20140329 Kern JK ExcelFile TM SHarm ReferenceList v33

8/11/2019 20140329 Kern JK ExcelFile TM SHarm ReferenceList v33

http://slidepdf.com/reader/full/20140329-kern-jk-excelfile-tm-sharm-referencelist-v33 1/39

Authors Year Journal

Li et al. 2014 ToxSci Advance Access

Trumpler et al. 2014 Trace Elements

Dorea et al. 2014 Journal of Toxicology & Environmental Health

Pieper et al. 2014 Metallomics.

Zhang et al. 2014 Graefes Arch Clin Exp Ophthalmol.

Staab et al. 2014 PLoS Genet.Wehe et al. 2014 Anal Bioanal Chem.

Marques et al. 2014 Environ Pollut.

Geier et al. 2013 Transl Neurodegener

Grønborg et al. 2013 JAMA Pediatr.

Chen et al. 2013 World J Pediatr.

Zimmermann et al. 2013 Neurotoxicology.

Goldman 2013 Hum Exp Toxicol.

Sharpe et al. 2013 J Toxicol.

Abdel-Rahman 2013 J Applied Pharmaceutical Science

Guzzi et al. 2012 Interdiscip Toxicol.

Zimmer et al. 2012 Environ Health Perspect.

li et al. 2012 PLoS One.

Mrozek-Budzyn et al. 2012 Neurotoxicol Teratol.

Blanuša et al. 2012 J Biomed Biotechnol.

Sharpe et al. 2012 J Toxicol.

Khan et al. 2012 J Physiol Pharmacol.

Ye et al. Abstract only 2012 Graefes Arch Clin Exp Ophthalmol.

Ida-Eto et al. 2012 Brain Dev.

Dorea et al. 2012 J Biomed Biotechnol.

Chauvat et al. 2012 J Immunol Methods.

Duszczyk-Budhathoki et al. 2012 Neurochem Res.Sulkowski et al. 2012 Cerebellum.

Barile et al. 2012 J Pediatr Psychol.

Ida-Eto et al. 2011 Neurosci Lett.

Secor et al. 2011 Int J Toxicol.

Olczak et al. 2011 Behav Brain Res.

Asadi et al. 2010 Int J Immunopathol Pharmacol.

Hunter et al. 2010 Dis Model Mech.

Olczak et al.a 2010 Folia Neuropathol.

Wyrembek et al. 2010 J Physiol Pharmacol.

Gallagher & Goodman 2010 J Toxicol Environ Health A.

Olczak et al.b 2010 Neurochem Res.

Hewitson et al. a 2010 J Toxicol Environ Health A.

Zieminska et al. 2010 Toxicology.

Rodrigues et al. 2010 Arch Toxicol.

Hewitson et al. b 2010 Acta Neurobiol Exp (Wars).

Paradis et al. 2010 Northeast Bioengineering Conference

Gardner et al. 2010 Toxicol Lett.

Migdal et al. 2010 Toxicology.

http://www.ncbi.nlm.nih.gov/pubmed/24549367

http://www.ncbi.nlm.nih.gov/pubmed/?term=Acute+exposure+to+thimerosal+induces+antiproliferative+properties%2C+apoptosis%2C+and+autophagy+activation+in+human+Chang+conjunctival+cells

http://www.ncbi.nlm.nih.gov/pubmed/?term=Regulation+of+Synaptic+nlg-1+Neuroligin+Abundance+by

http://www.ncbi.nlm.nih.gov/pubmed/?term=wehe+ca+and+astrocytes


http://www.ncbi.nlm.nih.gov/pubmed?term=Gr%C3%B8nborg%20TK%5BAuthor%5D&cauthor=true&cauthor_uid=23959427

http://www.ncbi.nlm.nih.gov/pubmed/?term=Recurrence+of+autism+spectrum+disorders+in+full-+and+half-siblings+and+trends+over+time%3A+a+population-based+cohort+study.


http://www.ncbi.nlm.nih.gov/pubmed/?term=zimmermann+lt+and+thimerosal






http://www.ncbi.nlm.nih.gov/pubmed?term=sharpe%20ma%20and%20thimerosal






http://www.ncbi.nlm.nih.gov/pubmed?term=Administration%20of%20thimerosal%20to%20infant%20rats%20increases%20overflow%20of%20glutamate%20and%20aspartate%20in%20the%20prefrontal%20cortex







http://www.ncbi.nlm.nih.gov/pubmed/?term=hunter+jw+and+single+neuroligin+gene





















http://www.ncbi.nlm.nih.gov/pubmed/?term=hunter+jw+and+single+neuroligin+gene







http://www.ncbi.nlm.nih.gov/pubmed?term=Administration%20of%20thimerosal%20to%20infant%20rats%20increases%20overflow%20of%20glutamate%20and%20aspartate%20in%20the%20prefrontal%20cortex






http://www.ncbi.nlm.nih.gov/pubmed?term=sharpe%20ma%20and%20thimerosal






http://www.ncbi.nlm.nih.gov/pubmed/?term=zimmermann+lt+and+thimerosal


http://www.ncbi.nlm.nih.gov/pubmed/?term=Recurrence+of+autism+spectrum+disorders+in+full-+and+half-siblings+and+trends+over+time%3A+a+population-based+cohort+study.

http://www.ncbi.nlm.nih.gov/pubmed?term=Gr%C3%B8nborg%20TK%5BAuthor%5D&cauthor=true&cauthor_uid=23959427


http://www.ncbi.nlm.nih.gov/pubmed/?term=wehe+ca+and+astrocytes

http://www.ncbi.nlm.nih.gov/pubmed/?term=Regulation+of+Synaptic+nlg-1+Neuroligin+Abundance+by

http://www.ncbi.nlm.nih.gov/pubmed/?term=Acute+exposure+to+thimerosal+induces+antiproliferative+properties%2C+apoptosis%2C+and+autophagy+activation+in+human+Chang+conjunctival+cells




Geier et al. 2010 Indian J Med Res.

Migdal et al. 2010 Toxicol Appl Pharmacol.

Geier et al. 2010 Med Sci Monit.

Marques et al. 2010 Acta Paediatr.

Minami et al. 2010 Cell Biol Toxicol.

Geier et al. 2009 Toxicol Environ Chem

Olczak et al. 2009 Brain Res.Kuo et al. 2009 Hum Exp Toxicol.

Marques et al. 2009 Cogn Behav Neurol.

Hashimoto et al. 2009 Toxicol In Vitro.

Peltz et al. 2009 Int J Toxicol.

Minami et al. 2009 Toxicology.

James et al. 2009 FASEB J.

Epstein et al. 2009 J Ocul Pharmacol Ther.

Tozzi et al. 2009 Pediatrics.

Branch 2009 Exp Toxicol Pathol.

Young et al. 2008 J Neurol Sci.

Geier et al. 2008 Neuro Endocrinol Lett.

Eke & Celik 2008 Toxicol In Vitro.

Wu et al. 2008 Chem Res Toxicol.

Laurente et al. 2007 Anales de la Facultad de Medicina

Park et al. 2007 J Toxicol Environ Health A.

Liu et al. 2007 Toxicol Sci.

Geier & Geier 2007 J Matern Fetal Neonatal Med.

Nguyen et al. 2007 Eye Contact Lens.

Lawton et al. 2007 Toxicol In Vitro.

Ribeiro et al. 2007 Neurosci Res.

Geier & Geier 2007 J Toxicol Environ Health A.Hagele et al. 2007 Int J Toxicol.

Yole et al. 2007 Toxicology.

Karsen et al. 2007 J Infect Dev Ctries.

Havarinasab et al. 2007 Toxicology.

Agrawal 2007 J Leukoc Biol.

Zheng & Dreskin 2007 Ann Allergy Asthma Immunol.

Geier & Geier 2006 Med Sci Monit.

Orct et al. 2006 J Appl Toxicol.

Lee et al. 2006 Environ Toxicol Pharmacol.

Goth et al. 2006 Environ Health Perspect.

Geier & Geier 2006 Neuro Endocrinol Lett.

Geier & Geier 2006 J Toxicol Environ Health A.

Woo et al. 2006 Mol Carcinog.

Herdman et al. 2006 Toxicol Sci.

Havarinasab & Hultman 2006 Toxicol Appl Pharmacol.

Pérez et al. 2006 J Lipid Res.

Burbacker et al. 2005 Environ Health Perspect.

Yel et al. 2005 Int J Mol Med.

Mutkus et al. 2005 Biol Trace Elem Res.

























































































Havarinasab et al. 2005 Toxicol Appl Pharmacol.

Chang et al. 2005 Pharmacol Res.

Parran et al. 2005 Toxicol Sci.


Lee-Wong et al. 2005 Ann Allergy Asthma Immunol.

Ueha-Ishibashi et al. 2005 Toxicol In Vitro.

James et al. 2005 Neurotoxicology.Humphrey et al. 2005 Neurotoxicology.

Geier & Geier 2004 Int J Toxicol.

Jin et al. 2004 Neurosci Lett.

Waly et al. 2004 Mol Psychiatry.

Ueha-Ishibashi et al. 2004 Toxicol In Vitro.

Hornig et al. 2004 Mol Psychiatry.

Bultynck et al. 2004 Biochem J.


Havarinasab et al. 2004 Toxicol Appl Pharmacol.

Ueha-Ishibashi et al. 2004 Toxicology.

Nakao et al. ordered, but not able to retrieve 2003 Natural Science Research

Qvarnström et al. 2003 Anal Chem.

Geier & Geier 2003 Pediatr Rehabil.

Alexandre et al. 2003 Biol Cell.

Baskin et al. 2003 Toxicol Sci.

Jan et al. 2003 Pharmacol Toxicol.

Koh et al. 2003 Australas J Dermatol.

Alexandre et al. 2003 Mol Reprod Dev.

Jain et al. 2003 J Pharm Pharmacol.

Geier & Geier 2003 Exp Biol Med (Maywood).

Westphal et al. 2003 Arch Toxicol.Vojdani et al. 2003 Int J Immunopathol Pharmacol.

Kim et al. 2002 Biochim Biophys Acta.

Hidalgo et al. 2002 Biol Res.

Makani et al. 2002 Genes Immun.

Kerst et al. 2002 J Membr Biol.

Müller et al. 2001 Int J Hyg Environ Health.

Montero et al. 2001 Cell Calcium.

Chen et al. abstract (in Chinese) 2000 Zhonghua Er Bi Yan Hou Ke Za Zhi.

Westphal et al. 2000 Int Arch Occup Environ Health.

Song et al. 2000 Brain Res.

Donoso et al. 2000 Biophys J.

Verstraeten et al. 1999 Abstract

Mihai et al. 1999 Cell Calcium.

Patrizi et al. 1999 Contact Dermatitis.

Chen et al. abstract only 1998 Acta Otolaryngol Suppl.

Karhapää et al. abstract 1996 Cell Calcium.

Nishio et al. abstract 1996 Neurochem Int.

Thrower et al. 1996 Biochem J.

Wiktorek et al. abstract 1996 Biochem Biophys Res Commun.







http://www.ncbi.nlm.nih.gov/pubmed?term=james%20sj%20and%20thimerosal%20neurotoxicity




http://www.ncbi.nlm.nih.gov/pubmed?term=waly%20m%20and%20activation%20of










http://www.ncbi.nlm.nih.gov/pubmed?term=baskin%20ds%20and%20thimerosal%20induces







http://www.ncbi.nlm.nih.gov/pubmed?term=Vojdani%20A%5BAuthor%5D&cauthor=true&cauthor_uid=14611720









http://www.ncbi.nlm.nih.gov/pubmed?term=song%20j%20and%20thimerosal

















http://www.ncbi.nlm.nih.gov/pubmed?term=song%20j%20and%20thimerosal









http://www.ncbi.nlm.nih.gov/pubmed?term=Vojdani%20A%5BAuthor%5D&cauthor=true&cauthor_uid=14611720







http://www.ncbi.nlm.nih.gov/pubmed?term=baskin%20ds%20and%20thimerosal%20induces










http://www.ncbi.nlm.nih.gov/pubmed?term=waly%20m%20and%20activation%20of




http://www.ncbi.nlm.nih.gov/pubmed?term=james%20sj%20and%20thimerosal%20neurotoxicity









Wu et al. abstract 1996 FEBS Lett.

Abramson et al. 1995 J Biol Chem.

Bootman et al. 1992 J Biol Chem.

Brunner et al. abstract 1991 Mutagenesis.

Withrow et al. abstract 1989 Photochem Photobiol.

Chanez et al. 1989 Neurotoxicology.

Chervonskaia et al. 1988 Zh Mikrobiol Epidemiol Immunobiol.Kravchenko et al. 1984 Zh Mikrobiol Epidemiol Immunobiol.

Kravchenko et al. 1982 Zh Mikrobiol Epidemiol Immunobiol.

Matheson et al. 1980 J Pediatr.

Anundi et al. 1979 Acta Pharmacol Toxicol.

Fagan et al. 1977 Arch Dis Child.

Parry abstract 1977 Mutat Res.

Heinonen et al. 1977 Publishing Sciences Group (book)

Blair et al. abstract 1975 Toxicology.

Braaten et al. 1975 Tissue Cell.

Gasset et al. abstract 1975 Arch Ophthamol.

Axton abstract 1972 Postgraduate Medical Journal

Itoi et al. (in Japanese) 1972 Jpn J Clin Ophthal.

Nelson & Gottshall 1967 Appl Microbiol.

Ellis 1943 Arch Ophthamol.

Kinsella 1941 Ann Intern Med.

Welch & Hunter 1940 Am J Public Health.

Welch 1939 J. Immunol.

Cummins 1937 Lancet

Salle & Lazarus 1935 Proc Soc Exp Biol Med.

Powell & Jamieson 1931 Am J Hyg.

Smithburn et al. 1930 J. Am. Med. Assoc.




http://www.ncbi.nlm.nih.gov/pubmed/?term=Mutagenesis+and+brunner+and+pig

http://www.ncbi.nlm.nih.gov/pubmed?term=chanez%20c%20and%20effects%20of%20organic

http://www.ncbi.nlm.nih.gov/pubmed/?term=Cytotoxic+action+of+the+chemical+substances+found+as+admixtures+in+medical

http://www.ncbi.nlm.nih.gov/pubmed/?term=Evaluation+of+the+toxic+action+of+prophylactic+and+therapeutic+preparations+on+cell+cultures.+III.+The







http://www.ncbi.nlm.nih.gov/pubmed/?term=Evaluation+of+the+toxic+action+of+prophylactic+and+therapeutic+preparations+on+cell+cultures.+III.+The

http://www.ncbi.nlm.nih.gov/pubmed/?term=Cytotoxic+action+of+the+chemical+substances+found+as+admixtures+in+medical

http://www.ncbi.nlm.nih.gov/pubmed?term=chanez%20c%20and%20effects%20of%20organic

http://www.ncbi.nlm.nih.gov/pubmed/?term=Mutagenesis+and+brunner+and+pig






Cmp General type of study Model System

TM tissue culture and functional testing animal

TM tissue culture human

TM clinical human



TM tissue culture animalTM tissue culture human

TM clinical human

TM epidemiology human children


TM tissue culture and functional testing animal

TM tissue culture animal

TM epidemiology human







TM tissue culture and urine animal

TM tissue culture brain




TM clinical human children

TM tissue culture immune

TM tissue culture brainTM tissue culture brain

TM clinical human children


TM tissue culture vascular

TM animal model animal


















TM tissue culture human and bacterial

TM clinical human infants



TM animal model rat infantsTM tissue culture immune

TM clinical human infants




TM tissue culture human children









TM tissue culture human and animal



TM case report human



TM case series human childrenTM tissue culture animal



























TM tissue culture humanTM tissue culture human





TM tissue culture and animal model animal















TM tissue culture humanTM clinical human








TM clinical human





TM clinical human














TM tissue culture humanTM tissue culture human




TM clinical human

TM tissue culture fungus





TM clinical human



TM clinical human

TM clinical human

TM tissue culture human & animal

TM tissue culture mammalian




TM human human



Type of Study

mice

human blood

human children

human

human

nematode (roundworm)human

human children

human children

human children

rat

rat

VAERS database

human

adult mice

human

human

mouse

human children

rat infants

human

rats

eyes

rats

human children

human

ratsrats

human children

rat infants

mouse

rat infants

human cells

nematodes

rat infants

rats

National Health Interview Survey 1997-2002

rats

newborn primates

rats

rats

rhesus macaque infants

snail

human

human



Vaccine Safety Datalink, birth cohorts, 1990-1996

human

human and bacterial

human infants

mice

human

ratshuman

human infants

rats

bovine

mice

lymphoblastoid cells (autistic vs controls)

human tissue

10 y follow up of pertussis vaccine trial in 1992-3

male and female CD1 mice

Vaccine Safety Datalink

children from Rh-negative mothers in the US prior to 2002

human

human?

hamsters 7 days old

murine and human

human

human children

human female

mice

mice brain

human childrenbovine

mice

human

murine

human

human

human children

rat infants

human

murine

human children

human children

human

human

murine

human

infant monkeys

human

Chinese hamster



mice

human

human

human children

human

young rats

humanhuman

human children

human

human

rats

mouse

chicken

human children

mouse

rat infants

human

mice

human children

mice

human

canine

human

mice

guinea-pig

human

humanhuman children

human

mammal

human

Xenopus laevis (frog)

human

human

guinea pig

human

rat

rabbit

infants

human

human children

guinea pig

rat

rabbit

rat

rat



mouse

rabbit

HeLa cells

pig

mouse

rat fetus

human diploid cellshuman cell line L-132

human cell line L-132

children

hepatocytes

human infants

yeast cells

50,000 pregnancies

monkeys

rat

rabbits

adults and children

rabbits

mouse

patients

patients with endocarditis

human & Guinea pig blood

whole blood

Guinea pigs

embryonic tissue

animals

human



More Specific Focus

brain tissue and developmental testing

human whole blood and physiological simulation solutions

Gesell Development Schedule (GDS) on children from two villages in Brazil

human astrocytes

human Chang conjunctival cells

transcriptome RNA sequencing to identify genes controlled by the SKN-1/Nrf2 negative regulator WDR-23 in thehuman astrocytes

children in Brazil

US children in the VSD

children (about 1.5 million) born in Denmark between January 1, 1980, and December 31, 2004

premature SD rats at a dose of 32.8, 65.6, 98.4 or 131.2 μg/kg

rat glioma cell

VAERS database during three consecutive flu seasons beginning 2008/2009

B-lymphocytes taken from individuals with autism, their nonautistic twins, and their nontwin siblings and controls

brain tissue

Jurkat T cells, a human T leukemia cell line

neural crest cells

mouse C2C12 myoblast cells

196 infants born between January 2001 and March 2003 to mothers in the first and second trimesters of pregnan

whole blood and urine and mass fractions of mercury in organs (kidneys, liver, brain, small intestine, and large int

astrocytes

cerebellum

conjunctival epithelial cells

brain

Amazonian infants

T cells in vitro

rat prefrontal cortexcerebellum

neuropsychological tests

early development of serotonergic neurons

aortic endothelial cell

behavioral tests

human leukemic cultured LAD2 mast cells

single neuroligin gene

brain

hippocampal neurons

boys 3-17 yo, born before 1999

brain

tested nine survival, motor, and sensorimotor reflexes

cerebellar granule cells

rat tissues (brain, heart, kidney and liver) and blood

amygdala growth

neuronal patterns

peripheral blood mononuclear cells in vitro

dendritic cells



premature puberty

dendritic cells (DCs)

human neuroblastoma cells/bacterial cells

Gesell Developmental Schedules (GDS) test

cerebellum and cerebrum

neuroblastoma cells and fetal cells

brain, liver and kidneysoral cancer cells

infant hair-Hg and Gesell schedules

thymocytes

pulmonary artery ECs

metallothionein (MT) mRNAs in cerebellum microglia cell line, C8-B4 cells

glutatione levels/redox

conjunctival and corneal epithelial cells

neuropsych testing

maximum tolerated dose

birth-7 months and birth-13 months

maternal Rh-negativity assessed among 298 Caucasian children with NDs and known Rh-status

cultured peripheral blood lymphocyte cells

interaction of thimerosal with topoisomerase II alpha and protein and nonprotein thiols and with DNA

encephalon

kidney cells

gastric cancer cells

children with autism spectrum disorder (ASD)

eyes

N2a neuroblastoma and rat C6 glioma cells

neuroblastoma N1E-115 cell line

children with apparent mercury toxic encephalopathies and regressive autistic disorderpulmonary artery endothelial cell

YAC-1 lymphoma cells

43 yo female given tetanus injection with recation to TM

autoimmune syndrome

dendritic cells

31 yo female, response to skin prick test with TM

Vaccine Adverse Event Reporting System (VAERS) from 1991 through 2004

distribution in blood and organs (kidney, liver and brain)

HeLa S epithelial cells

dendritic cells

Vaccine Adverse Event Reporting System (VAERS), from 1994 through 2000 in the United States

Vaccine Adverse Event Reporting System (VAERS), DTP and Hib vaccines in comparison to DTPH vaccine, from 19

leukemia cells

SK N SH (Human neuroblastoma cell line)

murine systemic autoimmune diseases

U937 phagocytes

mercury levels in the brain

neuronal cell

ovary (CHO) cells



immune response

osteoblast-like cells

neuroblastoma cell line (SH-SY5Y cells)

Vaccine Adverse Event Reporting System (VAERS), (DTaP) vaccines, from 1997 through 2001

patient who received an influenza vaccine

lymphocytes dissociated from thymic glands

neuroblastoma cells and glioblastoma cellsneuroblastoma cell line (SK-N-SH

Vaccine Adverse Event Reporting System (VAERS), (DTaP) vaccines, from 1997 through 2000

TRPV1, a receptor for capsaicin

SH-SY5Y human neuroblastoma cells

thymocytes

hippocampal neurons and neurological testing

B lymphoma cells

Evaluations of the Biological Surveillance Summaries of the Centers for Disease Control and Prevention

A.SW mice

cerebellar neurons

K562 human leukemia cells

organs

Vaccine Adverse Events Reporting System (VAERS)

mouse primary oocytes

cultured human neurons and fibroblasts

Madin Darby canine kidney (MDCK) cells

3.5 year old boy

mouse oocyte

cerebellar membranes

Vaccine Adverse Events Reporting System (VAERS)

lymphocyteslymphocyte receptors and tissue enzyme (DPP IV or CD26); human serum albumin in patients with autism

HeLa S cells

sarcoplasmic reticulum vesicles isolated from skeletal or cardiac mammalian muscle

Jurkat T cells (Human T cell lymphoblast-like cell line)

KCNE1-injected Xenopus laevis oocytes

erythrocytic GST T1 (glutathione-S-transferase T1)

intact HeLa cells

cochlear outer hair cells

Central European individuals with a positive patch-test reaction to thimerosal va healty controls

tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium channels in rat dorsal root ganglion neur

triad-enriched sarcoplasmic reticulum vesicles isolated from rabbit skeletal muscle

database from 4 HMOs contained immunization, medical visit, and demographic data on over 400,000 infants bo

calcium receptor in human parathyroid and rMTC6-23 cells

atopic children

guinea pig cochlear outer hair cells

GH4C1 pituitary cells

rabbit blood platelets

Ca2+ channel from rat cerebellum

intact glioma C6 cells



single pancreatic acinar cells

skeletal muscle sarcoplasmic reticulum

Fura-2-loaded HeLa cells

pig brain

mouse lymphoma

brain, total brain homogenate, synaptosomes and myelin

cytotoxic action (CTA) of chemical substances contained as admixturestested DTP vaccine on the cell line L-132

tested DTP vaccine on the cell line L-132

child given gammaglobulin preserved with TM

hepaocytes

13 cases of infants with exomphalos treated with TM

yeast cells

studied drug exposure during pregnancy and malformations in the infants

Squirrel monkeys were dosed intranasally

Rat, Wistar-Lewis, fetal 18-20 day gestation; (also neonatal 3-12 day old); primary cultures of endocrine pancreas

rabbits injected prenataly

adults and children

reproductive health in rabbits

mice injected with pertussis vaccine with TM and without TM

TM used in ophthamic ointment

13 cases of patients treated with TM for endocarditis

varying dilutions

compared the relative toxicity of Thimerosal with other germicide compounds, e.g., phenol or iodine

inoculated Guinea pigs

compared emryonic cells to bacterial cells

toxicity studies

21 adults with meningitis were given an injection IV 1% solution TM



When Exposed Sex-dependent Finding

first 4 months of life males more affected neural development delay, social int

na na Analogous behaviour of methylmerc

postnatal na children in the village with higher m

na na strongly disturbed poly(ADP-ribosyl)

na na Acute exposure to thimerosal induce

na na increased nuclear SKN-1::GFP in the ina na many-fold higher levels of Hg were p

postnatal na TM negativelly impacted children's p

postnatal na Increased risk of an ASD diagnosis

postnatal na Decrease in the rate of ASD with the

postnatal day 1 na Expression of DRD4 and 5-HT2AR an

na na Significant cytotoxicity (p<0.0001) w

prenatal na increased prenatal TM exposure resu

na na Autism families showed thimerosal h

adults na elevated brain nitric oxide and decre

na na thimerosal caused a significant decre

na na Thimerosal reduced NC cell migratio

na na thimerosal induces S phase arrest an

prenatal na An adverse effect of neonatal TCV ex

early postnatal life na TM-exposed group mercury retentio

na na inhibits mitochondrial respiration lea

prenatal males more affected expression of suppressor-of-white-a

na na DNA single- and double-strand break

prenatal na lasting impairment of brain monoami

na na a higher score of neurological develo

na na abortive activation of T cells followe

infant na rapid increase of glutamate overflowinfant males more affected aberrant cerebellar oxidative stress,

early life males more affected presence of tics

embryonic exposure na dramatic increase in the number of s

na na induced phospholipase D activation, i

early postnatal life males more affected impairments of locomotor activity an

na na TM induced significant vascular endo

na na single neuroligin gene (nlg-1) mutan

early postnatal life na degeneration of neurons and "dark"

na na damaged a significant proportion of

birth males more affected threefold greater odds for autism dia

early postnatal life na alterations in opiod recepters, degen

birth na delayed acquisition of neonatal refle

na na induced the rise in the intracellular c

na na mercury in tissues and blood followi

4 and 6 months na altered amygdala maturation

infant na a clear disruption of the baseline neu

na na decreases IFN-gamma release

na na a calcium (Ca2+) influx , induced glut



birth-7 months and birth-13 months na increased rate ratios for premature p

na na induced DC activation, as monitored

na na relative toxicity indices (human neur

prenatal na GDS at 6 months was significantly as

na na expressed metallothionein (MT) mes

na na mitochondrial damage, reduced oxid

early postnatal life no accumulates in the rat brain in signifina na killed cells in a concentration-depen

pre/post natal exposure to methyl and TM na GS at 6 months was significantly influ

na na increases intracellular Zn(2+) concen

na na activates vascular endothelial cell (E

na na MT-1 mRNA significantly decreased

na na thimerosal resulted in a greater decr

na ns ocular tissue damage

early postnatal life unclear girls with higher thimerosal intake ha

adult mice males more affected gender-selective toxicity

3 months of age na increased rate ratios were observed

prenatal na increases in maternal Rh-negativity a

na na genotoxic and cytotoxic effect

na na reacted rapidly with cysteine, GSH, h

7 days old na Neurotoxic effects were also produc

na na cytotoxicity on renal cells

na na reduced cell viability, apoptosis, and

na na children with ASDs (28.30%) were sig

na na total limbal stem cell (LSC) failure an

na na impaired neurite outgrowth

na na blockade of the resting state, hyperp

na na significant dose-response relationshina na endothelial lipid signaling enzyme, p

na na induced microtubule depolymerizati

na na hypersensitivity, myelodysplastic syn

na na activated the production of anti-fibril

na na induced increased TH2 (IL-5 and IL-1

na na generalized pruritus without hives, t

early postnatal life na reduction on neurodevelopmental di

na na high brain and blood concentrations

na na apoptosis, reduced cell viability and i

na na altered ATP-mediated interleukin-6 s

na na significantly increased adjusted (sex,

na na significantly increased odds ratios for

na na apoptosis, G(2)/M phase arrest, and

na na apoptosis in a neuroblastoma model

na na induced glomerular, mesangial and s

na na blocks the conversion of Arachidonic

na na There was a higher percentage of th

na na induced apoptosis was associated wi

na na caused significant but selective chan



na na initial immunosuppressive effects lea

na na induced cytosolic Ca2+ elevation and

na na elevated levels of fragmented DNA a

na na exposure to mercury from TCVs admi

na na generalized maculopapular eruption

na na depolarized the membranes, associa

na na induced cytotoxicity was associatedna na accumulated in the mitochondria; cy

na na evidence that administration of thim

na na blocked the capsaicin-activated inwa

na na inhibited both IGF-1- and dopamine-

na na induced decrease in cellular content

na na showed growth delay; reduced loco

na na induce isoform-specific conformatio

childhood na evidence showing a direct relationshi

na na induces in genetically susceptible mi

2 weeks na increased the intracellular concentra

na na potency of thimerosal to affect K562

na na was rapidly taken up in the organs of

childhood vaccines na occurrence of neurodevelopmental d

na na induces an instantaneous, complete

na na induces DNA breaks, caspase-3 activ

na na increases calcium levels in renal tubu

11 days prior to reaction na Wells' syndrome

na na irreversibly inhibits meiosis reinitiati

na na inhibitor of the binding of [(3)H]mep

childhood vaccines na an association between neurodevelo

na na induces micronuclei in the cytochalana na bind to lymphocyte receptors and/or

na na stimulates focal adhesion kinase and

na na increased susceptibility to stimulatio

na na induced apoptosis in T cells as deter

na na interacts with the cysteine residue C

na na inhibition of the human erythrocytic

na na increased the sensitivity to histamine

na na induced Ca2+ mobilization in isolated

na na homozygous gene deletions of the gl

na na blocked the two types of sodium cha

na na produced a significant increase of rel

postnata na elevated risk for the following disord

na na increases the responsiveness of the c

na na high frequency of sensitization to thi

na na induced Ca2+ mobilization in isolated

na na potently inhibited the Ba2+ currents

na na serotonin transport activity into rabb

na na enhances Ins(1,4,5)P3-induced Ca2+

na na inhibit phosphatidylserine synthesis



na na modulates the agonist-specific cytos

na na stimulate Ca2+ release from skeletal

na na stimulated Ca2+ spikes occurred in t

na na TM led to rapid inhibition of tubulin

na na TM was toxic to cells and highly mut

prenatal na inhibition of Na+K+ATPase activity

na na toxic at 0.8micrograms/ml; aluminuna na in a concentration of 1 in 10,000, con

na na most toxic effect on cells was caused

na na acrodynia or mercury poisoning resul

na na glutathione depletion and lipid perox

post natal na 10 out of 13 infants dies; Hg blood a

na na TM induced significant genetic altera

prenatal na TM was associated with malformatio

na na Mercury concentrations were signific

pre and post natal na destroys fibroblastoid cells

adult and prenatal na TM caused dose-dependent increase

na na Five out of the six patients died, and

prenatal na significantly increased numbers of de

na na Pertussis vaccines preserved with 0.0

na na Merthiolate is capable of causing an i

na na all patients receiving the Thimerosal

na na TM was more toxic for human cells t

na na TM was, by several orders of magnit

na na guinea-pigs inoculated with 1 c.cm. o

na na Thimerosal 35.3 times more toxic to

na na significant numbers of animals died

na na 20 of 21 people died with 24 hours, t



raction deficiency, and inclination of depression; alternation of a number of canonical pathways involvi

ry and ethylmercury species in human blood was shown and an ethylmercury-glutathione adduct was i

rcury exposure from maternal fish consumption and postnatal TCV had a significantly more severely aff

tion, a signalling reaction induced by DNA strand breaks

s antiproliferative properties, apoptosis, and autophagy activation in human Chang conjunctival cells

ntestine and also increased Pnlg-1::gfp fluorescence in motor neurons (TM interferes with brain structuresent in the cells with exposure to organic Hg compounds than inorganic Hg compounds

sychomotor developement

removal of TM from vaccines

learning function decreased, and apoptosis increased significantly in the 131.2 μg/kg group, Memory f

s observed; ethyl and methyl comparative; both transported by LAT equally

lted in an 11-fold increased fetal-loss rate

ypersensitivity, whereas none of the control individuals displayed this response.The thimerosal concent

sed brain glutathione levels, neuron degeneration and brain holes

ase in cellular viability at 1 μM (25%, p<0.05; IC50: 10 μM). Methyl mercury exhibited a significant decr

at least as potently and effectively as CH3HgCl (lowest effective concentration in the range of 1–5 nM),

d finally causes apoptosis via inhibition of PI3K/Akt/survivin signaling followed by activation of the mito

posure was observed for the psychomotor development index (PDI) only in the 12th and 24th months o

was higher in the brain, enteral excretion was similar, and urinary excretion was much lower compare

ding to a drop in the steady state membrane potential, but also concurrent with these phenomena incr

ricot-1 (SWAP-1), a gene negatively regulated by T3, was increased in TM-exposed males (61.1% increa

s

inergic system

pment at six months was negatively associated with exposure to additional TCV-EtHg

by cell death

hyroid hormone metabolism, and motor behavior in rat pups

erotonergic neurons localized to the lateral portion of the caudal raphe was observed

induced upstream phosphorylation of extracellular-regulated kinase 1/2 (ERK1/2) leading to downstrea

d increased anxiety/neophobia, prosocial interactions was reduced, frequency of asocial/antisocial int

thelial growth factor (VEGF)

ts were significantly more sensitive than wild-type animals to both inorganic (HgCl2) and organic thimer

neurons in the prefrontal and temporal cortex, the hippocampus and the cerebellum, pathological chan

eurons after 60-90 min exposure; reduced both NMDA and GABA responses

gnosis

erating neurons and loss of synaptic vesicle marker (synaptophysin)

es

lcium and zinc concentration and decrease in mitochondrial membrane potential

g TM treatment was predominantly found as Ino-Hg, but a considerable amount of Et-Hg was also foun

ronal communication pattern when the extracted central nervous system is exposed to Thimerosal

thione (GSH) depletion and reactive oxygen species



uberty

by CD86 and HLA-DR overexpression associated with the secretion of tumor necrosis factor alpha and in

blastoma cells/bacterial cells) were 2-phenoxyethanol (4.6-fold) < phenol (12.2-fold) < Thimerosal (>33

ociated with total mercury concentration of neonate's hair

senger RNA

ative-reduction activity, cellualr degeneration, and cell death

cant amounts and remains there longer than 30 days after the injection and also increased pain threshoent manner through apoptosis

enced by Hg exposure- methyl and TM

ration via decreasing cellular thiol content

) phospholipase D (PLD), suggesting mechanisms of mercury vasculotoxicity

ase in the GSH/GSSG ratio and increase in free radical generation in autism compared to control cells

d lower mean scores in the finger-tapping test with the dominant hand and in the Boston Naming Test

or autism, autism spectrum disorders, tics, attention deficit disorder, and emotional disturbances

mong children with NDs, autism spectrum disorders, and attention-deficit-disorder/attention-deficit-hy

uman serum albumin, and single-stranded DNA to form ethylmercury adducts, inhibited the decatenati

d at encephalic level: at hippocampus (regions CA1, CA3 and DG), cerebral cortex, and cerebellum (Pur

induced [Ca2+](i) increases via Ca2+ influx from the extracellular space

nificantly more likely (odds ratio 2.35, 95% confidence interval 1.17-4.52, p < 0.01) to have Rh-negative

corneal opacification

olarizing shifts of m(infinity) and h(infinity) curves, change in the voltage sensitivity and slower inactivati

between the severity of the regressive ASDs observed and the total mercury dose children received frospholipase D (PLD), enhanced reactive oxygen species generation, decrease of levels of total cellular t

n and inhibition of tubulin synthesis and/or beta-tubulin degradation

drome and pancytopenia.

larin autoantibodies (AFA), and induced a persistent Th1-skewed response

) and decreased TH1 (IFN-gamma) cytokine secretion from the T cells, depletion of intracellular glutathi

roat tightness, and a dry cough without wheezing on auscultation

sorders woth decreased use of TM in vaccines

ntracellular glutathione levels, and increase of genomic DNA fragmentation

ecretion, initially enhancing the rate of cytokine secretion but suppressing cytokine secretion overall in

age, vaccine type, vaccine manufacturer) risks of autism, speech disorders, mental retardation, persona

autism, speech disorders, mental retardation, infantile spasms, and thinking abnormalities reported to

DNA fragmentation in a dose-dependent manner.

via the cJun N-terminal kinase pathway

stemic vessel wall immune-complex deposits and antinuclear antibodies (ANA)

acid into arachidonoyl-CoA, and a CoA-independent transacylase inhibitor that blocks the movement of

total mercury in the brain that was in the form of inorganic mercury for the Thimerosal-exposed monk

h depolarization of mitochondrial membrane, generation of reactive oxygen species, and release of cyt

es in both glutamate transporter mRNA and protein expression in CHO cells



ding to a second phase with strong immunostimulation and autoimmunity, which is T-cell dependent, H

subsequent cell death in human osteosarcoma cells; concentrations of 5, 10 and 20 microM thimerosal

ppearing at 0.01 microM (apoptosis) to decrease at concentrations >1 microM (necrosis)

inistered in the US was a consistent significant risk factor for the development of NDs

ed with increasing the [Ca2+]I; induced an apoptotic change in membranes of almost all living cells

ith depletion of intracellular GSH in both cell lines ochrome c was shown to leak from the mitochondria, followed by caspase 9 cleavage within 8 h of trea

erosal-containing vaccines in the United States resulted in a significant number of children developing N

rd current (I(cap)) in cultured sensory neurons

timulated methylation with an IC(50) of 1 nM and eliminated MS activity

of glutathione and apoptosis

otion; exaggerated response to novelty; and densely packed, hyperchromic hippocampal neurons with

al changes in the N-terminal part of IP3R1, leading to the formation of a highly IP3-sensitive Ca2+-relea

p between increasing doses of mercury from thimerosal-containing vaccines and neurodevelopmental

e a systemic autoimmune syndrome

ion of Ca2+ ([Ca2+]i) in a concentration-dependent manner, decreased the cellular content of glutathio

cells was similar to that of methylmercury; inhibited the growth and increased the population of shrunk

the mice (kidney, liver, and mesenterial lymph nodes),

isorders following thimerosal-containing childhood vaccines does not appear to be coincidental

nd long-lasting microtubule interphasic network disassembly in mouse primary oocytes, correlated wit

tion, membrane damage, and cell death in cultured human neurons and fibroblasts

lar cells

n in mouse oocyte

ramine to histamine H(1) receptors in guinea-pig cerebellar membranes

pmental disorders and thimerosal-containing DTaP vaccines was found

in B block micronucleus test with human lymphocytestissue enzymes, resulting in autoimmune reaction in children with autism

cytoskeletal changes by redox modulation

by Ca2+ and decreased the inhibitory effect of Mg2+ in skeletal vesicles

ined by TUNEL and propidium iodide assays, suggesting a role of mercury in T cell apoptosis; and enha

14 in the S3 segment of KCNQ1, leading to a change of its gating properties.

glutathione-S-transferase T1 (GST T1)

of ER-Ca(2+)-release by about two orders of magnitude; thimerosal increased the [Ca(2+)](ER) steady-s


utathione S-transferases M1 and T1 are associated with thimerosal sensitization

nnels in a dose-dependent manner; the inhibitory effect of thimerosal was much more pronounced in T

ease rate constants and initial release rates at all [Mg(2+)] tested (up to 1 mM), and shifted the K(0.5) v

ers: autism (RR 7.6, 95% Cl = 1.8-31.5), non-organic sleep disorders (RR 5.0, 95% Cl = 1.6-15.9}, and spee

alcium receptor in human parathyroid and rMTC6-23 cells

erosal in atopic children


through voltage-operated Ca2+ channels

it blood platelets was inhibited

release by both altering the open times of the channel significantly and causing a shift to higher subcon

y 70%,



lic Ca2+ oscillatory patterns in single pancreatic acinar cells of mouse

muscle sarcoplasmic reticulum vesicles, inhibit high affinity [3H]ryanodine binding, and modify the chan

e absence of extracellular (Ca2+ o), suggesting that they result from mobilization of Ca2+ from intracell

ssembly abd disassembly of microtubules

genic

sulafte toxic at 500 micrograms/ml tained in one vaccine caused celluar damage

by components of pertussis antigens and merthiolate solution.

lted including nerve damage

idation

d tissue levels above toxic levels for fetuses and adults

tions at a level < 1ppb

ns in the children

antly raised over control values in brain (high dose group only), liver, muscle and kidney, but not in bloo

in fetal mortality and was found to cross the placental and blood brain barrier

necropsy showed extensive renal tubular necrosis in each case, and in two, evidence of diffuse intravas

ad fetuses (up to 18% of fetuses died following exposure) and increased fetal congenital anomalies (up

1%Merthiolate are more toxic for mice than unpreserved vaccines prepared from the same parent con

inflammation of the mucous membrane in patients

treatment died, and that following autopsy, some of the patients were determined to have died of mer

an bacterial cells (toxicity index=5.7) and was among the 10 germicides tested, had the ninth worst toxi

de, the most toxic compound tested

f the mixtures after 24 hours all died

embryonic cells than bacterial cells

ithin days of exposure

he 21st person started to recover, but after a second dose, he died



ng neuronal development, neuronal synaptic function, dysregulation of endocrine system

dentified.

ected children

ral proteins)

nction was significantly impaired by 65.6 (P<0.05), 98.4 and 131.2 μg/kg (P<0.001)

ration required to inhibit cell proliferation in these individuals was only 40% of controls. Cells hypersens

ase in cellular viability at 50 μM (33%, p<0.01; IC50: 65 μM). Mercuric chloride (HgCl2) did not show an

whereas inorganic mercury (HgCl2) was about 10-fold less potent

hondrial apoptotic pathway

f life. The overall deficit in the PDI attributable to neonatal TCV exposure measured over the course of t

to HgCl(2)-exposed sucklings.

ases the formation of superoxide, hydrogen peroxide, and Fenton/Haber-Weiss generated hydroxyl ra

e), but not in females; (p<0.05). Positively regulated T3-target genes, Purkinje cell protein 2 (Pcp2; p=0.

threonine phosphorylation of PLD(1), and caused loss of intracellular glutathione

ractions was increased in males, but decreased in females, marked decline in the density of striatal D2

osal

ges of the blood vessels in the temporal cortex, diminished synaptophysin reaction in the hippocampus,

d in the liver and brain.



terleukin 8, oxidative stress, monitored by ROS induction and depolarization of the mitochondrial mem

0-fold), TM more toxic to human cells than bacteria

ld

eractivity-disorder

n activity of DNA topoisomerase II alpha, induced single and double strand breaks in K562 cells were co

inje cells and granulose cells); with decrease in neuronal density, neuronal necrosis, axonal demyeliniza

mothers than controls (14.36%). Each ASD patient's mother was determined to have been administere

ing kinetics,

m Thimerosal-containing vaccines/Rho (D)-immune globulin preparationshiols

one (GSH)

DCs.

lity disorders, thinking abnormalities, ataxia, and NDs in general, with minimal systematic error or confo

VAERS were found following DTP vaccines in comparison to DTPH vaccines

AA within phospholipids

eys (34% vs. 7%).

ochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol.



-2 linked

killed 33, 55 and 100% cells, respectively

tment. In addition, poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment followi

Ds

altered glutamate receptors and transporters

se channel

isorders, and measles-containing vaccines and serious neurological disorders.

ne, and cytotoxic actions on cerebellar granule neurons

en; hypodiploidal cells was also greatly increased; thimerosal-induced apoptosis

h the irreversible inhibition of meiosis reinitiation

ced intracellular reactive oxygen species and reduced intracellular glutathione (GSH)

tate level in permeabilized cells; and inhibited also plasma membrane Ca(2+)extrusion and increased Ca

X-R sodium channels than TTX-S sodium channels; and the effect of thimerosal was irreversible

lue for Mg(2+) inhibition to 101 or 137 microM in triads actively or passively loaded with calcium, resp

ch disorders (RR 2.1, 95% (1=1.1-4.0)

uctance levels



nel activity of the reconstituted Ca2+ release protein

ular stores

ular coagulation.

to 9.1% of fetuses developed congenital anomalies following exposure)

entrate and containing the same number of organisms. An increase in mortality was observed when M

ury poisoning from the Thimerosal treatment.

icity index.



itive to thimerosal also had higher levels ofoxidative stress markers, protein carbonyls, and oxidant gen

y significant change in cellular survival.

he three-year follow-up (GEE) was significantly higher in TCV group.

ical. These oxidants increase the levels of cellular aldehyde/ketones. Additionally, we find a five-fold in

07) and Forkhead box protein P4 (FoxP4; p=0.08), showed a trend towards decreased expression in TM-

eceptors

atrophy of astroglia in the hippocampus and cerebellum, and positive caspase-3 reaction in Bergmann



brane

nsistent with a rapid induction of apoptosis

tion, and gliosis.

a TCR during her pregnancy.

unding, were associated with TCV exposure



g maximal caspase 3 activation, apoptosis and oncosis/necrosis

(2+)(Mn(2+)) entry through the plasma membrane

ctively. Further oxidation of vesicles with thimerosal completely suppressed the inhibitory effect of [M



rthiolate was injected separately, before or after an unpreserved saline suspension of pertussis vaccine



rationprotein carbonyls, and oxidant generation.

rease in the levels of oxidant damaged mitochondrial DNA bases and increases in the levels of mtDNA n

exposed males. The expression of deiodinase 2 (DIO2) showed a trend towards an increase in TM-expo

stroglia





(2+)] on CICR, yielding initial rates of CICR of 2 micromol/(mg x s) in the presence of 1 mM free [Mg(2+)





icks and blunt-ended breaks.

ed females,





].

Date post:	03-Jun-2018
Category:	Documents
Upload:	dabke1997
View:	220 times
Download:	0 times

20140329 Kern JK ExcelFile TM SHarm ReferenceList v33

Documents