pike Bethesda, Maryland 20814-3998 Telephone 301-634-7010 FAX 301-634-7014 Email: [email protected] http://www.faseb.org/meetings/

Federation of American Societies for Experimental Biology — Quality Life Through Research —

November 30, 2009 Dr. Simin Nikbin Meydani Tufts Univ. Jean Mayer USDA Human Nutrition Research Center on Aging Friedman School of Nutrition Science & Policy 711 Washington St. Boston, MA 02111 Re Proposal #: 11-05 Dear Dr. Nikbin Meydani: We would like to thank you for submitting a proposal for the 2011 FASEB Summer Research Conference series. After careful consideration by the Advisory Committee, the proposal entitled, "Nutritional Immunology: Role in Health & Disease" has been approved.

• There are a relatively low number of slots available for students and post-docs to present their research. The committee would you like you to include more short talks for the students and post-docs.

• The committee suggests putting more effort into promotion and marketing

of the conference to substantially increase attendance. Attendance at both past conferences (2003-83, 2007-82) has not reached the required 100 participants FASEB considers to be acceptable.

The committee also requests that you make every effort to include young investigators (poster presentation or a short talk) as early as possible within the conference agenda. This will have an enormous impact on one’s experience at the conference. This will also allow other participants to learn early on about their work and will then greatly increase interaction. During the recent review of the submitted proposals, the members of the Summer Research Conferences Advisory Committee decided that beginning in 2011, all conferences are to incorporate a “Meet the Experts” session into the program. This will allow the young investigators the opportunity to interact and network with the experts they admire. Planning details will be shared with you as we get further into the organizing of your conference We will soon begin the process of developing the conference schedule and will let you know the location and date of your conference as soon as this has been decided. Please keep in mind, location and date preferences are not guaranteed however we do our best to give you your first choice. In February, an Organizer Manual will be posted at our website (http://src.faseb.org) to assist you in your conference planning efforts.

Dr. Nikbin Meydani Page 2 Please be aware that by agreeing to be an Organizer/Co-organizer of a FASEB Summer Research Conference, that should you decided to cancel the conference for any reason, you will be held responsible for any fees related to the cancellation (i.e., fees charged by the host location). The Summer Research Conferences have been very successful over the years due to the commitment and dedication of the Organizers. On behalf of the Federation and the Summer Research Conferences Advisory Committee, your efforts in contributing to the success of the program are sincerely appreciated. A copy of this letter has also been sent to your co-organizer(s). Please do not hesitate to contact me by telephone at (301) 634-7093 or via email [email protected] should you have any questions. We look forward to working with you on this project over the next few years. Sincerely, Julie Levin Conference Manager FASEB Summer Research Conferences

Nutritional Immunology - COVERPAGE2013 FASEB Science Research ConferencesAdvisory Committee MeetingTopic for Consideration

FASEB 2015 SRC Proposal Beck and Calder revisedOverview of Program FlowDay One (1)Day TwoSpeaker 1: Melinda A. Beck, University of North Carolina at Chapel Hill, USA CS, WObesity impairs the immune response to infectious disease

Day ThreeDay FourSpeaker 2: Susan Prescott, University of Western Australia, Perth, Australia W, NEWEarly life programming of immune function alters later risk of non-communicable diseasesSpeaker 3: Thom McDade, Northwestern University, Evanston, USA CS, NEWImpact of early environment on later immune and inflammatory responsesDay Five

Speaker 2: Margherita Cantorna, Penn State University, University Park, USA CS, WVitamin D and immune mediated diseasesDay Six

beck NIH CVBIOGRAPHICAL SKETCHPersonal Statement: I am a Full Professor in the Department of Nutrition. I was the Co-Organizer for the previous SRC and successfully raised funds to support all of our speakers and to provide travel grants for students and post-docs. We have identi...Positions and HonorsAssociate Editor, Experimental Biology and Medicine15 Selected Peer-Reviewed PublicationsCompleted

biosketch_PCBIOGRAPHICAL SKETCHA. Personal StatementB. Positions and HonorsUPositions and Employment

2011 eval2011 reportNutritional Immunology - STATSSheet1

Nutritional Immunology - PAST ORGANIZERSheet1

11-05 Proposal decision letter

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