APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
1
APRIL 7-8-92020
Scientific secretariatJacques Elion (Paris)
UNESCOPARIS
4thGlobal Congresson Sickle Cell
Disease
General organization :MCO Congrès - Villa Gaby285 Corniche JF. Kennedy13007 MarseillePhone : +33 (0)4 95 09 38 00www.mcocongres.com
www.global-scd2020.com
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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ORGANIZATION Chair Co-chairIsaac Odame Canada Jacques Elion France
INTERNATIONAL SCIENTIFIC COMMITTEE ChairKalpna Gupta USA
Co-chairMariane de Montalembert France
• Miguel Aboud Lebanon• Kunle Adekile Nigeria• Marina Cavazzana France• Nicola Conran Brazil• Lucia De Franceschi Italy• Dapa Diallo Mali• Olivier Hermine France• Baba Inusa UK• Dipty Jain India• Jennifer Knigth-Madden Jamaica• Clarisse Lobo Brazil• Julie Makani Tanzania• Kwaku Ohene-Frempong Ghana• Mohammed Cherif Rahimy Benin• David Rees UK• Ibrahima Sanogo Ivory Coast• Hariom Sharma India• Swee Lay Thein USA• Léon Tshilolo DRC• Russell Ware USA
ORGANIZING COMMITTEE ChairCaroline Le Van Kim Paris
• Philippe Connes Lyon• Sara El Hoss Paris• Wassim El Nemer Paris• Claudine Lapouméroulie Paris• Caroline Le Van Kim Paris• Thierry Peyrard Paris• Brigitte Ranque Paris• Marc Romana Guadeloupe
CONGRESS SECRETARIAT Jacques ElionSandrine Laurance Joël Veiga
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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SPEAKERS & CHAIRS
Prof. Miguel Abboud Department of Pediatrics and Ado-lescent Medicine, American Univer-sity of Beirut, Lebanon
Prof. Adekunle Adekile Departments of Pediatrics, Faculty of Medicine, Kuwait University, Sa-fat, Kuwait
Dr Slimane Allali Department of General Pediatrics and Pediatric Infectious Diseases, Reference Center for Sickle Cell Disease, Necker Hospital,AP-HP, University of Paris. Laboratory of Excellence, GR-Ex, Paris, France
Dr Kofi Anie Haematology and Sickle Cell Centre, London North West Univer-sity Healthcare NHS Trust, London, UK, Imperial College London, Lon-don, UK
Dr Monica AsnaniCaribbean Institute for Health Re-search-Sickle Cell Unit, The Univer-sity of the West Indies, Kingston 7, Jamaica
Prof. Cheick Oumar Bagayogo CERTES, Bamako, Mali
Prof. Pablo Bartolucci APHP, Hôpitaux Universitaire Henri Mondor, Unité des Maladies Géné-tiques du Globule Rouge, Centre de Référence des Pathologies du Glo-bule Rouge, Créteil, France
Dr Francoise Bernaudin Drepagreffe Association and Clini-cal Research in the Referral Center for SCD in Créteil, France (CHIC hospital)
Dr John Brewin Kings College London University, Kings College Hospital NHS Foun-dation Trust, London, UK
Prof. Mohammed Cherif RahimyComprehensive Medical Mana-gement Center for Infants and Pregnant Women with Sickle Cell Disease, Facutly of Human Medical Sciences, University of Abomey-Calavi , Cotonou , Benin
Prof. Thomas Coates Division of Hematology, Child-ren’s Center for Cancer and Blood Diseases, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Prof. Philippe Connes Laboratory LIBM EA7424, Team «Vascular Biology and Red Blood Cell», University of Lyon 1, Lyon, France
Dr Nicola Conran Hematology Center, University of Campinas-UNICAMP, SP, Brazil
Dr Bernard Dauvergne Excecutive Director, ADDMEDICA, Paris, France
Prof. Lucia De Franceschi Department of Medicine, University of Verona and AOUI Verona, Policli-nico GB Rossi, Verona, Italy
Prof. Mariane De Montalembert Department of General Pediatrics and Pediatric Infectious Diseases, Reference Center for Sickle Cell Disease, Necker Hospital for Sick Children, Assistance Publique - Hô-pitaux de Paris (AP-HP), University of Paris, France
Prof. Michael DeBaun Department of Pediatrics, Center of Excellence in Sickle Cell Disease, Vanderbilt University School of Me-dicine, Nashville, TN, USA
Prof. Dapa Diallo Sickle Cell Disease Research and Control Center, Bamako, Mali
Prof. Jain DiptyIndira Gandhi Government Medical College, Maharashtra, India
Dr Wassim El NemerUniversity of Paris, INTS, INSERM 1134 Integrated Biology of the Red Cell, Laboratory of Excellence GR-Ex, Paris, France
Prof. Jacques ElionUniversity of Paris, INTS, INSERM 1134 Integrated Biology of the Red Cell, Laboratory of Excellence GR-Ex, Paris, France Dr Cristina Epalza Ibarrondo Pediatric Infectious Diseases Service, University Hospital, Madrid, Spain
Prof. Eliane Gluckman EUROCORD Paris, France
Prof. Kalpna Gupta Division of Hematology/Oncology, University of California, Irvine, CA, USA
Prof. Martin H Steinberg Boston University School of Medi-cine, Boston, MA, USA
Dr Marie-Dominique Hardy-Dessources Integrated Biology of the Red Cell, University of Antilles, UMR_S1134, Pointe-a-Pitre, France
Prof. Robert Hebbel University of Minnesota Medi-cal School, Hematology-Oncolo-gy-Transplantation Division and Vascular Biology Center, Minneapo-lis, MN, USA
Prof. Baba Inusa Department of Paediatric Haema-tology, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Mr David Issom Division of Medical Information Sciences - University Hospitals of Geneva Department of radiology and medical informatics - Univer-sity of Geneva, Switzerland Prof. Julie Kanter Division of Hematology & Oncolo-gy, University of Alabama Birmin-gham, Birmingham, Alabama, USA
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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SPEAKERS & CHAIRS
Prof. Ataga Kenneth Center for Sickle Cell Disease, Uni-versity of Tennessee Health Science Center, Memphis, TN, USA
Prof. Fenella Kirkham Consultant Paediatric Neurologist, King’s College Hospital and Univer-sity Hospital, Southampton; Prof.essor of Paediatric Neurology, UCL, University of Southampton, UK
Prof. Jennifer Knight-Madden Caribbean Institute for Health Re-search-Sickle Cell Unit, The Univer-sity of the West Indies, Kingston 7, Jamaica
Dr Berengere Koehl University of Paris, INTS, INSERM 1134 Integrated Biology of the Red Cell, Laboratory of Excellence GR-Ex; APHP, Robert Debré Hospital, Reference Centre of Sickle Cell Di-sease, Paris, France
Prof. Caroline Le Van KimUniversity of Paris, INTS, INSERM 1134 Integrated Biology of the Red Cell, Laboratory of Excellence GR-Ex, Paris, France
Dr Stephan Lobitz Gemeinschaftsklinikum Mittelrhein, Department of Pediatric Hemato-logy and Oncology, Cologne, Ger-many
Dr Clarisse Lobo Arthur Siqueira Cavalcanti Institute of Hematology (HEMORIO), Rio de Janeiro, RJ, Brazil
Prof. Julie Makani Department of Haematology and Blood Transfusion, School of Medi-cine, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania
Dr Patrick McGann Cancer and Blood Diseases Insti-tute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Dr Annarita Miccio Laboratory of Chromatin and gene regulation during development, Ins-titute Imagine, INSERM UMR1163, University of Paris, France Prof. Obiageli Nnodu University of Abuja, Abuja, Nigeria
Prof. Stephen Obaro Department of Pediatrics, Univer-sity of Nebraska Medical Center, Omaha, NE, USA
Prof. Isaac Odame Medical Director, Global Sickle Cell Disease Network, Canada
Prof. Solomon Ofori Acquah University of Pittsburgh, USA and University of Ghana, Ghana
Prof. Kuaku Ohene-FrempongSickle Cell Foundation of Ghana, Kumasi, Ghana Prof. Caterina P. Minniti Division of Hematology, Monte-fiore Medical Center, Albert Eins-tein College of Medicine, Bronx, NY, USA
Dr Siris Patel Sickle Cell Clinic and Molecular Bio-logy Laboratory, Odisha Sickle Cell Project (NHM), Veer Surendra Sai Institute of Medical Science and Re-search (VIMSAR), Burla, Sambalpur, Odisha, India
Dr Thierry Peyrard Centre National de Référence pour les Groupes Sanguins (CNRGS), Institut National de la Transfusion Sanguine (INTS)University of Paris, INSERM 1134 Integrated Biology of the Red Cell, Paris, France
Dr Frédéric B. PielDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College Lon-don, UK
Prof. France Pirenne Etablissement Français du Sang, INSERM U955, Université Paris Est Créteil, Créteil, France
Prof. Brigitte Ranque Internal Medicine Unit, Hôpital Eu-ropéen Georges Pompidou, Assis-tance Publique des Hôpitaux de Paris, Paris, France
Prof. David Rees Department of Haematological Medicine, King’s College Hospital, King’s College London, UK
Prof. Elizabeth S Klings The Pulmonary Center, Boston Uni-versity School of Medicine, Boston, MA, USA
Dr Laurent Savale AP-HP, Service de Pneumologie, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France
Dr Ana-Cristina Silva Pinto Hemocentro de Ribeirão Preto, Fa-cutly of Medicine, University of São Paulo (USP), Ribeirão Preto, SP, Brazil
Prof. Alexis Thompson Chair in Childhood Cancer and Blood Disorders, Hematology Sec-tion Head; Prof.essor of Pediatrics Ann & Robert H. Lurie Children’s Hospital of Chicago, USA
Prof. Leon ThsiloloCenter Hospitalier Mère-Enfant, CEFA / Monkole, Kinshasa, Demo-cratic Republic of the Congo
Dr Sonya Wang Department of Neurology, Univer-sity of Minnesota, USA
Prof. Russel Ware Cancer and Blood Diseases Insti-tute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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08:00 REGISTRATION
09:00 Welcome Speech by Organizers Prof. Jacques Elion & Prof. Isaac Odame
10:00 PLENARY SESSION 1 Chair: Prof. Isaac Odame• The Epidemiologies of Sickle Cell Disease Dr Frédéric Piel (London, UK)
10:20 COFFEE BREAK
PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
Pregnancy in Sickle Cell Disease Chairs: TBA
Pulmonary Dysfuctions and Acute Chest Syn-drome in Sickle Cell Disease Chairs: TBA
Pathophysiology and Basic Science (session 1) Chairs: Prof. Caroline Le Van Kim & Prof. Lucia De Franceschi
10:40 SCD and Pregnancy-US PerspectiveProf. Caterina P. Minniti (Bronx, USA)
Clinical and Research Priorities in Lung Disease in Sickle CellProf. Elizabeth S Klings (Boston, USA)
Ischemia-Reperfusion: Novel Therapeutic Targets Prof. Robert Hebbel (Minneapolis, USA)
11:00 Sickle Cell Disease and Female Health – The In-dian Perspective from the Odisha Sickle Cell ProjectDr Siris Patel (Sambalpur, Odisha, India)
Lung Disease in Sickle Cell Disease: Complications and Management Prof. Michael DeBaun (Nashville, USA)
Inflammation in Sickle Cell DiseaseDr Nicola Conran (Campinas, SP, Brazil)
11:20 Pregnancy and Sickle Cell Disease in AfricaProf. Mohammed Cherif Rahimy (Cotonou, Benin)
Pulmonary hypertension in SCD: from diagnosis to managmentDr Laurent Savale (Paris, France)
Neutrophils in Sickle Cell Disease: Role and Mecha-nism of ActionDr Berengere Koehl (Paris, France)
11:40 Oral Presentation selected from Abstract
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11:55 Oral Presentation selected from Abstract
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12:10 LUNCH / PATIENT SESSION
TUESDAY 7th APRIL
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
Hydroxycarbamidein Sickle Cell Disease Chairs: Prof. Russel Ware & Prof. Leon Thsilolo
Clinical Variability in Sickle Cell DiseaseChairs: TBA
Neonatal Screening in Sickle Cell Disease Chairs: TBA
14:00 HC: Optimal Dosing and Limited Lab Monitoring Dr Patrick McGann (Cincinnati, USA)
Clinical and Genetic Varia-bility in Sickle Cell Disease Prof. Martin H Steinberg (Boston, USA)
Neonatal Screening in the Northern HemisphereDr Stephan Lobitz (Cologne, Germany)
14:20 Hydroxycarbamide: The European Experience Prof. Mariane De Montalem-bert (Paris, France )
Environmental factors and Sickle Cell Disease: Effects and OutcomesProf. David Rees (London, UK)
Newborn Screening for Sickle Cell Disease in the CaribbeanProf. Jennifer Knight-Madden (Kingston, Jamaica)
14:40 HC: For a Wider access to Treat SCD Patients Worldwide Dr Bernard Dauvergne (Paris, France)
Genomics and Sickle Cell Disease in AfricaProf. Solomon Ofori Acquah (Pittsburgh, USA)
Neonatal Screening of Sickle Cell Disease in AfricaProf. Obiageli Nnodu (Abuja, Nigeria)
15:00 Oral Presentation selected from Abstract
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15:15 Oral Presentation selected from Abstract
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15:30 COFFEE BREAK
PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
Infection and Sickle Cell Disease Chairs: TBA
Pain and Sickle Cell Disease Chairs: Prof. Thomas Coates& TBA
Transition: from pediatric to adult care Chairs: Prof. Mariane De Montalembert & Prof Dapa Diallo
15:45 Infection and SCD in Africa - A Global ViewProf. Stephen Obaro (Omaha, USA)
Pain and SCD: Prevention and ManagementProf. Kalpna Gupta (Irvine, USA)
Title: TBC Prof. Baba Inusa (London, UK)
16:05 Life Threatening Infection in SCD –European Pers-pectiveDr Cristina Epalza Ibarrondo (Madrid, Spain)
Sleep and Music Interven-tions: Exploring Comple-mentary Approaches to PainDr Sonya Wang(Minnesota, USA)
Challenges and opportu-nities for adolescents with sickle cell diseaseDr Monika Asnani (Kingston, Jamaica)
16:25 Oral Presentation selected from Abstract
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16:40 Oral Presentation selected from Abstract
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16:55 18:00 Poster session A
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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08:00 REGISTRATION
09:00 PLENARY SESSIONA 45 Year Odyssey through the Sickle Cell Disease World.Chair: Prof. Isaac Odame SICKLE CELL DISEASE: IN A GLOBAL STATE OF MIND Chairs: Prof. Kalpna Gupta & Prof. Kuaku Ohene-Frempong
10:00 Progress in Sickle Cell Disease Care: Past, Present and FutureProf. Alexis Thompson (Chicago, USA)
10:20 The Genetics Behind Cerebrovascular Complications in SCD. Dr John Brewin (London, UK)
10:30 COFFEE BREAK
11:00
SICKLE CELL DISEASE: IN A GLOBAL STATE OF MIND Chairs: Prof. Jacques Elion & Dr Frédéric PielSCD care: The African Point of View. Prof. Leon Thsilolo (Kinshasa, Congo)
11:20 Living with Sickle Cell Disease: Promises and Challenges of Digital HealthMr David Issom (Geneva, Switzerland)
11:40 Abstract selected for the Dominique Labie Prize
11:50 Abstract selected for the Sir David Weatherall Prize
12:00 LUNCH / PATIENT SESSION
PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
Novel Therapies in Sickle Cell Disease Chairs: TBA & Dr Ana Cristina Silva Pinto
non-SS Disease Session Chairs: TBA
Pathophysiology and Basic Science (Session 2) Chairs: Dr Wassim El Nemer & Dr Nicola Conran
13:30 Gene Therapy for SCD: Progress and Future ChallengesProf. Julie Kanter (Alabama, USA)
SC Disease in West Africa Prof. Dapa Diallo (Bamako, Mali)
Research on Sickle Cell Mouse Models: Challenges and OutcomesProf. Lucia De Franceschi (Verona, Italy)
13:50 Hematopoietic Stem Cell Transplantation for Sickle Cell Disease: Outcomes and FutureProf. Eliane Gluckman (Paris, France)
Overview of SCD in the Mediterranean Region: A Closer Look at Sß-thalas-semia patientsProf. Miguel Abboud (Beirut, Lebanon)
Innate Immune Cells in SCD: A Focus on Mast CellsDr Slimane Allali(Paris, France)
14:10 Pharmacological Approaches to the Treatment of Sickle Cell DiseaseProf. Ataga Kenneth (Memphis, USA)
Compound Heterozygote Sickle Syndrome in the Gulf AreaProf. Adekunle Adekile (Safat, Kuwait)
CRISPR/Cas9-based Therapeutic Strategies for Sickle Cell DiseaseDr Annarita Miccio(Paris, France)
WEDNESDAY 8th APRIL
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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14:30 Oral Presentation selected from Abstract
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14:45 Oral Presentation selected from Abstract
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15:00 COFFEE BREAK
PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
Brain and Cerbrovascular complications Chairs: TBA
Psychosocial session Chairs: TBA
E-medicine Chairs: TBA
15:15 Neurological Damage in Sickle Cell Disease: Patho-physiology, Management & PreventionProf. Fenella Kirkham (London, UK)
Psychological Therapies for Sickle Cell DiseaseDr Kofi Anie (London, UK)
Digital Health: The African ExperienceProf. Cheick Oumar Bagayogo (Bamako, Mali)
15:35 Cerebral Vasculopathy in Children with SCD: Detection, Prevention and ManagementDr Françoise Bernaudin (Créteil, France)
Oral Presentation selected from Abstract
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15:50 Oral Presentation selected from Abstract
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16:10 Oral Presentation selected from Abstract
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16:4018:00 Poster session B
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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THURSDAY 9th APRIL
PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
TransfusionChairs: TBA
Mortality in Sickle Cell DiseaseChairs: TBA
Integrative Physiology and Sickle Cell DiseaseChairs: TBA
9:00 Update on New Blood Groups and Consequences on SCDDr Thierry Peyrard (Paris, France)
Mortality in SCD – Indian PerspectiveProf. Jain Dipty (Maharashtra, India)
Autonomic Nervous System, Vasoconstriction and the Transition from Steady State to Vasoocclusive CrisisProf. Thomas Coates(Los Angeles, California, USA)
9:20 TBA Mortality and Sickle Cell Disease in BrazilDr Clarisse Lobo(Rio de Janeiro, Brazil)
Beneficial Effect of Exer-cise in SCDProf. Pablo Bartolucci (Créteil, France)
9:40 Alloimmunization and Sickle Cell DiseaseProf. France Pirenne(Créteil, France)
Oral Presentation selected from Abstract
Sickle Cell Disease: From Acute Excercise to TrainingProf. Philippe Connes (Lyon, France)
10:00 Oral Presentation selected from Abstract
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10:15 Oral Presentation selected from Abstract
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10:30 COFFEE BREAK
PARALLEL SESSION 1 PARALLEL SESSION 2 PARALLEL SESSION 3
Partnership in Sickle Cell Disease between and wit-hin countries Chairs: TBA
Round Table Session «Article & Grant Writing»Chairs: TBA
Patient SessionChairs: TBA
11:00 Caribbean Network of Researchers on Sickle Cell Disease and ThalassemiaDr Marie-Dominique Hardy-Dessources (Pointe-a-Pitre, France)
Article WritingDr Lan Lan Smith (London, UK)
Program of session TBA
APRIL 7-8-92020
UNESCO PARIS
4th Global Congresson Sickle Cell
Diseasewww.global-scd2020.com
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11:20 Title: TBA Prof. Julie Makani (Dar-es-Salaam, Tanzania)
Program of session TBA Program of session TBA
11:40 African Research and Inno-vative Initiative for Sickle cell Education: Implication for Service Improvement" Prof. Baba Inusa (London, UK)
Program of session TBA Program of session TBA
12:00 Comprehensive System of Care for Sickle Cell Disease in BrazilDr Ana-Cristina Silva Pinto (Ribeirão Preto, Brazil)
Program of session TBA Program of session TBA
12:20 Challenges of SCD Cohort Studies in AfricaProf. Brigitte Ranque(Paris, France)
Program of session TBA Program of session TBA
12:40 LUNCH
14:00 ROUND TABLEToward a Global Coalition to Conquer Sickle Cell DiseaseChair: Prof. Isaac OdameParticipants: representatives of WHO, The World Bank, US Dept. of Health and Human Services, Pierre Fabre Foundation, Norvartis, Addmedica
16:00 Closing comments of the Chairs
