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The Challenge of Alzheimer’s
1. Understanding the Disease2. What’s the Big Deal? 3. Is There a Cure?4. What Can We Do For
Ourselves?
The Challenge of Alzheimer’s
Dementia vs. Alzheimer’s
Dementia • Brain failure• Irreversible• A symptom
Alzheimer’s • A disease
Causes of Dementia
1. Alzheimer’s (60% - 80%)2. Vascular dementia (10%)3. Brain trauma4. Lewy Body Disease5. Fronto-temporal dementia6. Parkinson’s dementia7. Others
The Invisible Disability
Healthy and Demented Brains
Healthy Brain
Demented Brain
Lose on the Left, Retain on the Right
Left Brain Right BrainLogic FeelingFacts Imagination
Words SymbolsKeeps control Takes risks
More than One Sufferer
1. Understanding the Disease2. What’s the Big Deal? 3. Is There a Cure?4. What Can We Do For
Ourselves?
The Challenge of Alzheimer’s
What’s the Big Deal?123456789
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The 6th leading cause of death in the US Up from 12th 15 years ago
What’s the Big Deal?
2015 2025 2050
Americans with Alzheimer’s
5 million
14 million
7 million
280%
What’s the Big Deal?
2015 2050
Cost of Care
$1.2 trillion
$226 billion
530%
The Hidden Cost • 15 million family caregivers
• 18 billion hours of unpaid care
• Additional medical problems... stress, anxiety
1. Understanding the Disease2. What’s the Big Deal? 3. Is There a Cure?4. What Can We Do For
Ourselves?
The Challenge of Alzheimer’s
Reaching Critical Mass
Early 1900s – Discovery
1970s – Modern research
1980s – Awareness
1990s - Treatments emerge
2000s – Better understanding of causes, better diagnoses
2010s – National Alzheimer’s Project Act
Hope or Hype?
Treatment Horizon• Drug development: mice + 15 years
• Five FDA-approved drugs: symptom improvement only
• New research targeting underlying cause• Biogen – BIIB 037– Promising trial results
– Early 2020s?
– Symptom improvement
Rotary in Action
• Cure Alzheimer’s Fund
Not Enough Research Funding
$591 million
US Federal Research Budget Today
Not Enough Research Funding
$591 million
$2 billion
US Federal Research Budget Today
What Experts Say We Need...
1. Understanding the Disease2. What’s the Big Deal? 3. Is There a Cure?4. What Can We Do For
Ourselves?
The Challenge of Alzheimer’s
Stay Busy!Postponing retirement by five years lowers your risk of dementia by:
Stay Busy!Postponing retirement by five years lowers your risk of dementia by:
15%
Get Plenty of Exercise!
Regular exercise can reduce your risk of Alzheimer’s by
Get Plenty of Exercise!
Regular exercise can reduce your risk of Alzheimer’s by
15%
Go Outside and Play!Active social relations reduce our risk of dementia by:
Go Outside and Play!Active social relations reduce our risk of dementia by:
50+%
Get Plenty of Rest!Sleep helps prevent dementia because:
Get Plenty of Rest!Sleep helps prevent dementia because:
Brain cells clean themselves during sleep
The Power of Healthy HabitsHow much does our risk of dementia decrease if we....• Exercise regularly• Maintain healthy bodyweight• At least five servings of fruits and
vegetables every day• Don’t smoke• Use alcohol in moderation
60%
• Raise money• Raise awareness• Offer support to caregivers and
loved ones• www.alz.org
What Can Rotarians Do?
Thank You