2014 Partnership Hub Report
Catalyzing Partnershipsfor Global Health
WIPO Re:Search Database Contribution - Sano�: Pentamidine samples for R&D (ID: 1341)
Annual ReportOpening Letter
Jennifer DentPresident, BVGH
1
Dear WIPO Re:Search Members and Friends,
I am proud of what has been accomplished in WIPO Re:Search over the past year and since its launch in October 2011. The Consortium was established to accelerate the development of drugs, vaccines, and diagnostics for malaria, tuberculosis, and neglected tropical diseases (NTDs) through collaborative research endeavors. At the close of 2014, 82 collaborations were in place between Members, including 38 established in 2014. A number of these collaborations have already obtained promising results, thus demonstrating the successful platform and potential impact of WIPO Re:Search.
As we embark on the fourth year of WIPO Re:Search, WIPO and
Members during and around the Annual Meeting. Our aim is to continue to provide a platform and partnering approach that meets the needs of Members while advancing the development of much needed products for neglected infectious diseases.
Throughout 2014, Members remained committed to the Consortium’s mission, eagerly sharing their assets, expertise, and ideas with one another. BVGH and WIPO were pleased to welcome Merck KGaA to WIPO Re:Search in 2014. We are excited by what Merck KGaA and our founding company Members, Alnylam, Eisai,
to research partnerships in 2015 and beyond. Examples of the founding company Members’ contributions to the WIPO Re:Search Database are highlighted throughout this report.
BVGH will continue to proactively engage Members and suggest unique partnerships in 2015. Now that several WIPO Re:Search
on identifying new partners who can contribute needed assets and expertise to ensure that these projects continue to move forward.
We are encouraged by the achievements WIPO Re:Search and its Members have had to date and we look forward to what will be accomplished in 2015. From all of us at BVGH, we are proud to be your partner in the joint mission to erase the burden that malaria, tuberculosis, and NTDs have on individuals across the globe.
The following report summarizes and describes BVGH’s key deliverables and accomplishments from 2014.
2014Partnering Objectives
and Achievements
*Diarrheal diseases not included in the list of qualifying WIPO Re:Search diseases; **Fungal disease, polio, RSV, multiple diseases
2
More and more, the global health community is embracing cross-sector collaborations as a critical element to ensure the expedient
development of products for neglected diseases. Now in its fourth year, WIPO Re:Search continues to establish meaningful cross-sector collaborations focused on developing products for these devastating diseases. In 2014, BVGH established 38 agreements between Members, bringing the total number of WIPO Re:Search agreements to 82. These 38 agreements spanned 13 diseases and involved 38 Members from 11 countries.
Malaria and tuberculosis continue to have the most agreements, with 44% of the partnerships established in 2014 and to date involving these two diseases. Other collaborations cover an additional 12 neglected diseases, including one new disease (neurocysticercosis) added in 2014. Drug discovery continued to be the primary focus of agreements established in 2014, and similar to past years, these agreements primarily involved sharing compounds to be screened.
BVGH continued to seek out new collaboration opportunities. By the end of 2014, 27 projects were in early-stage discussions between Members and 14 projects were in advanced negotiations.
BVGH’s objective was to establish 15 new agreements in 2014, which it far surpassed with 38 established over the year.
Partnering acrossthe globe
WIPO Re:Search Database Contribution - Alnylam: Intellectual property and know-how supporting Alnylam’s RNA interference (RNAi) platform technology (ID: 1362)
Drug (54)Diagnostic (14)Basic research (11)Vaccine/Adjuvant (3)
Human African trypanosomiasis (5)
Buruli ulcer (2)Chagas disease (6)
Diarrheal diseases (6)*Dengue (8)
Filarial diseases (5)Soil-transmitted helminthiases (7)
Malaria (22)Leishmaniasis (6)
Other (5)**
Tuberculosis (14)Schistosomiasis (9)
Neurocysticercosis (1)
*Diarrheal diseases not included in the list of qualifying WIPO Re:Search diseases; **Fungal disease, polio, RSV, multiple diseases
3
2014Partnering Objectives
and Achievements
4
While several Members have substan-tially leveraged WIPO Re:Search to advance their research goals, BVGH strives to encourage all Members to
explore and participate in collaborations.
Fifteen of the 38 Members participating in an agreement established in 2014 had not participated in a WIPO Re:Search collaboration before. A total of 49 Members have participated in a WIPO Re:Search partnership to date. Every single one of our 76 User and/or Provider Members has assets or research programs that could potentially be translated or incorporated into a product for a neglected disease. Thus it is BVGH’s continuing mission to ensure that
opportunities to participate and contribute to WIPO Re:Search.
The WIPO Re:Search consortium was established
access to industry assets. During 2012-2013 the majority of collaborations indeed involved
founding company Member. However, in 2014 this paradigm shifted. Sixty-six percent of new
neewteb stnemeerga devlovni spihsrentrap
Researchagreements
0 5 10 15 20 25
Malaria
Tuberculosis
Schistosomiasis
Dengue
Soil-transmitted helminthiases
Other
Diarrheal disease
Chagas disease
Leishmaniasis
Human African trypanosomiasis
Onchocerciasis
Buruli ulcer
Neurocysticercosis
Lymphatic �lariasis
2012
2014
2013
WIPO Re:Search Agreements by Disease
0 5 10 15 20 25 30 35 40 45 50 55
Drug
DiagnosticBasic research
Adjuvant/Vaccine
WIPO Re:Search Agreements by Product
Academic + Industry Industry + IndustryAcademic + Academic
2012 2013 2014
WIPO Re:Search Agreements by Partner
2012
2014
2013
WIPO Re:Search Database Contribution - Novartis: Novartis-GNF Malaria Box Dataset - hits from Plasmodium falciparum whole-cell screens (ID: 1861)
5
2014Recruitment Objectives
and Achievements
6
The output and impact of WIPO Re:Search correlates with the number of active User and/or Provider Members. Each Member brings a diverse set of skills,
expertise, interests, and assets that are integral to the success of the Consortium. To ensure a
BVGH continued to recruit new User Members in 2014. Fourteen new User Members joined WIPO Re:Search in 2014, including six developing world institutions. BVGH thus achieved its 2014 objective to recruit at least ten new User Members.
Financial stability and growth is critical to ensure that BVGH has the resources to engage Members, establish new partnerships, and support advancing collaborative research projects. In 2014 two new Funding Members joined WIPO Re:Search. In addition, BVGH
company Members of their continued commitment to WIPO Re:Search in 2015. BVGH met its 2014 objective of recruiting two new Funding Members.
Sixteen new Members joined WIPO Re:Search in 2014, bringing the total number of Members to 94 organizations from 26 countries. BVGH continues to focus on recruiting institutions located in the developing world. By the end of 2014, WIPO Re:Search included 28 developing world Members from15 countries.
NewMembers
Biomedical Research Institute
Central University of Ecuador*
Centre Pasteur du Cameroun*
Kineta, Inc
Merck KGaA
National Institute of Parasitic Diseases, Chinese CDC*
National University of Singapore
Noguchi Memorial Institute for Medical Research*
Salvensis
University of California, San Diego
University of Edinburgh
University of Ghana*
University of New South Wales
University of Yaoundé I*
Walter and Eliza Hall Institute of Medical Research
Washington University in St. Louis
* Developing world institution
Provider User
WIPO Re:Search Database Contribution - GlaxoSmithKline: Preparation of triazole derivatives as reversible inhibitors of bacterial methionine aminopeptidases (ID: 2063)
7
WIPO Re:Search Database Contribution - Eisai: Squalene synthase inhibitor (ID: 427)
Clinical
Pre-clinical
Optimization
Dose Response
Hits ID
Screening
Target Validation
Target ID
Discovery
Basic Research
Partnered project initiatedPartnered project terminated
Partnered project cancelled
AZ -
LSTM
Lym
phat
ic �
laria
sis
Schi
stos
omia
sis
Alny
lam
- Ab
erys
twyt
hAZ
- UCS
F
Eski
tis In
stitu
te -
Swiss
TPH
GSK -
UCSF
GSK -
UCSF
MSD
- UCS
F
Alny
lam
- Ab
erys
twyt
h
NIPD -
U of I
bada
n
MSD
- UCS
F
Human
Afri
can
try
pano
som
iasis
GSK -
Seat
tle B
ioM
ed
AZ -
NEUAZ
- UCS
F
AZ -
U of D
unde
eEi
sai -
NEU
Leish
man
iasis
UCSF
- Sta
nfor
d
AZ -
Stan
ford
AZ -
UCSF
AZ -
UCSF
AZ -
U of D
unde
e
AZ -
NEU
UCSF
- NIH
Diarr
heal
dise
ase
P�ze
r - PA
TH &
UVM
AZ -
Anac
orP�
zer -
CW
HMP�
zer -
PATH
Sano
� - C
WHM
McG
ill -
UBCAZ
- M
cGill
& D
NDiAZ
- M
cGill
AZ -
UCSF
McM
aste
r - U
SF
Soil-
tran
smitt
ed
hel
min
thia
ses
Eski
tis In
stitu
te -
Swiss
TPH
KCCR
- St
anfo
rdLS
TM -
UCSF
Chag
as d
iseas
e
UBC -
McG
ill
AZ -
UCSF
AZ -
UCSF
AZ -
U of D
unde
eUBC
- M
cGill
AZ -
NEU
Dengu
e St
anfo
rd -
Calte
ch
NIH -
Emor
y
Novar
tis -
McM
aste
rP�
zer -
60P
P�ze
r - 6
0P
KU -
Kine
ta
CPC
- Sta
nfor
dEm
ory -
WRA
IR
Onc
hoce
rcia
sis
AZ -
LSTM
PATH
- KC
CR
Aber
ystw
yth
- U o
f Bue
aUBC
- U o
f Bue
a
Buru
li ul
cer
AZ -
Swiss
TPH
UBC -
Swiss
TPH
AZ -
Anac
or
Eski
tis In
stitu
te -
AZAZ
- iT
hem
baGSK
- CW
HMGSK
- NII
IDRI
- M
RC S
outh
Afri
caM
SD -
Emor
yNIH
- ID
RI
GSK -
IDRI
U of M
aurit
ius -
Em
ory &
NEU
Tube
rcul
osis
PATH
- Ca
ltech
UBC -
U of I
bada
n
Alny
lam
- Tu
lane
NEU -
CWHM
AZ -
LSTM
AZ -
LSTM
Eisa
i - U
of D
unde
e
Eisa
i - U
of D
unde
e
P�ze
r - M
cGill
U of L
agos
- NIP
D
Mal
aria
AZ -
UCSF
GSK -
NIIGSK
- UW
GSK -
UW
GSK -
NII
PATH
- U o
f Cal
gary
NEU -
NII
Eisa
i - L
STM
U of L
agos
- St
anfo
rd
GSK -
MIT
U of L
agos
- St
anfo
rd
U of L
agos
- Nov
artis
AZ -
NEU
UBC -
U of I
bada
n
NEU -
McG
ill
MSD
- W
EHI
KCCR
- NEU
Emor
y - C
alte
ch
Eisa
i - ID
RIEm
ory -
Kin
eta
KU -
Eisa
i
Neuro
cyst
icer
cosis
Oth
er
2014Communication Objectives
and Achievements
8
An integral responsibility of the Partnership Hub is to maintain Members’ awareness of its activities and to bolster participation in new
partnerships. Through the monthly WIPO Re:Search Partnership Hub Snapshot, BVGH continued to announce new agreements and new Members and to highlight Members’ assets described in the WIPO Re:Search Database. The Snapshot newsletter was sent to more than 1,100
readership of 29%.
Increasing awareness of the achievements of WIPO Re:Search within the greater global health community is also of critical importance. In 2014 BVGH presented WIPO Re:Search at 14 meetings
to develop publications, including two articles
journals.
Conference presentation
Neglected Disease Conferences: Anthelmintics - From Discovery to Resistance, USA
2014 British Society for Parasitology Spring Meeting, UK
14th Annual Quebec Molecular Parasitology Symposium, Canada
University of Washington Bioengineering Department Seminar, USA
Advances in Medicinal Plants Research in Ghana
Keystone Symposium: The Modes of Action of Vaccine Adjuvants, USA
1st Annual COST Action: Targeted Chemotherapy Towards Diseases Caused by Endoparasites, France
63rd Annual ASTMH Annual Meeting, USA
University of Washington Bioengineering Department Seminar, USA
2014 Joint International Tropical Medicine Meeting & Foodborne Parasitic Zoonoses, Thailand
Global Public Health and Industry Conferences: 7th EDCTP Forum - The Partnership Journey: New Horizon for Better Health, Germany
2014 Life Sciences Innovation Northwest, USA
2014 BIO International Convention, USA Talk/panel Poster
WIPO Re:Search Database Contribution - MSD: Long chain fatty acyl elongase (LCE) inhibitors against protozoa (ID: 1001)
9
2014Communication Objectives
and Achievements
WIPO Re:Search in the News “WIPO Re:Search Helps Take the ‘Neglected’ out of Tropical Diseases”, WIPO Media Center, Jan. 2014
“Collaboration – Researcher from Nigeria Talks about Malaria and WIPO Re:Search”, Nigerian Law Intellectual Property Watch, Feb. 2014
Global Intellectual Property Center (GIPC) Interview, Francis Gurry, Feb. 2014
“2014 Special 301 Report” Best Intellectual Property Rights Practices by Trading Partners
Representative, Apr. 2014
“Ebola Needs a New Model of Drug Development”, The Seattle Times, Aug. 2014
“Emerging and Reemerging Neglected Tropical Diseases: a Review of Key Characteristics, Risk Factors, and the Policy and Innovation Environment”, Clinical Microbiology Reviews, Oct. 2014
“Neglected Diseases Research Gets a Boost as Merck KGaA Joins Consortium”, The Pharmaceutical Journal, Dec. 2014
10
Communication“WIPO Re:Search: Catalyzing Collaborations to Accelerate Product Development for Diseases of Poverty”Chemical ReviewsImpact factor: 45.7Featured collaborations: NIH + IDRI: natural products for tuberculosis AZ + Eskitis Institute: natural products for tuberculosis GSK + NII: kinase inhibitors for tuberculosis GSK + NII: kinase inhibitors for blood-stage malaria P�zer + PATH: data for drug repurposed for diarrheal disease
“WIPO Re:Search: Accelerating Anthelmintic Development Through Cross-Sector Partnerships”International Journal of Parasitology: Drugs and Drug ResistanceImpact factor: 2.5Featured collaborations: Swiss TPH + Eskitis Institute: natural products for schistosomiasis & soil-transmitted helminthiases (STH) McGill + AZ + Eskitis Institute: high-throughput screens for STH using C. elegans University of Buea + UBC: activity-guided fractionation of anti- onchocercal natural products Stanford + TBRI: hosting of Olfat Hammam UCSF + KNUST: hosting of Christian Agyare Novartis + University of Buea: hosting of Fidelis Cho-Ngwa
11
2014 and 2015Conclusions and
Objectives
12
BVGH met and exceeded all program objectives in 2014: Established 37 new agreements
Recruited 14 new “targeted” User Members
Recruited two new Funding Members
Continued communication activities
BVGH objectives and deliverables for 2015 include: Establish 20 new agreements*
Recruit at least eight “targeted” User Members and two Funding Members
Continue activities to increase awareness of WIPO Re:Search
Develop and implement surveys of Members’ expectations of WIPO Re:Search and the
Members.
*BVGH has begun implementing a more strategic approach to partnering. Partnering activities are now divided into three categories: new collaborations, advancing collaborations, and
strategic interests. BVGH will continue to facilitate collaborations between Members as it has in the past. However, in addition to these “standard” collaborations, BVGH will work with each Sponsor Member to establish collaborations that meet its particular strategies or interests,
disease or partner. In addition to facilitating
to encourage the continued advancement of previously-established WIPO Re:Search partnerships. BVGH will work with these partnerships’ Members to identify additional Members with the expertise needed to move a project forward.
WIPO Re:Search Database Contribution - P�zer: Nucleic acid coated-particles for delivery of
nucleic acid-based vaccines (ID: 941)
BIO Ventures for Global Health 401 Terry Avenue North, Seattle, WA 98109, USAEmail: [email protected] Website: http://www.bvgh.org
Developed in cooperation with our Sponsors: