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Meetings 01-02: Introduction to Animal Reproduction (2) Meetings 03-04: Reproductive Structures and their Functions (2)
Meetings 05-07: The HPG axis and its Liposoluble and Watersoluble Hormones (3) Meetings 08-09: The Neuroendocrine Control of Male and Female Puberty Onset (2)
Meetings 10-11: REVIEW AND TEST #1 Meetings 12-17: Female and Male Reproduction and Techniques for their Control (6) Meetings 18-19: REVIEW AND TEST #2
Meetings 20-21: Reproductive Behavior and the Spermatozoa in the Female Tract (2) Meetings 22-23: Embryogenesis, Placentation, Parturition and Lactation (3)
Meetings 24-25: Puerperium, Lactation and Reproductive Ageing (2) Meeting 26 Reproductive Pathology and Case Studies (1) Meetings 27-28: REVIEW AND TEST #3 AND TEST #4
Animal Reproduction 14
• JP Advis DVM, Ph.D.
Bartlett Hall, Animal Sciences, Cook,
(732) 932 - 9240, [email protected]
• Course website: rci.rutgers.edu/~advis
• Material to
be covered:
• About
lecture
slides: • There are not intended to be the sole source for studying the course material !!!!!!!!!!!!!!!!
• Slides are good to review the course material after you have study your course textbook
• Slides are a good indicator of the relative importance of lecture topics (see slide # per topic)
• Group slides by titles when using them to review course material. Match lectures and text.
Reproductive Cyclicity
# lectures for cumulative test # 02 book
12 Reproductive cyclicity: terminology and basic concepts 1 - 9
13 Reproductive cyclicity: the follicular phase 1 - 9
14 Reproductive cyclicity: the luteal phase 1 - 9
15 Reproductive cyclicity: techniques for controlling female reproductive processes
1 - 9
16 Endocrinology of the male and the spermatogenesis process 1 - 10
17 Endocrinology of the male and techniques to control male reproductive processes
1 - 10
18 REVIEW – material from lecture # 12 through lecture # 17 1 - 10
19 EXAM # 02 - material from lecture # 01 through lecture # 18 1 - 10
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
a view from
ovary and uterus
During the early luteal phase there is further thickening of the
endometrium, marked growth of the coiled arteries, and
increased complexity of the uterine glands. As the corpus luteum wanes, endometrial thickness is reduced by loss of
ground substance. Increased coiling of spiral arteries causes
ischemia and finally sloughing of endometrium. The upper
portion of the figure shows the corresponding events in the
ovary.
The menstrual and estrous cycle can be seen from
different viewpoints, but are basically the same cycle.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
The luteal phase consists of three processes:
luteinization, formation of a CL, and luteolysis.
LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
a view from the blood
The menstrual and estrous cycle can be seen from
different viewpoints, but are basically the same cycle.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
a view from
ovary and uterus
The menstrual and estrous cycle can be seen from
different viewpoints, but are basically the same cycle.
LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
The menstrual and estrous cycle can be seen from
different viewpoints, but are basically the same cycle.
last lecture
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
The luteal phase consists of three processes:
luteinization, formation of a CL, and luteolysis.
this lecture
Why do
changes in blood
P4 levels occur
from
1 – 7 ???
1
2
3
4
5
6
7
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Formation of the corpus luteum: the preovulatory follicle.
LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Formation of the corpus luteum: the corpus hemorragicum.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Formation of the corpus luteum: the functional CL.
LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Progesterone (P4) has many physiological effects.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Mechanism of progesterone synthesis by luteal cells.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Effect of total and unilateral uterectomy upon the
estrous cycle duration in ewes.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Effect of uterectomy upon estrous cycle duration in ewes.
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Changes in PGF2alpha, OT and OTr, during late diestrus
and proestrus. Possible ligands involved in luteolysis
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Proposed steps resulting in the loss of P4 production
from steroidogenic cells induced by PGF2alpha
How could P4
synthesis be
inhibited ???
What is apoptosis ???
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Proposed mechanism of luteolysis in primates.
Endometrial synthesis of PGF2alpha
Vasoconstriction of
endometrial arterioles
Endometrial necrosis
and sloughing (menses)
Linking OT
and PGF2a
Linking
OT and
PGF2a
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Luteolysis as the initiator of menses
(figure 9-15 in your textbook)
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Blood P4 profiles after CIDR insertion and removal in cows,
or how you can “make money” out of luteolysis
CIDR
insertion
removal
(hours)
(days)
(hours)
P4
P4
LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Blood P4 profiles in the women menstrual cycle after
following various hormonal contraception strategies
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
Influence of PGF2alpha upon cycle length
in the cow
normal estrous cycle –
estrus every 21 days
PGF2a injection day 0 – 6 no effect
PGF2a injection day 6 - 17 cows in estrus in 3 days
The luteal phase
LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
“punch line”, the closest it mimics the real
sequence, the better the technique would be
The luteal phase
How would you
synchronize an
estrous or
menstrual
cycle ???
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LECTURE #14
The luteal phase a view from ovary and uterus, a view from the blood, a view from the hypothalamus and pituitary
The control of luteinization
from corpus hemorragica to
corpus albicans, P4 secretion
The control of luteolysis
utero-ovarian vascular link,
PGF2a and OT, apoptosis
Estrous synchronization
use of CIDR in cows as a model for estrus synchronization
The luteal phase
Presynch and Ovsynch as methods to
synchronize ovulation in cows
Q6
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Comments on your weekly questions
