Navesh K. Sharma, DO, PhD Curriculum Vitae Navesh K. Sharma, DO, PhD Assistant Professor, Department of Radiation Oncology Adjunct Assistant Professor, Department of Diagnostic Radiology and Nuclear Medicine Medical Director of Radiation Oncology, Kaufman Cancer Center, University of Maryland, Upper Chesapeake Health University of Maryland School of Medicine Date December 23, 2013 Contact Information Navesh K. Sharma, DO, PhD University of Maryland, Upper Chesapeake Health Kaufman Cancer Center Department of Radiation Oncology 500 Upper Chesapeake Drive Bel Air, MD 21014, USA E-mail: [email protected]Tel: (443) 643-1873 Fax: (443) 643-1521 Education 1995 B.S. Biology (emphasis in genetics), Summa Cum Laude, St. Cloud State University, St. Cloud, MN 2000 Ph.D. Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA 2005 D.O. Medicine, Kansas City University of Medicine and Biosciences – COM, Kansas City, MO Post Graduate Education and Training 2001 Fellowship H. B. Wallace Postdoctoral Fellowship Department of Anatomy and Cell Biology University of Iowa College of Medicine, Iowa City, IA
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Navesh K. Sharma, DO, PhD
Curriculum Vitae
Navesh K. Sharma, DO, PhD
Assistant Professor, Department of Radiation Oncology
Adjunct Assistant Professor, Department of Diagnostic Radiology and Nuclear Medicine
Medical Director of Radiation Oncology, Kaufman Cancer Center, University of Maryland, Upper Chesapeake Health
University of Maryland School of Medicine
Date December 23, 2013
Contact Information
Navesh K. Sharma, DO, PhD University of Maryland, Upper Chesapeake Health Kaufman Cancer Center Department of Radiation Oncology
Medical Director, Department of Radiation Oncology, UCHS
Interim Director, Billing and Compliance, Department of Radiation Oncology, UMSOM
Secondary Academic Appointment
2011- Present Assistant Professor, Department of Diagnostic Radiology and Nuclear Medicine, UMSOM
Navesh K. Sharma, DO, PhD
Clinical Privileges
2010- Present
2010- Present
2013- Present
University of Maryland Medical Center, Baltimore, MD Baltimore VA Medical Center, Baltimore, MD Upper Chesapeake Medical Center, Bel Air, MD
Professional Memberships
1996- Present
2001- Present
2006- Present
2006- Present
2006- Present 2006- Present
2006- Present
2010- Present 2011- Present Honors and Awards
Undergraduate
11/1995
08/1997
Graduate School
12/1998
11/2000
Medical School
05/2002-03
American Association for Cancer Research
American Osteopathic Association
American Society for Radiation Oncology
American Society for Clinical Oncology
American Brachytherapy Society
Radiological Society of North America
Radiation Therapy Oncology Group
Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)
American College of Radiation Oncology
Graduated Summa cum Laude, St. Cloud State University, St. Cloud, MN
Inducted into Sigma Xi National Science Honor Society
Young Investigator Research Award, American Association for Cancer Research, Palm Springs, CA
Young Investigator Award, Society for Basic Urologic Research, Sanibel, FL
Excellence in Biomedical Research Fellowship, Kansas City University of Medicine and Biosciences, Kansas City, MO
Navesh K. Sharma, DO, PhD
2002, 03, 04 Best Medical Student Research Award, Kansas City University of Medicine and Biosciences, Kansas City, MO
05/2005 Basic Science Research Award, Kansas City University of Medicine and Biosciences, Kansas City, MO
Residency
08/2008 Selected for ASCO/ACR Methods in Clinical Cancer Research Workshop, Vail, CO
07/2008-06/09
09/2008
Chief Resident, Fox Chase Cancer Center, Philadelphia, PA
Radiation Therapy Oncology Group Fellowship, Philadelphia, PA
04/2009 Young Oncologist Essay Award, American Radium Society, Vancouver, BC
07/2009
02/2010
RSNA Roentgen Resident/Fellow Research Award
ASTRO Abstract Award- Multidisciplinary Head and Neck Cancer Meeting, Chandler, AZ
Attending Physician
2011 Selected for American Brachytherapy Society HDR Fellowship 2012 Awarded Department of Radiation Oncology Seed Grant for Research
Clinical Activities
Clinical Expertise
Liver-Directed Therapy
Gastrointestinal Malignancies
Lymphoma and Leukemia
Gynecological Malignancies
Genitourinary Malignancies
Head and Neck Malignancies
Breast Malignancies
Thoracic Malignancies
Technical Expertise
Transarterial Radioembolization/Selective Internal Radiation Therapy (SIRT) - leader of one of the largest programs in the country
Navesh K. Sharma, DO, PhD
Intensity Modulated Radiation Therapy (IMRT)
Image Guided Radiation Therapy (IGRT)
Stereotactic Radiosurgery (SRS)
Stereotactic Body Radiation Therapy (SBRT)
Total Body Irradiation (TBI)
High Dose Rate (HDR) Gynecologic Brachytherapy
Low Dose Rate (LDR) Prostate Brachytherapy
Scope of Clinical Practice Large cancer medical center
300-350 patient consultations per year
300 patients treated per year Clinical Duties: 4 days/week, 12 months/year
Clinical Trials
National/International Protocol Principal Investigator
2013- Present STXO l 12 (FOXFIRE Global): Assessment of Overall Survival of FOLFOX6m plus SIR-Spheres Microspheres Versus FOLFOX6m Alone as First-Line Treatment in Patients with Non-Resectable Liver Metastases from primary Colorectal Carcinoma in a Randomized Clinical Study
Institutional Principal Investigator of National/International Protocols
2011 - 2013
2012- Present 2012- Present
GCC 0654 H-28622: Randomized Comparative Study of FOLFOX6M Plus Sir-spheres versus FOLFOX6M Alone as First Line Treatment in Patients With Non-Resectable Liver Metastases From Primary Colorectal Cancer
RTOG 1114: Phase II Randomized Study of Rituximab, Methotrexate, Procarbazine, Vincristine, and Cytarabine With and Without Low-Dose Whole-Brain Radiotherapy for Primary Central Nervous System Lymphoma
RTOG 1271: A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision
Navesh K. Sharma, DO, PhD
Institutional Co- Investigator of National/International Protocols
2010 - Present
2011 - 2012
2011 - 2012
2011 - 2012
2011 -Present Teaching Service
RTOG 0724 - Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy
RTOG 1010 - A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of Her2-0ver expressing Esophageal Adenocarcinoma
CALGB 50801 - Phase II Trial of Respond-Adapted Therapy based on Positron Emission Tomography (PET) for Bulky Stage I and Stage II Classical Hodgkin Lymphoma (HL)
HO Rad Biodose - Radiation Biodosimetry in Patients Treated With A Single Dose of Radiation To Prevent Heterotopic Ossification
RTOG 0848: Phase III Trial Evaluating both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma
The University of Iowa College of Medicine (50-60 students)
1996
1997
1997
2000- 01
Graduate Teaching Assistant, Dental Histology, University of Iowa, Iowa City, IA
Graduate Teaching Assistant, Dental Gross Anatomy, University of Iowa, Iowa City, IA
Graduate Teaching Assistant, Medical Neuroscience, University of Iowa, Iowa City, IA
Graduate Instructor, University of Iowa Student Athlete Tutoring Program, Iowa City, IA
Navesh K. Sharma, DO, PhD
Kansas City University of Medicine and Biosciences- COM (1-2 students per session)
2002- 05 Peer Tutor, Medical Pharmacology, Kansas City University of Medicine and Biosciences, Kansas City, MO
Clinical Teaching Duties (University of Maryland Medical Center)
2011-Present Medical Advisor, Radiation Oncology Medical Dosimetry Program, UM SOM
Clinical Resident Lectures, UMSOM, Dept. of Radiation Oncology (15-20 attendees)
Sept 16, 2010
Nov 17, 2010
Dec 20, 2010
Mar 01 , 2011
Mar 03, 2011
May 11, 2011
Jun 08, 2011
Sep 07, 2011
Dec 05, 2011
Dec 07, 2011
Jan 30, 2012
Apr 02, 2012
Apr 12, 2012
Apr 19, 2012
Apr 26, 2012
May 07, 2012
May 14, 2012
May 14, 2012
Q & A on Breast Cancer-Breast Cancer: Jeopardy
Management of Malignant Liver Lesions
Rectal Cancer Management
SIRT Therapy and Clinical Applications
Wilms Tumor Management
Hodgkins Lymphoma Field Design Non Hodgkins Lymphoma – Management and Field Design
Thoracic Oral Boards Review
GI Mock Orals- Dr. Benjamin Laser
Gyn Oral Board Review
GI Mock Orals- Dr. Elizabeth Nichols
Lymphoma Mock Orals- Dr. Grace Kim
GI Mock Orals- Dr. Randi Cohen
Gyn Mock Orals- Dr. Randi Cohen
Lymphoma Mock Orals- Dr. Randi Cohen
Hodgkin's Lymphoma Lecture
Non-Hodgkin’s Lymphoma
GI/Gyn Mock Orals- Dr. Geoffrey Neuner
Navesh K. Sha rma, DO, Ph D
May 16, 2012 Lymphoma Jeopardy
May 21, 2012
Nov 11, 2012
Nov 21, 2012
Dec 5, 2012
Dec 10, 2012
May 13, 2012
May 15, 2013
May 19, 2013
May 19, 2013
Lymphoma Field Design Lecture
Gyn Journal Club
Gyn Jeopardy
Lymphoma mock orals- Dr. Sarah Grabowski
Treatment film rounds
Non-Hodgkin's Lymphoma: Updates in Field Design and Management
Hodgkin's Lymphoma Update
Gyn Mock Orals- Dr. Grace Kim
Gyn Mock Orals- Dr. Zain Hussain
Radiobiology Lecture Series, UMSOM, Dept. of Radiation Oncology (10-15 attendees)
Dec 8, 2010
Mar 9, 2011
Dec 14, 2011
Mar 13, 2013
Total Body Irradiation Effects
Review of Radiobiology for In-service exams
Effects of TBI on the developing fetus
Radiobiology Review: What's clinically relevant?
Resident Research Sponsorships/Mentorships, UMSOM, Dept. of Radiation Oncology
2010-2011
2010- 2011
Sarah Grabowski, MD Topic: The Efficacy of Selective Internal Radiation Therapy (SIRT) with Yttrium-90 (Y90) is Enhanced When Given in Low Volume Disease and in Conjunction With Other Liver-Directed Therapies Result: Accepted for presentation at the American Society for Radiation Oncology Annual Meeting, Miami, FL, October 2011
Elizabeth Nichols, MD Topic: Performance Status (PS), Number of Lesions and Interval from Metastatic Diagnosis to Treatment (IMDTT) Predict for Overall Survival (OS) in Patients Treated with Hepatic Transarterial Radioembolization (TARE) using Yttrium-90 (Y90) Microspheres. Result: Accepted for presentation at the American Society for Radiation Oncology Annual Meeting, Miami, FL, October 2011
Navesh K. Sharma, DO, PhD
Medical Student Mentoring
2012 2012-13
Duc Nguyen, BS (MS I) Topic: Low Dose RT plus modified Docetaxel, Cisplatin, 5-Fluorouracil (mDCF) Chemotherapy in the Treatment of Advanced Gastric/GE Junction Cancers: A Pilot Study Result: Awarded radiation oncology summer research fellowship and abstract presented at the American Society for Radiation Oncology Annual Meeting, Atlanta, GA, September 2013
Huma Chaudhry, BS (MSIII) Topic: 1. Association between k-Ras mutation status and outcomes in patients treated with radioembolization for metastatic colorectal cancer 2. The role of radiation therapy in pancreatic neuroendocrine malignancies Result: Both abstracts accepted for presentation at the American Society for Radiation Oncology Annual Meeting, Atlanta, GA, September 2013
Administrative Services National
2009- Present
2009- 2011
2009- Present
2010- Present
2011
2011- Present
2011- Present
2011- 2012
2013- Present
ASTRO Radiation and Cancer Biology Committee- Examination Subcommittee
Disease Specific Practice Guidelines- Rectum (Co-Leader)
Disease Specific Practice Guidelines- Anus (Co-Leader)
Disease Specific Practice Guidelines- Lymphoma (Co-Leader)
Radiation Oncology Residency Program (Associate Director)
IT Steering Committee (Physician Leader)
IT Committee (Co-Leader)
Medical Advisor, Radiation Oncology Medical Dosimetry Program
EMR Subcommittee (Physician Leader)
Radiation Oncology Billing and Compliance, Interim Director
Institutional (UMSOM)
Committees
2010- Present
20 1 0- Present
2011- Present
20 1 0- Present
20 1 0- Present
2012- Present
2013- Present
2013- Present
Tumor Boards
20 1 0- Present
20 1 0- Present
20 1 0- Present
Technology Research Review Committee
Cancer Research Committee
University of Maryland Dosimetry School Curriculum Committee
University of Maryland Dosimetry School Advisory Committee
American College of Surgeons accredited Cancer Committee
Institutional Review Board Consultant
Institutional Information Technology Committee
School of Medicine Council- Alternate
GI Tumor Board
GYN Tumor Board
Liver Tumor Board
Navesh K. Sharma, DO, PhD
2010- Present Lymphoma & Leukemia Tumor Board
2010- Present Pediatric Tumor Board
Other
2010- Present “Ask the Expert” (www.umm.edu website) – SIR – Spheres Therapy
Institutional (UMM-UCH)
Committees
2013- Present Cancer Advisory Board
2013- Present Cancer Committee
2013- Present Breast Cancer Committee
Tumor Boards
2013- Present Thoracic Tumor Board
2013- Present Breast Tumor Board
2013- Present General Tumor Board
2013- Present Lymphoma Tumor Board
2013- Present HMH Oncology Conference
Local/Regional
2010- 2013
Editorial Service
2010- Present
Pediatric Tumor Board, Children's National Medical Center (Washington, DC)
Associate Editor, ASTRO Radiation and Cancer Biology Practice Exam
Navesh K. Sharma, DO, PhD
Ad hoc Journal Review
2009- Present
2009- Present
2011- Present
2011- Present 2011- Present
2012- Present
2013- Present
American Journal of Clinical Oncology
Cancer
Journal of Nuclear Medicine and Radiation Therapy
Radiotherapy and Oncology
Cancer Chemotherapy and Pharmacology
Radiation Oncology
Thoracic Cancer
National Examination Question Writer
2009- Present ASTRO Annual Radiation and Cancer Biology Examination Guide
Publications
Peer-Reviewed Journal Articles
1. Luo J, Sharma NK, Seftor EA, DeLarco JE, Heidger PM, Hendrix MJC, Lubaroff DM. (1997). Heterogeneous Expression of lnvasive and Metastatic Properties in a Prostate Tumor Model. Pathol. Oncol. Res., 3: 264-271.
2. Sharma NK, Luo J, Kirschmann DA, O'Malley Y, Robbins ME, Akporiaye ET, Lubaroff DM, Heidger PM, Hendrix MJC. (1999). A Novel Immunological Model for the Study of Prostate Cancer. Cancer Res., 59: 2271-276.
3. Sharma NK, Seftor RE, Seftor EA, Gruman LM, Heidger PM, Cohen MB, Lubaroff DM, Hendrix MJC. (2002). Prostatic Tumor Cell Plasticity Involves Cooperative Interactions of Distinct Phenotypic Subpopulations: Role in Vasculogenic Mimicry. Prostate, 50(3): 189-201.
4. Sharma NK, Sorosky JI, Bender D, Fletcher MS, Sood AK. (2005). Malignant Mixed Mullerian Tumor (MMMT) of the Cervix. Gynecol. Oncol., 97(2): 442-5.
Navesh K. Sharma, DO, PhD
5. Anderson P, Freedman GM, Sharma NK, Nicolaou N, Topham N, Morrow M. (2009). Post-
mastectomy Chest Wall Radiation to a Temporary Tissue Expander or Permanent Breast Implant- Is There a Difference in Complication Rates? Int. J. Rad. Oncol. Biol. Phys., 74(1):81-5.
7. Turaka A, Li T, Sharma, NK, Li L, Nicolaou N, Mehra R, Burtness B, Cohen RB, Lango MN, Horwitz EM, Ridge JA, Feigenberg SJ. (2010). Increased Recurrences Using
Intensity Modulated Radiation Therapy in the Postoperative Setting. Am. J. Clin. Oncol., 33(6):599-603.
8. Cohen RJ, Sharma NK, Yu JQ, Wang L, Buyyounouski MK, Unger M, Borghaei H, King E, Scott W, Callahan E, Movsas B, and Feigenberg SJ (2010). A Phase I Radiation Dose Escalation of Stereotactic Body Radiotherapy for Malignant Lung Tumors. J. Biomed. Sci. Engg., 3(4):351-358.
9. Sharma NK, Li TL, Pollack A, Chen YT, Horwitz EM, Buyyounouski MK. (2011). Intensity Modulated Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Int. J. Rad. Oncol Biol. Phys., 80(2):43 7-44.
10. Sharma NK, Silverman JS, Li TL, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol NJ, Cohen SJ, Freedman GM, Konski AA. (2011). Decreased Post-treatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Gastrointest. Cancer Res., 4(3):84- 89.
11. Sharma NK, Pandya NB, Wong RK, Herman JM, Hanna NN, Laheru DA, Major P, Alexander HR, Kennedy NL, Regine WF. (2012). Evaluation of Low-Dose Fractioned Radiation Therapy as a Gemcitabine Chemopotentiator in Advanced Pancreas Cancer. J. Rad. Oncol. (Submitted).
12. Lubbe W, Cohen R, Sharma NK, Ruth K, Peter R, Li J, Buyyounouski M, Kutikov A, Chen D, Uzzo R, Horwitz E. (2012). Biochemical and Clinical Experience with Real-Time Intraoperatively Planned Permanent Prostate Brachytherapy. Brachytherapy, 11(3):209-13.
13. Mahmood U, Errens M, Zimrin A, Hanna N, Amin P, Sharma NK. (2012). The Remarkably Distensible Stomach: Case Report Highlighting Its Implications For Radiation Treatment Planning. Practical Rad. Oncol. 2(4):265-69.
14. Sharma NK, Silverman JS, Scott WJ, Borghaei H, Buyyounouski M, Movsas B, and Feigenberg SJ. (2012). FDG-PET Scans in the Management of Patient Care Following
Stereotactic Body Radiotherapy for Lung Cancer: A Surrogate for Response? Thoracic Cancer (In review)
Navesh K. Sharma, DO, PhD
15. Nichols RC Jr, Huh SN, Prado KL, Yi BY, Sharma NK, Ho MW, Hoppe BS, Mendenhall NP, Regine WF. (2012). Protons Offer Reduced Normal-Tissue Exposure for Patients Receiving Postoperative Radiotherapy for Resected Pancreatic Head Cancer. Int. J. Rad. Oncol. Biol. Biophys., 83(1): 158-63.
16. Feigenberg SJ, Campassi C, Sharma NK, Kesmodel SB, Tkaczuk K, Yu JQ. (2012). Integration of Modern Imaging Into the Multidisciplinary Setting: The Radiation Oncology Perspective. Applied Radiol. 41(3): 24-30.
17. Reese A, Feigenberg SJ, Husain Z, Webb TJ, Hausner PF, Edelman MJ, Feliciano J, Tkaczuk K and Sharma NK. (2013). Stereotactic Ablative Therapy: Im pact on the Immune System and Potential for Future Therapeutic Modulation. Mol. Cell. Pharmacol. (Accepted).
18. Reese AS, Yang X, Laser B, Lu W, Sharma NK, Feigenberg SJ, Regine WF, Yi B. (2013). Deformable Image Registration (DIR) as a Method to Assess Motion for Pancreatic Cancer using 4D Computed Tomography (CT) Scans, J. of Applied Clin. Medical Physics (In Revision).
19. Nguyen, D. M., Chang, E.T., Sharma, N., and Carrier, F. (2013). Contribution of Dual Oxidase 2 (DUOX2) to Hyper Radiosensitivity in Human Gastric Cancer Cells, Radiation Research (In review).
Invited Commentaries
1. Sharma NK and Regine W. (2011) Radiation Therapy in Resected Pancreatic Cancer: Clearing Up the Fog. Oncol., 25(8): 1-3.
Book Chapters
1. Hendrix MJC, Luo J, Seftor EA, Sharma NK, Heidger PM, Cohen MB, Bhatty R, Chunthapong J, Seftor REB, Lubaroff DM. (2007) Epithelial-mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity. In Metastasis of Prostate Cancer Ablin RJ, and Mason MD, eds.; Springer: Amsterdam, Vol. 10, pp 127-141.
2. Feigenberg SJ, Cohen R, Sharma NK, Husain Z, Chen S and Dawson LA. (2013) Stereotactic Body Radiation Therapy. In Principles and Practice of Stereotactic Radiosurgery, 2nd edition, Chin L and Regine WF, eds.; Springer: New York (In press)
Selected Abstracts
Oral Presentation
1. Maniotis AJ, Hess AR, Seftor REB, Seftor EA, Sharma N, Gruman-Gardner LM, Folberg R, and Hendrix MJC. Vascular Channel Formation by Human Melanoma Cells In Vitro and In Vivo: Vasculogenic Mimicry. Oral presentation at the ARVO annual meeting, April 1998.
2. Sharma N, Seftor REB, Seftor EA, Heidger PM, Cohen MB, Folberg R, Miller, GJ, Lubaroff DM, and Hendrix MJC. Vasculogenic Mimicry by Aggressive Prostate Cancer: Molecular Mechanisms Contributing to Invasive Behavior. Oral presentation at the FASEB Annual Meeting, April 2000. FASEB J. 14: A272, 2000.
Navesh K. Sharma, DO, PhD
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3. Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Dynamic Remodeling of Prostate Adenocarcinoma Microenvironment: Role of lndividual Tumor Cell Populations in Development of Patterned Tubular Intratumoral Networks. Oral presentation at the Society for Basic Urologic Research Fall Symposium, November, 2000.
4. Sharma NK. Dynamic Remodeling of Prostatic Adenocarcinoma Microenvironment by Tumor Cells: A Mechanism for Tumor Survival and Dissemination? Oral presentation at the 10th Annual U H S Research Symposium, January 2002.
5. Sharma NK, Sharma CG, and Peffley OM. Genistein, Perillyl Alcohol and y-Tocotrienol Differentially Influence PC3 and DU145 Prostate Cancer Cells In Vitro. Oral presentation at the 11th Annual UHS Research Symposium, January 2003.
6. Sharma NK, Pollack A, Horwitz EM, Li T, and Buyyounouski MK. Intensity Modulate Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Oral Presentation at the 49th ASTRO annual meeting, October, 2007. Int. J. Rad. Oncol. Biol. Phys., 69 (3): SI O, 2007.
7. Sharma NK, Silverman JS, Li T, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol N, Cohen SJ, Freedman GM, and Konski AA. Decreased Post-Treatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Oral presentation at the 90th ARS annual meeting, May, 2008. Oncology, 22(4): 7, 2008.
8. Sharma NK, Ruth K, Yu JQ, Nicolaou N, Buyyounouski MK, Konski AA Movsas B, and Feigenberg
SJ. A 55% Decrease in Maximal 18-Flurodeoxyglucose Positron Emission Tomography (FDG-PET) Standardized Uptake Value (SUV) May Predict for Local Control Following Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 4th International Conference on Translational Research March, 2009. Radiother. Oncol., 90(3):S46, 2009.
9. Sharma NK, Ruth K, Movsas B, Yu JQ, Buyyounouski MK, Konski AA, Lally BE, and Feigenberg SJ. A Low Initial Standardized Uptake Value on FDG-PET Scan May Predict for Decreased Local Control in Patients Treated with Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 91st ARS annual meeting, April, 2009.
10. Sharma NK, Harris, J, Horwitz EM, Langer CJ, Nicolaou N, Kies M, Curran WJ, Wong S, Ang KK. Age, Performance Status and Interval From Prior Radiation Therapy to Recurrence Predict for Overall Survival (OS) in Re-irradiated Head and Neck Cancer Patients Treated on RTOG 9911: Results of a Recursive Partitioning Analysis. Plenary presentation at the ATSRO/ASCO/AHNS multidisciplinary head and neck cancer meeting, February 2010.
11. Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Dynamic Remodeling of Prostate Adenocarcinoma Microenvironment: Role of lndividual Tumor Cell Populations in Development of Patterned Tubular Intratumoral Networks. Oral presentation at the Society for Basic Urologic Research Fall Symposium, November, 2000.
Navesh K. Sharma, DO, PhD
'
12. Sharma NK. Dynamic Remodeling of Prostatic Adenocarcinoma Microenvironment by Tumor Cells: A Mechanism for Tumor Survival and Dissemination? Oral presentation at the 10th Annual U H S Research Symposium, January 2002.
13. Sharma NK, Sharma CG, and Peffley OM. Genistein, Perillyl Alcohol and y-Tocotrienol Differentially Influence PC3 and DU145 Prostate Cancer Cells In Vitro. Oral presentation at the 11th Annual UHS Research Symposium, January 2003.
14. Sharma NK, Pollack A, Horwitz EM, Li T, and Buyyounouski MK. Intensity Modulate Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Oral Presentation at the 49th ASTRO annual meeting, October, 2007. Int. J. Rad. Oncol. Biol. Phys., 69 (3): SI O, 2007.
15. Sharma NK, Silverman JS, Li T, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol N, Cohen SJ, Freedman GM, and Konski AA. Decreased Post-Treatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Oral presentation at the 90th ARS annual meeting, May, 2008. Oncology, 22(4): 7, 2008.
16. Sharma NK, Ruth K, Yu JQ, Nicolaou N, Buyyounouski MK, Konski AA Movsas B, and Feigenberg SJ. A 55% Decrease in Maximal 18-Flurodeoxyglucose Positron Emission Tomography (FDG-PET) Standardized Uptake Value (SUV) May Predict for Local Control Following Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 4th International Conference on Translational Research March, 2009. Radiother. Oncol., 90(3):S46, 2009.
17. Sharma NK, Ruth K, Movsas B, Yu JQ, Buyyounouski MK, Konski AA, Lally BE, and Feigenberg SJ. A Low Initial Standardized Uptake Value on FDG-PET Scan May Predict for Decreased Local Control in Patients Treated with Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 91st ARS annual meeting, April, 2009.
18. Sharma NK, Harris, J, Horwitz EM, Langer CJ, Nicolaou N, Kies M, Curran WJ, Wong S, Ang KK.
Age, Performance Status and Interval From Prior Radiation Therapy to Recurrence Predict for Overall Survival (OS) in Re-irradiated Head and Neck Cancer Patients Treated on RTOG 9911: Results of a Recursive Partitioning Analysis. Plenary presentation at the ATSRO/ASCO/AHNS multidisciplinary head and neck cancer meeting, February 2010.
19. Sharma NK, Pandya N, Wong R, Herman J, Hanna NN, Laheru DA, Major P, Alexander HR, Kennedy N, Regine WF. Low Dose Upper Abdominal Radiation Therapy (LD- UART) Potentiates Gemcitabine in Patients with Advanced, Unresectable Pancreatic Cancer (PC): Final Results from a Phase II Multi-Institutional Study. Int. J. of Rad Onc. Biol. Phys., 78(3): S103, 2010.
Navesh K. Sharma, DO, PhD
20. Garofalo M, Moughan J, Hong T, Bendell J, Berger A, Lerma F, Lee R, Anne P, Sharma NK, Crane C. RTOG 0822: A Phase II Study of Preoperative (PREOP) Chemoradiotherapy (CRT) Using IMRT in Combination with Capecitabine (C) and Oxaliplatn (O) for Patients with Locally Advanced Rectal Cancer. Int J. of Rad. Oncol. Biol. Phys., 81(2): S3-4, 2011.
21. Kennedy AS, Ball D, Cohen S, Cohn M, Coldwell A, Drooz A, Ehrenwald E, Kanani S, Moeslein FM, Nutting CW, Putnam SG, Rose SC, Savin M, Schirm S, Sharma NK and Wang E. Multicenter Comparison of Safety and Efficacy of Yttrium-90 Resin Microspheres in Elderly (2: 70 years) and Younger Patients with Unresectable Liver- Dominant Metastatic Colorectal Cancer. CIRSE meeting, September 2013.
Poster Presentation
1. Sharma N, Luo J. Seftor EA, DeLarco JE, Heidger PM, Hendrix MJC and Lubaroff DM. Phenotypic Correlates of Invasion in Prostatic Cancer Cells. Poster presentation at the AACR annual meeting, April 1997. Proc. Amer. Assoc. Cancer Res., 38: 547, 1997.
2. Luo J, Sharma N, Seftor EA, Heidger PM, Lubaroff DM, and Hendrix MJC. Heterogeneous Expression of E-cadherin/catenin Complex and its Modulation by E- cadherin Transfection in Prostate Cancer Cells. Poster presentation at the AA CR annual meeting, April 1998. Proc. Amer. Assoc. Cancer. Res., 39: 500, 1998.
3. Sharma N, Luo J, Lubaroff DM, Heidger PM, and Hendrix MJC. A Novel Tumor- Immunological Model for the Study of Prostate Cancer. Poster presentation at the AACR annual meeting, April 1998. Proc. Amer. Assoc. Cancer. Res., 39: 614, 1998.
4. Sharma N, Luo J, Maniotis AJ, Kirschmann DA, Heidger PM, Lubaroff DM, and Hendrix MJC. Tumor Cell Mediated Immunosuppression and Angiogenesis in the Dunning Gelatin-Sponge Retrieval System. Poster presentation at the AACR special meeting “New Research Approaches in the Prevention and Cure of Prostate Cancer,” December 1998.
5. Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Formation of Patterned Intratumoral Networks in Aggressive Heterogeneous Prostate Cancer: Molecular Determinants and Role of Individual Populations. Poster presentation at the AACR annual meeting, April 2001. Proc. Amer. Cancer. Res., 42: 110, 2001.
6. Sharma NK, Hentosh P, and Peffley DM. Differential Inhibition of lnvasive Properties in PC3 and DU I 45 Prostate Cancer Cells by Genistein, Perillyl Alcohol and y-Tocotrienol. Poster presentation at the AACR annual meeting, July 2003. Proc. Amer. Assoc. Cancer Res.,44: 611, 2003.
Navesh K. Sharma, DO, PhD
7. Sharma NK, Sharma CG, and Peffley DM. Inhibition of Molecular Pathways Involved in Prostatic Adenocarcinoma Invasion and Metastasis by Genistein and Perillyl Alcohol: A Potential Therapeutic Intervention Strategy? Poster presentation at the 12th Annual UHS Research Symposium, January 2004.
8. Sharma NK, Ruth K, Horwitz E, Buyyounouski M, and Pollack A. Statin use During Radiation Therapy Does not Improve Outcome: The Fox-Chase Experience. Poster presentation at the 48th ASTRO annual meeting, November 2006. Int. J. Rad. Oncol. Biol. Phys., 66(3): S366, 2006.
10. Feigenberg SJ, Sharma NK, Wang L, Cohen R, Buyyounouski MK, Lally BE, and
Movsas B. Phase I Dose Escalation Trial of Image Guided Stereotactic Body Radiotherapy for Lung Tumors. Poster discussion at the 50th annual ASTRO meeting, September, 2008. Int. J. Rad. Oncol. Biol. Phys., 72(1): SJ 14, 2008.
11. Sharma NK, Ruth K, Konski AA, Buyyounouski MK, Nicolaou N, Lally BE, Yu JQ, Langer CJ, Movsas B, and Feigenberg SJ. Low Morbidity and Excellent Local Control Using Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Tumors. Poster Presentation at the 50th annual ASTRO meeting, September, 2008. Int. J. Rad. Oncol. Biol. Phys., 72(1): S454, 2008.
12. Cohen RJ, Sharma NK, Li J, Ruth KJ, Buyyounouski MK, Crawford K, Uzzo RG, Horwitz EM. Sleeved Seeds Decrease Post-implant Hotspots in Real-time Intra- operatively Planned Permanent 1-125 Prostate Implants. Poster presentation at the 2009 annual ABS meeting, May, 2009. Brachytherapy, 8(2): 179.
13. Sharma NK, Cohen RJ, Ruth KJ, Crawford K, Li J, Buyyounouski MK, Feigenberg SJ, Uzzo RG, Horwitz EM. Sleeved Seeds Decrease Gastrointestinal and Genitourinary Toxicity Profiles in Real-time Intra-operatively Planned Permanent 1-125 implants. Poster presentation at the 2009 Annual ABS meeting, May, 2009. Brachytherapy, 8(2): 179.
14. Cohen RJ, Sharma NK, Ruth KJ, Buyyounouski MK, Li J, Crawford K, Feigenberg SJ, Chen DYT, Uzzo RG, Horwitz EM. Is MRI-based Week Three Post-implant Dosimetry Necessary following LDR Prostate Brachytherapy? Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys., 75(3): S298, 2009.
15. Horwitz EM, Ruth KJ, Sharma NK, Chen DYT, Buyyounouski MK, Uzzo RG. Undetectable Post-treatment PSA Following 3DCRT or IMRT Alone for Patients with Low or Intermediate Risk Prostate Cancer is an Independent Predictor of Biochemical and Clinical Outcome. Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys., 75(3): S301, 2009.
Navesh K. Sharma, DO, PhD
16. Sharma NK, Ruth KJ, Boorjian SA, Uzzo RG, Buyyounouski MK, Horwitz EM. Initial PSA (iPSA) and Radiation Dose Predict for an Undetectable PSA Following 3DCRT or IMRT for Low-intermediate Risk Prostate Cancer. Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys., 75(3): S313, 2009.
17. Nichols R, Huh S, Prado K, Yi BY, Sharma NK, Ho MW, Hoppe BS, Mendenhall WM, Mendenhall NP, Regine WF. Protons Offer Reduced Normal Tissue Exposure for Patients Receiving Postoperative Radiotherapy (RT) for Resected Pancreatic Head Cancer, Poster Presentation at the 52nd annual ASTRO meeting, November 2010. Int, J. of Rad Oncol. Biol. Phys., 78(3): S332, 2010.
18. Horwitz EM, Sharma NK, Ruth K, Silverman JS, Buyyounouski MK, Chen DYT, Greenberg RE, Uzzo RG. The Role of Adjuvant and Salvage Post-Prostatectomy IMRT or 3DCRT: The Fox Chase Experience, Poster Presentation at the 52nd annual ASTRO meeting, November 2010. Int, J. of Rad Onc. Biol. Phys., 78(3): S333-8334, 2010.
19. Sharma NK, Mahmood U, Hanna N, Alexander HR, Pandya N, Horiba M, and Regine WR. Effects of Racial/Social Factors and INT-0116/MAGIC Trials Publication on Radiation Therapy (RT) Utilization for Gastric Cancer. Int. J. of Rad Oncol. Biol. Phys., 81(2): S327, 2011.
20. Nichols EM, Grabowski S, Hanlon A, Regine WR, Patel R, Kudryasheva S, Garofalo M, Amin P, Moeslein F, and Sharma NK. Performance Status (PS), Number of Lesions and Interval from Metastatic Diagnosis to Treatment (IMDTT) Predict for Overall Survival (OS) in Patients Treated with Hepatic Transarterial Radioembolization (TARE) using Yttrium-90 (Y90) Microspheres. Int. J. Rad. Oncol. Biol. Phys., 81(2): S2281, 2011.
21. Grabowski S, Nichols EM, Hanlon A, Regine WR, Patel R, Kudryasheva S, Garofalo M, Amin P, Moeslein F, and Sharma NK. The Efficacy of Selective Internal Radiation therapy (SIRT) with Yttrium-90 (Y90) is Enhanced When Given in Low Volume Disease and in Conjunction With Other Liver-Directed Therapies. Int. J. Rad. Oncol. Biol. Phys., 81(2): S2296, 2011.
22. Sharma NK, Nichols EM, Grabowski S, Amin P, Garofalo M, Hanlon A, Patel R, Horiba M and Moeslein F. Early Intervention with Selective Internal Radiation Therapy (SIRT) Improves Local/Systemic Options. Radiother. Oncol., 103(2): S161, 2012.
23. Kennedy AS, Ball D, Cohen SJ, Cohn M, Coldwell DM, Drooz A, Ehrenwald E, Kanani S, Rose SC, Nutting CW, Moeslein FM, Savin M, Schirm Sabine, Sharma NK, Wang E., U.S. patients receiving resin 90Y microspheres for unresectable colorectal liver metastases: A multicenter study of 506 patients. J. Clin. Oncol., 30, 2012.
Navesh K. Sharma, DO, PhD
24. Yang X, Reese AS, Mutaf YD, Prado KL, Sharma NK, Feigenberg SJ, Regine WF, Yi B. Dosimetric Validation of Respiratory Motion Margins for Patients With Pancreatic Cancer Using Deformable 40 Contour Propagation. Int. J. Rad. Oncol. Biol. Phys., 84(3): S778- 8779, 2012.
25. Lu W, Sharma NK, Feigenberg SJ, Regine WF, Yi B. Deformable Image Registration as a Method to Assess Motion for Pancreatic Cancer Using 4D Computed Tomography (CT) Scans. Int. J. Rad. Oncol. Biol. Phys., 84(3): S771, 2012.
26. Kennedy AS, Ball D, Cohen S, Cohn M, Coldwell A, Drooz A, Ehrenwald E, Kanani S, Moeslein FM, Nutting CW, Putnam SG, Rose SC, Savin M, Schirm S, Sharma NK and Wang E. Safety and Efficacy of Yttrium-90 Resin Microspheres in Elderly (> 70 years) Compared to Younger Patients with Colorectal Liver Metastases. ASCO meeting, June 2013.
27. Sharma NK, Chaudhry H, Horiba M, Hanna NN, Alexander HR, Hausner PF, Regine WF, Amin PP, Kudryasheva S, Moeslein FM. Association Between K-ras Mutation Status And Survival In mCRC Patients Undergoing Selective Internal Radiation Therapy (SIRT) to the Liver Using Yttrium-90 Coated Resin Microspheres. ASTRO meeting, September 2013.
28. Rutenberg MS, Errens MA, Sharma NK, Yang X, Yi B, Regine WF. A Comparison Between Consensus Guidelines Based PTVs And 4D-CT Based PTVs For Locally Advanced Pancreatic Cancer: Implications For Therapy. Digital poster discussion at the ASTRO meeting, September 2013.
29. Carrier F, Chang ET, Nguyen D, Sharma NK. Investigation of Low Dose Fractionated Radiation Therapy as a Chemopotentiator in Advanced/Metastatic Gastrointestinal Carcinoma. ASTRO meeting, September 2013.
30. Mooney K, Chen S, Feigenberg SJ, Sharma NK, D'Souza WD. A Population-based Treatment Margin for Respiratory Motion of Lung Tumors. ASTRO meeting, September 2013.
31. Chaudhry HE, Ellison TA, Maidment III BW, Regine WF, Alexander HR, Hanna NN, Wolfgang CL, Morris CG, Herman JM, Sharma NK. Radiation Therapy in Pancreatic Neuroendocrine Tumors: Favorable Outcomes and Low Toxicity in a Multi-Institutional Experience. ASTRO meeting, September 2013.
32. Cohen RJ, Li L, Mahmood U, Hanlon A, Citron W, Oh M, Dragula C, Cheston S, Sharma NK, Feigenberg SJ. Adjuvant Radiation Improves Breast Cancer Specific Survival in the Eldest Early-Stage Breast Cancer Patients. ASTRO meeting, September 2013.
Navesh K. Sharma, DO, PhD
Authored Research Protocols
1. Sharma NK, Mehra R, Feigenberg SJ (co-principal investigators). A Phase I Study to Determine the Maximum Tolerable Dose (MTD) and Safety of the Mammalian Target of Rapamycin (mTOR) Inhibitor, RAD00 l , With Erlotinib™ and Concurrent External Beam Radiotherapy in the Re-irradiation Setting for Squamous Cell Carcinoma of the Head and Neck.
2. Sharma NK (PI). GCC1324: Neoadjuvant FOLFIRINOX and Stereotactic Body Radiotherapy (SBRT) Followed by Definitive Surgery for Patients with Borderline Resectable Pancreatic Adenocarcinoma: A Single Arm Pilot Study.
3. Sharma NK (PI). GCC 1314: Low Dose Fractionated Radiation Therapy as a Chemopotentiator of FOLFOX Treatment in Select Rectal Cancer Patients Treated with a Neoadjuvant Combined Modality Approach.
Invited Lectures
UMSOM, Dept. Of Internal Medicine
Sep 27, 2010 Radiation Oncology Emergencies and Appropriate Management
UMSOM, Dept. Of Family Medicine
Oct 26, 2010 Principles of Radiation Oncology
School of Medicine Lectures UMSOM Cancer Interest Group (approx. 50 attendees)
Nov 5, 2010 The Role of Radiation Oncology in Gynecologic Cancers and Why Radiation Oncology is an Excellent Career Choice
Grand Rounds, UMSOM, Division of Medical Oncology
Nov 24, 2010 Selective Internal Radiation Therapy and Stereotactic Body Radiotherapy in the Management of Liver Tumors
University of Maryland Colorectal Cancer Conference
Apr 8, 2011 Rectal Cancer- Past, Present and Future Roles for RT
UMSOM, Dept. Of Surgery
Jun 9, 2011 Surgery and RT - Complementary Local Modalities
UMSOM, Division of Medical Oncology
Jun 16, 2011 Combined Modality Therapy and the Role of Radiation Oncology
Navesh K. Sharma, DO, PhD
SIRFLOX International Investigators Meeting
Oct 16, 2011 Selective Internal Radiation Therapy using Y90 Microspheres: A Radiation Oncologists Perspective
Community Clinical Lecture: Frederick Hematology Oncology
Nov 11, 2011 The SIRFLOX Trial: Improving Recruitment and Maintaining Quality
7th Annual Mid-Atlantic ASTRO Review Course
Jan 5, 2012 Lymphoma/Sarcoma- Best of ASTRO
UMSOM, Dept. of Obstetrics/Gynecology
May 1, 2012 Radiation Oncology in the Management of Gynecologic Malignancies
UMSOM, Division of Transplant Surgery
Jul 2, 2012 Radiation Therapy in Liver Malignancies- Changing Perspectives
Carolinas Medical Center, Liver Oncology Section
Nov 13, 2012 Liver Directed Therapy Using Y90 Labeled Microspheres
Upper Chesapeake Medical Center
Dec 12, 2012 Radiation Safety and Fluoroscopy
Jul 23, 2013 Fluoroscopy Radiation Safety
Nov 12, 2013 Safe Usage of Medical Fluoroscopy
8th Annual Mid-Atlantic ASTRO Review Course
Jan 10, 2013 Gynecological Malignancies- Best of ASTRO
FOXFIRE Global Investigators Meeting
Mar 9, 2013 Improving Outcomes in Liver Predominant mCRC with Combined Modality Therapy
Nov 13, 2013 FOXFIRE SIV Global Update
Navesh K. Sharma, DO, PhD
UMSOM, Division of Medical Oncology
Apr 5, 2013 Technological Advances in Radiation Oncology- Reduced Toxicity Through Improved Targeting
Women in Defense: Aberdeen Proving Ground
Oct 10, 2013 Breast Cancer Awareness
14th Annual MedStar Health Radiation Oncology Symposium
Oct 19, 2013 Y90 Radioembolization for Primary and Metastatic Liver Tumors
