TOXI-LAB The changing colors of drug identificationStandardized, simplified, documented, thin layer chromatography

You can spot the difference

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TOXI-LAB Drug Detection SystemScreen for over 700 drugs - with reliable results in less than one hour.

TOXI-LAB AB

Test for over 700 illicit, prescription, and nonprescription drugs with just one analysis. The TOXI-LAB AB Drug Detection System gives you all the supplies you need - including pre-made extraction tubes, chromatograms, standards, and reagent concentrates - to get reproducible results in just one hour.

• Comprehensive: One simple screening method for polydrug specimens.

• Information-rich: Features a database with extensive US and international drug photodocumentation.

• Cost-effective: Low startup costs with no expensive instrument maintenance or maintenance contracts.

• Environmentally friendly: No spraying of reagents.

The TOXI-LAB AB Procedure

1. Extraction

Pipet the sample into the extraction tube. Mix and centrifuge.

2. Concentration

Place a blank disc in a concentration cup for each sample. Transfer the upper (organic) layer from the extraction tube into the cup. Evaporate the organic layer to concentrate the analyte onto the disc.

3. Inoculation

Insert the dry disc into one of the center spaces (sample channels) of the TOXI-LAB Chromatogram.

4. Development

Develop the TOXI-LAB Chromatogram in developing solution. Pink dye markers will migrate with the solvent front. Remove the TOXI-LAB Chromatogram and dry it briefly.

5. Detection

A broad spectrum of analytes can be detected and differentiated by position (Rf) and color reaction through the detection stages.

TOXI-LAB AB consists of simple steps using specially modified reagents, materials, standards, and procedures. These special products and procedures significantly speed up the analysis and make results far more reproducible.

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Confirm marijuana metabolite at the same cutoff recommended for GC/MS

THC II and THC II Plus

Now you can screen or confirm for D9-THC-COOH in urine and get results in 20 minutes. TOXI-LAB THC II gives you a sensitivity of 15 ng/mL for both screening and confirmation - the same cutoff recommended for GC/MS by US SAMHSA guidelines. Additionally, this off-line analysis provides more GC/MS availability.

• Quick: Results in 20 minutes.

• Specific: No interfering substances.

• Cost-effective: Low startup cost and no capital investment. No expensive instrument maintenance or maintenance contracts.

Stage I

Stage II

Stage III

Stage IV Stage IStage II

TOXI-LAB B

TOXI-LAB A

phenobarbital

phenobarbital standard

amphetamine

amphetamine standard

codeine standard

codeine

secobarbital standard

secobarbital

It’s easy to spot hundreds of drugs with TOXI-LAB’s unique system of color reactions

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TOXI-LAB Identify and differentiate drugs with ease

morphine

hydromorphonedihydrocodeine

hydrocodone6-monoacetylmorphine

codeine

oxycodone

hydrocodone

metabolite

Differentiate individual opiates

LTD Opiate

When you need to know exactly which analyte produced a positive opiate class drug screen result, turn to the TOXI-LAB LTD Opiate System. With TOXI-LAB LTD, you can distinguish between morphine, normorphine, 6-monoacetylmorphine (6-MAM), hydromorphone, codeine, norcodeine, hydrocodone, dihydrocodeine, and oxycodone.

• Quick: Analyzes 10 to 20 specimens in 60 minutes.

• Specific: Differentiates individual drugs in the Opiate class.

• Sensitive: Limit of detection is 200 ng/mL.

Pinpoint “Rave” party drugs with ease

Sympathomimetic Amine (SMA)

Differentiation Special Procedures

From ecstasy to methamphetamine, the TOXI-LAB Sympathomimetic Amine (Amphetamines) Special Procedures can help you quickly detect and differentiate SMAs - up to 10 specimens in 45 minutes.

• Quick: Analyzes 10 specimens in 45 minutes.

• Specific: Differentiates MDMA, MDA, MDEA, amphetamine, methamphetamine, PMA, MBDB and BDB, ephedrine/pseudoephedrine, phentermine, phenylpropanolamine, and phenethylamine.

• Sensitive: Limit of detection is 250-500 ng/mL for most SMAs.

phentermine

MDEA

MDMA

methamphetamine

MBDB

amphetamine

PPABDB

MDAPMA

PEA

ephedrine

pseudoephedrine

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TOXI-LAB Identify and differentiate drugs with ease

Boost GC/MS and LC/MS efficiency

TOXI-TUBES

Use the quickest, easiest, and cleanest liquid/liquid extraction procedure available to increase your GC/MS and LC/MS efficiency. TOXI-TUBES give you a clean one-step process for extracting a broad range of drugs from biological or non-biological specimens.

• Boost GC/MS and LC/MS efficiency with fast simple drug extractions.

• Reduce risk of system downtime and increase throughput by reducing column changes.

• Quickly, easily, cleanly extract drugs from samples.

Nordiazepam

Oxazepam

Bromazepam

Flunitrazepam

Prazepam

Selected profiles of five benzodiazepines extracted from a whole blood sample using TOXI•TUBES A. Each drug was spiked at 50 ng/mL in blood.

Benzodiazepine Recovery ratio (%)

Whole Blood

Urine

Nordiazepam 75.5 88.2

Oxazepam 72.0 85.9

Bromazepam 67.8 91.2

Flunitrazepam 72.7 89.8

Prazepam 74.7 93.2

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TOXI-LAB AA-Tramadol

a-metabolites

Stage III

Stage IV

TOXI-LAB Quick and easy drug detection

TOXI-LAB

For over 35 years, the TOXI-LAB family of products has been the reliable choice for customers in the medical, industrial, forensic, and veterinary fields. Only TOXI-LAB has simplified and standardized thin layer chromatography (TLC), allowing you to quickly and easily identify specific analytes in a specimen, not just the drug class.

TOXI-LAB combines Rf with four stages of color reactions providing greater identification power than many other drug detection methods. You get reproducible results every time with TOXI-LAB’s built-in quality control and extensive drug photo-documented database.

Whether your lab is new to toxicology, upgrading from classical thin layer, or looking to supplement your current methodologies, TOXI-LAB is your clear choice for simplified and standardized thin layer chromatography.

Stage I

Stage II

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Agilent TOF LC/MS systems deliver exceptional MS analyses

Robust instruments and dedicated columns Agilent Technologies

In the forensics and investigative fields, much depends on the accuracy of your results. Whether testing for poisons in a forensics investigation, screening athletes for performance enhancing drugs, analyzing samples for recreational drugs, or checking a crime scene for explosive residues, lives and professions can depend on the accuracy of your equipment and the methods you use.

Agilent Technologies leads the industry with robust instruments, dedicated columns and sample prep technologies that confirm and quantify thousands of substances. Our workflow solutions let you maintain stringent practices, from sample preparation to analysis, which stand up to forensic scrutiny. When combined with our informatics architecture, you can manage large quantities of data while preserving the integrity and security of your results, and ensuring that justice is served.

• Use the Agilent 7000 Series Triple Quadrupole GC/MS by coupling the 7890A Chromatograph with the 7000B MS and an Agilent J&W HP-5ms Ultra Inert GC column to confirm and quantitate synthetic cannabinoids in herbal incense blends.

• The Agilent 6550 iFunnel Q-TOF LC/MS is the ultimate instrument for the analysis of unknown drugs, delivering low femtogram-level sensitivity with high resolution and accurate mass. When you are performing drug separation, you can trust Agilent's portfolio of LC and LC/MS columns to deliver the reproducible results you need.

Ensure excellent results with Agilent J&W GC columns

Agilent manufactures the widest portfolio of LC and LC/MS columns

Superior quality Agilent GC/MS systems

Learn morewww.agilent.com/chem/toxilab

Buy onlinewww.agilent.com/chem/store

Find an Agilent office or authorized distributorwww.agilent.com/chem/contactus

U.S. and Canada1-800-227-9770, agilent_inquiries@agilent com

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Agilent shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing,

performance, or use of this material.

Information, descriptions, and specifications in this publication are subject to change without notice.

© Agilent Technologies, Inc., 2012 Published in the USA, October 31, 2012

Publication Number 5991-1532EN

Agilent chemistries: providing you confidence and control

Agilent’s broad chemistries selection puts you in control of even the most difficult analyses. We manufacture columns and media that suit nearly every technique for small molecule analyses.

You can be confident that Agilent’s meticulous end-to-end oversight of production delivers you the highest column consistency and performance. With more than 40 years of experience in the production of polymers and silica chemistries, our team is committed to the continuous development of new column advances, so you stay ahead of the curve with the technology that will make you the most productive.

You can count on Agilent to support you at every step. Agilent’s infrastructure enables a delivery network that gets you what you need fast, anywhere in the world. That infrastructure also provides worldwide columns and chemistries technical support, as well as speedy problem resolution if you need it.

TOXI-LAB Customer Service and Technical support

Email: toxilab@agilent.com

Tel: 800-227-9770

Fax: 949-639-1326