23 May 2002 - 2 June 2002

24 May 2002 From genes to drugs via crystallography

19 May 1996 Experimental and computational approaches

to structure based drug design

11 June 1989 Three dimensional molecular structure and drug action

01 April 1983X-ray crystallography and drug action

Course 9 Series 1

Course 15 Series 2

Course 24 Series 3

Course 33Series 4

Function

Sequence Structure

Sequence

Function Structure

Genomic data

Function

Sequence Structure

Sequence

Function Structure

Genomic data

Completed sequences of genomes (>60)

find all folds structural biology

functionalgenomics

Diagnosis Treatment Screening

Target identificationSelectivity

Modelling

Fundamental understanding of biology

protein evolution

Better sourcesNew detectors

Automation :qualityCrystal freezing MAD phasing

Automatic map interpretationSoftware integration

CRYSTALLISATIONScreening Kits

RoboticsImproved Plate designs

Mini incubatorsData tracking Software

ImagingLiquid handling : nL

Automation

base

• Limited proteolysis, MS• Recombinant DNA

technology• Constructs operating in

more than one system• Miniaturisation :

expression & purification

CLONING &

PURIFICATION

Data Collection

Structure solution

Form to function•Motifs•Alignments•Classification•Mechanisms

Structure Analyses

Genomics

MolecularBiology

PhysicsBioinformatics

Computational Science

Chemistry

Pharmacology

MathematicsStatistics

Crystallography

NMR

Molecular Modelling

Structural Biology

Biochemistry

EM

Proteomics

Synergy of several disciplines

Sequence

Function Structure

GenomeGenes

Empirical MethodsPredictive Techniques

Approaches

ProspectsMethods Tools

Achievements

Overviewof the genetics-based drug design process

Sequence

Function Structure

Genomic data

Diagnosis TreatmentScreening

Target identificationSelectivity

Modelling

Drug design

Powers Pitfalls

SequenceExpressionPrediction

Genes DMPK propertiesCase studies

Drugs

Screening DockingOptimisation

Crystallography

Mass spectroscopyElectron microscopyNMR spectroscopy

Crystallography

Plenary Lectures

SequenceExpressionPrediction

Genes

DMPK propertiesCase studies

Drugs

Screening DockingOptimisation

Crystallography

Mass spectroscopyElectron microscopyNMR spectroscopy

Crystallography Crystallisation (W1)

Metal ions (W8)

NorthWestern

DOCK(W5)

PDB (W2)

WHATCHECK (W6)

Bioinformatics (W7)CSD (W4)

FlexX (W3)

Workshops

SequenceExpressionPrediction

Genes

DMPK propertiesCase studies

Drugs

Screening DockingOptimisation

Crystallography

Mass spectroscopyElectron microscopyNMR spectroscopy

Crystallography

Crystallisation (W1)

Metal ions (W8)

NorthWesternDOCK(W5)

PDB (W2)

WHATCHECK (W6)

Bioinformatics (W7)

CSD (W4)

FlexX (W3)

Posters Discussions

Recreation

ProfessionalContacts

Plenary Lectures

Workshops

A NATO Advanced Research Workshop

Cosmetic and Therapeutic Chemicals

Professor Janus LipkowskiInstitute of Physical ChemistryAcademy of Sciences,Warsaw, Poland

Professor Georges TsoucarisCentre de recherche et de Restauration des Musees de FranceCNRS, Paris France

Directors

Elsevier

Sponsors