2. Safe Harbor Statement This presentation contains certain
forward-looking statements about Cytori Therapeutics, Inc. All
statements, other than statements of historical fact, that address
activities, events or developments that we intend, expect, project,
believe or anticipate will or may occur in the future are
forward-looking statements. Such statements are based upon certain
assumptions and assessments made by our management in light of
their experience and their perception of historical trends, current
conditions, expected future developments and other factors they
believe to be appropriate. The forward-looking statements included
in this presentation involve known and unknown risks that relate to
Cytoris future events or future financial performance and the
actual results could differ materially from those discussed in this
presentation. Risks and uncertainties that may cause Cytori's
actual results to differ materially from those discussed in the
presentation can be found in the "Risk Factors" section of Cytoris
Form 10-K, Forms 10-Q and other filings with the United States
Securities and Exchange Commission. We would advise reading our
most recent annual report on Form 10-K and quarterly report on Form
10-Q filed with the United States Securities and Exchange
Commission for a more detailed description of these risks. The
forward-looking statements contained in this presentation represent
Cytoris estimates and assumptions only as of the date of this
presentation and Cytori undertakes no duty or obligation to update
or revise publicly any forward-looking statements contained in this
presentation as a result of new information, future events or
changes in Cytoris expectations.
3. Cytori Investment Summary Highlights Phase II U.S. heart
failure trial U.S. government contract (BARDA) for thermal burns
Pipeline of therapeutic indications from independent studies
Adipose-derived cell therapy with device model Cardiovascular
disease & soft tissue injury Product & contract revenue
partially offsets cash burn Thousands of patients treated
worldwide
5. System: Low six figure ASP Next-generation system COGS <
$10,000 Per-procedure consumable: $8,000-$12,000 for vascular
indications $2,000-$3,000 for soft tissue >80% GM Cell therapies
via proprietary device & single-use consumables = Favorable
pricing and margin opportunity Cytori Cell Therapy: Commercial
Model & Economics
6. Therapeutic Focus CARDIAC SOFT TISSUE COMMERCIAL RESEARCH
MARKET U.S. Phase II in CHF Long term data from CHF and AMI trials
in EU Burns: U.S. govt contract worth up to $106 MM Hamstring
injury: U.S. trial EU/Japan approvals Research sales 50+ studies
completed, ongoing or planned
7. Cardiac Cell Therapy Damage to the heart leads to reduced
function, heart failure and death Current therapy does not address
damage to the heart muscle
8. PRECISE Pilot Showed Proof-of-Concept PRECISE TRIAL: 27
patient double-blind, randomized, placebo controlled European trial
Intramyocardial injection using electromechanical mapping in area
with inducible ischemia 18 month data presented, publication in
process DATA SUMMARY: Feasibility (Exercise Tolerance) VO2Max
(maximum oxygen consumption): improvement (p